Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CDK7 (cyclin dependent kinase 7)

Identity

Alias_namescyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase)
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)
Alias_symbol (synonym)CAK1
CDKN7
MO15
STK1
CAK
Other aliasHCAK
p39MO15
HGNC (Hugo) CDK7
LocusID (NCBI) 1022
Atlas_Id 40035
Location 5q13.2  [Link to chromosome band 5q13]
Location_base_pair Starts at 69234795 and ends at 69277430 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDK7 (5q13.2) / CCNB1 (5q13.2)CDK7 (5q13.2) / MATR3 (5q31.2)CDK7 (5q13.2) / RGS20 (8q11.23)
CDK7 (5q13.2) / RIN3 (14q32.12)CDK7 5q13.2 / CCNB1 5q13.2CDK7 5q13.2 / RGS20 8q11.23
CDK7 5q13.2 / RIN3 14q32.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDK7   1778
Cards
Entrez_Gene (NCBI)CDK7  1022  cyclin dependent kinase 7
AliasesCAK; CAK1; CDKN7; HCAK; 
MO15; STK1; p39MO15
GeneCards (Weizmann)CDK7
Ensembl hg19 (Hinxton)ENSG00000134058 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134058 [Gene_View]  chr5:69234795-69277430 [Contig_View]  CDK7 [Vega]
ICGC DataPortalENSG00000134058
TCGA cBioPortalCDK7
AceView (NCBI)CDK7
Genatlas (Paris)CDK7
WikiGenes1022
SOURCE (Princeton)CDK7
Genetics Home Reference (NIH)CDK7
Genomic and cartography
GoldenPath hg38 (UCSC)CDK7  -     chr5:69234795-69277430 +  5q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK7  -     5q13.2   [Description]    (hg19-Feb_2009)
EnsemblCDK7 - 5q13.2 [CytoView hg19]  CDK7 - 5q13.2 [CytoView hg38]
Mapping of homologs : NCBICDK7 [Mapview hg19]  CDK7 [Mapview hg38]
OMIM601955   
Gene and transcription
Genbank (Entrez)AK026509 AK308493 AM392563 AM392604 AM392628
RefSeq transcript (Entrez)NM_001324069 NM_001324070 NM_001324071 NM_001324072 NM_001324074 NM_001324075 NM_001324077 NM_001324078 NM_001799
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDK7
Cluster EST : UnigeneHs.184298 [ NCBI ]
CGAP (NCI)Hs.184298
Alternative Splicing GalleryENSG00000134058
Gene ExpressionCDK7 [ NCBI-GEO ]   CDK7 [ EBI - ARRAY_EXPRESS ]   CDK7 [ SEEK ]   CDK7 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1022
GTEX Portal (Tissue expression)CDK7
Protein : pattern, domain, 3D structure
UniProt/SwissProtP50613   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP50613  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP50613
Splice isoforms : SwissVarP50613
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   
PhosPhoSitePlusP50613
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK7
DMDM Disease mutations1022
Blocks (Seattle)CDK7
PDB (SRS)1LG3    1PA8    1UA2    2HIC   
PDB (PDBSum)1LG3    1PA8    1UA2    2HIC   
PDB (IMB)1LG3    1PA8    1UA2    2HIC   
PDB (RSDB)1LG3    1PA8    1UA2    2HIC   
Structural Biology KnowledgeBase1LG3    1PA8    1UA2    2HIC   
SCOP (Structural Classification of Proteins)1LG3    1PA8    1UA2    2HIC   
CATH (Classification of proteins structures)1LG3    1PA8    1UA2    2HIC   
SuperfamilyP50613
Human Protein AtlasENSG00000134058
Peptide AtlasP50613
HPRD15993
IPIIPI00000685   IPI00967990   IPI00964272   IPI00964898   IPI00965416   IPI00968303   IPI00964544   IPI00965167   IPI00967260   IPI00964080   
Protein Interaction databases
DIP (DOE-UCLA)P50613
IntAct (EBI)P50613
FunCoupENSG00000134058
BioGRIDCDK7
STRING (EMBL)CDK7
ZODIACCDK7
Ontologies - Pathways
QuickGOP50613
