| Nomenclature |
|---|
| HGNC (Hugo) | CDK5 1774 |
| Cards |
|---|
| Entrez_Gene (NCBI) | CDK5 cyclin dependent kinase 5 |
| Aliases | LIS7; PSSALRE |
| GeneCards (Weizmann) | CDK5 |
| Ensembl hg19 (Hinxton) | ENSG00000164885 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000164885 [Gene_View] ENSG00000164885 [Sequence] chr7:151053815-151057897 [Contig_View] CDK5 [Vega] |
| ICGC DataPortal | ENSG00000164885 |
| TCGA cBioPortal | CDK5 |
| AceView (NCBI) | CDK5 |
| Genatlas (Paris) | CDK5 |
| SOURCE (Princeton) | CDK5 |
| Genetics Home Reference (NIH) | CDK5 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | CDK5 - chr7:151053815-151057897 - 7q36.1 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | CDK5 - 7q36.1 [Description] (hg19-Feb_2009) |
| GoldenPath | CDK5 - 7q36.1 [CytoView hg19] CDK5 - 7q36.1 [CytoView hg38] |
| ImmunoBase | ENSG00000164885 |
| genome Data Viewer NCBI | CDK5 [Mapview hg19] |
| OMIM | 123831 616342 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK026533 AY049778 AY927560 BC005115 BP309068 |
| RefSeq transcript (Entrez) | NM_001164410 NM_004935 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | CDK5 |
| Alternative Splicing Gallery | ENSG00000164885 |
| Gene Expression | CDK5 [ NCBI-GEO ] CDK5 [ EBI - ARRAY_EXPRESS ]
CDK5 [ SEEK ] CDK5 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | CDK5 [ Firebrowse - Broad ] |
| Genevisible | Expression of CDK5 in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 1020 |
| GTEX Portal (Tissue expression) | CDK5 |
| Human Protein Atlas | ENSG00000164885-CDK5 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q00535 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q00535 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q00535 |
| Splice isoforms : SwissVar | Q00535 |
| Catalytic activity : Enzyme | 2.7.11.1 [ Enzyme-Expasy ] 2.7.11.12.7.11.1 [ IntEnz-EBI ] 2.7.11.1 [ BRENDA ] 2.7.11.1 [ KEGG ] [ MEROPS ] |
| PhosPhoSitePlus | Q00535 |
| Domaine pattern : Prosite (Expaxy) | PROTEIN_KINASE_ATP (PS00107) PROTEIN_KINASE_DOM (PS50011) PROTEIN_KINASE_ST (PS00108) |
| Domains : Interpro (EBI) | Kinase-like_dom_sf Prot_kinase_dom Protein_kinase_ATP_BS Ser/Thr_kinase_AS |
| Domain families : Pfam (Sanger) | Pkinase (PF00069) |
| Domain families : Pfam (NCBI) | pfam00069 |
| Domain families : Smart (EMBL) | S_TKc (SM00220) |
| Conserved Domain (NCBI) | CDK5 |
| Blocks (Seattle) | CDK5 |
| PDB (RSDB) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| PDB Europe | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| PDB (PDBSum) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| PDB (IMB) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| Structural Biology KnowledgeBase | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| SCOP (Structural Classification of Proteins) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| CATH (Classification of proteins structures) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| Superfamily | Q00535 |
| Human Protein Atlas [tissue] | ENSG00000164885-CDK5 [tissue] |
| Peptide Atlas | Q00535 |
| HPRD | 00449 |
| IPI | IPI00023530 IPI00827700 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q00535 |
| IntAct (EBI) | Q00535 |
| BioGRID | CDK5 |
| STRING (EMBL) | CDK5 |
| ZODIAC | CDK5 |
| Ontologies - Pathways |
|---|
| QuickGO | Q00535 |
| Ontology : AmiGO | regulation of transcription involved in G1/S transition of mitotic cell cycle microtubule cytoskeleton organization neuron migration synaptic transmission, dopaminergic p53 binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ErbB-2 class receptor binding protein binding ATP binding nucleus nucleus nucleoplasm nucleoplasm cytoplasm cytoplasm cytosol microtubule plasma membrane protein phosphorylation protein phosphorylation intracellular protein transport nucleocytoplasmic transport mitochondrion organization cell-matrix adhesion chemical synaptic transmission axonogenesis synapse assembly skeletal muscle tissue development microtubule binding motor neuron axon guidance visual learning response to wounding Schwann cell development postsynaptic density membrane synaptic vesicle exocytosis regulation of macroautophagy kinase activity phosphorylation protein kinase 5 complex histone phosphorylation peptidyl-serine phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation sensory perception