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CDKL1 (cyclin dependent kinase like 1)

Identity

Alias_namescyclin-dependent kinase-like 1 (CDC2-related kinase)
Alias_symbol (synonym)KKIALRE
Other aliasP42
HGNC (Hugo) CDKL1
LocusID (NCBI) 8814
Atlas_Id 43203
Location 14q21.3  [Link to chromosome band 14q21]
Location_base_pair Starts at 50331926 and ends at 50397404 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDKL1 (14q21.3) / ATL1 (14q22.1)NEMF (14q21.3) / CDKL1 (14q21.3)CDKL1 14q21.3 / ATL1 14q22.1
NEMF 14q21.3 / CDKL1 14q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDKL1   1781
Cards
Entrez_Gene (NCBI)CDKL1  8814  cyclin dependent kinase like 1
AliasesKKIALRE; P42
GeneCards (Weizmann)CDKL1
Ensembl hg19 (Hinxton)ENSG00000100490 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100490 [Gene_View]  chr14:50331926-50397404 [Contig_View]  CDKL1 [Vega]
ICGC DataPortalENSG00000100490
TCGA cBioPortalCDKL1
AceView (NCBI)CDKL1
Genatlas (Paris)CDKL1
WikiGenes8814
SOURCE (Princeton)CDKL1
Genetics Home Reference (NIH)CDKL1
Genomic and cartography
GoldenPath hg38 (UCSC)CDKL1  -     chr14:50331926-50397404 -  14q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDKL1  -     14q21.3   [Description]    (hg19-Feb_2009)
EnsemblCDKL1 - 14q21.3 [CytoView hg19]  CDKL1 - 14q21.3 [CytoView hg38]
Mapping of homologs : NCBICDKL1 [Mapview hg19]  CDKL1 [Mapview hg38]
OMIM603441   
Gene and transcription
Genbank (Entrez)AA742987 AA780354 AF390028 AK093741 AK308732
RefSeq transcript (Entrez)NM_001282236 NM_004196
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDKL1
Cluster EST : UnigeneHs.679430 [ NCBI ]
CGAP (NCI)Hs.679430
Alternative Splicing GalleryENSG00000100490
Gene ExpressionCDKL1 [ NCBI-GEO ]   CDKL1 [ EBI - ARRAY_EXPRESS ]   CDKL1 [ SEEK ]   CDKL1 [ MEM ]
Gene Expression Viewer (FireBrowse)CDKL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8814
GTEX Portal (Tissue expression)CDKL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ00532   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ00532  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ00532
Splice isoforms : SwissVarQ00532
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   
PhosPhoSitePlusQ00532
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDKL1
DMDM Disease mutations8814
Blocks (Seattle)CDKL1
PDB (SRS)4AGU   
PDB (PDBSum)4AGU   
PDB (IMB)4AGU   
PDB (RSDB)4AGU   
Structural Biology KnowledgeBase4AGU   
SCOP (Structural Classification of Proteins)4AGU   
CATH (Classification of proteins structures)4AGU   
SuperfamilyQ00532
Human Protein AtlasENSG00000100490
Peptide AtlasQ00532
HPRD10348
IPIIPI01017912   IPI00973840   IPI00979218   IPI00979838   IPI00023527   
Protein Interaction databases
DIP (DOE-UCLA)Q00532
IntAct (EBI)Q00532
FunCoupENSG00000100490
BioGRIDCDKL1
STRING (EMBL)CDKL1
ZODIACCDKL1
Ontologies - Pathways
QuickGOQ00532
Ontology : AmiGOcyclin-dependent protein serine/threonine kinase activity  ATP binding  nucleus  nucleoplasm  cytoplasm  protein phosphorylation  heart development  intracellular membrane-bounded organelle  regulation of cell cycle  extracellular exosome  
Ontology : EGO-EBIcyclin-dependent protein serine/threonine kinase activity  ATP binding  nucleus  nucleoplasm  cytoplasm  protein phosphorylation  heart development  intracellular membrane-bounded organelle  regulation of cell cycle  extracellular exosome  
NDEx NetworkCDKL1
Atlas of Cancer Signalling NetworkCDKL1
Wikipedia pathwaysCDKL1
Orthology - Evolution
OrthoDB8814
GeneTree (enSembl)ENSG00000100490
Phylogenetic Trees/Animal Genes : TreeFamCDKL1
HOVERGENQ00532
HOGENOMQ00532
Homologs : HomoloGeneCDKL1
Homology/Alignments : Family Browser (UCSC)CDKL1
Gene fusions - Rearrangements
Fusion : MitelmanCDKL1/ATL1 [14q21.3/14q22.1]  
Fusion : MitelmanNEMF/CDKL1 [14q21.3/14q21.3]  [t(14;14)(q21;q21)]  
Fusion: TCGACDKL1 14q21.3 ATL1 14q22.1 OV
Fusion: TCGANEMF 14q21.3 CDKL1 14q21.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDKL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDKL1
dbVarCDKL1
ClinVarCDKL1
1000_GenomesCDKL1 
Exome Variant ServerCDKL1
ExAC (Exome Aggregation Consortium)CDKL1 (select the gene name)
Genetic variants : HAPMAP8814
Genomic Variants (DGV)CDKL1 [DGVbeta]
DECIPHERCDKL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDKL1 
Mutations
ICGC Data PortalCDKL1 
TCGA Data PortalCDKL1 
Broad Tumor PortalCDKL1
OASIS PortalCDKL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDKL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDKL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDKL1
DgiDB (Drug Gene Interaction Database)CDKL1
DoCM (Curated mutations)CDKL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDKL1 (select a term)
intoGenCDKL1
Cancer3DCDKL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603441   
Orphanet
MedgenCDKL1
Genetic Testing Registry CDKL1
NextProtQ00532 [Medical]
TSGene8814
GENETestsCDKL1
Huge Navigator CDKL1 [HugePedia]
snp3D : Map Gene to Disease8814
BioCentury BCIQCDKL1
ClinGenCDKL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8814
Chemical/Pharm GKB GenePA26317
Clinical trialCDKL1
Miscellaneous
canSAR (ICR)CDKL1 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDKL1
EVEXCDKL1
GoPubMedCDKL1
iHOPCDKL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:10:00 CEST 2017

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