Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CDKN2C (cyclin dependent kinase inhibitor 2C)

Identity

Alias_namescyclin-dependent kinase inhibitor 2C (p18
Alias_symbol (synonym)INK4C
p18
Other aliasp18-INK4C
HGNC (Hugo) CDKN2C
LocusID (NCBI) 1031
Atlas_Id 190
Location 1p32.3  [Link to chromosome band 1p32]
Location_base_pair Starts at 50969970 and ends at 50974637 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;5)(p32;q31) without TAL1 rearrangement

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Neuro-Endocrine/Endocrine system: Carcinoid tumors

Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Dysplastic nevus syndrome (DNS)

External links

Nomenclature
HGNC (Hugo)CDKN2C   1789
Cards
Entrez_Gene (NCBI)CDKN2C  1031  cyclin dependent kinase inhibitor 2C
AliasesINK4C; p18; p18-INK4C
GeneCards (Weizmann)CDKN2C
Ensembl hg19 (Hinxton)ENSG00000123080 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123080 [Gene_View]  chr1:50969970-50974637 [Contig_View]  CDKN2C [Vega]
ICGC DataPortalENSG00000123080
TCGA cBioPortalCDKN2C
AceView (NCBI)CDKN2C
Genatlas (Paris)CDKN2C
WikiGenes1031
SOURCE (Princeton)CDKN2C
Genetics Home Reference (NIH)CDKN2C
Genomic and cartography
GoldenPath hg38 (UCSC)CDKN2C  -     chr1:50969970-50974637 +  1p32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDKN2C  -     1p32.3   [Description]    (hg19-Feb_2009)
EnsemblCDKN2C - 1p32.3 [CytoView hg19]  CDKN2C - 1p32.3 [CytoView hg38]
Mapping of homologs : NCBICDKN2C [Mapview hg19]  CDKN2C [Mapview hg38]
OMIM603369   
Gene and transcription
Genbank (Entrez)AF041248 AK021794 AK091170 BC000598 BC005041
RefSeq transcript (Entrez)NM_001262 NM_078626
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDKN2C
Cluster EST : UnigeneHs.525324 [ NCBI ]
CGAP (NCI)Hs.525324
Alternative Splicing GalleryENSG00000123080
Gene ExpressionCDKN2C [ NCBI-GEO ]   CDKN2C [ EBI - ARRAY_EXPRESS ]   CDKN2C [ SEEK ]   CDKN2C [ MEM ]
Gene Expression Viewer (FireBrowse)CDKN2C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1031
GTEX Portal (Tissue expression)CDKN2C
Human Protein AtlasENSG00000123080-CDKN2C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42773   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42773  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42773
Splice isoforms : SwissVarP42773
PhosPhoSitePlusP42773
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)CDKN2C
DMDM Disease mutations1031
Blocks (Seattle)CDKN2C
PDB (SRS)1BU9    1G3N    1IHB    1MX2    1MX4    1MX6   
PDB (PDBSum)1BU9    1G3N    1IHB    1MX2    1MX4    1MX6   
PDB (IMB)1BU9    1G3N    1IHB    1MX2    1MX4    1MX6   
PDB (RSDB)1BU9    1G3N    1IHB    1MX2    1MX4    1MX6   
Structural Biology KnowledgeBase1BU9    1G3N    1IHB    1MX2    1MX4    1MX6   
SCOP (Structural Classification of Proteins)1BU9    1G3N    1IHB    1MX2    1MX4    1MX6   
CATH (Classification of proteins structures)1BU9    1G3N    1IHB    1MX2    1MX4    1MX6   
SuperfamilyP42773
Human Protein Atlas [tissue]ENSG00000123080-CDKN2C [tissue]
Peptide AtlasP42773
HPRD04534
IPIIPI00001564   
Protein Interaction databases
DIP (DOE-UCLA)P42773
IntAct (EBI)P42773
FunCoupENSG00000123080
BioGRIDCDKN2C
STRING (EMBL)CDKN2C
ZODIACCDKN2C
Ontologies - Pathways
QuickGOP42773
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  cyclin-dependent protein serine/threonine kinase inhibitor activity  protein binding  nucleus  cytoplasm  cytosol  cell cycle arrest  negative regulation of cell proliferation  protein kinase binding  negative regulation of cell growth  negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle  negative regulation of phosphorylation  oligodendrocyte differentiation  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  cyclin-dependent protein serine/threonine kinase inhibitor activity  protein binding  nucleus  cytoplasm  cytosol  cell cycle arrest  negative regulation of cell proliferation  protein kinase binding  negative regulation of cell growth  negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle  negative regulation of phosphorylation  oligodendrocyte differentiation  
Pathways : BIOCARTACyclins and Cell Cycle Regulation [Genes]   
Pathways : KEGGCell cycle   
NDEx NetworkCDKN2C
Atlas of Cancer Signalling NetworkCDKN2C
Wikipedia pathwaysCDKN2C
Orthology - Evolution
OrthoDB1031
GeneTree (enSembl)ENSG00000123080
Phylogenetic Trees/Animal Genes : TreeFamCDKN2C
HOVERGENP42773
HOGENOMP42773
Homologs : HomoloGeneCDKN2C
Homology/Alignments : Family Browser (UCSC)CDKN2C
Gene fusions - Rearrangements
Fusion : QuiverCDKN2C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDKN2C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDKN2C
dbVarCDKN2C
ClinVarCDKN2C
1000_GenomesCDKN2C 
Exome Variant ServerCDKN2C
ExAC (Exome Aggregation Consortium)ENSG00000123080
GNOMAD BrowserENSG00000123080
Genetic variants : HAPMAP1031
Genomic Variants (DGV)CDKN2C [DGVbeta]
DECIPHERCDKN2C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDKN2C 
Mutations
ICGC Data PortalCDKN2C 
TCGA Data PortalCDKN2C 
Broad Tumor PortalCDKN2C
OASIS PortalCDKN2C [ Somatic mutations - Copy number]
Cancer Gene: CensusCDKN2C 
Somatic Mutations in Cancer : COSMICCDKN2C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDKN2C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDKN2C
DgiDB (Drug Gene Interaction Database)CDKN2C
DoCM (Curated mutations)CDKN2C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDKN2C (select a term)
intoGenCDKN2C
Cancer3DCDKN2C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603369   
Orphanet121   
DisGeNETCDKN2C
MedgenCDKN2C
Genetic Testing Registry CDKN2C
NextProtP42773 [Medical]
TSGene1031
GENETestsCDKN2C
Target ValidationCDKN2C
Huge Navigator CDKN2C [HugePedia]
snp3D : Map Gene to Disease1031
BioCentury BCIQCDKN2C
ClinGenCDKN2C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1031
Chemical/Pharm GKB GenePA26322
Drug Sensitivity CDKN2C
Clinical trialCDKN2C
Miscellaneous
canSAR (ICR)CDKN2C (select the gene name)
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDKN2C
EVEXCDKN2C
GoPubMedCDKN2C
iHOPCDKN2C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Feb 28 13:05:41 CET 2018
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