of pain protein kinase binding cerebellar cortex formation hippocampus development layer formation in cerebral cortex central nervous system neuron development corpus callosum development lamellipodium cell junction filopodium neuron differentiation neuron differentiation regulation of cell migration axon dendrite growth cone negative regulation of axon extension acetylcholine receptor activator activity cortical actin cytoskeleton organization neuron projection development neuron projection development negative regulation of protein ubiquitination neuromuscular junction negative regulation of synaptic plasticity positive regulation of protein binding receptor catabolic process positive regulation of glial cell apoptotic process synaptic transmission, glutamatergic protein localization to synapse serine phosphorylation of STAT protein regulation of apoptotic process neuron projection neuronal cell body receptor clustering ErbB-3 class receptor binding perikaryon positive regulation of neuron apoptotic process negative regulation of cell cycle positive regulation of protein kinase activity negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of calcium ion-dependent exocytosis protein autophosphorylation negative regulation of protein export from nucleus ephrin receptor binding behavioral response to cocaine tau protein binding regulation of synaptic plasticity regulation of synaptic plasticity synaptic vesicle endocytosis synaptic vesicle transport rhythmic process axon extension oligodendrocyte differentiation dendrite morphogenesis tau-protein kinase activity tau-protein kinase activity cell division neuron apoptotic process neuron apoptotic process Hsp90 protein binding regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential regulation of dendritic spine morphogenesis calcium ion import regulation of cell cycle arrest positive regulation of protein targeting to membrane Schaffer collateral - CA1 synapse presynapse synapse pruning glutamatergic synapse regulation of neurotransmitter receptor activity voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration protein serine kinase activity protein threonine kinase activity negative regulation of neuron death positive regulation of voltage-gated calcium channel activity regulation of signal transduction by p53 class mediator regulation of protein localization to plasma membrane regulation of synaptic vesicle recycling cellular response to amyloid-beta positive regulation of actin cytoskeleton reorganization |
| Ontology : EGO-EBI | regulation of transcription involved in G1/S transition of mitotic cell cycle microtubule cytoskeleton organization neuron migration synaptic transmission, dopaminergic p53 binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ErbB-2 class receptor binding protein binding ATP binding nucleus nucleus nucleoplasm nucleoplasm cytoplasm cytoplasm cytosol microtubule plasma membrane protein phosphorylation protein phosphorylation intracellular protein transport nucleocytoplasmic transport mitochondrion organization cell-matrix adhesion chemical synaptic transmission axonogenesis synapse assembly skeletal muscle tissue development microtubule binding motor neuron axon guidance visual learning response to wounding Schwann cell development postsynaptic density membrane synaptic vesicle exocytosis regulation of macroautophagy kinase activity phosphorylation protein kinase 5 complex histone phosphorylation peptidyl-serine phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation sensory perception of pain protein kinase binding cerebellar cortex formation hippocampus development layer formation in cerebral cortex central nervous system neuron development corpus callosum development lamellipodium cell junction filopodium neuron differentiation neuron differentiation regulation of cell migration axon dendrite growth cone negative regulation of axon extension acetylcholine receptor activator activity cortical actin cytoskeleton organization neuron projection development neuron projection development negative regulation of protein ubiquitination neuromuscular junction negative regulation of synaptic plasticity positive regulation of protein binding receptor catabolic process positive regulation of glial cell apoptotic process synaptic transmission, glutamatergic protein localization to synapse serine