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CDKN2C (cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4))

Identity

Other namesINK4C
p18
p18-INK4C
HGNC (Hugo) CDKN2C
LocusID (NCBI) 1031
Location 1p32.3
Location_base_pair Starts at 51434367 and ends at 51440306 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945

External links

Nomenclature
HGNC (Hugo)CDKN2C   1789
Cards
Entrez_Gene (NCBI)CDKN2C  1031  cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
GeneCards (Weizmann)CDKN2C
Ensembl hg19 (Hinxton)ENSG00000123080 [Gene_View]  chr1:51434367-51440306 [Contig_View]  CDKN2C [Vega]
Ensembl hg38 (Hinxton)ENSG00000123080 [Gene_View]  chr1:51434367-51440306 [Contig_View]  CDKN2C [Vega]
ICGC DataPortalENSG00000123080
cBioPortalCDKN2C
AceView (NCBI)CDKN2C
Genatlas (Paris)CDKN2C
WikiGenes1031
SOURCE (Princeton)CDKN2C
Genomic and cartography
GoldenPath hg19 (UCSC)CDKN2C  -     chr1:51434367-51440306 +  1p32.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CDKN2C  -     1p32.3   [Description]    (hg38-Dec_2013)
EnsemblCDKN2C - 1p32.3 [CytoView hg19]  CDKN2C - 1p32.3 [CytoView hg38]
Mapping of homologs : NCBICDKN2C [Mapview hg19]  CDKN2C [Mapview hg38]
OMIM603369   
Gene and transcription
Genbank (Entrez)AF041248 AK021794 AK091170 BC000598 BC005041
RefSeq transcript (Entrez)NM_001262 NM_078626
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NT_032977 NW_001838579 NW_004929290
Consensus coding sequences : CCDS (NCBI)CDKN2C
Cluster EST : UnigeneHs.525324 [ NCBI ]
CGAP (NCI)Hs.525324
Alternative Splicing : Fast-db (Paris)GSHG0000501
Alternative Splicing GalleryENSG00000123080
Gene ExpressionCDKN2C [ NCBI-GEO ]     CDKN2C [ SEEK ]   CDKN2C [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42773 (Uniprot)
NextProtP42773  [Medical]
With graphics : InterProP42773
Splice isoforms : SwissVarP42773 (Swissvar)
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom   
Related proteins : CluSTrP42773
Domain families : Pfam (Sanger)Ank (PF00023)   
Domain families : Pfam (NCBI)pfam00023   
Domain families : Smart (EMBL)ANK (SM00248)  
DMDM Disease mutations1031
Blocks (Seattle)P42773
PDB (SRS)1BU9    1G3N    1IHB    1MX2    1MX4    1MX6   
PDB (PDBSum)1BU9    1G3N    1IHB    1MX2    1MX4    1MX6   
PDB (IMB)1BU9    1G3N    1IHB    1MX2    1MX4    1MX6   
PDB (RSDB)1BU9    1G3N    1IHB    1MX2    1MX4    1MX6   
Human Protein AtlasENSG00000123080
Peptide AtlasP42773
HPRD04534
IPIIPI00001564   
Protein Interaction databases
DIP (DOE-UCLA)P42773
IntAct (EBI)P42773
FunCoupENSG00000123080
BioGRIDCDKN2C
IntegromeDBCDKN2C
STRING (EMBL)CDKN2C
Ontologies - Pathways
QuickGOP42773
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  mitotic cell cycle  cyclin-dependent protein serine/threonine kinase inhibitor activity  protein binding  nucleus  cytoplasm  cytosol  cell cycle arrest  negative regulation of cell proliferation  protein kinase binding  negative regulation of cell growth  negative regulation of phosphorylation  oligodendrocyte differentiation  negative regulation of protein serine/threonine kinase activity  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  mitotic cell cycle  cyclin-dependent protein serine/threonine kinase inhibitor activity  protein binding  nucleus  cytoplasm  cytosol  cell cycle arrest  negative regulation of cell proliferation  protein kinase binding  negative regulation of cell growth  negative regulation of phosphorylation  oligodendrocyte differentiation  negative regulation of protein serine/threonine kinase activity  
Pathways : BIOCARTACyclins and Cell Cycle Regulation [Genes]   
Pathways : KEGGCell cycle    HTLV-I infection    Transcriptional misregulation in cancer   
Protein Interaction DatabaseCDKN2C
DoCM (Curated mutations)CDKN2C
Wikipedia pathwaysCDKN2C
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCDKN2C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDKN2C
dbVarCDKN2C
ClinVarCDKN2C
1000_GenomesCDKN2C 
Exome Variant ServerCDKN2C
SNP (GeneSNP Utah)CDKN2C
SNP : HGBaseCDKN2C
Genetic variants : HAPMAPCDKN2C
Genomic VariantsCDKN2C  CDKN2C [DGVbeta]
Mutations
ICGC Data PortalENSG00000123080 
Cancer Gene: CensusCDKN2C 
Somatic Mutations in Cancer : COSMICCDKN2C 
CONAN: Copy Number AnalysisCDKN2C 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:51434367-51440306
Mutations and Diseases : HGMDCDKN2C
OMIM603369   
MedgenCDKN2C
NextProtP42773 [Medical]
GENETestsCDKN2C
Disease Genetic AssociationCDKN2C
Huge Navigator CDKN2C [HugePedia]  CDKN2C [HugeCancerGEM]
snp3D : Map Gene to Disease1031
DGIdb (Drug Gene Interaction db)CDKN2C
General knowledge
Homologs : HomoloGeneCDKN2C
Homology/Alignments : Family Browser (UCSC)CDKN2C
Phylogenetic Trees/Animal Genes : TreeFamCDKN2C
Chemical/Protein Interactions : CTD1031
Chemical/Pharm GKB GenePA26322
Drug Sensitivity CDKN2C
Clinical trialCDKN2C
Cancer Resource (Charite)ENSG00000123080
Other databases
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
CoreMineCDKN2C
GoPubMedCDKN2C
iHOPCDKN2C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 20:45:59 CET 2014
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