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CDKL2 (cyclin dependent kinase like 2)

Identity

Alias_namescyclin-dependent kinase-like 2 (CDC2-related kinase)
Alias_symbol (synonym)P56
KKIAMRE
Other alias
HGNC (Hugo) CDKL2
LocusID (NCBI) 8999
Atlas_Id 43204
Location 4q21.1  [Link to chromosome band 4q21]
Location_base_pair Starts at 75576494 and ends at 75630540 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDKL2 (4q21.1) / CXCL11 (4q21.1)CDKL2 (4q21.1) / G3BP2 (4q21.1)CDKL2 (4q21.1) / ULK4 (3p22.1)
CDKL2 4q21.1 / CXCL11 4q21.1CDKL2 4q21.1 / G3BP2 4q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDKL2   1782
Cards
Entrez_Gene (NCBI)CDKL2  8999  cyclin dependent kinase like 2
AliasesKKIAMRE; P56
GeneCards (Weizmann)CDKL2
Ensembl hg19 (Hinxton)ENSG00000138769 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138769 [Gene_View]  chr4:75576494-75630540 [Contig_View]  CDKL2 [Vega]
ICGC DataPortalENSG00000138769
TCGA cBioPortalCDKL2
AceView (NCBI)CDKL2
Genatlas (Paris)CDKL2
WikiGenes8999
SOURCE (Princeton)CDKL2
Genetics Home Reference (NIH)CDKL2
Genomic and cartography
GoldenPath hg38 (UCSC)CDKL2  -     chr4:75576494-75630540 -  4q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDKL2  -     4q21.1   [Description]    (hg19-Feb_2009)
EnsemblCDKL2 - 4q21.1 [CytoView hg19]  CDKL2 - 4q21.1 [CytoView hg38]
Mapping of homologs : NCBICDKL2 [Mapview hg19]  CDKL2 [Mapview hg38]
OMIM603442   
Gene and transcription
Genbank (Entrez)AA813092 AK294866 AK309127 AK312490 BC017417
RefSeq transcript (Entrez)NM_001330724 NM_003948
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDKL2
Cluster EST : UnigeneHs.591698 [ NCBI ]
CGAP (NCI)Hs.591698
Alternative Splicing GalleryENSG00000138769
Gene ExpressionCDKL2 [ NCBI-GEO ]   CDKL2 [ EBI - ARRAY_EXPRESS ]   CDKL2 [ SEEK ]   CDKL2 [ MEM ]
Gene Expression Viewer (FireBrowse)CDKL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8999
GTEX Portal (Tissue expression)CDKL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92772   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92772  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92772
Splice isoforms : SwissVarQ92772
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   
PhosPhoSitePlusQ92772
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDKL2
DMDM Disease mutations8999
Blocks (Seattle)CDKL2
PDB (SRS)4AAA    4BBM   
PDB (PDBSum)4AAA    4BBM   
PDB (IMB)4AAA    4BBM   
PDB (RSDB)4AAA    4BBM   
Structural Biology KnowledgeBase4AAA    4BBM   
SCOP (Structural Classification of Proteins)4AAA    4BBM   
CATH (Classification of proteins structures)4AAA    4BBM   
SuperfamilyQ92772
Human Protein AtlasENSG00000138769
Peptide AtlasQ92772
HPRD16021
IPIIPI00940400   IPI00022541   IPI00964304   
Protein Interaction databases
DIP (DOE-UCLA)Q92772
IntAct (EBI)Q92772
FunCoupENSG00000138769
BioGRIDCDKL2
STRING (EMBL)CDKL2
ZODIACCDKL2
Ontologies - Pathways
QuickGOQ92772
Ontology : AmiGOprotein kinase activity  cyclin-dependent protein serine/threonine kinase activity  ATP binding  nucleus  nucleus  cytoplasm  centrosome  protein phosphorylation  signal transduction  sex differentiation  regulation of cell cycle  positive regulation of protein targeting to mitochondrion  
Ontology : EGO-EBIprotein kinase activity  cyclin-dependent protein serine/threonine kinase activity  ATP binding  nucleus  nucleus  cytoplasm  centrosome  protein phosphorylation  signal transduction  sex differentiation  regulation of cell cycle  positive regulation of protein targeting to mitochondrion  
NDEx NetworkCDKL2
Atlas of Cancer Signalling NetworkCDKL2
Wikipedia pathwaysCDKL2
Orthology - Evolution
OrthoDB8999
GeneTree (enSembl)ENSG00000138769
Phylogenetic Trees/Animal Genes : TreeFamCDKL2
HOVERGENQ92772
HOGENOMQ92772
Homologs : HomoloGeneCDKL2
Homology/Alignments : Family Browser (UCSC)CDKL2
Gene fusions - Rearrangements
Fusion : MitelmanCDKL2/CXCL11 [4q21.1/4q21.1]  
Fusion : MitelmanCDKL2/G3BP2 [4q21.1/4q21.1]  [t(4;4)(q21;q21)]  
Fusion: TCGACDKL2 4q21.1 CXCL11 4q21.1 LUAD
Fusion: TCGACDKL2 4q21.1 G3BP2 4q21.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDKL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDKL2
dbVarCDKL2
ClinVarCDKL2
1000_GenomesCDKL2 
Exome Variant ServerCDKL2
ExAC (Exome Aggregation Consortium)CDKL2 (select the gene name)
Genetic variants : HAPMAP8999
Genomic Variants (DGV)CDKL2 [DGVbeta]
DECIPHERCDKL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDKL2 
Mutations
ICGC Data PortalCDKL2 
TCGA Data PortalCDKL2 
Broad Tumor PortalCDKL2
OASIS PortalCDKL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDKL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDKL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDKL2
DgiDB (Drug Gene Interaction Database)CDKL2
DoCM (Curated mutations)CDKL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDKL2 (select a term)
intoGenCDKL2
Cancer3DCDKL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603442   
Orphanet
MedgenCDKL2
Genetic Testing Registry CDKL2
NextProtQ92772 [Medical]
TSGene8999
GENETestsCDKL2
Target ValidationCDKL2
Huge Navigator CDKL2 [HugePedia]
snp3D : Map Gene to Disease8999
BioCentury BCIQCDKL2
ClinGenCDKL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8999
Chemical/Pharm GKB GenePA26318
Clinical trialCDKL2
Miscellaneous
canSAR (ICR)CDKL2 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDKL2
EVEXCDKL2
GoPubMedCDKL2
iHOPCDKL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:27:49 CEST 2017

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