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CDK9 (cyclin-dependent kinase 9)

Identity

Alias_namesCDC2L4
cyclin-dependent kinase 9 (CDC2-related kinase)
Alias_symbol (synonym)PITALRE
C-2k
TAK
Other aliasCTK1
HGNC (Hugo) CDK9
LocusID (NCBI) 1025
Atlas_Id 43202
Location 9q34.11  [Link to chromosome band 9q34]
Location_base_pair Starts at 130548305 and ends at 130553052 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CDK9 (9q34.11) / CDK9 (9q34.11)CLU (8p21.1) / CDK9 (9q34.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDK9   1780
Cards
Entrez_Gene (NCBI)CDK9  1025  cyclin-dependent kinase 9
AliasesC-2k; CDC2L4; CTK1; PITALRE; 
TAK
GeneCards (Weizmann)CDK9
Ensembl hg19 (Hinxton)ENSG00000136807 [Gene_View]  chr9:130548305-130553052 [Contig_View]  CDK9 [Vega]
Ensembl hg38 (Hinxton)ENSG00000136807 [Gene_View]  chr9:130548305-130553052 [Contig_View]  CDK9 [Vega]
ICGC DataPortalENSG00000136807
TCGA cBioPortalCDK9
AceView (NCBI)CDK9
Genatlas (Paris)CDK9
WikiGenes1025
SOURCE (Princeton)CDK9
Genetics Home Reference (NIH)CDK9
Genomic and cartography
GoldenPath hg19 (UCSC)CDK9  -     chr9:130548305-130553052 +  9q34.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CDK9  -     9q34.11   [Description]    (hg38-Dec_2013)
EnsemblCDK9 - 9q34.11 [CytoView hg19]  CDK9 - 9q34.11 [CytoView hg38]
Mapping of homologs : NCBICDK9 [Mapview hg19]  CDK9 [Mapview hg38]
OMIM603251   
Gene and transcription
Genbank (Entrez)AB451289 AB451421 AK313828 BC001968 BE549667
RefSeq transcript (Entrez)NM_001261
RefSeq genomic (Entrez)NC_000009 NC_018920 NG_033942 NT_008470 NW_004929366
Consensus coding sequences : CCDS (NCBI)CDK9
Cluster EST : UnigeneHs.706809 [ NCBI ]
CGAP (NCI)Hs.706809
Alternative Splicing GalleryENSG00000136807
Gene ExpressionCDK9 [ NCBI-GEO ]   CDK9 [ EBI - ARRAY_EXPRESS ]   CDK9 [ SEEK ]   CDK9 [ MEM ]
Gene Expression Viewer (FireBrowse)CDK9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1025
GTEX Portal (Tissue expression)CDK9
Protein : pattern, domain, 3D structure
UniProt/SwissProtP50750   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP50750  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP50750
Splice isoforms : SwissVarP50750
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   
PhosPhoSitePlusP50750
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDK9
DMDM Disease mutations1025
Blocks (Seattle)CDK9
PDB (SRS)1PF6    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5   
PDB (PDBSum)1PF6    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5   
PDB (IMB)1PF6    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5   
PDB (RSDB)1PF6    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5   
Structural Biology KnowledgeBase1PF6    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5   
SCOP (Structural Classification of Proteins)1PF6    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5   
CATH (Classification of proteins structures)1PF6    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5   
SuperfamilyP50750
Human Protein AtlasENSG00000136807
Peptide AtlasP50750
HPRD16016
IPIIPI00301923   IPI00552413   
Protein Interaction databases
DIP (DOE-UCLA)P50750
IntAct (EBI)P50750
FunCoupENSG00000136807
BioGRIDCDK9
STRING (EMBL)CDK9
ZODIACCDK9
Ontologies - Pathways
QuickGOP50750
