| Nomenclature |
|---|
| HGNC (Hugo) | CDK5 1774 |
| Cards |
|---|
| Entrez_Gene (NCBI) | CDK5 1020 cyclin dependent kinase 5 |
| Aliases | LIS7; PSSALRE |
| GeneCards (Weizmann) | CDK5 |
| Ensembl hg19 (Hinxton) | ENSG00000164885 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000164885 [Gene_View] ENSG00000164885 [Sequence] chr7:151053812-151057965 [Contig_View] CDK5 [Vega] |
| ICGC DataPortal | ENSG00000164885 |
| TCGA cBioPortal | CDK5 |
| AceView (NCBI) | CDK5 |
| Genatlas (Paris) | CDK5 |
| WikiGenes | 1020 |
| SOURCE (Princeton) | CDK5 |
| Genetics Home Reference (NIH) | CDK5 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | CDK5 - chr7:151053812-151057965 - 7q36.1 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | CDK5 - 7q36.1 [Description] (hg19-Feb_2009) |
| Ensembl | CDK5 - 7q36.1 [CytoView hg19] CDK5 - 7q36.1 [CytoView hg38] |
| Mapping of homologs : NCBI | CDK5 [Mapview hg19] CDK5 [Mapview hg38] |
| OMIM | 123831 616342 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK026533 AY049778 AY927560 BC005115 BP309068 |
| RefSeq transcript (Entrez) | NM_001164410 NM_004935 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | CDK5 |
| Cluster EST : Unigene | Hs.647078 [ NCBI ] |
| CGAP (NCI) | Hs.647078 |
| Alternative Splicing Gallery | ENSG00000164885 |
| Gene Expression | CDK5 [ NCBI-GEO ] CDK5 [ EBI - ARRAY_EXPRESS ]
CDK5 [ SEEK ] CDK5 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | CDK5 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 1020 |
| GTEX Portal (Tissue expression) | CDK5 |
| Human Protein Atlas | ENSG00000164885-CDK5 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q00535 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q00535 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q00535 |
| Splice isoforms : SwissVar | Q00535 |
| Catalytic activity : Enzyme | 2.7.11.1 [ Enzyme-Expasy ] 2.7.11.12.7.11.1 [ IntEnz-EBI ] 2.7.11.1 [ BRENDA ] 2.7.11.1 [ KEGG ] |
| PhosPhoSitePlus | Q00535 |
| Domaine pattern : Prosite (Expaxy) | PROTEIN_KINASE_ATP (PS00107) PROTEIN_KINASE_DOM (PS50011) PROTEIN_KINASE_ST (PS00108) |
| Domains : Interpro (EBI) | Kinase-like_dom_sf Prot_kinase_dom Protein_kinase_ATP_BS Ser/Thr_kinase_AS |
| Domain families : Pfam (Sanger) | Pkinase (PF00069) |
| Domain families : Pfam (NCBI) | pfam00069 |
| Domain families : Smart (EMBL) | S_TKc (SM00220) |
| Conserved Domain (NCBI) | CDK5 |
| DMDM Disease mutations | 1020 |
| Blocks (Seattle) | CDK5 |
| PDB (SRS) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| PDB (PDBSum) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| PDB (IMB) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| PDB (RSDB) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| Structural Biology KnowledgeBase | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| SCOP (Structural Classification of Proteins) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| CATH (Classification of proteins structures) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| Superfamily | Q00535 |
| Human Protein Atlas [tissue] | ENSG00000164885-CDK5 [tissue] |
| Peptide Atlas | Q00535 |
| HPRD | 00449 |
| IPI | IPI00023530 IPI00827700 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q00535 |
| IntAct (EBI) | Q00535 |
| FunCoup | ENSG00000164885 |
| BioGRID | CDK5 |
| STRING (EMBL) | CDK5 |
| ZODIAC | CDK5 |
| Ontologies - Pathways |
|---|
| QuickGO | Q00535 |
| Ontology : AmiGO | microtubule cytoskeleton organization neuron migration synaptic transmission, dopaminergic p53 binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ErbB-2 class receptor binding protein binding ATP binding nucleus nucleus nucleus nucleoplasm cytoplasm cytoplasm cytosol cytosol cytosol microtubule plasma membrane protein phosphorylation protein phosphorylation intracellular protein transport nucleocytoplasmic transport mitochondrion organization cell cycle cell-matrix adhesion chemical synaptic transmission axonogenesis synapse assembly skeletal muscle tissue development microtubule binding motor neuron axon guidance cell