CDK6 (cyclin dependent kinase 6)

2003-02-01  

Identity

HGNC
LOCATION
7q21.2
LOCUSID
ALIAS
MCPH12,PLSTIRE
FUSION GENES

Other Information

Locus ID:

NCBI: 1021
MIM: 603368
HGNC: 1777
Ensembl: ENSG00000105810

Variants:

dbSNP: 1021
ClinVar: 1021
TCGA: ENSG00000105810
COSMIC: CDK6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105810ENST00000265734Q00534
ENSG00000105810ENST00000424848Q00534

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
p53 signaling pathwayKEGGko04115
Pancreatic cancerKEGGko05212
GliomaKEGGko05214
MelanomaKEGGko05218
Chronic myeloid leukemiaKEGGko05220
Small cell lung cancerKEGGko05222
Non-small cell lung cancerKEGGko05223
Cell cycleKEGGhsa04110
p53 signaling pathwayKEGGhsa04115
Pathways in cancerKEGGhsa05200
Pancreatic cancerKEGGhsa05212
GliomaKEGGhsa05214
MelanomaKEGGhsa05218
Chronic myeloid leukemiaKEGGhsa05220
Small cell lung cancerKEGGhsa05222
Non-small cell lung cancerKEGGhsa05223
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Cell cycle - G1/S transitionKEGGhsa_M00692
Cell cycle - G1/S transitionKEGGM00692
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1 PhaseREACTOMER-HSA-69236
Cyclin D associated events in G1REACTOMER-HSA-69231
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oncogene Induced SenescenceREACTOMER-HSA-2559585
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444552HypertensionDiseaseLiterature, MultilinkAnnotationassociated24560520

References

Pubmed IDYearTitleCitations
255247982015The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study.448
183919522008Genome-wide association analysis identifies 20 loci that influence adult height.322
187948532008Common variants at CD40 and other loci confer risk of rheumatoid arthritis.199
184063532008Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest.181
274841762016Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma.143
220126192011The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.135
250020282014CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors.128
203541912010Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts.127
200862452010microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma.118
212782462011Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer.100

Citation

Dessen P

CDK6 (cyclin dependent kinase 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/321/cdk6