| Nomenclature | | HGNC (Hugo) | CDK5 1774 |
| Cards | | Entrez_Gene (NCBI) | CDK5 1020 cyclin-dependent kinase 5 |
| GeneCards (Weizmann) | CDK5 |
| Ensembl (Hinxton) | [Gene_View] chr7:150750902-150755052 [Contig_View] CDK5 [Vega] |
| cBioPortal | CDK5 |
| AceView (NCBI) | CDK5 |
| Genatlas (Paris) | CDK5 |
| WikiGenes | 1020 |
| SOURCE (Princeton) | NM_001164410 NM_004935 |
| Genomic and cartography | | GoldenPath (UCSC) | CDK5 - 7q36.1 chr7:150750902-150755052 - 7q36.1 [Description] (hg19-Feb_2009) |
| Ensembl | CDK5 - 7q36.1 [CytoView] |
| Mapping of homologs : NCBI | CDK5 [Mapview] |
| OMIM | 123831 |
| Gene and transcription |
| Genbank (Entrez) | AK026533 AY049778 AY927560 BC005115 BP309068 |
| RefSeq transcript (Entrez) | NM_001164410 NM_004935 |
| RefSeq genomic (Entrez) | AC_000139 NC_000007 NC_018918 NT_007933 NW_001839088 NW_004929333 |
| Consensus coding sequences : CCDS (NCBI) | CDK5 |
| Cluster EST : Unigene | Hs.647078 [ NCBI ] |
| CGAP (NCI) | Hs.647078 |
| Alternative Splicing : Fast-db (Paris) | GSHG0028714 |
| Gene Expression | CDK5 [ NCBI-GEO ] CDK5 [ SEEK ] CDK5 [ MEM ] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q00535 (Uniprot) |
| NextProt | Q00535 [Medical] |
| With graphics : InterPro | Q00535 |
| Splice isoforms : SwissVar | Q00535 (Swissvar) |
| Catalytic activity : Enzyme | 2.7.11.22 [ Enzyme-Expasy ] 2.7.11.222.7.11.22 [ IntEnz-EBI ] 2.7.11.22 [ BRENDA ] 2.7.11.22 [ KEGG ] |
| Domaine pattern : Prosite (Expaxy) | PROTEIN_KINASE_ATP (PS00107) PROTEIN_KINASE_DOM (PS50011) PROTEIN_KINASE_ST (PS00108) |
| Domains : Interpro (EBI) | Kinase-like_dom [organisation] Prot_kinase_dom [organisation] Protein_kinase_ATP_BS [organisation] Ser/Thr_dual-sp_kinase_dom [organisation] Ser/Thr_kinase_AS [organisation] |
| Related proteins : CluSTr | Q00535 |
| Domain families : Pfam (Sanger) | Pkinase (PF00069) |
| Domain families : Pfam (NCBI) | pfam00069 |
| Domain families : Smart (EMBL) | S_TKc (SM00220) |
| DMDM Disease mutations | 1020 |
| Blocks (Seattle) | Q00535 |
| PDB (SRS) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| PDB (PDBSum) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| PDB (IMB) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| PDB (RSDB) | 1H4L 1LFR 1UNG 1UNH 1UNL 3O0G 4AU8 |
| Peptide Atlas | Q00535 |
| HPRD | 00449 |
| IPI | IPI00023530 IPI00827700 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q00535 |
| IntAct (EBI) | Q00535 |
| BioGRID | CDK5 |
| InParanoid | Q00535 |
| Interologous Interaction database | Q00535 |
| IntegromeDB | CDK5 |
| STRING (EMBL) | CDK5 |
| Ontologies - Pathways | | Ontology : AmiGO | neuron migration synaptic transmission, dopaminergic p53 binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ErbB-2 class receptor binding protein binding ATP binding nucleus cytoplasm cytosol intracellular protein transport nucleocytoplasmic transport cell cycle cell-matrix adhesion synaptic transmission axon guidance synapse assembly skeletal muscle tissue development blood coagulation motor neuron axon guidance cell proliferation visual learning embryo development Schwann cell development postsynaptic density membrane synaptic vesicle exocytosis kinase activity phosphorylation cyclin-dependent protein kinase 5 holoenzyme complex peptidyl-serine phosphorylation peptidyl-threonine phosphorylation sensory perception of pain cerebellar cortex formation hippocampus development layer formation in cerebral cortex central nervous system neuron development corpus callosum development lamellipodium cell junction filopodium neuron differentiation neuron differentiation regulation of cell migration axon dendrite growth cone negative regulation of axon extension acetylcholine receptor activator activity cortical actin cytoskeleton organization neuron projection development negative regulation of protein ubiquitination neuromuscular junction negative regulation of synaptic plasticity positive regulation of protein binding receptor catabolic process serine phosphorylation of STAT3 protein synaptic transmission, glutamatergic protein localization to synapse regulation of apoptotic process neuronal cell body receptor clustering ErbB-3 class receptor binding perikaryon positive regulation of neuron apoptotic process regulated secretory pathway postsynaptic membrane negative regulation of cell cycle positive regulation of protein kinase activity negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of calcium ion-dependent exocytosis protein autophosphorylation negative regulation of protein export from nucleus ephrin receptor binding behavioral response to cocaine regulation of synaptic plasticity regulation of synaptic plasticity synaptic vesicle endocytosis rhythmic process axon extension oligodendrocyte differentiation dendrite morphogenesis tau-protein kinase activity cell division neuron apoptotic process regulation of excitatory postsynaptic membrane potential regulation of dendritic spine morphogenesis calcium ion import regulation of cell cycle arrest positive regulation of protein targeting to membrane negative regulation of neuron death positive regulation of actin cytoskeleton reorganization positive regulation of receptor activity positive regulation of receptor activity |
