CDKL5 (cyclin-dependent kinase-like 5)

Identity

Other names	ISSX
	STK9
HGNC	CDKL5
Location	Xp22
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	CDKL5   11411
Entrez_Gene	CDKL5  6792  cyclin-dependent kinase-like 5
	Cards
GeneCards	CDKL5
Ensembl	CDKL5 [Search_View]   ENSG00000008086 [Gene_View]
Genatlas	CDKL5
GeneLynx	CDKL5
eGenome	CDKL5
euGene	6792
	Genomic and cartography
GoldenPath	CDKL5  -  Xp22   chrX:18370265-18581670 +  Xp22.13   [Description]    (hg18-March_2006)
Ensembl	CDKL5 - Xp22.13 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	CDKL5
	Gene and transcription
Genbank	AI286150 [ ENTREZ ]
Genbank	AK307444 [ ENTREZ ]
Genbank	AL704691 [ ENTREZ ]
Genbank	AY217744 [ ENTREZ ]
Genbank	BC010966 [ ENTREZ ]
RefSeq	NM_001037343 [ SRS ]    NM_001037343 [ ENTREZ ]
RefSeq	NM_003159 [ SRS ]    NM_003159 [ ENTREZ ]
RefSeq	AC_000066 [ SRS ]    AC_000066 [ ENTREZ ]
RefSeq	AC_000155 [ SRS ]    AC_000155 [ ENTREZ ]
RefSeq	NC_000023 [ SRS ]    NC_000023 [ ENTREZ ]
RefSeq	NT_011757 [ SRS ]    NT_011757 [ ENTREZ ]
RefSeq	NW_001842360 [ SRS ]    NW_001842360 [ ENTREZ ]
RefSeq	NW_927700 [ SRS ]    NW_927700 [ ENTREZ ]
AceView	CDKL5 AceView - NCBI
Unigene	Hs.659851 [ SRS ]    Hs.659851 [ NCBI ]     HS659851 [ spliceNest ]
Fast-db	2798 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O76039 [ SRS]    O76039 [ EXPASY ]     O76039 [ INTERPRO ]     O76039 [ UNIPROT ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR002290 Ser_thr_pkinase [ SRS ]    IPR002290 Ser_thr_pkinase [ EBI ]
CluSTr	O76039
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Smart	SM00220 S_TKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	O76039 CDKL5_HUMAN [ Domain structure ]   O76039 CDKL5_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	O76039
HPRD	02190
	Protein Interaction databases
DIP	O76039
IntAct	O76039
	Polymorphism : SNP, mutations, diseases
OMIM	300203;308350;312750    [ map ]
GENECLINICS	300203;308350;312750
SNP	CDKL5 [dbSNP-NCBI]
SNP	NM_001037343 [SNP-NCI]
SNP	NM_003159 [SNP-NCI]
SNP	CDKL5 [GeneSNPs - Utah]  CDKL5] [HGBASE - SRS]
HAPMAP	CDKL5 [HAPMAP]
COSMIC	CDKL5 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	CDKL5
	General knowledge
Family Browser	CDKL5 [UCSC Family Browser]
SOURCE	NM_001037343
SOURCE	NM_003159
SMD	Hs.659851
SAGE	Hs.659851
Enzyme	2.7.11.22 [ Enzyme-Expasy ]   2.7.11.22 [ Enzyme-SRS ]   2.7.11.22 [ IntEnz-EBI ]   2.7.11.22 [ BRENDA ]   2.7.11.22 [ KEGG ]   2.7.11.22 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	cyclin-dependent protein kinase activity [Amigo]  cyclin-dependent protein kinase activity
GO	ATP binding [Amigo]  ATP binding
GO	nucleus [Amigo]  nucleus
GO	transferase activity [Amigo]  transferase activity
GO	protein amino acid autophosphorylation [Amigo]  protein amino acid autophosphorylation
PubGene	CDKL5
TreeFam	CDKL5
CTD	6792 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	CDKL5 Related clones (RZPD - Berlin)
	PubMed
PubMed	20 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:04:33 2008