| Nomenclature |
|---|
| HGNC (Hugo) | CDK5 1774 |
| Cards |
|---|
| Entrez_Gene (NCBI) | CDK5 1020 cyclin-dependent kinase 5 |
| Aliases | LIS7; PSSALRE |
| GeneCards (Weizmann) | CDK5 |
| Ensembl hg19 (Hinxton) | ENSG00000164885 [Gene_View] chr7:150750899-150755052 [Contig_View] CDK5 [Vega] |
| Ensembl hg38 (Hinxton) | ENSG00000164885 [Gene_View] chr7:150750899-150755052 [Contig_View] CDK5 [Vega] |
| ICGC DataPortal | ENSG00000164885 |
| TCGA cBioPortal | CDK5 |
| AceView (NCBI) | CDK5 |
| Genatlas (Paris) | CDK5 |
| WikiGenes | 1020 |
| SOURCE (Princeton) | CDK5 |
| Genomic and cartography |
|---|
| GoldenPath hg19 (UCSC) | CDK5 - chr7:150750899-150755052 - 7q36.1 [Description] (hg19-Feb_2009) |
| GoldenPath hg38 (UCSC) | CDK5 - 7q36.1 [Description] (hg38-Dec_2013) |
| Ensembl | CDK5 - 7q36.1 [CytoView hg19] CDK5 - 7q36.1 [CytoView hg38] |
| Mapping of homologs : NCBI | CDK5 [Mapview hg19] CDK5 [Mapview hg38] |
| OMIM | 123831 616342 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK026533 AY049778 AY927560 BC005115 BP309068 |
| RefSeq transcript (Entrez) | NM_001164410 NM_004935 |
| RefSeq genomic (Entrez) | NC_000007 NC_018918 NG_042167 NT_007933 NW_004929333 |
| Consensus coding sequences : CCDS (NCBI) | CDK5 |
| Cluster EST : Unigene | Hs.647078 [ NCBI ] |
| CGAP (NCI) | Hs.647078 |
| Alternative Splicing Gallery | ENSG00000164885 |
| Gene Expression | CDK5 [ NCBI-GEO ] CDK5 [ EBI - ARRAY_EXPRESS ]
CDK5 [ SEEK ] CDK5 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | CDK5 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 1020 |
| GTEX Portal (Tissue expression) | CDK5 |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q00535 (Uniprot) |
| NextProt | Q00535 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q00535 |
| Splice isoforms : SwissVar | Q00535 (Swissvar) |
| Catalytic activity : Enzyme | 2.7.11.1 [ Enzyme-Expasy ] 2.7.11.12.7.11.1 [ IntEnz-EBI ] 2.7.11.1 [ BRENDA ] 2.7.11.1 [ KEGG ] |
| PhosPhoSitePlus | Q00535 |
| Domaine pattern : Prosite (Expaxy) | PROTEIN_KINASE_ATP (PS00107) PROTEIN_KINASE_DOM (PS50011) PROTEIN_KINASE_ST (PS00108) |
| Domains : Interpro (EBI) | Kinase-like_dom Prot_kinase_dom Protein_kinase_ATP_BS Ser/Thr_dual-sp_kinase Ser/Thr_kinase_AS |
| Domain families : Pfam (Sanger) | Pkinase (PF00069) |
| Domain families : Pfam (NCBI) | pfam00069 |
| Domain families : Smart (EMBL) | S_TKc (SM00220) |
| DMDM Disease mutations | 1020 |
| Blocks (Seattle) | CDK5 |
| PDB (SRS) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| PDB (PDBSum) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| PDB (IMB) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| PDB (RSDB) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| Structural Biology KnowledgeBase | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| SCOP (Structural Classification of Proteins) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| CATH (Classification of proteins structures) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| Superfamily | Q00535 |
| Human Protein Atlas | ENSG00000164885 |
| Peptide Atlas | Q00535 |
| HPRD | 00449 |
| IPI | IPI00023530 IPI00827700 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q00535 |
| IntAct (EBI) | Q00535 |
| FunCoup | ENSG00000164885 |
| BioGRID | CDK5 |
| STRING (EMBL) | CDK5 |
| ZODIAC | CDK5 |
| Ontologies - Pathways |
|---|
| QuickGO | Q00535 |
