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CDKN2C (cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4))

Identity

Other namesINK4C
p18
p18-INK4C
HGNC (Hugo) CDKN2C
Location 1p33
Location_base_pair Starts at 51206955 and ends at 51212894 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CDKN2C   1789
Entrez_Gene (NCBI)CDKN2C  1031  cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
Cards
GeneCards (Weizmann)CDKN2C
Ensembl (Hinxton)ENSG00000123080 [Gene_View]  CDKN2C [Vega]
AceView (NCBI)CDKN2C
Genatlas (Paris)CDKN2C
euGene (Indiana)1031
SOURCE (Stanford)NM_001262 NM_078626
Gene Expression (Array Express) ENSG00000123080
Genomic and cartography
GoldenPath (UCSC)CDKN2C  -  1p33   chr1:51206955-51212894 +  1p33   [Description]    (hg18-March_2006)
EnsemblCDKN2C - 1p33 [CytoView]
Mapping of homologs : NCBICDKN2C [Mapview]
OMIM603369   
Gene and transcription
Gene : Genbank (Entrez)AF041248 AK021794 AK091170 BC000598 BC005041
Reference sequence (RefSeq transcript) :SRSNM_001262 NM_078626
Reference transcript : EntrezNM_001262 NM_078626
RefSeq genomic : SRSAC_000044 AC_000133 NC_000001 NT_032977 NW_001838579 NW_921351
RefSeq genomic : EntrezAC_000044 AC_000133 NC_000001 NT_032977 NW_001838579 NW_921351
Consensus coding sequences : CCDS NCBICDKN2C
Cluster EST : UnigeneHs.719924 [ SRS ] Hs.719924 [ NCBI ]
Alternative Splicing : Fast-db (Paris)15971
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP42773 (SRS) P42773 (Expasy) P42773 (Uniprot)
With graphics : InterProP42773
Splice isoforms : VarSplice FASTAP42773(VarSplice FASTA)
Domaine pattern : Prosite (SRS)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domain pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (SRS)Ankyrin_rpt    Ankyrin_rpt-contain_dom   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom   
Related proteins : CluSTrP42773
Domain families : Pfam SRSAnk (PF00023)   
Domain families : Pfam SangerAnk (PF00023)   
Domain families : Pfam NCBIpfam00023   
Domain families : Smart EMBLANK (SM00248)  
Blocks (Seattle)P42773
Crystal structure of protein : PDB SRS1BU9    1G3N    1IHB    1MX2    1MX4    1MX6   
Crystal structure of protein : PDBSum1BU9    1G3N    1IHB    1MX2    1MX4    1MX6   
Crystal structure of protein : IMB1BU9    1G3N    1IHB    1MX2    1MX4    1MX6   
Crystal structure of protein : PDB RSDB1BU9    1G3N    1IHB    1MX2    1MX4    1MX6   
HPRD04534
Protein Interaction databases
DIP (DOE-UCLA)P42773
IntAct (EBI)P42773
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBICDKN2C
SNP : GeneSNP UtahCDKN2C
SNP : HGBaseCDKN2C
Genetic variants : HAPMAPCDKN2C
Somatic Mutations in Cancer : COSMICCDKN2C 
Mutations and Diseases : HGMDCDKN2C
Hereditary diseases : OMIM603369   
Hereditary diseases : GENETests603369   
Diseases : Genetic AssociationCDKN2C
General knowledge
Homologs : HomoloGeneCDKN2C
Homology/Alignments : Family Browser UCSCCDKN2C
Phylogenetic Trees/Animal Genes : TreeFamCDKN2C
Chemical/Protein Interactions : CTD1031
Keywords Ontology : AmiGOregulation of cyclin-dependent protein kinase activity  G1/S transition of mitotic cell cycle  cyclin-dependent protein kinase inhibitor activity  protein binding  nucleus  cytoplasm  induction of apoptosis  cell cycle  cell cycle arrest  negative regulation of cell proliferation  protein kinase binding  negative regulation of cell growth  negative regulation of phosphorylation  oligodendrocyte differentiation  
Keywords Ontology : EGO-EBIregulation of cyclin-dependent protein kinase activity  G1/S transition of mitotic cell cycle  cyclin-dependent protein kinase inhibitor activity  protein binding  nucleus  cytoplasm  induction of apoptosis  cell cycle  cell cycle arrest  negative regulation of cell proliferation  protein kinase binding  negative regulation of cell growth  negative regulation of phosphorylation  oligodendrocyte differentiation  
Pathways : BIOCARTACyclins and Cell Cycle Regulation [Genes]   
Pathways : KEGGCell cycle
Other databases
Probes
Probes : ImagenesCDKN2C Related clones (RZPD - Berlin)
Literature
PubMed46 Pubmed reference(s) in Entrez
PubGeneCDKN2C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:33:49 CET 2010
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