Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CDK9 (cyclin dependent kinase 9)

Identity

Alias (NCBI)C-2k
CDC2L4
CTK1
PITALRE
TAK
HGNC (Hugo) CDK9
HGNC Alias symbPITALRE
C-2k
TAK
HGNC Previous nameCDC2L4
HGNC Previous namecyclin-dependent kinase 9 (CDC2-related kinase)
LocusID (NCBI) 1025
Atlas_Id 43202
Location 9q34.11  [Link to chromosome band 9q34]
Location_base_pair Starts at 127786034 and ends at 127790785 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDK9 (9q34.11)::CDK9 (9q34.11)CLU (8p21.1)::CDK9 (9q34.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(4;11)(q21;q23) KMT2A::AFF1


External links

 

Nomenclature
HGNC (Hugo)CDK9   1780
Cards
Entrez_Gene (NCBI)CDK9    cyclin dependent kinase 9
AliasesC-2k; CDC2L4; CTK1; PITALRE; 
TAK
GeneCards (Weizmann)CDK9
Ensembl hg19 (Hinxton)ENSG00000136807 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136807 [Gene_View]  ENSG00000136807 [Sequence]  chr9:127786034-127790785 [Contig_View]  CDK9 [Vega]
ICGC DataPortalENSG00000136807
TCGA cBioPortalCDK9
AceView (NCBI)CDK9
Genatlas (Paris)CDK9
SOURCE (Princeton)CDK9
Genetics Home Reference (NIH)CDK9
Genomic and cartography
GoldenPath hg38 (UCSC)CDK9  -     chr9:127786034-127790785 +  9q34.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDK9  -     9q34.11   [Description]    (hg19-Feb_2009)
GoldenPathCDK9 - 9q34.11 [CytoView hg19]  CDK9 - 9q34.11 [CytoView hg38]
ImmunoBaseENSG00000136807
Genome Data Viewer NCBICDK9 [Mapview hg19]  
OMIM603251   
Gene and transcription
Genbank (Entrez)AB451289 AB451421 AK313828 BC001968 BE549667
RefSeq transcript (Entrez)NM_001261
Consensus coding sequences : CCDS (NCBI)CDK9
Gene ExpressionCDK9 [ NCBI-GEO ]   CDK9 [ EBI - ARRAY_EXPRESS ]   CDK9 [ SEEK ]   CDK9 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK9 [ Firebrowse - Broad ]
GenevisibleExpression of CDK9 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1025
GTEX Portal (Tissue expression)CDK9
Human Protein AtlasENSG00000136807-CDK9 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP50750   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP50750  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP50750
PhosPhoSitePlusP50750
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK9
PDB (RSDB)1PF6    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5    5L1Z    6CYT    6GZH   
PDB Europe1PF6    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5    5L1Z    6CYT    6GZH   
PDB (PDBSum)1PF6    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5    5L1Z    6CYT    6GZH   
PDB (IMB)1PF6    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5    5L1Z    6CYT    6GZH   
Structural Biology KnowledgeBase1PF6    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5    5L1Z    6CYT    6GZH   
SCOP (Structural Classification of Proteins)1PF6    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5    5L1Z    6CYT    6GZH   
CATH (Classification of proteins structures)1PF6    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5    5L1Z    6CYT    6GZH   
SuperfamilyP50750
AlphaFold pdb e-kbP50750   
Human Protein Atlas [tissue]ENSG00000136807-CDK9 [tissue]
HPRD16016
Protein Interaction databases
DIP (DOE-UCLA)P50750
IntAct (EBI)P50750
BioGRIDCDK9
STRING (EMBL)CDK9
ZODIACCDK9
Ontologies - Pathways
QuickGOP50750
Ontology : AmiGORNA polymerase II cis-regulatory region sequence-specific DNA binding  transcription coactivator binding  DNA binding  chromatin binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  DNA repair  regulation of DNA repair  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  protein phosphorylation  protein phosphorylation  protein phosphorylation  regulation of mitotic cell cycle  transcription elongation factor complex  cyclin/CDK positive transcription elongation factor complex  cyclin/CDK positive transcription elongation factor complex  cell population proliferation  RNA polymerase II CTD heptapeptide repeat kinase activity  RNA polymerase II CTD heptapeptide repeat kinase activity  response to xenobiotic stimulus  positive regulation of cardiac muscle hypertrophy  membrane  mediator complex  PML body  protein kinase binding  regulation of histone modification  replication fork processing  