Ontology : AmiGORNA polymerase II core promoter sequence-specific DNA binding  transcription coactivator binding  DNA binding  chromatin binding  protein kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  nucleoplasm  cytoplasm  DNA repair  regulation of DNA repair  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  protein phosphorylation  regulation of mitotic cell cycle  transcription elongation factor complex  positive transcription elongation factor complex b  cell proliferation  RNA polymerase II carboxy-terminal domain kinase activity  positive regulation of cardiac muscle hypertrophy  membrane  kinase activity  PML body  regulation of histone modification  replication fork processing  positive regulation of histone phosphorylation  response to drug  snRNA transcription from RNA polymerase II promoter  intracellular membrane-bounded organelle  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of viral transcription  regulation of muscle cell differentiation  negative regulation of cell cycle arrest  cellular response to cytokine stimulus  7SK snRNA binding  negative regulation of mRNA polyadenylation  positive regulation of mRNA 3'-UTR binding  positive regulation of histone H2B ubiquitination  
Ontology : EGO-EBIRNA polymerase II core promoter sequence-specific DNA binding  transcription coactivator binding  DNA binding  chromatin binding  protein kinase activity  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  nucleoplasm  cytoplasm  DNA repair  regulation of DNA repair  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  protein phosphorylation  regulation of mitotic cell cycle  transcription elongation factor complex  positive transcription elongation factor complex b  cell proliferation  RNA polymerase II carboxy-terminal domain kinase activity  positive regulation of cardiac muscle hypertrophy  membrane  kinase activity  PML body  regulation of histone modification  replication fork processing  positive regulation of histone phosphorylation  response to drug  snRNA transcription from RNA polymerase II promoter  intracellular membrane-bounded organelle  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of viral transcription  regulation of muscle cell differentiation  negative regulation of cell cycle arrest  cellular response to cytokine stimulus  7SK snRNA binding  negative regulation of mRNA polyadenylation  positive regulation of mRNA 3'-UTR binding  positive regulation of histone H2B ubiquitination  
Pathways : KEGGTranscriptional misregulation in cancer   
NDEx NetworkCDK9
Atlas of Cancer Signalling NetworkCDK9
Wikipedia pathwaysCDK9
Orthology - Evolution
OrthoDB1025
GeneTree (enSembl)ENSG00000136807
Phylogenetic Trees/Animal Genes : TreeFamCDK9
HOVERGENP50750
HOGENOMP50750
Homologs : HomoloGeneCDK9
Homology/Alignments : Family Browser (UCSC)CDK9
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDK9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDK9
dbVarCDK9
ClinVarCDK9
1000_GenomesCDK9 
Exome Variant ServerCDK9
ExAC (Exome Aggregation Consortium)CDK9 (select the gene name)
Genetic variants : HAPMAP1025
Genomic Variants (DGV)CDK9 [DGVbeta]
DECIPHER (Syndromes)9:130548305-130553052  ENSG00000136807
CONAN: Copy Number AnalysisCDK9 
Mutations
ICGC Data PortalCDK9 
TCGA Data PortalCDK9 
Broad Tumor PortalCDK9
OASIS PortalCDK9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDK9  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDK9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDK9
DgiDB (Drug Gene Interaction Database)CDK9
DoCM (Curated mutations)CDK9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDK9 (select a term)
intoGenCDK9
Cancer3DCDK9(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603251   
Orphanet
MedgenCDK9
Genetic Testing Registry CDK9
NextProtP50750 [Medical]
TSGene1025
GENETestsCDK9
Huge Navigator CDK9 [HugePedia]
snp3D : Map Gene to Disease1025
BioCentury BCIQCDK9
ClinGenCDK9
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1025
Chemical/Pharm GKB GenePA26316
Clinical trialCDK9
Miscellaneous
canSAR (ICR)CDK9 (select the gene name)
Probes
Litterature
PubMed370 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDK9
EVEXCDK9
GoPubMedCDK9
iHOPCDK9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:59:47 CET 2017

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