| Ontology : AmiGO | neuron migration synaptic transmission, dopaminergic p53 binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ErbB-2 class receptor binding protein binding ATP binding nucleus nucleus nucleoplasm cytoplasm cytoplasm cytosol cytoskeleton plasma membrane intracellular protein transport nucleocytoplasmic transport cell cycle cell-matrix adhesion synaptic transmission synapse assembly skeletal muscle tissue development motor neuron axon guidance cytoskeletal protein binding cell proliferation visual learning response to wounding Schwann cell development postsynaptic density membrane synaptic vesicle exocytosis regulation of macroautophagy kinase activity phosphorylation cyclin-dependent protein kinase 5 holoenzyme complex peptidyl-serine phosphorylation peptidyl-threonine phosphorylation sensory perception of pain protein kinase binding cerebellar cortex formation hippocampus development layer formation in cerebral cortex central nervous system neuron development corpus callosum development lamellipodium cell junction filopodium neuron differentiation neuron differentiation regulation of cell migration axon dendrite growth cone negative regulation of axon extension acetylcholine receptor activator activity cortical actin cytoskeleton organization neuron projection development negative regulation of protein ubiquitination neuromuscular junction negative regulation of synaptic plasticity positive regulation of protein binding receptor catabolic process serine phosphorylation of STAT3 protein synaptic transmission, glutamatergic protein localization to synapse regulation of apoptotic process neuronal cell body receptor clustering ErbB-3 class receptor binding perikaryon positive regulation of neuron apoptotic process postsynaptic membrane negative regulation of cell cycle positive regulation of protein kinase activity negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of calcium ion-dependent exocytosis protein autophosphorylation negative regulation of protein export from nucleus ephrin receptor binding behavioral response to cocaine regulation of synaptic plasticity regulation of synaptic plasticity synaptic vesicle endocytosis rhythmic process axon extension oligodendrocyte differentiation dendrite morphogenesis tau-protein kinase activity cell division neuron apoptotic process excitatory postsynaptic potential regulation of dendritic spine morphogenesis calcium ion import regulation of cell cycle arrest positive regulation of protein targeting to membrane presynapse negative regulation of neuron death regulation of signal transduction by p53 class mediator regulation of synaptic vesicle recycling positive regulation of actin cytoskeleton reorganization positive regulation of receptor activity |
| Ontology : EGO-EBI | neuron migration synaptic transmission, dopaminergic p53 binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ErbB-2 class receptor binding protein binding ATP binding nucleus nucleus nucleoplasm cytoplasm cytoplasm cytosol cytoskeleton plasma membrane intracellular protein transport nucleocytoplasmic transport cell cycle cell-matrix adhesion synaptic transmission synapse assembly skeletal muscle tissue development motor neuron axon guidance cytoskeletal protein binding cell proliferation visual learning response to wounding Schwann cell development postsynaptic density membrane synaptic vesicle exocytosis regulation of macroautophagy kinase activity phosphorylation cyclin-dependent protein kinase 5 holoenzyme complex peptidyl-serine phosphorylation peptidyl-threonine phosphorylation sensory perception of pain protein kinase binding cerebellar cortex formation hippocampus development layer formation in cerebral cortex central nervous system neuron development corpus callosum development lamellipodium cell junction filopodium neuron differentiation neuron differentiation regulation of cell migration axon dendrite growth cone negative regulation of axon extension acetylcholine receptor activator activity cortical actin cytoskeleton organization neuron projection development negative regulation of protein ubiquitination neuromuscular junction negative regulation of synaptic plasticity positive regulation of protein binding receptor catabolic process serine phosphorylation of STAT3 protein