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CDK7 (cyclin dependent kinase 7)

Identity

Alias (NCBI)CAK
CAK1
CDKN7
HCAK
MO15
STK1
p39MO15
HGNC (Hugo) CDK7
HGNC Alias symbCAK1
CDKN7
MO15
STK1
CAK
HGNC Previous namecyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase)
 cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)
LocusID (NCBI) 1022
Atlas_Id 40035
Location 5q13.2  [Link to chromosome band 5q13]
Location_base_pair Starts at 69234886 and ends at 69277430 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDK7 (5q13.2)::CCNB1 (5q13.2)CDK7 (5q13.2)::MATR3 (5q31.2)CDK7 (5q13.2)::RGS20 (8q11.23)
CDK7 (5q13.2)::RIN3 (14q32.12)CDK7 5q13.2::CCNB1 5q13.2CDK7 5q13.2::RGS20 8q11.23
CDK7 5q13.2::RIN3 14q32.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CDK7   1778
Cards
Entrez_Gene (NCBI)CDK7    cyclin dependent kinase 7
AliasesCAK; CAK1; CDKN7; HCAK; 
MO15; STK1; p39MO15
GeneCards (Weizmann)CDK7
Ensembl hg19 (Hinxton)ENSG00000134058 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134058 [Gene_View]  ENSG00000134058 [Sequence]  chr5:69234886-69277430 [Contig_View]  CDK7 [Vega]
ICGC DataPortalENSG00000134058
TCGA cBioPortalCDK7
AceView (NCBI)CDK7
Genatlas (Paris)CDK7
SOURCE (Princeton)CDK7
Genetics Home Reference (NIH)CDK7
Genomic and cartography
GoldenPath hg38 (UCSC)CDK7  -     chr5:69234886-69277430 +  5q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK7  -     5q13.2   [Description]    (hg19-Feb_2009)
GoldenPathCDK7 - 5q13.2 [CytoView hg19]  CDK7 - 5q13.2 [CytoView hg38]
ImmunoBaseENSG00000134058
Genome Data Viewer NCBICDK7 [Mapview hg19]  
OMIM601955   
Gene and transcription
Genbank (Entrez)AK026509 AK308493 BC000834 BC005298 BI520184
RefSeq transcript (Entrez)NM_001324069 NM_001324070 NM_001324071 NM_001324072 NM_001324074 NM_001324075 NM_001324077 NM_001324078 NM_001799
Consensus coding sequences : CCDS (NCBI)CDK7
Gene ExpressionCDK7 [ NCBI-GEO ]   CDK7 [ EBI - ARRAY_EXPRESS ]   CDK7 [ SEEK ]   CDK7 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK7 [ Firebrowse - Broad ]
GenevisibleExpression of CDK7 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1022
GTEX Portal (Tissue expression)CDK7
Human Protein AtlasENSG00000134058-CDK7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP50613   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP50613  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP50613
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP50613
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)CDK7    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK7
PDB (RSDB)1LG3    1PA8    1UA2    2HIC    6O9L    6XBZ    6XD3   
PDB Europe1LG3    1PA8    1UA2    2HIC    6O9L    6XBZ    6XD3   
PDB (PDBSum)1LG3    1PA8    1UA2    2HIC    6O9L    6XBZ    6XD3   
PDB (IMB)1LG3    1PA8    1UA2    2HIC    6O9L    6XBZ    6XD3   
Structural Biology KnowledgeBase1LG3    1PA8    1UA2    2HIC    6O9L    6XBZ    6XD3   
SCOP (Structural Classification of Proteins)1LG3    1PA8    1UA2    2HIC    6O9L    6XBZ    6XD3   
CATH (Classification of proteins structures)1LG3    1PA8    1UA2    2HIC    6O9L    6XBZ    6XD3   
SuperfamilyP50613
AlphaFold pdb e-kbP50613   
Human Protein Atlas [tissue]ENSG00000134058-CDK7 [tissue]
HPRD15993
Protein Interaction databases
DIP (DOE-UCLA)P50613
IntAct (EBI)P50613
BioGRIDCDK7
STRING (EMBL)CDK7
ZODIACCDK7
Ontologies - Pathways
QuickGOP50613