proliferation visual learning response to wounding Schwann cell development postsynaptic density membrane synaptic vesicle exocytosis regulation of macroautophagy kinase activity phosphorylation protein kinase 5 complex peptidyl-serine phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation sensory perception of pain protein kinase binding cerebellar cortex formation hippocampus development layer formation in cerebral cortex central nervous system neuron development corpus callosum development lamellipodium cell junction filopodium neuron differentiation neuron differentiation regulation of cell migration axon dendrite growth cone negative regulation of axon extension acetylcholine receptor activator activity cortical actin cytoskeleton organization neuron projection development neuron projection development negative regulation of protein ubiquitination neuromuscular junction negative regulation of synaptic plasticity positive regulation of protein binding receptor catabolic process positive regulation of glial cell apoptotic process synaptic transmission, glutamatergic protein localization to synapse serine phosphorylation of STAT protein regulation of apoptotic process neuron projection neuronal cell body receptor clustering ErbB-3 class receptor binding perikaryon positive regulation of neuron apoptotic process postsynaptic membrane negative regulation of cell cycle positive regulation of protein kinase activity negative regulation of proteolysis negative regulation of transcription, DNA-templated protein autophosphorylation negative regulation of protein export from nucleus ephrin receptor binding behavioral response to cocaine regulation of synaptic plasticity regulation of synaptic plasticity synaptic vesicle endocytosis synaptic vesicle transport rhythmic process axon extension oligodendrocyte differentiation dendrite morphogenesis tau-protein kinase activity cell division neuron apoptotic process neuron apoptotic process Hsp90 protein binding regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential regulation of dendritic spine morphogenesis calcium ion import regulation of cell cycle arrest positive regulation of protein targeting to membrane Schaffer collateral - CA1 synapse presynapse synapse pruning glutamatergic synapse voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration negative regulation of neuron death regulation of protein localization to plasma membrane regulation of synaptic vesicle recycling cellular response to amyloid-beta positive regulation of actin cytoskeleton reorganization positive regulation of signaling receptor activity |
| Ontology : EGO-EBI | microtubule cytoskeleton organization neuron migration synaptic transmission, dopaminergic p53 binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ErbB-2 class receptor binding protein binding ATP binding nucleus nucleus nucleus nucleoplasm cytoplasm cytoplasm cytosol cytosol cytosol microtubule plasma membrane protein phosphorylation protein phosphorylation intracellular protein transport nucleocytoplasmic transport mitochondrion organization cell cycle cell-matrix adhesion chemical synaptic transmission axonogenesis synapse assembly skeletal muscle tissue development microtubule binding motor neuron axon guidance cell proliferation visual learning response to wounding Schwann cell development postsynaptic density membrane synaptic vesicle exocytosis regulation of macroautophagy kinase activity phosphorylation protein kinase 5 complex peptidyl-serine phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation sensory perception of pain protein kinase binding cerebellar cortex formation hippocampus development layer formation in cerebral cortex central nervous system neuron development corpus callosum development lamellipodium cell junction filopodium neuron differentiation neuron differentiation regulation of cell migration axon dendrite growth cone negative regulation of axon extension acetylcholine receptor activator activity cortical actin cytoskeleton organization neuron projection development