Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CDK5R1 (cyclin-dependent kinase 5, regulatory subunit 1 (p35))

Identity

Alias_namescyclin-dependent kinase 5
Alias_symbol (synonym)p35nck5a
Nck5a
p35
Other aliasCDK5P35
CDK5R
NCK5A
p23
p25
HGNC (Hugo) CDK5R1
LocusID (NCBI) 8851
Atlas_Id 40034
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 30814105 and ends at 30818271 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDK5R1   1775
Cards
Entrez_Gene (NCBI)CDK5R1  8851  cyclin-dependent kinase 5, regulatory subunit 1 (p35)
AliasesCDK5P35; CDK5R; NCK5A; p23; 
p25; p35; p35nck5a
GeneCards (Weizmann)CDK5R1
Ensembl hg19 (Hinxton)ENSG00000176749 [Gene_View]  chr17:30814105-30818271 [Contig_View]  CDK5R1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000176749 [Gene_View]  chr17:30814105-30818271 [Contig_View]  CDK5R1 [Vega]
ICGC DataPortalENSG00000176749
TCGA cBioPortalCDK5R1
AceView (NCBI)CDK5R1
Genatlas (Paris)CDK5R1
WikiGenes8851
SOURCE (Princeton)CDK5R1
Genetics Home Reference (NIH)CDK5R1
Genomic and cartography
GoldenPath hg19 (UCSC)CDK5R1  -     chr17:30814105-30818271 +  17q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CDK5R1  -     17q11.2   [Description]    (hg38-Dec_2013)
EnsemblCDK5R1 - 17q11.2 [CytoView hg19]  CDK5R1 - 17q11.2 [CytoView hg38]
Mapping of homologs : NCBICDK5R1 [Mapview hg19]  CDK5R1 [Mapview hg38]
OMIM603460   
Gene and transcription
Genbank (Entrez)AK095754 BC020580 BC026347 BC030792 BC032081
RefSeq transcript (Entrez)NM_003885
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)CDK5R1
Cluster EST : UnigeneHs.500015 [ NCBI ]
CGAP (NCI)Hs.500015
Alternative Splicing GalleryENSG00000176749
Gene ExpressionCDK5R1 [ NCBI-GEO ]   CDK5R1 [ EBI - ARRAY_EXPRESS ]   CDK5R1 [ SEEK ]   CDK5R1 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK5R1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8851
GTEX Portal (Tissue expression)CDK5R1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15078   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15078  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15078
Splice isoforms : SwissVarQ15078
PhosPhoSitePlusQ15078
Domains : Interpro (EBI)CDK5_activator    Cyclin-like   
Domain families : Pfam (Sanger)CDK5_activator (PF03261)   
Domain families : Pfam (NCBI)pfam03261   
Conserved Domain (NCBI)CDK5R1
DMDM Disease mutations8851
Blocks (Seattle)CDK5R1
PDB (SRS)1H4L    1UNG    1UNH    1UNL    3O0G   
PDB (PDBSum)1H4L    1UNG    1UNH    1UNL    3O0G   
PDB (IMB)1H4L    1UNG    1UNH    1UNL    3O0G   
PDB (RSDB)1H4L    1UNG    1UNH    1UNL    3O0G   
Structural Biology KnowledgeBase1H4L    1UNG    1UNH    1UNL    3O0G   
SCOP (Structural Classification of Proteins)1H4L    1UNG    1UNH    1UNL    3O0G   
CATH (Classification of proteins structures)1H4L    1UNG    1UNH    1UNL    3O0G   
SuperfamilyQ15078
Human Protein AtlasENSG00000176749
Peptide AtlasQ15078
HPRD04586
IPIIPI00014316   
Protein Interaction databases
DIP (DOE-UCLA)Q15078
IntAct (EBI)Q15078
FunCoupENSG00000176749
BioGRIDCDK5R1
STRING (EMBL)CDK5R1
ZODIACCDK5R1
Ontologies - Pathways
QuickGOQ15078
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  neuron migration  protein kinase activity  cyclin-dependent protein serine/threonine kinase activity  calcium ion binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  plasma membrane  neuron cell-cell adhesion  G-protein coupled acetylcholine receptor signaling pathway  axon guidance  axonal fasciculation  brain development  brain development  cell proliferation  embryo development  postsynaptic density  membrane  regulation of macroautophagy  kinase activity  cyclin-dependent protein kinase 5 holoenzyme complex  cyclin-dependent protein kinase 5 activator activity  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  protein kinase binding  cerebellum development  superior olivary nucleus maturation  hippocampus development  layer formation in cerebral cortex  neuron differentiation  axon  dendrite  growth cone  negative regulation of axon extension  neuron projection development  neuromuscular junction  regulation of actin cytoskeleton organization  serine phosphorylation of STAT3 protein  ionotropic glutamate receptor signaling pathway  neuronal cell body  dendritic spine  intracellular membrane-bounded organelle  contractile fiber  positive regulation of neuron apoptotic process  protein serine/threonine kinase activator activity  protein serine/threonine kinase activator activity  cadherin binding  regulation of neuron differentiation  negative regulation of transcription, DNA-templated  