Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CDK8 (cyclin dependent kinase 8)

Identity

Alias_namescyclin-dependent kinase 8
Alias_symbol (synonym)K35
Other alias
HGNC (Hugo) CDK8
LocusID (NCBI) 1024
Atlas_Id 40036
Location 13q12.13  [Link to chromosome band 13q12]
Location_base_pair Starts at 26254104 and ends at 26405236 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDK8 (13q12.13) / IKZF3 (17q12)PACS1 (11q13.1) / CDK8 (13q12.13)RPL7L1 (6p21.1) / CDK8 (13q12.13)
CDK8 13q12.13 / IKZF3 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(6;13)(p21;q12) RPL7L1/CDK8
t(13;17)(q12;q12) CDK8/IKZF3

External links

Nomenclature
HGNC (Hugo)CDK8   1779
Cards
Entrez_Gene (NCBI)CDK8  1024  cyclin dependent kinase 8
AliasesK35
GeneCards (Weizmann)CDK8
Ensembl hg19 (Hinxton)ENSG00000132964 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132964 [Gene_View]  chr13:26254104-26405236 [Contig_View]  CDK8 [Vega]
ICGC DataPortalENSG00000132964
TCGA cBioPortalCDK8
AceView (NCBI)CDK8
Genatlas (Paris)CDK8
WikiGenes1024
SOURCE (Princeton)CDK8
Genetics Home Reference (NIH)CDK8
Genomic and cartography
GoldenPath hg38 (UCSC)CDK8  -     chr13:26254104-26405236 +  13q12.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK8  -     13q12.13   [Description]    (hg19-Feb_2009)
EnsemblCDK8 - 13q12.13 [CytoView hg19]  CDK8 - 13q12.13 [CytoView hg38]
Mapping of homologs : NCBICDK8 [Mapview hg19]  CDK8 [Mapview hg38]
OMIM603184   
Gene and transcription
Genbank (Entrez)AK296084 AK296875 AY702976 BC069634 BC094784
RefSeq transcript (Entrez)NM_001260 NM_001318368 NM_001346501
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDK8
Cluster EST : UnigeneHs.695166 [ NCBI ]
CGAP (NCI)Hs.695166
Alternative Splicing GalleryENSG00000132964
Gene ExpressionCDK8 [ NCBI-GEO ]   CDK8 [ EBI - ARRAY_EXPRESS ]   CDK8 [ SEEK ]   CDK8 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1024
GTEX Portal (Tissue expression)CDK8
Human Protein AtlasENSG00000132964-CDK8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49336   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49336  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49336
Splice isoforms : SwissVarP49336
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   
PhosPhoSitePlusP49336
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK8
DMDM Disease mutations1024
Blocks (Seattle)CDK8
PDB (SRS)3RGF    4CRL    4F6S    4F6U    4F6W    4F70    4F7J    4F7L    4F7N    4F7S    4G6L    5BNJ    5CEI    5FGK    5HBE    5HBH    5HBJ    5HNB    5HVY    5I5Z    5ICP    5IDN    5IDP   
PDB (PDBSum)3RGF    4CRL    4F6S    4F6U    4F6W    4F70    4F7J    4F7L    4F7N    4F7S    4G6L    5BNJ    5CEI    5FGK    5HBE    5HBH    5HBJ    5HNB    5HVY    5I5Z    5ICP    5IDN    5IDP   
PDB (IMB)3RGF    4CRL    4F6S    4F6U    4F6W    4F70    4F7J    4F7L    4F7N    4F7S    4G6L    5BNJ    5CEI    5FGK    5HBE    5HBH    5HBJ    5HNB    5HVY    5I5Z    5ICP    5IDN    5IDP   
PDB (RSDB)3RGF    4CRL    4F6S    4F6U    4F6W    4F70    4F7J    4F7L    4F7N    4F7S    4G6L    5BNJ    5CEI    5FGK    5HBE    5HBH    5HBJ    5HNB    5HVY    5I5Z    5ICP    5IDN    5IDP   
Structural Biology KnowledgeBase3RGF    4CRL    4F6S    4F6U    4F6W    4F70    4F7J    4F7L    4F7N    4F7S    4G6L    5BNJ    5CEI    5FGK    5HBE    5HBH    5HBJ    5HNB    5HVY    5I5Z    5ICP    5IDN    5IDP   
