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CDKL3 (cyclin dependent kinase like 3)

Identity

Alias_namescyclin-dependent kinase-like 3
Alias_symbol (synonym)NKIAMRE
Other alias
HGNC (Hugo) CDKL3
LocusID (NCBI) 51265
Atlas_Id 40037
Location 5q31.1  [Link to chromosome band 5q31]
Location_base_pair Starts at 134298424 and ends at 134367074 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDH1 (16q22.1) / CDKL3 (5q31.1)PPP2CA (5q31.1) / CDKL3 (5q31.1)SKP1 (5q31.1) / CDKL3 (5q31.1)
CDH1 16q22.1 / CDKL3 5q31.1PPP2CA 5q31.1 / CDKL3 5q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)CDKL3   15483
Cards
Entrez_Gene (NCBI)CDKL3  51265  cyclin dependent kinase like 3
AliasesNKIAMRE
GeneCards (Weizmann)CDKL3
Ensembl hg19 (Hinxton)ENSG00000006837 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000006837 [Gene_View]  chr5:134298424-134367074 [Contig_View]  CDKL3 [Vega]
ICGC DataPortalENSG00000006837
TCGA cBioPortalCDKL3
AceView (NCBI)CDKL3
Genatlas (Paris)CDKL3
WikiGenes51265
SOURCE (Princeton)CDKL3
Genetics Home Reference (NIH)CDKL3
Genomic and cartography
GoldenPath hg38 (UCSC)CDKL3  -     chr5:134298424-134367074 -  5q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDKL3  -     5q31.1   [Description]    (hg19-Feb_2009)
EnsemblCDKL3 - 5q31.1 [CytoView hg19]  CDKL3 - 5q31.1 [CytoView hg38]
Mapping of homologs : NCBICDKL3 [Mapview hg19]  CDKL3 [Mapview hg38]
OMIM608459   
Gene and transcription
Genbank (Entrez)AF130372 AK294559 AK294740 AK297586 AK299305
RefSeq transcript (Entrez)NM_001113575 NM_001300853 NM_001349363 NM_001349364 NM_001349365 NM_001349366 NM_016508
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDKL3
Cluster EST : UnigeneHs.719926 [ NCBI ]
CGAP (NCI)Hs.719926
Alternative Splicing GalleryENSG00000006837
Gene ExpressionCDKL3 [ NCBI-GEO ]   CDKL3 [ EBI - ARRAY_EXPRESS ]   CDKL3 [ SEEK ]   CDKL3 [ MEM ]
Gene Expression Viewer (FireBrowse)CDKL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51265
GTEX Portal (Tissue expression)CDKL3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IVW4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IVW4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IVW4
Splice isoforms : SwissVarQ8IVW4
Catalytic activity : Enzyme2.7.11.22 [ Enzyme-Expasy ]   2.7.11.222.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   
PhosPhoSitePlusQ8IVW4
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDKL3
DMDM Disease mutations51265
Blocks (Seattle)CDKL3
PDB (SRS)3ZDU   
PDB (PDBSum)3ZDU   
PDB (IMB)3ZDU   
PDB (RSDB)3ZDU   
Structural Biology KnowledgeBase3ZDU   
SCOP (Structural Classification of Proteins)3ZDU   
CATH (Classification of proteins structures)3ZDU   
SuperfamilyQ8IVW4
Human Protein AtlasENSG00000006837
Peptide AtlasQ8IVW4
IPIIPI00217158   IPI00655579   IPI00926402   IPI00909377   IPI00980358   IPI00980495   IPI00973928   IPI00982398   IPI01020964   IPI00979779   IPI00978376   IPI00973837   
Protein Interaction databases
DIP (DOE-UCLA)Q8IVW4
IntAct (EBI)Q8IVW4
FunCoupENSG00000006837
BioGRIDCDKL3
STRING (EMBL)CDKL3
ZODIACCDKL3
Ontologies - Pathways
QuickGOQ8IVW4
Ontology : AmiGOprotein kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cellular protein modification process  protein phosphorylation  negative regulation of axon extension  positive regulation of dendrite morphogenesis  regulation of cell cycle  dendrite extension  
Ontology : EGO-EBIprotein kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cellular protein modification process  protein phosphorylation  negative regulation of axon extension  positive regulation of dendrite morphogenesis  regulation of cell cycle  dendrite extension  
NDEx NetworkCDKL3
Atlas of Cancer Signalling NetworkCDKL3
Wikipedia pathwaysCDKL3
Orthology - Evolution
OrthoDB51265
GeneTree (enSembl)ENSG00000006837
Phylogenetic Trees/Animal Genes : TreeFamCDKL3
HOVERGENQ8IVW4
HOGENOMQ8IVW4
Homologs : HomoloGeneCDKL3
Homology/Alignments : Family Browser (UCSC)CDKL3
Gene fusions - Rearrangements
Fusion : MitelmanCDH1/CDKL3 [16q22.1/5q31.1]  [t(5;16)(q31;q22)]  
Fusion : MitelmanPPP2CA/CDKL3 [5q31.1/5q31.1]  [t(5;5)(q31;q31)]  
Fusion : MitelmanSKP1/CDKL3 [5q31.1/5q31.1]  [t(5;5)(q31;q31)]  
Fusion: TCGACDH1 16q22.1 CDKL3 5q31.1 LUAD
Fusion: TCGAPPP2CA 5q31.1 CDKL3 5q31.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDKL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDKL3
dbVarCDKL3
ClinVarCDKL3
1000_GenomesCDKL3 
Exome Variant ServerCDKL3
ExAC (Exome Aggregation Consortium)CDKL3 (select the gene name)
Genetic variants : HAPMAP51265
Genomic Variants (DGV)CDKL3 [DGVbeta]
DECIPHERCDKL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDKL3 
Mutations
ICGC Data PortalCDKL3 
TCGA Data PortalCDKL3 
Broad Tumor PortalCDKL3
OASIS PortalCDKL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDKL3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDKL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDKL3
DgiDB (Drug Gene Interaction Database)CDKL3
DoCM (Curated mutations)CDKL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDKL3 (select a term)
intoGenCDKL3
Cancer3DCDKL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608459   
Orphanet
MedgenCDKL3
Genetic Testing Registry CDKL3
NextProtQ8IVW4 [Medical]
TSGene51265
GENETestsCDKL3
Target ValidationCDKL3
Huge Navigator CDKL3 [HugePedia]
snp3D : Map Gene to Disease51265
BioCentury BCIQCDKL3
ClinGenCDKL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51265
Chemical/Pharm GKB GenePA26319
Clinical trialCDKL3
Miscellaneous
canSAR (ICR)CDKL3 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDKL3
EVEXCDKL3
GoPubMedCDKL3
iHOPCDKL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:27:49 CEST 2017

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