CDKN1C (cyclin dependent kinase inhibitor 1C)

2003-02-01  

Identity

HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
BWCR,BWS,KIP2,WBS,p57,p57Kip2
FUSION GENES

Other Information

Locus ID:

NCBI: 1028
MIM: 600856
HGNC: 1786
Ensembl: ENSG00000129757

Variants:

dbSNP: 1028
ClinVar: 1028
TCGA: ENSG00000129757
COSMIC: CDKN1C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129757ENST00000380725A6NK88
ENSG00000129757ENST00000414822P49918
ENSG00000129757ENST00000430149P49918
ENSG00000129757ENST00000440480P49918
ENSG00000129757ENST00000647251A0A2R8YFP9

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1 PhaseREACTOMER-HSA-69236
Cyclin D associated events in G1REACTOMER-HSA-69231

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185210802008MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma.229
129257362003Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.110
86101621996Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15.72
191415852009Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states.70
193402972009CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cells.68
184307302008Hypoxia-mediated selective mRNA translation by an internal ribosome entry site-independent mechanism.53
226347512012Mutations in the PCNA-binding domain of CDKN1C cause IMAGe syndrome.48
195444582009MicroRNA 92b controls the G1/S checkpoint gene p57 in human embryonic stem cells.47
169507722006CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene.46
212787842011MicroRNA-221 inhibits CDKN1C/p57 expression in human colorectal carcinoma.38

Citation

Dessen P

CDKN1C (cyclin dependent kinase inhibitor 1C)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/306/cdkn1c