neuron projection development negative regulation of protein ubiquitination neuromuscular junction negative regulation of synaptic plasticity positive regulation of protein binding receptor catabolic process positive regulation of glial cell apoptotic process synaptic transmission, glutamatergic protein localization to synapse serine phosphorylation of STAT protein regulation of apoptotic process neuron projection neuronal cell body receptor clustering ErbB-3 class receptor binding perikaryon positive regulation of neuron apoptotic process postsynaptic membrane negative regulation of cell cycle positive regulation of protein kinase activity negative regulation of proteolysis negative regulation of transcription, DNA-templated protein autophosphorylation negative regulation of protein export from nucleus ephrin receptor binding behavioral response to cocaine regulation of synaptic plasticity regulation of synaptic plasticity synaptic vesicle endocytosis synaptic vesicle transport rhythmic process axon extension oligodendrocyte differentiation dendrite morphogenesis tau-protein kinase activity cell division neuron apoptotic process neuron apoptotic process Hsp90 protein binding regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential regulation of dendritic spine morphogenesis calcium ion import regulation of cell cycle arrest positive regulation of protein targeting to membrane Schaffer collateral - CA1 synapse presynapse synapse pruning glutamatergic synapse voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration negative regulation of neuron death regulation of protein localization to plasma membrane regulation of synaptic vesicle recycling cellular response to amyloid-beta positive regulation of actin cytoskeleton reorganization positive regulation of signaling receptor activity |
| Pathways : KEGG | Axon guidance Alzheimer's disease Cocaine addiction |
| NDEx Network | CDK5 |
| Atlas of Cancer Signalling Network | CDK5 |
| Wikipedia pathways | CDK5 |
| Orthology - Evolution |
|---|
| OrthoDB | 1020 |
| GeneTree (enSembl) | ENSG00000164885 |
| Phylogenetic Trees/Animal Genes : TreeFam | CDK5 |
| HOVERGEN | Q00535 |
| HOGENOM | Q00535 |
| Homologs : HomoloGene | CDK5 |
| Homology/Alignments : Family Browser (UCSC) | CDK5 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | CDK5 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | CDK5 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | CDK5 |
| dbVar | CDK5 |
| ClinVar | CDK5 |
| 1000_Genomes | CDK5 |
| Exome Variant Server | CDK5 |
| ExAC (Exome Aggregation Consortium) | ENSG00000164885 |
| GNOMAD Browser | ENSG00000164885 |
| Varsome Browser | CDK5 |
| Genetic variants : HAPMAP | 1020 |
| Genomic Variants (DGV) | CDK5 [DGVbeta] |
| DECIPHER | CDK5 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | CDK5 |
| Mutations |
|---|
| ICGC Data Portal | CDK5 |
| TCGA Data Portal | CDK5 |
| Broad Tumor Portal | CDK5 |
| OASIS Portal | CDK5 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | CDK5 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | CDK5 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search CDK5 |
| DgiDB (Drug Gene Interaction Database) | CDK5 |
| DoCM (Curated mutations) | CDK5 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | CDK5 (select a term) |
| intoGen | CDK5 |
| Cancer3D | CDK5(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 123831 616342 |
| Orphanet | |
| DisGeNET | CDK5 |
| Medgen | CDK5 |
| Genetic Testing Registry | CDK5
|
| NextProt | Q00535 [Medical] |
| TSGene | 1020 |
| GENETests | CDK5 |
| Target Validation | CDK5 |
| Huge Navigator |
CDK5 [HugePedia] |
| snp3D : Map Gene to Disease | 1020 |
| BioCentury BCIQ | CDK5 |
| ClinGen | CDK5 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 1020 |
| Chemical/Pharm GKB Gene | PA26310 |
| Clinical trial | CDK5 |
| Miscellaneous |
|---|
| canSAR (ICR) | CDK5 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 330 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | CDK5 |
| EVEX | CDK5 |
| GoPubMed | CDK5 |
| iHOP | CDK5 |