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  transcription coactivator activity  protein kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  holo TFIIH complex  cytoplasm  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, preincision complex assembly  transcription initiation from RNA polymerase I promoter  transcription elongation from RNA polymerase I promoter  termination of RNA polymerase I transcription  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  protein phosphorylation  cell cycle arrest  protein C-terminus binding  DNA-dependent ATPase activity  cell proliferation  RNA polymerase II carboxy-terminal domain kinase activity  kinase activity  cyclin-dependent protein kinase activating kinase holoenzyme complex  androgen receptor signaling pathway  snRNA transcription from RNA polymerase II promoter  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  perinuclear region of cytoplasm  androgen receptor binding  protein stabilization  cell division  TFIIK complex  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  transcription coactivator activity  protein kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  holo TFIIH complex  cytoplasm  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, preincision complex assembly  transcription initiation from RNA polymerase I promoter  transcription elongation from RNA polymerase I promoter  termination of RNA polymerase I transcription  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  protein phosphorylation  cell cycle arrest  protein C-terminus binding  DNA-dependent ATPase activity  cell proliferation  RNA polymerase II carboxy-terminal domain kinase activity  kinase activity  cyclin-dependent protein kinase activating kinase holoenzyme complex  androgen receptor signaling pathway  snRNA transcription from RNA polymerase II promoter  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  perinuclear region of cytoplasm  androgen receptor binding  protein stabilization  cell division  TFIIK complex  
Pathways : BIOCARTADegradation of the RAR and RXR by the proteasome [Genes]    Estrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes]    Cyclins and Cell Cycle Regulation [Genes]    Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle [Genes]   
Pathways : KEGGBasal transcription factors    Nucleotide excision repair    Cell cycle   
NDEx NetworkCDK7
Atlas of Cancer Signalling NetworkCDK7
Wikipedia pathwaysCDK7
Orthology - Evolution
OrthoDB1022
GeneTree (enSembl)ENSG00000134058
Phylogenetic Trees/Animal Genes : TreeFamCDK7
HOVERGENP50613
HOGENOMP50613
Homologs : HomoloGeneCDK7
Homology/Alignments : Family Browser (UCSC)CDK7
Gene fusions - Rearrangements
Fusion : MitelmanCDK7/CCNB1 [5q13.2/5q13.2]  
Fusion : MitelmanCDK7/RGS20 [5q13.2/8q11.23]  [t(5;8)(q13;q11)]  
Fusion : MitelmanCDK7/RIN3 [5q13.2/14q32.12]  [t(5;14)(q13;q32)]  
Fusion: TCGACDK7 5q13.2 CCNB1 5q13.2 BRCA
Fusion: TCGACDK7 5q13.2 RGS20 8q11.23 BRCA
Fusion: TCGACDK7 5q13.2 RIN3 14q32.12 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK7
dbVarCDK7
ClinVarCDK7
1000_GenomesCDK7 
Exome Variant ServerCDK7
ExAC (Exome Aggregation Consortium)CDK7 (select the gene name)
Genetic variants : HAPMAP1022
Genomic Variants (DGV)CDK7 [DGVbeta]
DECIPHERCDK7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK7 
Mutations
ICGC Data PortalCDK7 
TCGA Data PortalCDK7 
Broad Tumor PortalCDK7
OASIS PortalCDK7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDK7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK7
DgiDB (Drug Gene Interaction Database)CDK7
DoCM (Curated mutations)CDK7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK7 (select a term)
intoGenCDK7
Cancer3DCDK7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601955   
Orphanet
MedgenCDK7
Genetic Testing Registry CDK7
NextProtP50613 [Medical]
TSGene1022
GENETestsCDK7
Target ValidationCDK7
Huge Navigator CDK7 [HugePedia]
snp3D : Map Gene to Disease1022
BioCentury BCIQCDK7
ClinGenCDK7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1022
Chemical/Pharm GKB GenePA26314
Clinical trialCDK7
Miscellaneous
canSAR (ICR)CDK7 (select the gene name)
Probes
Litterature
PubMed163 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK7
EVEXCDK7
GoPubMedCDK7
iHOPCDK7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:01:44 CEST 2017

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