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CDKN2D (cyclin dependent kinase inhibitor 2D)

Identity

Alias_namescyclin-dependent kinase inhibitor 2D (p19
Alias_symbol (synonym)INK4D
p19
Other aliasp19-INK4D
HGNC (Hugo) CDKN2D
LocusID (NCBI) 1032
Atlas_Id 40038
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 10566462 and ends at 10568955 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDKN2D (19p13.2) / WDFY2 (13q14.3)CDKN2D 19p13.2 / WDFY2 13q14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Testis: Spermatocytic seminoma


External links

Nomenclature
HGNC (Hugo)CDKN2D   1790
Cards
Entrez_Gene (NCBI)CDKN2D  1032  cyclin dependent kinase inhibitor 2D
AliasesINK4D; p19; p19-INK4D
GeneCards (Weizmann)CDKN2D
Ensembl hg19 (Hinxton)ENSG00000129355 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129355 [Gene_View]  chr19:10566462-10568955 [Contig_View]  CDKN2D [Vega]
ICGC DataPortalENSG00000129355
TCGA cBioPortalCDKN2D
AceView (NCBI)CDKN2D
Genatlas (Paris)CDKN2D
WikiGenes1032
SOURCE (Princeton)CDKN2D
Genetics Home Reference (NIH)CDKN2D
Genomic and cartography
GoldenPath hg38 (UCSC)CDKN2D  -     chr19:10566462-10568955 -  19p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDKN2D  -     19p13.2   [Description]    (hg19-Feb_2009)
EnsemblCDKN2D - 19p13.2 [CytoView hg19]  CDKN2D - 19p13.2 [CytoView hg38]
Mapping of homologs : NCBICDKN2D [Mapview hg19]  CDKN2D [Mapview hg38]
OMIM600927   
Gene and transcription
Genbank (Entrez)BC001822 BG719545 BI462387 BI669755 CR542158
RefSeq transcript (Entrez)NM_001800 NM_079421
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDKN2D
Cluster EST : UnigeneHs.435051 [ NCBI ]
CGAP (NCI)Hs.435051
Alternative Splicing GalleryENSG00000129355
Gene ExpressionCDKN2D [ NCBI-GEO ]   CDKN2D [ EBI - ARRAY_EXPRESS ]   CDKN2D [ SEEK ]   CDKN2D [ MEM ]
Gene Expression Viewer (FireBrowse)CDKN2D [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1032
GTEX Portal (Tissue expression)CDKN2D
Human Protein AtlasENSG00000129355-CDKN2D [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55273   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55273  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55273
Splice isoforms : SwissVarP55273
PhosPhoSitePlusP55273
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom   
Domain families : Pfam (Sanger)Ank_2 (PF12796)   
Domain families : Pfam (NCBI)pfam12796   
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)CDKN2D
DMDM Disease mutations1032
Blocks (Seattle)CDKN2D
PDB (SRS)1BD8    1BI8   
PDB (PDBSum)1BD8    1BI8   
PDB (IMB)1BD8    1BI8   
PDB (RSDB)1BD8    1BI8   
Structural Biology KnowledgeBase1BD8    1BI8   
SCOP (Structural Classification of Proteins)1BD8    1BI8   
CATH (Classification of proteins structures)1BD8    1BI8   
SuperfamilyP55273
Human Protein Atlas [tissue]ENSG00000129355-CDKN2D [tissue]
Peptide AtlasP55273
HPRD02957
IPIIPI00024008   
Protein Interaction databases
DIP (DOE-UCLA)P55273
IntAct (EBI)P55273
FunCoupENSG00000129355
BioGRIDCDKN2D
STRING (EMBL)CDKN2D
ZODIACCDKN2D
Ontologies - Pathways
QuickGOP55273
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  DNA synthesis involved in DNA repair  cyclin-dependent protein serine/threonine kinase inhibitor activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  cytosol  cell cycle arrest  negative regulation of cell proliferation  response to UV  protein kinase binding  negative regulation of cell growth  response to retinoic acid  response to vitamin D  negative regulation of phosphorylation  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  autophagic cell death  negative regulation of protein serine/threonine kinase activity  negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  DNA synthesis involved in DNA repair  cyclin-dependent protein serine/threonine kinase inhibitor activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  cytosol  cell cycle arrest  negative regulation of cell proliferation  response to UV  protein kinase binding  negative regulation of cell growth  response to retinoic acid  response to vitamin D  negative regulation of phosphorylation  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  autophagic cell death  negative regulation of protein serine/threonine kinase activity  negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  
Pathways : BIOCARTACell Cycle: G2/M Checkpoint [Genes]    Cyclins and Cell Cycle Regulation [Genes]   
Pathways : KEGGFoxO signaling pathway    Cell cycle   
NDEx NetworkCDKN2D
Atlas of Cancer Signalling NetworkCDKN2D
Wikipedia pathwaysCDKN2D
Orthology - Evolution
OrthoDB1032
GeneTree (enSembl)ENSG00000129355
Phylogenetic Trees/Animal Genes : TreeFamCDKN2D
HOVERGENP55273
HOGENOMP55273
Homologs : HomoloGeneCDKN2D
Homology/Alignments : Family Browser (UCSC)CDKN2D
Gene fusions - Rearrangements
Fusion : MitelmanCDKN2D/WDFY2 [19p13.2/13q14.3]  
Tumor Fusion PortalCDKN2D
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDKN2D [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDKN2D
dbVarCDKN2D
ClinVarCDKN2D
1000_GenomesCDKN2D 
Exome Variant ServerCDKN2D
ExAC (Exome Aggregation Consortium)ENSG00000129355
GNOMAD BrowserENSG00000129355
Genetic variants : HAPMAP1032
Genomic Variants (DGV)CDKN2D [DGVbeta]
DECIPHERCDKN2D [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDKN2D 
Mutations
ICGC Data PortalCDKN2D 
TCGA Data PortalCDKN2D 
Broad Tumor PortalCDKN2D
OASIS PortalCDKN2D [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDKN2D  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDKN2D
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDKN2D
DgiDB (Drug Gene Interaction Database)CDKN2D
DoCM (Curated mutations)CDKN2D (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDKN2D (select a term)
intoGenCDKN2D
Cancer3DCDKN2D(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600927   
Orphanet3560   
DisGeNETCDKN2D
MedgenCDKN2D
Genetic Testing Registry CDKN2D
NextProtP55273 [Medical]
TSGene1032
GENETestsCDKN2D
Target ValidationCDKN2D
Huge Navigator CDKN2D [HugePedia]
snp3D : Map Gene to Disease1032
BioCentury BCIQCDKN2D
ClinGenCDKN2D
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1032
Chemical/Pharm GKB GenePA26323
Clinical trialCDKN2D
Miscellaneous
canSAR (ICR)CDKN2D (select the gene name)
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDKN2D
EVEXCDKN2D
GoPubMedCDKN2D
iHOPCDKN2D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:07:10 CET 2017

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