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CDK2AP2 (cyclin dependent kinase 2 associated protein 2)

Identity

Alias_namesCDK2-associated protein 2
Alias_symbol (synonym)DOC-1R
p14
Other alias
HGNC (Hugo) CDK2AP2
LocusID (NCBI) 10263
Atlas_Id 40352
Location 11q13.2  [Link to chromosome band 11q13]
Location_base_pair Starts at 67506490 and ends at 67508187 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDK2AP2 (11q13.2) / CDK2AP2 (11q13.2)CDK2AP2 (11q13.2) / GPAT4 (8p11.21)CDK2AP2 (11q13.2) / HOOK2 (19p13.2)
CDK2AP2 (11q13.2) / PFDN5 (12q13.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Soft tissue tumors: an overview


External links

Nomenclature
HGNC (Hugo)CDK2AP2   30833
Cards
Entrez_Gene (NCBI)CDK2AP2  10263  cyclin dependent kinase 2 associated protein 2
AliasesDOC-1R; p14
GeneCards (Weizmann)CDK2AP2
Ensembl hg19 (Hinxton)ENSG00000167797 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167797 [Gene_View]  chr11:67506490-67508187 [Contig_View]  CDK2AP2 [Vega]
ICGC DataPortalENSG00000167797
TCGA cBioPortalCDK2AP2
AceView (NCBI)CDK2AP2
Genatlas (Paris)CDK2AP2
WikiGenes10263
SOURCE (Princeton)CDK2AP2
Genetics Home Reference (NIH)CDK2AP2
Genomic and cartography
GoldenPath hg38 (UCSC)CDK2AP2  -     chr11:67506490-67508187 -  11q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK2AP2  -     11q13.2   [Description]    (hg19-Feb_2009)
EnsemblCDK2AP2 - 11q13.2 [CytoView hg19]  CDK2AP2 - 11q13.2 [CytoView hg38]
Mapping of homologs : NCBICDK2AP2 [Mapview hg19]  CDK2AP2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF089814 AK001498 AK308725 AK310197 BC002850
RefSeq transcript (Entrez)NM_001271849 NM_005851
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDK2AP2
Cluster EST : UnigeneHs.523835 [ NCBI ]
CGAP (NCI)Hs.523835
Alternative Splicing GalleryENSG00000167797
Gene ExpressionCDK2AP2 [ NCBI-GEO ]   CDK2AP2 [ EBI - ARRAY_EXPRESS ]   CDK2AP2 [ SEEK ]   CDK2AP2 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK2AP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10263
GTEX Portal (Tissue expression)CDK2AP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75956   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75956  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75956
Splice isoforms : SwissVarO75956
PhosPhoSitePlusO75956
Domains : Interpro (EBI)DOC_1/2   
Domain families : Pfam (Sanger)CDK2AP (PF09806)   
Domain families : Pfam (NCBI)pfam09806   
Conserved Domain (NCBI)CDK2AP2
DMDM Disease mutations10263
Blocks (Seattle)CDK2AP2
PDB (SRS)2M1L   
PDB (PDBSum)2M1L   
PDB (IMB)2M1L   
PDB (RSDB)2M1L   
Structural Biology KnowledgeBase2M1L   
SCOP (Structural Classification of Proteins)2M1L   
CATH (Classification of proteins structures)2M1L   
SuperfamilyO75956
Human Protein AtlasENSG00000167797
Peptide AtlasO75956
HPRD13242
IPIIPI00027439   IPI00977146   IPI00977642   
Protein Interaction databases
DIP (DOE-UCLA)O75956
IntAct (EBI)O75956
FunCoupENSG00000167797
BioGRIDCDK2AP2
STRING (EMBL)CDK2AP2
ZODIACCDK2AP2
Ontologies - Pathways
QuickGOO75956
Ontology : AmiGOprotein binding  nucleus  cytoplasm  microtubule  regulation of microtubule cytoskeleton organization  regulation of stem cell division  negative regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBIprotein binding  nucleus  cytoplasm  microtubule  regulation of microtubule cytoskeleton organization  regulation of stem cell division  negative regulation of G1/S transition of mitotic cell cycle  
NDEx NetworkCDK2AP2
Atlas of Cancer Signalling NetworkCDK2AP2
Wikipedia pathwaysCDK2AP2
Orthology - Evolution
OrthoDB10263
GeneTree (enSembl)ENSG00000167797
Phylogenetic Trees/Animal Genes : TreeFamCDK2AP2
HOVERGENO75956
HOGENOMO75956
Homologs : HomoloGeneCDK2AP2
Homology/Alignments : Family Browser (UCSC)CDK2AP2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK2AP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK2AP2
dbVarCDK2AP2
ClinVarCDK2AP2
1000_GenomesCDK2AP2 
Exome Variant ServerCDK2AP2
ExAC (Exome Aggregation Consortium)CDK2AP2 (select the gene name)
Genetic variants : HAPMAP10263
Genomic Variants (DGV)CDK2AP2 [DGVbeta]
DECIPHERCDK2AP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK2AP2 
Mutations
ICGC Data PortalCDK2AP2 
TCGA Data PortalCDK2AP2 
Broad Tumor PortalCDK2AP2
OASIS PortalCDK2AP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK2AP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDK2AP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK2AP2
DgiDB (Drug Gene Interaction Database)CDK2AP2
DoCM (Curated mutations)CDK2AP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK2AP2 (select a term)
intoGenCDK2AP2
Cancer3DCDK2AP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenCDK2AP2
Genetic Testing Registry CDK2AP2
NextProtO75956 [Medical]
TSGene10263
GENETestsCDK2AP2
Target ValidationCDK2AP2
Huge Navigator CDK2AP2 [HugePedia]
snp3D : Map Gene to Disease10263
BioCentury BCIQCDK2AP2
ClinGenCDK2AP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10263
Chemical/Pharm GKB GenePA128394572
Clinical trialCDK2AP2
Miscellaneous
canSAR (ICR)CDK2AP2 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK2AP2
EVEXCDK2AP2
GoPubMedCDK2AP2
iHOPCDK2AP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:27:46 CEST 2017

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