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CDK5R2 (cyclin dependent kinase 5 regulatory subunit 2)

Identity

Alias_namescyclin-dependent kinase 5
Alias_symbol (synonym)p39nck5ai
P39
NCK5AI
Other alias
HGNC (Hugo) CDK5R2
LocusID (NCBI) 8941
Atlas_Id 46984
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 218959628 and ends at 218962155 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDK5R2 (2q35) / CRAMP1 (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDK5R2   1776
Cards
Entrez_Gene (NCBI)CDK5R2  8941  cyclin dependent kinase 5 regulatory subunit 2
AliasesNCK5AI; P39; p39nck5ai
GeneCards (Weizmann)CDK5R2
Ensembl hg19 (Hinxton)ENSG00000171450 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171450 [Gene_View]  chr2:218959628-218962155 [Contig_View]  CDK5R2 [Vega]
ICGC DataPortalENSG00000171450
TCGA cBioPortalCDK5R2
AceView (NCBI)CDK5R2
Genatlas (Paris)CDK5R2
WikiGenes8941
SOURCE (Princeton)CDK5R2
Genetics Home Reference (NIH)CDK5R2
Genomic and cartography
GoldenPath hg38 (UCSC)CDK5R2  -     chr2:218959628-218962155 +  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK5R2  -     2q35   [Description]    (hg19-Feb_2009)
EnsemblCDK5R2 - 2q35 [CytoView hg19]  CDK5R2 - 2q35 [CytoView hg38]
Mapping of homologs : NCBICDK5R2 [Mapview hg19]  CDK5R2 [Mapview hg38]
OMIM603764   
Gene and transcription
Genbank (Entrez)AI084857 BC009910 BC041771 BG703026 BT007437
RefSeq transcript (Entrez)NM_003936
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDK5R2
Cluster EST : UnigeneHs.158460 [ NCBI ]
CGAP (NCI)Hs.158460
Alternative Splicing GalleryENSG00000171450
Gene ExpressionCDK5R2 [ NCBI-GEO ]   CDK5R2 [ EBI - ARRAY_EXPRESS ]   CDK5R2 [ SEEK ]   CDK5R2 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK5R2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8941
GTEX Portal (Tissue expression)CDK5R2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13319   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13319  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13319
Splice isoforms : SwissVarQ13319
PhosPhoSitePlusQ13319
Domains : Interpro (EBI)CDK5_activator    Cyclin-like   
Domain families : Pfam (Sanger)CDK5_activator (PF03261)   
Domain families : Pfam (NCBI)pfam03261   
Conserved Domain (NCBI)CDK5R2
DMDM Disease mutations8941
Blocks (Seattle)CDK5R2
SuperfamilyQ13319
Human Protein AtlasENSG00000171450
Peptide AtlasQ13319
HPRD04790
IPIIPI00012738   IPI00985276   
Protein Interaction databases
DIP (DOE-UCLA)Q13319
IntAct (EBI)Q13319
FunCoupENSG00000171450
BioGRIDCDK5R2
STRING (EMBL)CDK5R2
ZODIACCDK5R2
Ontologies - Pathways
QuickGOQ13319
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  neuron migration  cytoplasm  plasma membrane  lipid binding  cyclin-dependent protein kinase 5 holoenzyme complex  cyclin-dependent protein kinase 5 activator activity  cerebellum development  superior olivary nucleus maturation  hippocampus development  layer formation in cerebral cortex  positive regulation of calcium ion-dependent exocytosis  positive regulation of protein serine/threonine kinase activity  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  neuron migration  cytoplasm  plasma membrane  lipid binding  cyclin-dependent protein kinase 5 holoenzyme complex  cyclin-dependent protein kinase 5 activator activity  cerebellum development  superior olivary nucleus maturation  hippocampus development  layer formation in cerebral cortex  positive regulation of calcium ion-dependent exocytosis  positive regulation of protein serine/threonine kinase activity  
NDEx NetworkCDK5R2
Atlas of Cancer Signalling NetworkCDK5R2
Wikipedia pathwaysCDK5R2
Orthology - Evolution
OrthoDB8941
GeneTree (enSembl)ENSG00000171450
Phylogenetic Trees/Animal Genes : TreeFamCDK5R2
HOVERGENQ13319
HOGENOMQ13319
Homologs : HomoloGeneCDK5R2
Homology/Alignments : Family Browser (UCSC)CDK5R2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK5R2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK5R2
dbVarCDK5R2
ClinVarCDK5R2
1000_GenomesCDK5R2 
Exome Variant ServerCDK5R2
ExAC (Exome Aggregation Consortium)CDK5R2 (select the gene name)
Genetic variants : HAPMAP8941
Genomic Variants (DGV)CDK5R2 [DGVbeta]
DECIPHERCDK5R2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK5R2 
Mutations
ICGC Data PortalCDK5R2 
TCGA Data PortalCDK5R2 
Broad Tumor PortalCDK5R2
OASIS PortalCDK5R2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK5R2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDK5R2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK5R2
DgiDB (Drug Gene Interaction Database)CDK5R2
DoCM (Curated mutations)CDK5R2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK5R2 (select a term)
intoGenCDK5R2
Cancer3DCDK5R2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603764   
Orphanet
MedgenCDK5R2
Genetic Testing Registry CDK5R2
NextProtQ13319 [Medical]
TSGene8941
GENETestsCDK5R2
Target ValidationCDK5R2
Huge Navigator CDK5R2 [HugePedia]
snp3D : Map Gene to Disease8941
BioCentury BCIQCDK5R2
ClinGenCDK5R2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8941
Chemical/Pharm GKB GenePA26312
Clinical trialCDK5R2
Miscellaneous
canSAR (ICR)CDK5R2 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK5R2
EVEXCDK5R2
GoPubMedCDK5R2
iHOPCDK5R2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:27:47 CEST 2017

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