synaptic transmission, glutamatergic protein localization to synapse regulation of apoptotic process neuronal cell body receptor clustering ErbB-3 class receptor binding perikaryon positive regulation of neuron apoptotic process postsynaptic membrane negative regulation of cell cycle positive regulation of protein kinase activity negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of calcium ion-dependent exocytosis protein autophosphorylation negative regulation of protein export from nucleus ephrin receptor binding behavioral response to cocaine regulation of synaptic plasticity regulation of synaptic plasticity synaptic vesicle endocytosis rhythmic process axon extension oligodendrocyte differentiation dendrite morphogenesis tau-protein kinase activity cell division neuron apoptotic process excitatory postsynaptic potential regulation of dendritic spine morphogenesis calcium ion import regulation of cell cycle arrest positive regulation of protein targeting to membrane presynapse negative regulation of neuron death regulation of signal transduction by p53 class mediator regulation of synaptic vesicle recycling positive regulation of actin cytoskeleton reorganization positive regulation of receptor activity |
| Pathways : BIOCARTA | FOSB gene expression and drug abuse [Genes] Deregulation of CDK5 in Alzheimers Disease [Genes] Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway [Genes] Rac 1 cell motility signaling pathway [Genes] Bioactive Peptide Induced Signaling Pathway [Genes] Estrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes] Reelin Signaling Pathway [Genes] Lissencephaly gene (LIS1) in neuronal migration and development [Genes] Regulation of ck1/cdk5 by type 1 glutamate receptors [Genes] |
| Pathways : KEGG | Axon guidance Alzheimer's disease Cocaine addiction |
| NDEx Network | CDK5 |
| Atlas of Cancer Signalling Network | CDK5 |
| Wikipedia pathways | CDK5 |
| Orthology - Evolution |
|---|
| OrthoDB | 1020 |
| GeneTree (enSembl) | ENSG00000164885 |
| Phylogenetic Trees/Animal Genes : TreeFam | CDK5 |
| Homologs : HomoloGene | CDK5 |
| Homology/Alignments : Family Browser (UCSC) | CDK5 |
| Gene fusions - Rearrangements |
|---|
| Polymorphisms : SNP, variants |
|---|
| NCBI Variation Viewer | CDK5 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | CDK5 |
| dbVar | CDK5 |
| ClinVar | CDK5 |
| 1000_Genomes | CDK5 |
| Exome Variant Server | CDK5 |
| ExAC (Exome Aggregation Consortium) | CDK5 (select the gene name) |
| Genetic variants : HAPMAP | 1020 |
| Genomic Variants (DGV) | CDK5 [DGVbeta] |
| Mutations |
|---|
| ICGC Data Portal | CDK5 |
| TCGA Data Portal | CDK5 |
| Broad Tumor Portal | CDK5 |
| OASIS Portal | CDK5 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | CDK5 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search CDK5 |
| DgiDB (Drug Gene Interaction Database) | CDK5 |
| DoCM (Curated mutations) | CDK5 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | CDK5 (select a term) |
| intoGen | CDK5 |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] |
| Diseases |
|---|
| DECIPHER (Syndromes) | 7:150750899-150755052 ENSG00000164885 |
| CONAN: Copy Number Analysis | CDK5 |
| Mutations and Diseases : HGMD | CDK5 |
| OMIM | 123831 616342 |
| Medgen | CDK5 |
| Genetic Testing Registry | CDK5
|
| NextProt | Q00535 [Medical] |
| TSGene | 1020 |
| GENETests | CDK5 |
| Huge Navigator |
CDK5 [HugePedia] |
| snp3D : Map Gene to Disease | 1020 |
| BioCentury BCIQ | CDK5 |
| ClinGen | CDK5 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 1020 |
| Chemical/Pharm GKB Gene | PA26310 |
| Clinical trial | CDK5 |
| Miscellaneous |
|---|
| canSAR (ICR) | CDK5 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 281 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | CDK5 |
| EVEX | CDK5 |
| GoPubMed | CDK5 |
| iHOP | CDK5 |
