Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CDK5 (cyclin-dependent kinase 5)

Identity

Alias_symbol (synonym)PSSALRE
HGNC (Hugo) CDK5
LocusID (NCBI) 1020
Atlas_Id 40033
Location 7q36.1  [Link to chromosome band 7q36]
Location_base_pair Starts at 150750899 and ends at 150755052 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AGAP3 (7q36.1) / CDK5 (7q36.1)CDK5 (7q36.1) / SDCBP (8q12.1)RPLP0 (12q24.23) / CDK5 (7q36.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  ins(9;4)(q33;q12q25) CDK5RAP2/PDGFRA


External links

Nomenclature
HGNC (Hugo)CDK5   1774
Cards
Entrez_Gene (NCBI)CDK5  1020  cyclin-dependent kinase 5
AliasesLIS7; PSSALRE
GeneCards (Weizmann)CDK5
Ensembl hg19 (Hinxton)ENSG00000164885 [Gene_View]  chr7:150750899-150755052 [Contig_View]  CDK5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000164885 [Gene_View]  chr7:150750899-150755052 [Contig_View]  CDK5 [Vega]
ICGC DataPortalENSG00000164885
TCGA cBioPortalCDK5
AceView (NCBI)CDK5
Genatlas (Paris)CDK5
WikiGenes1020
SOURCE (Princeton)CDK5
Genetics Home Reference (NIH)CDK5
Genomic and cartography
GoldenPath hg19 (UCSC)CDK5  -     chr7:150750899-150755052 -  7q36.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CDK5  -     7q36.1   [Description]    (hg38-Dec_2013)
EnsemblCDK5 - 7q36.1 [CytoView hg19]  CDK5 - 7q36.1 [CytoView hg38]
Mapping of homologs : NCBICDK5 [Mapview hg19]  CDK5 [Mapview hg38]
OMIM123831   616342   
Gene and transcription
Genbank (Entrez)AK026533 AY049778 AY927560 BC005115 BP309068
RefSeq transcript (Entrez)NM_001164410 NM_004935
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_042167 NT_007933 NW_004929333
Consensus coding sequences : CCDS (NCBI)CDK5
Cluster EST : UnigeneHs.647078 [ NCBI ]
CGAP (NCI)Hs.647078
Alternative Splicing GalleryENSG00000164885
Gene ExpressionCDK5 [ NCBI-GEO ]   CDK5 [ EBI - ARRAY_EXPRESS ]   CDK5 [ SEEK ]   CDK5 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1020
GTEX Portal (Tissue expression)CDK5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ00535   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ00535  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ00535
Splice isoforms : SwissVarQ00535
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ00535
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK5
DMDM Disease mutations1020
Blocks (Seattle)CDK5
PDB (SRS)1H4L    1LFR    1UNG    1UNH    1UNL    3O0G    4AU8   
PDB (PDBSum)1H4L    1LFR    1UNG    1UNH    1UNL    3O0G    4AU8   
PDB (IMB)1H4L    1LFR    1UNG    1UNH    1UNL    3O0G    4AU8   
PDB (RSDB)1H4L    1LFR    1UNG    1UNH    1UNL    3O0G    4AU8   
Structural Biology KnowledgeBase1H4L    1LFR    1UNG    1UNH    1UNL    3O0G    4AU8   
SCOP (Structural Classification of Proteins)1H4L    1LFR    1UNG    1UNH    1UNL    3O0G    4AU8   
CATH (Classification of proteins structures)1H4L    1LFR    1UNG    1UNH    1UNL    3O0G    4AU8   
SuperfamilyQ00535
Human Protein AtlasENSG00000164885
Peptide AtlasQ00535
HPRD00449
IPIIPI00023530   IPI00827700   
Protein Interaction databases
DIP (DOE-UCLA)Q00535
IntAct (EBI)Q00535
FunCoupENSG00000164885
BioGRIDCDK5
STRING (EMBL)CDK5
ZODIACCDK5
Ontologies - Pathways
QuickGOQ00535
Ontology : AmiGOneuron migration  synaptic transmission, dopaminergic  p53 binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  ErbB-2 class receptor binding  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  cytoskeleton  plasma membrane  intracellular protein transport  nucleocytoplasmic transport  cell cycle  cell-matrix adhesion  synaptic transmission  synapse assembly  skeletal muscle tissue development  motor neuron axon guidance  cytoskeletal protein binding  cell proliferation  visual learning  response to wounding  Schwann cell development  postsynaptic density  membrane  synaptic vesicle exocytosis  regulation of macroautophagy  kinase activity  phosphorylation  cyclin-dependent protein kinase 5 holoenzyme complex  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  sensory perception of pain  protein kinase binding  cerebellar cortex formation  hippocampus development  layer formation in cerebral cortex  central nervous system neuron development  corpus callosum development  lamellipodium  cell junction  filopodium  neuron differentiation  neuron differentiation  regulation of cell migration  axon  dendrite  growth cone  negative regulation of axon extension  acetylcholine receptor activator activity  cortical actin cytoskeleton organization  neuron projection development  negative regulation of protein ubiquitination  neuromuscular junction  negative regulation of synaptic plasticity  positive regulation of protein binding  receptor catabolic process  serine phosphorylation of STAT3 protein  synaptic transmission, glutamatergic  protein localization to synapse  regulation of apoptotic process  neuronal cell body  receptor clustering  ErbB-3 class receptor binding  perikaryon  positive regulation of neuron apoptotic process  postsynaptic membrane  negative regulation of cell cycle  positive regulation of protein kinase activity  negative regulation of proteolysis  negative regulation of transcription, DNA-templated  positive regulation of calcium ion-dependent exocytosis  protein autophosphorylation  negative regulation of protein export from nucleus  ephrin receptor binding  behavioral response to cocaine  regulation of synaptic plasticity  regulation of synaptic plasticity  synaptic vesicle endocytosis  rhythmic process  axon extension  oligodendrocyte differentiation  dendrite morphogenesis  tau-protein kinase activity  cell division  neuron apoptotic process  excitatory postsynaptic potential  regulation of dendritic spine morphogenesis  calcium ion import  regulation of cell cycle arrest  positive regulation of protein targeting to membrane  presynapse  negative regulation of neuron death  regulation of signal transduction by p53 class mediator  regulation of synaptic vesicle recycling  positive regulation of actin cytoskeleton reorganization  positive regulation of receptor activity  