ephrin receptor binding  ephrin receptor signaling pathway  perinuclear region of cytoplasm  rhythmic process  regulation of dendritic spine morphogenesis  regulation of microtubule cytoskeleton organization  positive regulation of cell cycle arrest  positive regulation of protein serine/threonine kinase activity  positive regulation of protein targeting to membrane  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  neuron migration  protein kinase activity  cyclin-dependent protein serine/threonine kinase activity  calcium ion binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  plasma membrane  neuron cell-cell adhesion  G-protein coupled acetylcholine receptor signaling pathway  axon guidance  axonal fasciculation  brain development  brain development  cell proliferation  embryo development  postsynaptic density  membrane  regulation of macroautophagy  kinase activity  cyclin-dependent protein kinase 5 holoenzyme complex  cyclin-dependent protein kinase 5 activator activity  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  protein kinase binding  cerebellum development  superior olivary nucleus maturation  hippocampus development  layer formation in cerebral cortex  neuron differentiation  axon  dendrite  growth cone  negative regulation of axon extension  neuron projection development  neuromuscular junction  regulation of actin cytoskeleton organization  serine phosphorylation of STAT3 protein  ionotropic glutamate receptor signaling pathway  neuronal cell body  dendritic spine  intracellular membrane-bounded organelle  contractile fiber  positive regulation of neuron apoptotic process  protein serine/threonine kinase activator activity  protein serine/threonine kinase activator activity  cadherin binding  regulation of neuron differentiation  negative regulation of transcription, DNA-templated  ephrin receptor binding  ephrin receptor signaling pathway  perinuclear region of cytoplasm  rhythmic process  regulation of dendritic spine morphogenesis  regulation of microtubule cytoskeleton organization  positive regulation of cell cycle arrest  positive regulation of protein serine/threonine kinase activity  positive regulation of protein targeting to membrane  regulation of signal transduction by p53 class mediator  
Pathways : BIOCARTAReelin Signaling Pathway [Genes]    Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway [Genes]    Rac 1 cell motility signaling pathway [Genes]    Regulation of ck1/cdk5 by type 1 glutamate receptors [Genes]    Lissencephaly gene (LIS1) in neuronal migration and development [Genes]    Deregulation of CDK5 in Alzheimers Disease [Genes]   
Pathways : KEGGAlzheimer's disease    Cocaine addiction   
NDEx NetworkCDK5R1
Atlas of Cancer Signalling NetworkCDK5R1
Wikipedia pathwaysCDK5R1
Orthology - Evolution
OrthoDB8851
GeneTree (enSembl)ENSG00000176749
Phylogenetic Trees/Animal Genes : TreeFamCDK5R1
HOVERGENQ15078
HOGENOMQ15078
Homologs : HomoloGeneCDK5R1
Homology/Alignments : Family Browser (UCSC)CDK5R1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK5R1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK5R1
dbVarCDK5R1
ClinVarCDK5R1
1000_GenomesCDK5R1 
Exome Variant ServerCDK5R1
ExAC (Exome Aggregation Consortium)CDK5R1 (select the gene name)
Genetic variants : HAPMAP8851
Genomic Variants (DGV)CDK5R1 [DGVbeta]
DECIPHER (Syndromes)17:30814105-30818271  ENSG00000176749
CONAN: Copy Number AnalysisCDK5R1 
Mutations
ICGC Data PortalCDK5R1 
TCGA Data PortalCDK5R1 
Broad Tumor PortalCDK5R1
OASIS PortalCDK5R1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK5R1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDK5R1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK5R1
DgiDB (Drug Gene Interaction Database)CDK5R1
DoCM (Curated mutations)CDK5R1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK5R1 (select a term)
intoGenCDK5R1
Cancer3DCDK5R1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603460   
Orphanet
MedgenCDK5R1
Genetic Testing Registry CDK5R1
NextProtQ15078 [Medical]
TSGene8851
GENETestsCDK5R1
Huge Navigator CDK5R1 [HugePedia]
snp3D : Map Gene to Disease8851
BioCentury BCIQCDK5R1
ClinGenCDK5R1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8851
Chemical/Pharm GKB GenePA26311
Clinical trialCDK5R1
Miscellaneous
canSAR (ICR)CDK5R1 (select the gene name)
Probes
Litterature
PubMed94 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK5R1
EVEXCDK5R1
GoPubMedCDK5R1
iHOPCDK5R1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 12:59:46 CET 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.