Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CDK5 (cyclin dependent kinase 5)

Identity

Alias (NCBI)LIS7
PSSALRE
HGNC (Hugo) CDK5
HGNC Alias symbPSSALRE
LocusID (NCBI) 1020
Atlas_Id 40033
Location 7q36.1  [Link to chromosome band 7q36]
Location_base_pair Starts at 151053815 and ends at 151057897 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AGAP3 (7q36.1) / CDK5 (7q36.1)CDK5 (7q36.1) / SDCBP (8q12.1)RPLP0 (12q24.23) / CDK5 (7q36.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  ins(9;4)(q33;q12q25) CDK5RAP2/PDGFRA

External links

 

Nomenclature
HGNC (Hugo)CDK5   1774
Cards
Entrez_Gene (NCBI)CDK5    cyclin dependent kinase 5
AliasesLIS7; PSSALRE
GeneCards (Weizmann)CDK5
Ensembl hg19 (Hinxton)ENSG00000164885 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164885 [Gene_View]  ENSG00000164885 [Sequence]  chr7:151053815-151057897 [Contig_View]  CDK5 [Vega]
ICGC DataPortalENSG00000164885
TCGA cBioPortalCDK5
AceView (NCBI)CDK5
Genatlas (Paris)CDK5
SOURCE (Princeton)CDK5
Genetics Home Reference (NIH)CDK5
Genomic and cartography
GoldenPath hg38 (UCSC)CDK5  -     chr7:151053815-151057897 -  7q36.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK5  -     7q36.1   [Description]    (hg19-Feb_2009)
GoldenPathCDK5 - 7q36.1 [CytoView hg19]  CDK5 - 7q36.1 [CytoView hg38]
ImmunoBaseENSG00000164885
Genome Data Viewer NCBICDK5 [Mapview hg19]  
OMIM123831   616342   
Gene and transcription
Genbank (Entrez)AK026533 AY049778 AY927560 BC005115 BP309068
RefSeq transcript (Entrez)NM_001164410 NM_004935
Consensus coding sequences : CCDS (NCBI)CDK5
Gene ExpressionCDK5 [ NCBI-GEO ]   CDK5 [ EBI - ARRAY_EXPRESS ]   CDK5 [ SEEK ]   CDK5 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK5 [ Firebrowse - Broad ]
GenevisibleExpression of CDK5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1020
GTEX Portal (Tissue expression)CDK5
Human Protein AtlasENSG00000164885-CDK5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ00535   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ00535  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ00535
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ00535
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK5
PDB (RSDB)1H4L    1LFR    1UNG    1UNH    1UNL    3O0G    4AU8   
PDB Europe1H4L    1LFR    1UNG    1UNH    1UNL    3O0G    4AU8   
PDB (PDBSum)1H4L    1LFR    1UNG    1UNH    1UNL    3O0G    4AU8   
PDB (IMB)1H4L    1LFR    1UNG    1UNH    1UNL    3O0G    4AU8   
Structural Biology KnowledgeBase1H4L    1LFR    1UNG    1UNH    1UNL    3O0G    4AU8   
SCOP (Structural Classification of Proteins)1H4L    1LFR    1UNG    1UNH    1UNL    3O0G    4AU8   
CATH (Classification of proteins structures)1H4L    1LFR    1UNG    1UNH    1UNL    3O0G    4AU8   
SuperfamilyQ00535
AlphaFold pdb e-kbQ00535   
Human Protein Atlas [tissue]ENSG00000164885-CDK5 [tissue]
HPRD00449
Protein Interaction databases
DIP (DOE-UCLA)Q00535
IntAct (EBI)Q00535
BioGRIDCDK5
STRING (EMBL)CDK5
ZODIACCDK5
Ontologies - Pathways
QuickGOQ00535
Ontology : AmiGOregulation of transcription involved in G1/S transition of mitotic cell cycle  microtubule cytoskeleton organization  neuron migration  synaptic transmission, dopaminergic  p53 binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  ErbB-2 class receptor binding  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  cytosol  microtubule  plasma membrane  protein phosphorylation  protein phosphorylation  intracellular protein transport  nucleocytoplasmic transport  mitochondrion organization  cell-matrix adhesion  chemical synaptic transmission  axonogenesis  synapse assembly  skeletal muscle tissue development  microtubule binding  motor neuron axon guidance  visual learning  response to wounding  Schwann cell development  postsynaptic density  membrane  synaptic vesicle exocytosis  regulation of macroautophagy  kinase activity  phosphorylation  protein kinase 5 complex  histone phosphorylation  peptidyl-serine phosphorylation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  sensory perception of pain  protein kinase binding  cerebellar cortex formation  hippocampus development  layer formation in cerebral cortex  central nervous system neuron development  corpus callosum development  