Identity
HGNC
LOCATION
2q35
LOCUSID
ALIAS
NCK5AI,P39,p39nck5ai
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8941
MIM: 603764
HGNC: 1776
Ensembl: ENSG00000171450
Variants:
dbSNP: 8941
ClinVar: 8941
TCGA: ENSG00000171450
COSMIC: CDK5R2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000171450 | ENST00000302625 | Q13319 |
Expression (GTEx)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 30452490 | 2018 | Hyper-phosphorylation of Rb S249 together with CDK5R2/p39 overexpression are associated with impaired cell adhesion and epithelial-to-mesenchymal transition: Implications as a potential lung cancer grading and staging biomarker. | 5 |
| 30452490 | 2018 | Hyper-phosphorylation of Rb S249 together with CDK5R2/p39 overexpression are associated with impaired cell adhesion and epithelial-to-mesenchymal transition: Implications as a potential lung cancer grading and staging biomarker. | 5 |
| 25128817 | 2015 | The Cdk5 activator P39 specifically links muskelin to myosin II and regulates stress fiber formation and actin organization in lens. | 10 |
| 25128817 | 2015 | The Cdk5 activator P39 specifically links muskelin to myosin II and regulates stress fiber formation and actin organization in lens. | 10 |
| 24085300 | 2013 | Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators. | 6 |
| 24085300 | 2013 | Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators. | 6 |
| 20936377 | 2011 | Decreased expression of p39 is associated with a poor prognosis in human hepatocellular carcinoma. | 10 |
| 20936377 | 2011 | Decreased expression of p39 is associated with a poor prognosis in human hepatocellular carcinoma. | 10 |
| 20518484 | 2010 | Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39. | 28 |
| 20518484 | 2010 | Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39. | 28 |
| 15917097 | 2005 | Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease. | 15 |
| 15917097 | 2005 | Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease. | 15 |
| 11784720 | 2002 | Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. | 34 |
| 11784720 | 2002 | Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29. | 34 |
Citation
Dessen P
CDK5R2 (cyclin dependent kinase 5 regulatory subunit 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46984/cdk5r2