SCOP (Structural Classification of Proteins)3RGF    4CRL    4F6S    4F6U    4F6W    4F70    4F7J    4F7L    4F7N    4F7S    4G6L    5BNJ    5CEI    5FGK    5HBE    5HBH    5HBJ    5HNB    5HVY    5I5Z    5ICP    5IDN    5IDP   
CATH (Classification of proteins structures)3RGF    4CRL    4F6S    4F6U    4F6W    4F70    4F7J    4F7L    4F7N    4F7S    4G6L    5BNJ    5CEI    5FGK    5HBE    5HBH    5HBJ    5HNB    5HVY    5I5Z    5ICP    5IDN    5IDP   
SuperfamilyP49336
Human Protein Atlas [tissue]ENSG00000132964-CDK8 [tissue]
Peptide AtlasP49336
HPRD04422
IPIIPI00026791   IPI00879595   IPI00470693   
Protein Interaction databases
DIP (DOE-UCLA)P49336
IntAct (EBI)P49336
FunCoupENSG00000132964
BioGRIDCDK8
STRING (EMBL)CDK8
ZODIACCDK8
Ontologies - Pathways
QuickGOP49336
Ontology : AmiGOprotein kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  transcription initiation from RNA polymerase II promoter  protein phosphorylation  regulation of mitotic cell cycle  RNA polymerase II carboxy-terminal domain kinase activity  mediator complex  protein complex  positive regulation of transcription by RNA polymerase II  
Ontology : EGO-EBIprotein kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  transcription initiation from RNA polymerase II promoter  protein phosphorylation  regulation of mitotic cell cycle  RNA polymerase II carboxy-terminal domain kinase activity  mediator complex  protein complex  positive regulation of transcription by RNA polymerase II  
Pathways : BIOCARTAEstrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes]   
NDEx NetworkCDK8
Atlas of Cancer Signalling NetworkCDK8
Wikipedia pathwaysCDK8
Orthology - Evolution
OrthoDB1024
GeneTree (enSembl)ENSG00000132964
Phylogenetic Trees/Animal Genes : TreeFamCDK8
HOVERGENP49336
HOGENOMP49336
Homologs : HomoloGeneCDK8
Homology/Alignments : Family Browser (UCSC)CDK8
Gene fusions - Rearrangements
Fusion : MitelmanCDK8/IKZF3 [13q12.13/17q12]  
Fusion : MitelmanRPL7L1/CDK8 [6p21.1/13q12.13]  [t(6;13)(p21;q12)]  
Fusion: TCGA_MDACCCDK8 13q12.13 IKZF3 17q12 BRCA
Fusion PortalCDK8 13q12.13 IKZF3 17q12 BRCA
Fusion : QuiverCDK8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK8
dbVarCDK8
ClinVarCDK8
1000_GenomesCDK8 
Exome Variant ServerCDK8
ExAC (Exome Aggregation Consortium)ENSG00000132964
GNOMAD BrowserENSG00000132964
Genetic variants : HAPMAP1024
Genomic Variants (DGV)CDK8 [DGVbeta]
DECIPHERCDK8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK8 
Mutations
ICGC Data PortalCDK8 
TCGA Data PortalCDK8 
Broad Tumor PortalCDK8
OASIS PortalCDK8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDK8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK8
DgiDB (Drug Gene Interaction Database)CDK8
DoCM (Curated mutations)CDK8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK8 (select a term)
intoGenCDK8
Cancer3DCDK8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603184   
Orphanet
DisGeNETCDK8
MedgenCDK8
Genetic Testing Registry CDK8
NextProtP49336 [Medical]
TSGene1024
GENETestsCDK8
Target ValidationCDK8
Huge Navigator CDK8 [HugePedia]
snp3D : Map Gene to Disease1024
BioCentury BCIQCDK8
ClinGenCDK8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1024
Chemical/Pharm GKB GenePA26315
Clinical trialCDK8
Miscellaneous
canSAR (ICR)CDK8 (select the gene name)
Probes
Litterature
PubMed113 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK8
EVEXCDK8
GoPubMedCDK8
iHOPCDK8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Feb 28 13:05:38 CET 2018
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