Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CDK5 (cyclin-dependent kinase 5)

Identity

Other namesPSSALRE
HGNC (Hugo) CDK5
LocusID (NCBI) 1020
Location 7q36.1
Location_base_pair Starts at 150750902 and ends at 150755052 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615

External links

Nomenclature
HGNC (Hugo)CDK5   1774
Cards
Entrez_Gene (NCBI)CDK5  1020  cyclin-dependent kinase 5
GeneCards (Weizmann)CDK5
Ensembl hg19 (Hinxton) [Gene_View]  chr7:150750902-150755052 [Contig_View]  CDK5 [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chr7:150750902-150755052 [Contig_View]  CDK5 [Vega]
cBioPortalCDK5
AceView (NCBI)CDK5
Genatlas (Paris)CDK5
WikiGenes1020
SOURCE (Princeton)CDK5
Genomic and cartography
GoldenPath hg19 (UCSC)CDK5  -     chr7:150750902-150755052 -  7q36.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CDK5  -     7q36.1   [Description]    (hg38-Dec_2013)
EnsemblCDK5 - 7q36.1 [CytoView hg19]  CDK5 - 7q36.1 [CytoView hg38]
Mapping of homologs : NCBICDK5 [Mapview hg19]  CDK5 [Mapview hg38]
OMIM123831   
Gene and transcription
Genbank (Entrez)AK026533 AY049778 AY927560 BC005115 BP309068
RefSeq transcript (Entrez)NM_001164410 NM_004935
RefSeq genomic (Entrez)AC_000139 NC_000007 NC_018918 NT_007933 NW_001839088 NW_004929333
Consensus coding sequences : CCDS (NCBI)CDK5
Cluster EST : UnigeneHs.647078 [ NCBI ]
CGAP (NCI)Hs.647078
Alternative Splicing : Fast-db (Paris)GSHG0028714
Gene ExpressionCDK5 [ NCBI-GEO ]     CDK5 [ SEEK ]   CDK5 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ00535 (Uniprot)
NextProtQ00535  [Medical]
With graphics : InterProQ00535
Splice isoforms : SwissVarQ00535 (Swissvar)
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Related proteins : CluSTrQ00535
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM Disease mutations1020
Blocks (Seattle)Q00535
PDB (SRS)1H4L    1LFR    1UNG    1UNH    1UNL    3O0G    4AU8   
PDB (PDBSum)1H4L    1LFR    1UNG    1UNH    1UNL    3O0G    4AU8   
PDB (IMB)1H4L    1LFR    1UNG    1UNH    1UNL    3O0G    4AU8   
PDB (RSDB)1H4L    1LFR    1UNG    1UNH    1UNL    3O0G    4AU8   
Peptide AtlasQ00535
HPRD00449
IPIIPI00023530   IPI00827700   
Protein Interaction databases
DIP (DOE-UCLA)Q00535
IntAct (EBI)Q00535
BioGRIDCDK5
IntegromeDBCDK5
STRING (EMBL)CDK5
Ontologies - Pathways
QuickGOQ00535
Ontology : AmiGOneuron migration  synaptic transmission, dopaminergic  p53 binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  ErbB-2 class receptor binding  protein binding  ATP binding  nucleus  cytoplasm  cytosol  intracellular protein transport  nucleocytoplasmic transport  cell cycle  cell-matrix adhesion  synaptic transmission  axon guidance  synapse assembly  skeletal muscle tissue development  blood coagulation  motor neuron axon guidance  cell proliferation  visual learning  embryo development  Schwann cell development  postsynaptic density  membrane  synaptic vesicle exocytosis  kinase activity  phosphorylation  cyclin-dependent protein kinase 5 holoenzyme complex  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  sensory perception of pain  cerebellar cortex formation  hippocampus development  layer formation in cerebral cortex  central nervous system neuron development  corpus callosum development  lamellipodium  cell junction  filopodium  neuron differentiation  neuron differentiation  regulation of cell migration  axon  dendrite  growth cone  negative regulation of axon extension  acetylcholine receptor activator activity  cortical actin cytoskeleton organization  neuron projection development  negative regulation of protein ubiquitination  neuromuscular junction  negative regulation of synaptic plasticity  positive regulation of protein binding  receptor catabolic process  serine phosphorylation of STAT3 protein  synaptic transmission, glutamatergic  protein localization to synapse  regulation of apoptotic process  neuronal cell body  receptor clustering  ErbB-3 class receptor binding  perikaryon  positive regulation of neuron apoptotic process  regulated secretory pathway  postsynaptic membrane  negative regulation of cell cycle  positive regulation of protein kinase activity  negative regulation of proteolysis  negative regulation of transcription, DNA-templated  positive regulation of calcium ion-dependent exocytosis  protein autophosphorylation  negative regulation of protein export from nucleus  ephrin receptor binding  behavioral response to cocaine  regulation of synaptic plasticity  regulation of synaptic plasticity  synaptic vesicle endocytosis  rhythmic process  axon extension  oligodendrocyte differentiation  dendrite morphogenesis  tau-protein kinase activity  cell division  neuron apoptotic process  regulation of excitatory postsynaptic membrane potential  regulation of dendritic spine morphogenesis  calcium ion import  regulation of cell cycle arrest  positive regulation of protein targeting to membrane  negative regulation of neuron death  positive regulation of actin cytoskeleton reorganization  positive regulation of receptor activity  positive regulation of receptor activity  
