CDK5R2 (cyclin dependent kinase 5 regulatory subunit 2)

2007-04-01  

Identity

HGNC
LOCATION
2q35
LOCUSID
ALIAS
NCK5AI,P39,p39nck5ai
FUSION GENES

Other Information

Locus ID:

NCBI: 8941
MIM: 603764
HGNC: 1776
Ensembl: ENSG00000171450

Variants:

dbSNP: 8941
ClinVar: 8941
TCGA: ENSG00000171450
COSMIC: CDK5R2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171450ENST00000302625Q13319

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

References

Pubmed IDYearTitleCitations
117847202002Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29.29
205184842010Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39.21
159170972005Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease.11
251288172015The Cdk5 activator P39 specifically links muskelin to myosin II and regulates stress fiber formation and actin organization in lens.7
209363772011Decreased expression of p39 is associated with a poor prognosis in human hepatocellular carcinoma.4
240853002013Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators.3
304524902018Hyper-phosphorylation of Rb S249 together with CDK5R2/p39 overexpression are associated with impaired cell adhesion and epithelial-to-mesenchymal transition: Implications as a potential lung cancer grading and staging biomarker.1

Citation

Dessen P

CDK5R2 (cyclin dependent kinase 5 regulatory subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46984/cdk5r2