phosphorylation of STAT protein regulation of apoptotic process neuron projection neuronal cell body receptor clustering ErbB-3 class receptor binding perikaryon positive regulation of neuron apoptotic process negative regulation of cell cycle positive regulation of protein kinase activity negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of calcium ion-dependent exocytosis protein autophosphorylation negative regulation of protein export from nucleus ephrin receptor binding behavioral response to cocaine tau protein binding regulation of synaptic plasticity regulation of synaptic plasticity synaptic vesicle endocytosis synaptic vesicle transport rhythmic process axon extension oligodendrocyte differentiation dendrite morphogenesis tau-protein kinase activity tau-protein kinase activity cell division neuron apoptotic process neuron apoptotic process Hsp90 protein binding regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential regulation of dendritic spine morphogenesis calcium ion import regulation of cell cycle arrest positive regulation of protein targeting to membrane Schaffer collateral - CA1 synapse presynapse synapse pruning glutamatergic synapse regulation of neurotransmitter receptor activity voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration protein serine kinase activity protein threonine kinase activity negative regulation of neuron death positive regulation of voltage-gated calcium channel activity regulation of signal transduction by p53 class mediator regulation of protein localization to plasma membrane regulation of synaptic vesicle recycling cellular response to amyloid-beta positive regulation of actin cytoskeleton reorganization |
| Pathways : BIOCARTA | FOSB gene expression and drug abuse [Genes] Deregulation of CDK5 in Alzheimers Disease [Genes] Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway [Genes] Rac 1 cell motility signaling pathway [Genes] Bioactive Peptide Induced Signaling Pathway [Genes] Estrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes] Reelin Signaling Pathway [Genes] Lissencephaly gene (LIS1) in neuronal migration and development [Genes] Regulation of ck1/cdk5 by type 1 glutamate receptors [Genes] |
| Pathways : KEGG | Axon guidance Alzheimer's disease Cocaine addiction |
| NDEx Network | CDK5 |
| Atlas of Cancer Signalling Network | CDK5 |
| Wikipedia pathways | CDK5 |
| Orthology - Evolution |
|---|
| OrthoDB | 1020 |
| GeneTree (enSembl) | ENSG00000164885 |
| Phylogenetic Trees/Animal Genes : TreeFam | CDK5 |
| HOGENOM | Q00535 |
| Homologs : HomoloGene | CDK5 |
| Homology/Alignments : Family Browser (UCSC) | CDK5 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | CDK5 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | CDK5 [hg38] |
| dbVar | CDK5 |
| ClinVar | CDK5 |
| Monarch | CDK5 |
| 1000_Genomes | CDK5 |
| Exome Variant Server | CDK5 |
| GNOMAD Browser | ENSG00000164885 |
| Varsome Browser | CDK5 |
| Genomic Variants (DGV) | CDK5 [DGVbeta] |
| DECIPHER | CDK5 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | CDK5 |
| Mutations |
|---|
| ICGC Data Portal | CDK5 |
| TCGA Data Portal | CDK5 |
| Broad Tumor Portal | CDK5 |
| OASIS Portal | CDK5 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | CDK5 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | CDK5 |
| Mutations and Diseases : HGMD | CDK5 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search CDK5 |
| DgiDB (Drug Gene Interaction Database) | CDK5 |
| DoCM (Curated mutations) | CDK5 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | CDK5 (select a term) |
| intoGen | CDK5 |
| Cancer3D | CDK5(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 123831 616342 |
| Orphanet | |
| DisGeNET | CDK5 |
| Medgen | CDK5 |
| Genetic Testing Registry | CDK5
|
| NextProt | Q00535 [Medical] |
| GENETests | CDK5 |
| Target Validation | CDK5 |
| Huge Navigator |
CDK5 [HugePedia] |
| ClinGen | CDK5 |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | CDK5 |
| Protein Interactions : CTD | |
| Pharm GKB Gene | PA26310 |
| Pharm GKB Pathways | PA162355621 |
| Pharos | Q00535 |
| Clinical trial | CDK5 |
| Miscellaneous |
|---|
| canSAR (ICR) | CDK5 (select the gene name) |
| Harmonizome | CDK5 |
| DataMed Index | CDK5 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 395 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | CDK5 |
