Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CDK2 (cyclin dependent kinase 2)

Identity

Other aliasCDKN2
p33(CDK2)
HGNC (Hugo) CDK2
LocusID (NCBI) 1017
Atlas_Id 40031
Location 12q13.2  [Link to chromosome band 12q13]
Location_base_pair Starts at 55966769 and ends at 55972789 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CCND1 (11q13.3) / CDK2 (12q13.2)MT2A (16q12.2) / CDK2 (12q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDK2   1771
Cards
Entrez_Gene (NCBI)CDK2  1017  cyclin dependent kinase 2
AliasesCDKN2; p33(CDK2)
GeneCards (Weizmann)CDK2
Ensembl hg19 (Hinxton)ENSG00000123374 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123374 [Gene_View]  chr12:55966769-55972789 [Contig_View]  CDK2 [Vega]
ICGC DataPortalENSG00000123374
TCGA cBioPortalCDK2
AceView (NCBI)CDK2
Genatlas (Paris)CDK2
WikiGenes1017
SOURCE (Princeton)CDK2
Genetics Home Reference (NIH)CDK2
Genomic and cartography
GoldenPath hg38 (UCSC)CDK2  -     chr12:55966769-55972789 +  12q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK2  -     12q13.2   [Description]    (hg19-Feb_2009)
EnsemblCDK2 - 12q13.2 [CytoView hg19]  CDK2 - 12q13.2 [CytoView hg38]
Mapping of homologs : NCBICDK2 [Mapview hg19]  CDK2 [Mapview hg38]
OMIM116953   
Gene and transcription
Genbank (Entrez)AA789250 AA810989 AB012305 AK291941 AK293246
RefSeq transcript (Entrez)NM_001290230 NM_001798 NM_052827
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDK2
Cluster EST : UnigeneHs.689624 [ NCBI ]
CGAP (NCI)Hs.689624
Alternative Splicing GalleryENSG00000123374
Gene ExpressionCDK2 [ NCBI-GEO ]   CDK2 [ EBI - ARRAY_EXPRESS ]   CDK2 [ SEEK ]   CDK2 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1017
GTEX Portal (Tissue expression)CDK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP24941   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP24941  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP24941
Splice isoforms : SwissVarP24941
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   
PhosPhoSitePlusP24941
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK2
DMDM Disease mutations1017
Blocks (Seattle)CDK2
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP24941
Human Protein AtlasENSG00000123374
Peptide AtlasP24941
HPRD00310
IPIIPI00031681   IPI00910650   IPI01025000   IPI01025117   IPI00260318   
Protein Interaction databases
DIP (DOE-UCLA)P24941
IntAct (EBI)P24941
FunCoupENSG00000123374
BioGRIDCDK2
STRING (EMBL)CDK2
ZODIACCDK2
Ontologies - Pathways
QuickGOP24941
Ontology : AmiGOG1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  cyclin-dependent protein kinase holoenzyme complex  chromosome, telomeric region  condensed chromosome  X chromosome  Y chromosome  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  cytoplasm  endosome  centrosome  cytosol  DNA replication  DNA repair  protein phosphorylation  potassium ion transport  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  centriole replication  Ras protein signal transduction  multicellular organism development  positive regulation of cell proliferation  response to organic substance  regulation of G2/M transition of mitotic cell cycle  Cajal body  kinase activity  histone phosphorylation  peptidyl-serine phosphorylation  protein domain specific binding  cyclin binding  cyclin binding  mitotic G1 DNA damage checkpoint  positive regulation of DNA-dependent DNA replication initiation  histone kinase activity  positive regulation of transcription, DNA-templated  metal ion binding  centrosome duplication  cell division  meiotic cell cycle  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  regulation of gene silencing  cellular response to nitric oxide  cyclin A1-CDK2 complex  cyclin A2-CDK2 complex  cyclin E1-CDK2 complex  cyclin E2-CDK2 complex  cyclin-dependent protein kinase activity  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  cyclin-dependent protein kinase holoenzyme complex  chromosome, telomeric region  condensed chromosome  X chromosome  Y chromosome  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  cytoplasm  endosome  centrosome  cytosol  DNA replication  DNA repair  protein phosphorylation  potassium ion transport  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  centriole replication  Ras protein signal transduction  multicellular organism development  positive regulation of cell proliferation  response to organic substance  regulation of G2/M transition of mitotic cell cycle  Cajal body  kinase activity  histone phosphorylation  peptidyl-serine phosphorylation  protein domain specific binding  cyclin binding  cyclin binding  mitotic G1 DNA damage checkpoint  positive regulation of DNA-dependent DNA replication initiation  histone kinase activity  positive regulation of transcription, DNA-templated  metal ion binding  centrosome duplication  cell division  meiotic cell cycle  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  regulation of gene silencing  cellular response to nitric oxide  cyclin A1-CDK2 complex  cyclin A2-CDK2 complex  cyclin E1-CDK2 complex  cyclin E2-CDK2 complex  cyclin-dependent protein kinase activity  regulation of signal transduction by p53 class mediator  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
NDEx NetworkCDK2
Atlas of Cancer Signalling NetworkCDK2
Wikipedia pathwaysCDK2
Orthology - Evolution
OrthoDB1017
GeneTree (enSembl)ENSG00000123374
Phylogenetic Trees/Animal Genes : TreeFamCDK2
HOVERGENP24941
HOGENOMP24941
Homologs : HomoloGeneCDK2
Homology/Alignments : Family Browser (UCSC)CDK2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK2
dbVarCDK2
ClinVarCDK2
1000_GenomesCDK2 
Exome Variant ServerCDK2
ExAC (Exome Aggregation Consortium)CDK2 (select the gene name)
Genetic variants : HAPMAP1017
Genomic Variants (DGV)CDK2 [DGVbeta]
DECIPHERCDK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK2 
Mutations
ICGC Data PortalCDK2 
TCGA Data PortalCDK2 
Broad Tumor PortalCDK2
OASIS PortalCDK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK2
DgiDB (Drug Gene Interaction Database)CDK2
DoCM (Curated mutations)CDK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK2 (select a term)
intoGenCDK2
Cancer3DCDK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM116953   
Orphanet
MedgenCDK2
Genetic Testing Registry CDK2
NextProtP24941 [Medical]
TSGene1017
GENETestsCDK2
Target ValidationCDK2
Huge Navigator CDK2 [HugePedia]
snp3D : Map Gene to Disease1017
BioCentury BCIQCDK2
ClinGenCDK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1017
Chemical/Pharm GKB GenePA101
Clinical trialCDK2
Miscellaneous
canSAR (ICR)CDK2 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK2
EVEXCDK2
GoPubMedCDK2
iHOPCDK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:27:46 CEST 2017

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