lamellipodium  cell junction  filopodium  neuron differentiation  neuron differentiation  regulation of cell migration  axon  dendrite  growth cone  negative regulation of axon extension  acetylcholine receptor activator activity  cortical actin cytoskeleton organization  neuron projection development  neuron projection development  negative regulation of protein ubiquitination  neuromuscular junction  negative regulation of synaptic plasticity  positive regulation of protein binding  receptor catabolic process  positive regulation of glial cell apoptotic process  synaptic transmission, glutamatergic  protein localization to synapse  serine phosphorylation of STAT protein  regulation of apoptotic process  neuron projection  neuronal cell body  receptor clustering  ErbB-3 class receptor binding  perikaryon  positive regulation of neuron apoptotic process  negative regulation of cell cycle  positive regulation of protein kinase activity  negative regulation of proteolysis  negative regulation of transcription, DNA-templated  positive regulation of calcium ion-dependent exocytosis  protein autophosphorylation  negative regulation of protein export from nucleus  ephrin receptor binding  behavioral response to cocaine  tau protein binding  regulation of synaptic plasticity  regulation of synaptic plasticity  synaptic vesicle endocytosis  synaptic vesicle transport  rhythmic process  axon extension  oligodendrocyte differentiation  dendrite morphogenesis  tau-protein kinase activity  tau-protein kinase activity  cell division  neuron apoptotic process  neuron apoptotic process  regulation of cell cycle  Hsp90 protein binding  regulation of synaptic transmission, glutamatergic  excitatory postsynaptic potential  regulation of dendritic spine morphogenesis  calcium ion import  positive regulation of protein targeting to membrane  Schaffer collateral - CA1 synapse  presynapse  synapse pruning  glutamatergic synapse  voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels  induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration  protein serine kinase activity  protein threonine kinase activity  negative regulation of neuron death  positive regulation of voltage-gated calcium channel activity  regulation of signal transduction by p53 class mediator  regulation of protein localization to plasma membrane  regulation of synaptic vesicle recycling  cellular response to amyloid-beta  positive regulation of actin cytoskeleton reorganization  
Ontology : EGO-EBIregulation of transcription involved in G1/S transition of mitotic cell cycle  microtubule cytoskeleton organization  neuron migration  synaptic transmission, dopaminergic  p53 binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  ErbB-2 class receptor binding  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  cytosol  microtubule  plasma membrane  protein phosphorylation  protein phosphorylation  intracellular protein transport  nucleocytoplasmic transport  mitochondrion organization  cell-matrix adhesion  chemical synaptic transmission  axonogenesis  synapse assembly  skeletal muscle tissue development  microtubule binding  motor neuron axon guidance  visual learning  response to wounding  Schwann cell development  postsynaptic density  membrane  synaptic vesicle exocytosis  regulation of macroautophagy  kinase activity  phosphorylation  protein kinase 5 complex  histone phosphorylation  peptidyl-serine phosphorylation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  sensory perception of pain  protein kinase binding  cerebellar cortex formation  hippocampus development  layer formation in cerebral cortex  central nervous system neuron development  corpus callosum development  lamellipodium  cell junction  filopodium  neuron differentiation  neuron differentiation  regulation of cell migration  axon  dendrite  growth cone  negative regulation of axon extension  acetylcholine receptor activator activity  cortical actin cytoskeleton organization  neuron projection development  neuron projection development  negative regulation of protein ubiquitination  neuromuscular junction  negative regulation of synaptic plasticity  positive regulation of protein binding  receptor catabolic process  positive regulation