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  transcription factor TFIIH core complex  fibrillar center  protein kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription factor TFIIH holo complex  cytoplasm  cytosol  plasma membrane  DNA repair  transcription by RNA polymerase II  transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  protein phosphorylation  cell cycle  protein C-terminus binding  ATP-dependent activity, acting on DNA  RNA polymerase II CTD heptapeptide repeat kinase activity  RNA polymerase II CTD heptapeptide repeat kinase activity  cyclin-dependent protein kinase activating kinase holoenzyme complex  cyclin-dependent protein kinase activating kinase holoenzyme complex  snRNA transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  perinuclear region of cytoplasm  protein stabilization  cell division  regulation of cell cycle  CAK-ERCC2 complex  phosphorylation of RNA polymerase II C-terminal domain  transcription factor TFIIK complex  transcription factor TFIIK complex  protein serine kinase activity  regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  transcription factor TFIIH core complex  fibrillar center  protein kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  transcription factor TFIIH holo complex  cytoplasm  cytosol  plasma membrane  DNA repair  transcription by RNA polymerase II  transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  protein phosphorylation  cell cycle  protein C-terminus binding  ATP-dependent activity, acting on DNA  RNA polymerase II CTD heptapeptide repeat kinase activity  RNA polymerase II CTD heptapeptide repeat kinase activity  cyclin-dependent protein kinase activating kinase holoenzyme complex  cyclin-dependent protein kinase activating kinase holoenzyme complex  snRNA transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  perinuclear region of cytoplasm  protein stabilization  cell division  regulation of cell cycle  CAK-ERCC2 complex  phosphorylation of RNA polymerase II C-terminal domain  transcription factor TFIIK complex  transcription factor TFIIK complex  protein serine kinase activity  regulation of G1/S transition of mitotic cell cycle  
Pathways : BIOCARTABIOCARTA_EFPPATHWAY    BIOCARTA_CELLCYCLEPATHWAY    BIOCARTA_PTC1PATHWAY   
Pathways : KEGGKEGG_NUCLEOTIDE_EXCISION_REPAIR    KEGG_CELL_CYCLE   
NDEx NetworkCDK7
Atlas of Cancer Signalling NetworkCDK7
Wikipedia pathwaysCDK7
Orthology - Evolution
OrthoDB1022
GeneTree (enSembl)ENSG00000134058
Phylogenetic Trees/Animal Genes : TreeFamCDK7
Homologs : HomoloGeneCDK7
Homology/Alignments : Family Browser (UCSC)CDK7
Gene fusions - Rearrangements
Fusion : MitelmanCDK7::CCNB1 [5q13.2/5q13.2]  
Fusion : MitelmanCDK7::RGS20 [5q13.2/8q11.23]  
Fusion : MitelmanCDK7::RIN3 [5q13.2/14q32.12]  
Fusion : QuiverCDK7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK7
dbVarCDK7
ClinVarCDK7
MonarchCDK7
1000_GenomesCDK7 
Exome Variant ServerCDK7
GNOMAD BrowserENSG00000134058
Varsome BrowserCDK7
ACMGCDK7 variants
VarityP50613
Genomic Variants (DGV)CDK7 [DGVbeta]
DECIPHERCDK7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK7 
Mutations
ICGC Data PortalCDK7 
TCGA Data PortalCDK7 
Broad Tumor PortalCDK7
OASIS PortalCDK7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK7  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCDK7
Mutations and Diseases : HGMDCDK7
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCDK7
DgiDB (Drug Gene Interaction Database)CDK7
DoCM (Curated mutations)CDK7
CIViC (Clinical Interpretations of Variants in Cancer)CDK7
Cancer3DCDK7
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601955   
Orphanet
DisGeNETCDK7
MedgenCDK7
Genetic Testing Registry CDK7
NextProtP50613 [Medical]
GENETestsCDK7
Target ValidationCDK7
Huge Navigator CDK7 [HugePedia]
ClinGenCDK7
Clinical trials, drugs, therapy
MyCancerGenomeCDK7
Protein Interactions : CTDCDK7
Pharm GKB GenePA26314
PharosP50613
Clinical trialCDK7
Miscellaneous
canSAR (ICR)CDK7
HarmonizomeCDK7
ARCHS4CDK7
DataMed IndexCDK7
Probes
Litterature
PubMed205 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCDK7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:26:50 CET 2022

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