CDKN2B (cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4))

Identity

Other names	CDK4I
	INK4B
	MTS2
	P15
	TP15
	p15INK4b
HGNC	CDKN2B
Location	9p21
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	CDKN2B   1788
Entrez_Gene	CDKN2B  1030  cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
	Cards
GeneCards	CDKN2B
Ensembl	CDKN2B [Search_View]   ENSG00000147883 [Gene_View]
Genatlas	CDKN2B
GeneLynx	CDKN2B
eGenome	CDKN2B
euGene	1030
	Genomic and cartography
GoldenPath	CDKN2B  -  9p21   chr9:21992902-21999312 -  9p21.3   [Description]    (hg18-March_2006)
Ensembl	CDKN2B - 9p21.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	CDKN2B
	Gene and transcription
Genbank	AF004819 [ ENTREZ ]
Genbank	AF488409 [ ENTREZ ]
Genbank	AF488410 [ ENTREZ ]
Genbank	AF488731 [ ENTREZ ]
Genbank	AM392641 [ ENTREZ ]
RefSeq	NM_004936 [ SRS ]    NM_004936 [ ENTREZ ]
RefSeq	NM_078487 [ SRS ]    NM_078487 [ ENTREZ ]
RefSeq	AC_000052 [ SRS ]    AC_000052 [ ENTREZ ]
RefSeq	AC_000141 [ SRS ]    AC_000141 [ ENTREZ ]
RefSeq	NC_000009 [ SRS ]    NC_000009 [ ENTREZ ]
RefSeq	NT_008413 [ SRS ]    NT_008413 [ ENTREZ ]
RefSeq	NW_001839149 [ SRS ]    NW_001839149 [ ENTREZ ]
RefSeq	NW_924062 [ SRS ]    NW_924062 [ ENTREZ ]
AceView	CDKN2B AceView - NCBI
Unigene	Hs.72901 [ SRS ]    Hs.72901 [ NCBI ]     HS72901 [ spliceNest ]
Fast-db	3535 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O15125 [ SRS]    O15125 [ EXPASY ]     O15125 [ INTERPRO ]     O15125 [ UNIPROT ]
Prosite	PS50297 ANK_REP_REGION [ SRS ]    PS50297 ANK_REP_REGION [ Expasy ]
Interpro	IPR002110 ANK [ SRS ]    IPR002110 ANK [ EBI ]
CluSTr	O15125
Blocks	O15125
HPRD	02696
	Protein Interaction databases
DIP	O15125
IntAct	O15125
	Polymorphism : SNP, mutations, diseases
OMIM	600431    [ map ]
GENECLINICS	600431
SNP	CDKN2B [dbSNP-NCBI]
SNP	NM_004936 [SNP-NCI]
SNP	NM_078487 [SNP-NCI]
SNP	CDKN2B [GeneSNPs - Utah]  CDKN2B] [HGBASE - SRS]
HAPMAP	CDKN2B [HAPMAP]
COSMIC	CDKN2B [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	CDKN2B
	General knowledge
Family Browser	CDKN2B [UCSC Family Browser]
SOURCE	NM_004936
SOURCE	NM_078487
SMD	Hs.72901
SAGE	Hs.72901
GO	regulation of cyclin-dependent protein kinase activity [Amigo]  regulation of cyclin-dependent protein kinase activity
GO	G2/M transition of mitotic cell cycle [Amigo]  G2/M transition of mitotic cell cycle
GO	cyclin-dependent protein kinase inhibitor activity [Amigo]  cyclin-dependent protein kinase inhibitor activity
GO	cyclin-dependent protein kinase inhibitor activity [Amigo]  cyclin-dependent protein kinase inhibitor activity
GO	protein binding [Amigo]  protein binding
GO	nucleus [Amigo]  nucleus
GO	cytoplasm [Amigo]  cytoplasm
GO	cell cycle arrest [Amigo]  cell cycle arrest
GO	kinase activity [Amigo]  kinase activity
GO	protein kinase binding [Amigo]  protein kinase binding
GO	positive regulation of transforming growth factor beta receptor signaling pathway [Amigo]  positive regulation of transforming growth factor beta receptor signaling pathway
GO	G1/S transition checkpoint [Amigo]  G1/S transition checkpoint
GO	cellular response to extracellular stimulus [Amigo]  cellular response to extracellular stimulus
GO	cellular response to nutrient [Amigo]  cellular response to nutrient
GO	negative regulation of phosphorylation [Amigo]  negative regulation of phosphorylation
GO	negative regulation of cell cycle [Amigo]  negative regulation of cell cycle
GO	negative regulation of epithelial cell proliferation [Amigo]  negative regulation of epithelial cell proliferation
BIOCARTA	Cyclins and Cell Cycle Regulation    [Genes]
BIOCARTA	Cell Cycle: G1/S Check Point    [Genes]
KEGG	Cell cycle
KEGG	TGF-beta signaling pathway
PubGene	CDKN2B
TreeFam	CDKN2B
CTD	1030 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	CDKN2B Related clones (RZPD - Berlin)
	PubMed
PubMed	101 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:04:34 2008