CDK5RAP3 (CDK5 regulatory subunit associated protein 3)

2007-02-01  

Identity

HGNC
LOCATION
17q21.32
LOCUSID
ALIAS
C53,HSF-27,IC53,LZAP,MST016,OK/SW-cl.114,PP1553
FUSION GENES

Other Information

Locus ID:

NCBI: 80279
MIM: 608202
HGNC: 18673
Ensembl: ENSG00000108465

Variants:

dbSNP: 80279
ClinVar: 80279
TCGA: ENSG00000108465
COSMIC: CDK5RAP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108465ENST00000338399Q96JB5
ENSG00000108465ENST00000536708Q96JB5
ENSG00000108465ENST00000577664J3QRX0
ENSG00000108465ENST00000578018J3KTA5
ENSG00000108465ENST00000578525J3KS63
ENSG00000108465ENST00000579175J3QQY1
ENSG00000108465ENST00000579605J3KRK4
ENSG00000108465ENST00000579632J3QS62
ENSG00000108465ENST00000580391J3QQS7
ENSG00000108465ENST00000580670J3QL95
ENSG00000108465ENST00000583352J3QL86
ENSG00000108465ENST00000583363J3KSD0
ENSG00000108465ENST00000583697J3QRM1
ENSG00000108465ENST00000584991J3KRI2

Expression (GTEx)

0
50
100
150
200
250
300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
177852052007LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB.46
202280632010A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling.38
213859012011Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis.30
175496662007Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma.28
157905662005Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint.27
161739222006A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2.20
192238572009Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation.17
214654712012Nuclear γ-tubulin associates with nucleoli and interacts with tumor suppressor protein C53.13
228600852012CDK5RAP3 is a novel repressor of p14ARF in hepatocellular carcinoma cells.13
277936952017CDK5RAP3 acts as a tumor suppressor in gastric cancer through inhibition of β-catenin signaling.13

Citation

Dessen P

CDK5RAP3 (CDK5 regulatory subunit associated protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43880/cdk5rap3