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CDK5RAP3 (CDK5 regulatory subunit associated protein 3)

Identity

Alias_symbol (synonym)MST016
FLJ13660
C53
IC53
HSF-27
OK/SW-cl.114
LZAP
Other aliasPP1553
HGNC (Hugo) CDK5RAP3
LocusID (NCBI) 80279
Atlas_Id 43880
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 47970528 and ends at 47981786 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDK5RAP3 (17q21.32) / NCAPD3 (11q25)CDK5RAP3 (17q21.32) / RNF43 (17q22)CDK5RAP3 (17q21.32) / TRERF1 (6p21.1)
LOC100507412 (-) / CDK5RAP3 (17q21.32)NF1 (17q11.2) / CDK5RAP3 (17q21.32)RACK1 (5q35.3) / CDK5RAP3 (17q21.32)
CDK5RAP3 17q21.32 / RNF43 17q22NF1 17q11.2 / CDK5RAP3 17q21.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDK5RAP3   18673
Cards
Entrez_Gene (NCBI)CDK5RAP3  80279  CDK5 regulatory subunit associated protein 3
AliasesC53; HSF-27; IC53; LZAP; 
MST016; OK/SW-cl.114; PP1553
GeneCards (Weizmann)CDK5RAP3
Ensembl hg19 (Hinxton)ENSG00000108465 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108465 [Gene_View]  chr17:47970528-47981786 [Contig_View]  CDK5RAP3 [Vega]
ICGC DataPortalENSG00000108465
TCGA cBioPortalCDK5RAP3
AceView (NCBI)CDK5RAP3
Genatlas (Paris)CDK5RAP3
WikiGenes80279
SOURCE (Princeton)CDK5RAP3
Genetics Home Reference (NIH)CDK5RAP3
Genomic and cartography
GoldenPath hg38 (UCSC)CDK5RAP3  -     chr17:47970528-47981786 +  17q21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK5RAP3  -     17q21.32   [Description]    (hg19-Feb_2009)
EnsemblCDK5RAP3 - 17q21.32 [CytoView hg19]  CDK5RAP3 - 17q21.32 [CytoView hg38]
Mapping of homologs : NCBICDK5RAP3 [Mapview hg19]  CDK5RAP3 [Mapview hg38]
OMIM608202   
Gene and transcription
Genbank (Entrez)AA427702 AB062433 AF110322 AF217982 AF343090
RefSeq transcript (Entrez)NM_001278197 NM_001278198 NM_001278216 NM_001278217 NM_025197 NM_176095 NM_176096
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDK5RAP3
Cluster EST : UnigeneHs.20157 [ NCBI ]
CGAP (NCI)Hs.20157
Alternative Splicing GalleryENSG00000108465
Gene ExpressionCDK5RAP3 [ NCBI-GEO ]   CDK5RAP3 [ EBI - ARRAY_EXPRESS ]   CDK5RAP3 [ SEEK ]   CDK5RAP3 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK5RAP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80279
GTEX Portal (Tissue expression)CDK5RAP3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96JB5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96JB5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96JB5
Splice isoforms : SwissVarQ96JB5
PhosPhoSitePlusQ96JB5
Domains : Interpro (EBI)DUF773   
Domain families : Pfam (Sanger)DUF773 (PF05600)   
Domain families : Pfam (NCBI)pfam05600   
Conserved Domain (NCBI)CDK5RAP3
DMDM Disease mutations80279
Blocks (Seattle)CDK5RAP3
SuperfamilyQ96JB5
Human Protein AtlasENSG00000108465
Peptide AtlasQ96JB5
HPRD12190
IPIIPI00414442   IPI00018780   IPI00187145   
Protein Interaction databases
DIP (DOE-UCLA)Q96JB5
IntAct (EBI)Q96JB5
FunCoupENSG00000108465
BioGRIDCDK5RAP3
STRING (EMBL)CDK5RAP3
ZODIACCDK5RAP3
Ontologies - Pathways
QuickGOQ96JB5
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  negative regulation of protein phosphorylation  protein binding  nucleus  nucleolus  nucleolus  cytoplasm  centrosome  cytosol  microtubule  mitotic G2 DNA damage checkpoint  brain development  cell proliferation  regulation of phosphatase activity  endomembrane system  membrane  protein kinase binding  protein kinase binding  apoptotic nuclear changes  cyclin binding  endoplasmic reticulum unfolded protein response  positive regulation of protein ubiquitination  negative regulation of NF-kappaB transcription factor activity  protein complex  negative regulation of MAP kinase activity  negative regulation of protein kinase activity by regulation of protein phosphorylation  ubiquitin-like protein ligase binding  mitotic G2/M transition checkpoint  regulation of neuron differentiation  positive regulation