of glial cell apoptotic process  synaptic transmission, glutamatergic  protein localization to synapse  serine phosphorylation of STAT protein  regulation of apoptotic process  neuron projection  neuronal cell body  receptor clustering  ErbB-3 class receptor binding  perikaryon  positive regulation of neuron apoptotic process  negative regulation of cell cycle  positive regulation of protein kinase activity  negative regulation of proteolysis  negative regulation of transcription, DNA-templated  positive regulation of calcium ion-dependent exocytosis  protein autophosphorylation  negative regulation of protein export from nucleus  ephrin receptor binding  behavioral response to cocaine  tau protein binding  regulation of synaptic plasticity  regulation of synaptic plasticity  synaptic vesicle endocytosis  synaptic vesicle transport  rhythmic process  axon extension  oligodendrocyte differentiation  dendrite morphogenesis  tau-protein kinase activity  tau-protein kinase activity  cell division  neuron apoptotic process  neuron apoptotic process  regulation of cell cycle  Hsp90 protein binding  regulation of synaptic transmission, glutamatergic  excitatory postsynaptic potential  regulation of dendritic spine morphogenesis  calcium ion import  positive regulation of protein targeting to membrane  Schaffer collateral - CA1 synapse  presynapse  synapse pruning  glutamatergic synapse  voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels  induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration  protein serine kinase activity  protein threonine kinase activity  negative regulation of neuron death  positive regulation of voltage-gated calcium channel activity  regulation of signal transduction by p53 class mediator  regulation of protein localization to plasma membrane  regulation of synaptic vesicle recycling  cellular response to amyloid-beta  positive regulation of actin cytoskeleton reorganization  
Pathways : BIOCARTAFOSB gene expression and drug abuse [Genes]    Deregulation of CDK5 in Alzheimers Disease [Genes]    Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway [Genes]    Rac 1 cell motility signaling pathway [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]    Estrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes]    Reelin Signaling Pathway [Genes]    Lissencephaly gene (LIS1) in neuronal migration and development [Genes]    Regulation of ck1/cdk5 by type 1 glutamate receptors [Genes]   
Pathways : KEGGAxon guidance    Alzheimer's disease    Cocaine addiction   
NDEx NetworkCDK5
Atlas of Cancer Signalling NetworkCDK5
Wikipedia pathwaysCDK5
Orthology - Evolution
OrthoDB1020
GeneTree (enSembl)ENSG00000164885
Phylogenetic Trees/Animal Genes : TreeFamCDK5
Homologs : HomoloGeneCDK5
Homology/Alignments : Family Browser (UCSC)CDK5
Gene fusions - Rearrangements
Fusion : QuiverCDK5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK5
dbVarCDK5
ClinVarCDK5
MonarchCDK5
1000_GenomesCDK5 
Exome Variant ServerCDK5
GNOMAD BrowserENSG00000164885
Varsome BrowserCDK5
ACMGCDK5 variants
VarityQ00535
Genomic Variants (DGV)CDK5 [DGVbeta]
DECIPHERCDK5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK5 
Mutations
ICGC Data PortalCDK5 
TCGA Data PortalCDK5 
Broad Tumor PortalCDK5
OASIS PortalCDK5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCDK5
Mutations and Diseases : HGMDCDK5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCDK5
DgiDB (Drug Gene Interaction Database)CDK5
DoCM (Curated mutations)CDK5
CIViC (Clinical Interpretations of Variants in Cancer)CDK5
Cancer3DCDK5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123831    616342   
Orphanet
DisGeNETCDK5
MedgenCDK5
Genetic Testing Registry CDK5
NextProtQ00535 [Medical]
GENETestsCDK5
Target ValidationCDK5
Huge Navigator CDK5 [HugePedia]
ClinGenCDK5
Clinical trials, drugs, therapy
MyCancerGenomeCDK5
Protein Interactions : CTDCDK5
Pharm GKB GenePA26310
Pharm GKB PathwaysPA162355621   
PharosQ00535
Clinical trialCDK5
Miscellaneous
canSAR (ICR)CDK5
HarmonizomeCDK5
DataMed IndexCDK5
Probes
Litterature
PubMed400 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCDK5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:03:18 CEST 2021
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