Ontology : EGO-EBIneuron migration  synaptic transmission, dopaminergic  p53 binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  ErbB-2 class receptor binding  protein binding  ATP binding  nucleus  cytoplasm  cytosol  intracellular protein transport  nucleocytoplasmic transport  cell cycle  cell-matrix adhesion  synaptic transmission  axon guidance  synapse assembly  skeletal muscle tissue development  blood coagulation  motor neuron axon guidance  cell proliferation  visual learning  embryo development  Schwann cell development  postsynaptic density  membrane  synaptic vesicle exocytosis  kinase activity  phosphorylation  cyclin-dependent protein kinase 5 holoenzyme complex  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  sensory perception of pain  cerebellar cortex formation  hippocampus development  layer formation in cerebral cortex  central nervous system neuron development  corpus callosum development  lamellipodium  cell junction  filopodium  neuron differentiation  neuron differentiation  regulation of cell migration  axon  dendrite  growth cone  negative regulation of axon extension  acetylcholine receptor activator activity  cortical actin cytoskeleton organization  neuron projection development  negative regulation of protein ubiquitination  neuromuscular junction  negative regulation of synaptic plasticity  positive regulation of protein binding  receptor catabolic process  serine phosphorylation of STAT3 protein  synaptic transmission, glutamatergic  protein localization to synapse  regulation of apoptotic process  neuronal cell body  receptor clustering  ErbB-3 class receptor binding  perikaryon  positive regulation of neuron apoptotic process  regulated secretory pathway  postsynaptic membrane  negative regulation of cell cycle  positive regulation of protein kinase activity  negative regulation of proteolysis  negative regulation of transcription, DNA-templated  positive regulation of calcium ion-dependent exocytosis  protein autophosphorylation  negative regulation of protein export from nucleus  ephrin receptor binding  behavioral response to cocaine  regulation of synaptic plasticity  regulation of synaptic plasticity  synaptic vesicle endocytosis  rhythmic process  axon extension  oligodendrocyte differentiation  dendrite morphogenesis  tau-protein kinase activity  cell division  neuron apoptotic process  regulation of excitatory postsynaptic membrane potential  regulation of dendritic spine morphogenesis  calcium ion import  regulation of cell cycle arrest  positive regulation of protein targeting to membrane  negative regulation of neuron death  positive regulation of actin cytoskeleton reorganization  positive regulation of receptor activity  positive regulation of receptor activity  
Pathways : BIOCARTAFOSB gene expression and drug abuse [Genes]    Deregulation of CDK5 in Alzheimers Disease [Genes]    Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway [Genes]    Rac 1 cell motility signaling pathway [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]    Estrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes]    Reelin Signaling Pathway [Genes]    Lissencephaly gene (LIS1) in neuronal migration and development [Genes]    Regulation of ck1/cdk5 by type 1 glutamate receptors [Genes]   
Pathways : KEGGAxon guidance    Alzheimer's disease    Cocaine addiction   
Protein Interaction DatabaseCDK5
DoCM (Curated mutations)CDK5
Wikipedia pathwaysCDK5
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCDK5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK5
dbVarCDK5
ClinVarCDK5
1000_GenomesCDK5 
Exome Variant ServerCDK5
SNP (GeneSNP Utah)CDK5
SNP : HGBaseCDK5
Genetic variants : HAPMAPCDK5
Genomic VariantsCDK5  CDK5 [DGVbeta]
Mutations
Somatic Mutations in Cancer : COSMICCDK5 
CONAN: Copy Number AnalysisCDK5 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:150750902-150755052
Mutations and Diseases : HGMDCDK5
OMIM123831   
MedgenCDK5
NextProtQ00535 [Medical]
GENETestsCDK5
Disease Genetic AssociationCDK5
Huge Navigator CDK5 [HugePedia]  CDK5 [HugeCancerGEM]
snp3D : Map Gene to Disease1020
DGIdb (Drug Gene Interaction db)CDK5
General knowledge
Homologs : HomoloGeneCDK5
Homology/Alignments : Family Browser (UCSC)CDK5
Phylogenetic Trees/Animal Genes : TreeFamCDK5
Chemical/Protein Interactions : CTD1020
Chemical/Pharm GKB GenePA26310
Clinical trialCDK5
Other databases
Probes
Litterature
PubMed247 Pubmed reference(s) in Entrez
CoreMineCDK5
GoPubMedCDK5
iHOPCDK5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 20:45:42 CET 2014
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