of transcription from RNA polymerase II promoter  mitogen-activated protein kinase binding  NF-kappaB binding  protein ufmylation  negative regulation of protein serine/threonine kinase activity  MDM2/MDM4 family protein binding  positive regulation of protein localization to nucleus  positive regulation of signal transduction by p53 class mediator  negative regulation of cellular protein catabolic process  positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  negative regulation of protein phosphorylation  protein binding  nucleus  nucleolus  nucleolus  cytoplasm  centrosome  cytosol  microtubule  mitotic G2 DNA damage checkpoint  brain development  cell proliferation  regulation of phosphatase activity  endomembrane system  membrane  protein kinase binding  protein kinase binding  apoptotic nuclear changes  cyclin binding  endoplasmic reticulum unfolded protein response  positive regulation of protein ubiquitination  negative regulation of NF-kappaB transcription factor activity  protein complex  negative regulation of MAP kinase activity  negative regulation of protein kinase activity by regulation of protein phosphorylation  ubiquitin-like protein ligase binding  mitotic G2/M transition checkpoint  regulation of neuron differentiation  positive regulation of transcription from RNA polymerase II promoter  mitogen-activated protein kinase binding  NF-kappaB binding  protein ufmylation  negative regulation of protein serine/threonine kinase activity  MDM2/MDM4 family protein binding  positive regulation of protein localization to nucleus  positive regulation of signal transduction by p53 class mediator  negative regulation of cellular protein catabolic process  positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  
NDEx NetworkCDK5RAP3
Atlas of Cancer Signalling NetworkCDK5RAP3
Wikipedia pathwaysCDK5RAP3
Orthology - Evolution
OrthoDB80279
GeneTree (enSembl)ENSG00000108465
Phylogenetic Trees/Animal Genes : TreeFamCDK5RAP3
HOVERGENQ96JB5
HOGENOMQ96JB5
Homologs : HomoloGeneCDK5RAP3
Homology/Alignments : Family Browser (UCSC)CDK5RAP3
Gene fusions - Rearrangements
Fusion : MitelmanCDK5RAP3/RNF43 [17q21.32/17q22]  
Fusion : MitelmanNF1/CDK5RAP3 [17q11.2/17q21.32]  [t(17;17)(q11;q21)]  
Fusion: TCGACDK5RAP3 17q21.32 RNF43 17q22 BRCA
Fusion: TCGANF1 17q11.2 CDK5RAP3 17q21.32 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK5RAP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK5RAP3
dbVarCDK5RAP3
ClinVarCDK5RAP3
1000_GenomesCDK5RAP3 
Exome Variant ServerCDK5RAP3
ExAC (Exome Aggregation Consortium)CDK5RAP3 (select the gene name)
Genetic variants : HAPMAP80279
Genomic Variants (DGV)CDK5RAP3 [DGVbeta]
DECIPHERCDK5RAP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK5RAP3 
Mutations
ICGC Data PortalCDK5RAP3 
TCGA Data PortalCDK5RAP3 
Broad Tumor PortalCDK5RAP3
OASIS PortalCDK5RAP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK5RAP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDK5RAP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK5RAP3
DgiDB (Drug Gene Interaction Database)CDK5RAP3
DoCM (Curated mutations)CDK5RAP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK5RAP3 (select a term)
intoGenCDK5RAP3
Cancer3DCDK5RAP3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608202   
Orphanet
MedgenCDK5RAP3
Genetic Testing Registry CDK5RAP3
NextProtQ96JB5 [Medical]
TSGene80279
GENETestsCDK5RAP3
Huge Navigator CDK5RAP3 [HugePedia]
snp3D : Map Gene to Disease80279
BioCentury BCIQCDK5RAP3
ClinGenCDK5RAP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80279
Chemical/Pharm GKB GenePA38633
Clinical trialCDK5RAP3
Miscellaneous
canSAR (ICR)CDK5RAP3 (select the gene name)
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK5RAP3
EVEXCDK5RAP3
GoPubMedCDK5RAP3
iHOPCDK5RAP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:09:59 CEST 2017

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