Ontology : EGO-EBIneuron migration  synaptic transmission, dopaminergic  p53 binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  ErbB-2 class receptor binding  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytosol  cytoskeleton  plasma membrane  intracellular protein transport  nucleocytoplasmic transport  cell cycle  cell-matrix adhesion  synaptic transmission  synapse assembly  skeletal muscle tissue development  motor neuron axon guidance  cytoskeletal protein binding  cell proliferation  visual learning  response to wounding  Schwann cell development  postsynaptic density  membrane  synaptic vesicle exocytosis  regulation of macroautophagy  kinase activity  phosphorylation  cyclin-dependent protein kinase 5 holoenzyme complex  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  sensory perception of pain  protein kinase binding  cerebellar cortex formation  hippocampus development  layer formation in cerebral cortex  central nervous system neuron development  corpus callosum development  lamellipodium  cell junction  filopodium  neuron differentiation  neuron differentiation  regulation of cell migration  axon  dendrite  growth cone  negative regulation of axon extension  acetylcholine receptor activator activity  cortical actin cytoskeleton organization  neuron projection development  negative regulation of protein ubiquitination  neuromuscular junction  negative regulation of synaptic plasticity  positive regulation of protein binding  receptor catabolic process  serine phosphorylation of STAT3 protein  synaptic transmission, glutamatergic  protein localization to synapse  regulation of apoptotic process  neuronal cell body  receptor clustering  ErbB-3 class receptor binding  perikaryon  positive regulation of neuron apoptotic process  postsynaptic membrane  negative regulation of cell cycle  positive regulation of protein kinase activity  negative regulation of proteolysis  negative regulation of transcription, DNA-templated  positive regulation of calcium ion-dependent exocytosis  protein autophosphorylation  negative regulation of protein export from nucleus  ephrin receptor binding  behavioral response to cocaine  regulation of synaptic plasticity  regulation of synaptic plasticity  synaptic vesicle endocytosis  rhythmic process  axon extension  oligodendrocyte differentiation  dendrite morphogenesis  tau-protein kinase activity  cell division  neuron apoptotic process  excitatory postsynaptic potential  regulation of dendritic spine morphogenesis  calcium ion import  regulation of cell cycle arrest  positive regulation of protein targeting to membrane  presynapse  negative regulation of neuron death  regulation of signal transduction by p53 class mediator  regulation of synaptic vesicle recycling  positive regulation of actin cytoskeleton reorganization  positive regulation of receptor activity  
Pathways : BIOCARTAFOSB gene expression and drug abuse [Genes]    Deregulation of CDK5 in Alzheimers Disease [Genes]    Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway [Genes]    Rac 1 cell motility signaling pathway [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]    Estrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes]    Reelin Signaling Pathway [Genes]    Lissencephaly gene (LIS1) in neuronal migration and development [Genes]    Regulation of ck1/cdk5 by type 1 glutamate receptors [Genes]   
Pathways : KEGGAxon guidance    Alzheimer's disease    Cocaine addiction   
NDEx NetworkCDK5
Atlas of Cancer Signalling NetworkCDK5
Wikipedia pathwaysCDK5
Orthology - Evolution
OrthoDB1020
GeneTree (enSembl)ENSG00000164885
Phylogenetic Trees/Animal Genes : TreeFamCDK5
HOVERGENQ00535
HOGENOMQ00535
Homologs : HomoloGeneCDK5
Homology/Alignments : Family Browser (UCSC)CDK5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK5
dbVarCDK5
ClinVarCDK5
1000_GenomesCDK5 
Exome Variant ServerCDK5
ExAC (Exome Aggregation Consortium)CDK5 (select the gene name)
Genetic variants : HAPMAP1020
Genomic Variants (DGV)CDK5 [DGVbeta]
DECIPHER (Syndromes)7:150750899-150755052  ENSG00000164885
CONAN: Copy Number AnalysisCDK5 
Mutations
ICGC Data PortalCDK5 
TCGA Data PortalCDK5 
Broad Tumor PortalCDK5
OASIS PortalCDK5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDK5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK5
DgiDB (Drug Gene Interaction Database)CDK5
DoCM (Curated mutations)CDK5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK5 (select a term)
intoGenCDK5
Cancer3DCDK5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123831    616342   
Orphanet
MedgenCDK5
Genetic Testing Registry CDK5
NextProtQ00535 [Medical]
TSGene1020
GENETestsCDK5
Huge Navigator CDK5 [HugePedia]
snp3D : Map Gene to Disease1020
BioCentury BCIQCDK5
ClinGenCDK5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1020
Chemical/Pharm GKB GenePA26310
Clinical trialCDK5
Miscellaneous
canSAR (ICR)CDK5 (select the gene name)
Probes
Litterature
PubMed281 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK5
EVEXCDK5
GoPubMedCDK5
iHOPCDK5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:33:34 CET 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.