positive regulation of transcription elongation from RNA polymerase II promoter  positive regulation of histone phosphorylation  cytoplasmic ribonucleoprotein granule  positive regulation by host of viral transcription  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  regulation of muscle cell differentiation  regulation of cell cycle  P-TEFb complex  phosphorylation of RNA polymerase II C-terminal domain  cellular response to cytokine stimulus  7SK snRNA binding  protein serine kinase activity  negative regulation of mRNA polyadenylation  phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter  phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter  positive regulation of mRNA 3'-UTR binding  positive regulation of histone H2B ubiquitination  
Ontology : EGO-EBIRNA polymerase II cis-regulatory region sequence-specific DNA binding  transcription coactivator binding  DNA binding  chromatin binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  nucleoplasm  DNA repair  regulation of DNA repair  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  protein phosphorylation  protein phosphorylation  protein phosphorylation  regulation of mitotic cell cycle  transcription elongation factor complex  cyclin/CDK positive transcription elongation factor complex  cyclin/CDK positive transcription elongation factor complex  cell population proliferation  RNA polymerase II CTD heptapeptide repeat kinase activity  RNA polymerase II CTD heptapeptide repeat kinase activity  response to xenobiotic stimulus  positive regulation of cardiac muscle hypertrophy  membrane  mediator complex  PML body  protein kinase binding  regulation of histone modification  replication fork processing  positive regulation of transcription elongation from RNA polymerase II promoter  positive regulation of histone phosphorylation  cytoplasmic ribonucleoprotein granule  positive regulation by host of viral transcription  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  regulation of muscle cell differentiation  regulation of cell cycle  P-TEFb complex  phosphorylation of RNA polymerase II C-terminal domain  cellular response to cytokine stimulus  7SK snRNA binding  protein serine kinase activity  negative regulation of mRNA polyadenylation  phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter  phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter  positive regulation of mRNA 3'-UTR binding  positive regulation of histone H2B ubiquitination  
NDEx NetworkCDK9
Atlas of Cancer Signalling NetworkCDK9
Wikipedia pathwaysCDK9
Orthology - Evolution
OrthoDB1025
GeneTree (enSembl)ENSG00000136807
Phylogenetic Trees/Animal Genes : TreeFamCDK9
Homologs : HomoloGeneCDK9
Homology/Alignments : Family Browser (UCSC)CDK9
Gene fusions - Rearrangements
Fusion : QuiverCDK9
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK9
dbVarCDK9
ClinVarCDK9
MonarchCDK9
1000_GenomesCDK9 
Exome Variant ServerCDK9
GNOMAD BrowserENSG00000136807
Varsome BrowserCDK9
ACMGCDK9 variants
VarityP50750
Genomic Variants (DGV)CDK9 [DGVbeta]
DECIPHERCDK9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDK9 
Mutations
ICGC Data PortalCDK9 
TCGA Data PortalCDK9 
Broad Tumor PortalCDK9
OASIS PortalCDK9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK9  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCDK9
Mutations and Diseases : HGMDCDK9
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCDK9
DgiDB (Drug Gene Interaction Database)CDK9
DoCM (Curated mutations)CDK9
CIViC (Clinical Interpretations of Variants in Cancer)CDK9
Cancer3DCDK9
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603251   
Orphanet
DisGeNETCDK9
MedgenCDK9
Genetic Testing Registry CDK9
NextProtP50750 [Medical]
GENETestsCDK9
Target ValidationCDK9
Huge Navigator CDK9 [HugePedia]
ClinGenCDK9
Clinical trials, drugs, therapy
MyCancerGenomeCDK9
Protein Interactions : CTDCDK9
Pharm GKB GenePA26316
PharosP50750
Clinical trialCDK9
Miscellaneous
canSAR (ICR)CDK9
HarmonizomeCDK9
ARCHS4CDK9
DataMed IndexCDK9
Probes
Litterature
PubMed494 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCDK9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 20 12:26:51 CET 2022

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