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CDKL4 (cyclin dependent kinase like 4)

Identity

Alias_namescyclin-dependent kinase-like 4
Other alias-
HGNC (Hugo) CDKL4
LocusID (NCBI) 344387
Atlas_Id 43205
Location 2p22.1  [Link to chromosome band 2p22]
Location_base_pair Starts at 39178547 and ends at 39229588 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDKL4 (2p22.1) / SP3 (2q31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDKL4   19287
Cards
Entrez_Gene (NCBI)CDKL4  344387  cyclin dependent kinase like 4
Aliases
GeneCards (Weizmann)CDKL4
Ensembl hg19 (Hinxton)ENSG00000205111 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000205111 [Gene_View]  chr2:39178547-39229588 [Contig_View]  CDKL4 [Vega]
ICGC DataPortalENSG00000205111
TCGA cBioPortalCDKL4
AceView (NCBI)CDKL4
Genatlas (Paris)CDKL4
WikiGenes344387
SOURCE (Princeton)CDKL4
Genetics Home Reference (NIH)CDKL4
Genomic and cartography
GoldenPath hg38 (UCSC)CDKL4  -     chr2:39178547-39229588 -  2p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDKL4  -     2p22.1   [Description]    (hg19-Feb_2009)
EnsemblCDKL4 - 2p22.1 [CytoView hg19]  CDKL4 - 2p22.1 [CytoView hg38]
Mapping of homologs : NCBICDKL4 [Mapview hg19]  CDKL4 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AY845084 AY847283 BC144460 BC172293
RefSeq transcript (Entrez)NM_001009565 NM_001346911
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDKL4
Cluster EST : UnigeneHs.403201 [ NCBI ]
CGAP (NCI)Hs.403201
Alternative Splicing GalleryENSG00000205111
Gene ExpressionCDKL4 [ NCBI-GEO ]   CDKL4 [ EBI - ARRAY_EXPRESS ]   CDKL4 [ SEEK ]   CDKL4 [ MEM ]
Gene Expression Viewer (FireBrowse)CDKL4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)344387
GTEX Portal (Tissue expression)CDKL4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5MAI5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5MAI5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5MAI5
Splice isoforms : SwissVarQ5MAI5
PhosPhoSitePlusQ5MAI5
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)CDKL4
DMDM Disease mutations344387
Blocks (Seattle)CDKL4
SuperfamilyQ5MAI5
Human Protein AtlasENSG00000205111
Peptide AtlasQ5MAI5
HPRD16698
IPIIPI00872721   IPI00260216   IPI00916594   IPI00916466   
Protein Interaction databases
DIP (DOE-UCLA)Q5MAI5
IntAct (EBI)Q5MAI5
FunCoupENSG00000205111
BioGRIDCDKL4
STRING (EMBL)CDKL4
ZODIACCDKL4
Ontologies - Pathways
QuickGOQ5MAI5
Ontology : AmiGOcyclin-dependent protein serine/threonine kinase activity  ATP binding  nucleus  cytoplasm  protein phosphorylation  regulation of cell cycle  
Ontology : EGO-EBIcyclin-dependent protein serine/threonine kinase activity  ATP binding  nucleus  cytoplasm  protein phosphorylation  regulation of cell cycle  
NDEx NetworkCDKL4
Atlas of Cancer Signalling NetworkCDKL4
Wikipedia pathwaysCDKL4
Orthology - Evolution
OrthoDB344387
GeneTree (enSembl)ENSG00000205111
Phylogenetic Trees/Animal Genes : TreeFamCDKL4
HOVERGENQ5MAI5
HOGENOMQ5MAI5
Homologs : HomoloGeneCDKL4
Homology/Alignments : Family Browser (UCSC)CDKL4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDKL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDKL4
dbVarCDKL4
ClinVarCDKL4
1000_GenomesCDKL4 
Exome Variant ServerCDKL4
ExAC (Exome Aggregation Consortium)CDKL4 (select the gene name)
Genetic variants : HAPMAP344387
Genomic Variants (DGV)CDKL4 [DGVbeta]
DECIPHERCDKL4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDKL4 
Mutations
ICGC Data PortalCDKL4 
TCGA Data PortalCDKL4 
Broad Tumor PortalCDKL4
OASIS PortalCDKL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDKL4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDKL4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDKL4
DgiDB (Drug Gene Interaction Database)CDKL4
DoCM (Curated mutations)CDKL4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDKL4 (select a term)
intoGenCDKL4
Cancer3DCDKL4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenCDKL4
Genetic Testing Registry CDKL4
NextProtQ5MAI5 [Medical]
TSGene344387
GENETestsCDKL4
Target ValidationCDKL4
Huge Navigator CDKL4 [HugePedia]
snp3D : Map Gene to Disease344387
BioCentury BCIQCDKL4
ClinGenCDKL4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD344387
Chemical/Pharm GKB GenePA134892546
Clinical trialCDKL4
Miscellaneous
canSAR (ICR)CDKL4 (select the gene name)
Probes
Litterature
PubMed4 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDKL4
EVEXCDKL4
GoPubMedCDKL4
iHOPCDKL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:57:30 CEST 2017

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