| Ontology : EGO-EBI | neuron migration synaptic transmission, dopaminergic p53 binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ErbB-2 class receptor binding protein binding ATP binding nucleus cytoplasm cytosol intracellular protein transport nucleocytoplasmic transport cell cycle cell-matrix adhesion synaptic transmission axon guidance synapse assembly skeletal muscle tissue development blood coagulation motor neuron axon guidance cell proliferation visual learning embryo development Schwann cell development postsynaptic density membrane synaptic vesicle exocytosis kinase activity phosphorylation cyclin-dependent protein kinase 5 holoenzyme complex peptidyl-serine phosphorylation peptidyl-threonine phosphorylation sensory perception of pain cerebellar cortex formation hippocampus development layer formation in cerebral cortex central nervous system neuron development corpus callosum development lamellipodium cell junction filopodium neuron differentiation neuron differentiation regulation of cell migration axon dendrite growth cone negative regulation of axon extension acetylcholine receptor activator activity cortical actin cytoskeleton organization neuron projection development negative regulation of protein ubiquitination neuromuscular junction negative regulation of synaptic plasticity positive regulation of protein binding receptor catabolic process serine phosphorylation of STAT3 protein synaptic transmission, glutamatergic protein localization to synapse regulation of apoptotic process neuronal cell body receptor clustering ErbB-3 class receptor binding perikaryon positive regulation of neuron apoptotic process regulated secretory pathway postsynaptic membrane negative regulation of cell cycle positive regulation of protein kinase activity negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of calcium ion-dependent exocytosis protein autophosphorylation negative regulation of protein export from nucleus ephrin receptor binding behavioral response to cocaine regulation of synaptic plasticity regulation of synaptic plasticity synaptic vesicle endocytosis rhythmic process axon extension oligodendrocyte differentiation dendrite morphogenesis tau-protein kinase activity cell division neuron apoptotic process regulation of excitatory postsynaptic membrane potential regulation of dendritic spine morphogenesis calcium ion import regulation of cell cycle arrest positive regulation of protein targeting to membrane negative regulation of neuron death positive regulation of actin cytoskeleton reorganization positive regulation of receptor activity positive regulation of receptor activity |
| Pathways : BIOCARTA | FOSB gene expression and drug abuse [Genes] Deregulation of CDK5 in Alzheimers Disease [Genes] Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway [Genes] Rac 1 cell motility signaling pathway [Genes] Bioactive Peptide Induced Signaling Pathway [Genes] Estrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes] Reelin Signaling Pathway [Genes] Lissencephaly gene (LIS1) in neuronal migration and development [Genes] Regulation of ck1/cdk5 by type 1 glutamate receptors [Genes] |
| Pathways : KEGG | Axon guidance Alzheimer's disease Cocaine addiction |
| Protein Interaction Database | CDK5 |
| Wikipedia pathways | CDK5 |
| Gene fusion - rearrangments | | Polymorphisms : SNP, mutations, diseases | | SNP Single Nucleotide Polymorphism (NCBI) | CDK5 |
| snp3D : Map Gene to Disease | 1020 |
| SNP (GeneSNP Utah) | CDK5 |
| SNP : HGBase | CDK5 |
| Genetic variants : HAPMAP | CDK5 |
| Exome Variant | CDK5 |
| 1000_Genomes | CDK5 |
| Somatic Mutations in Cancer : COSMIC | CDK5 |
| CONAN: Copy Number Analysis | CDK5 |
| Mutations and Diseases : HGMD | CDK5 |
| Genomic Variants | CDK5 CDK5 [DGVbeta] |
| dbVar | CDK5 |
| ClinVar | CDK5 |
| Pred. of missenses | PolyPhen-2 SIFT(SG) SIFT(JCVI) Align-GVGD MutAssessor Mutanalyser |
| Pred. splices | GeneSplicer Human Splicing Finder MaxEntScan |
| Diseases | | OMIM | 123831 |
| Medgen | CDK5 |
| GENETests | CDK5 |
| Disease Genetic Association | CDK5 |
| Huge Navigator |
CDK5 [HugePedia] CDK5 [HugeCancerGEM] |
| General knowledge |
|---|
| Homologs : HomoloGene | CDK5 |
| Homology/Alignments : Family Browser (UCSC) | CDK5 |
| Phylogenetic Trees/Animal Genes : TreeFam | CDK5 |
| Chemical/Protein Interactions : CTD | 1020 |
| Chemical/Pharm GKB Gene | PA26310 |
| Clinical trial | CDK5 |
| Other databases | | Probes |
|---|
| Litterature | | PubMed | 247 Pubmed reference(s) in Entrez |
| CoreMine | CDK5 |
| iHOP | CDK5 |
| OncoSearch | CDK5 |
