Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CDKN2D (cyclin dependent kinase inhibitor 2D)

Identity

Alias (NCBI)INK4D
p19
p19-INK4D
HGNC (Hugo) CDKN2D
HGNC Alias symbINK4D
p19
HGNC Previous namecyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
LocusID (NCBI) 1032
Atlas_Id 40038
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 10566460 and ends at 10568979 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDKN2D (19p13.2) / WDFY2 (13q14.3)CDKN2D 19p13.2 / WDFY2 13q14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)CDKN2D   1790
Cards
Entrez_Gene (NCBI)CDKN2D    cyclin dependent kinase inhibitor 2D
AliasesINK4D; p19; p19-INK4D
GeneCards (Weizmann)CDKN2D
Ensembl hg19 (Hinxton)ENSG00000129355 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129355 [Gene_View]  ENSG00000129355 [Sequence]  chr19:10566460-10568979 [Contig_View]  CDKN2D [Vega]
ICGC DataPortalENSG00000129355
TCGA cBioPortalCDKN2D
AceView (NCBI)CDKN2D
Genatlas (Paris)CDKN2D
SOURCE (Princeton)CDKN2D
Genetics Home Reference (NIH)CDKN2D
Genomic and cartography
GoldenPath hg38 (UCSC)CDKN2D  -     chr19:10566460-10568979 -  19p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDKN2D  -     19p13.2   [Description]    (hg19-Feb_2009)
GoldenPathCDKN2D - 19p13.2 [CytoView hg19]  CDKN2D - 19p13.2 [CytoView hg38]
ImmunoBaseENSG00000129355
genome Data Viewer NCBICDKN2D [Mapview hg19]  
OMIM600927   
Gene and transcription
Genbank (Entrez)BC001822 BG719545 BI462387 BI669755 CR542158
RefSeq transcript (Entrez)NM_001800 NM_079421
Consensus coding sequences : CCDS (NCBI)CDKN2D
Alternative Splicing GalleryENSG00000129355
Gene ExpressionCDKN2D [ NCBI-GEO ]   CDKN2D [ EBI - ARRAY_EXPRESS ]   CDKN2D [ SEEK ]   CDKN2D [ MEM ]
Gene Expression Viewer (FireBrowse)CDKN2D [ Firebrowse - Broad ]
GenevisibleExpression of CDKN2D in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1032
GTEX Portal (Tissue expression)CDKN2D
Human Protein AtlasENSG00000129355-CDKN2D [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55273   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55273  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55273
PhosPhoSitePlusP55273
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Ankyrin_rpt-contain_sf   
Domain families : Pfam (Sanger)Ank_2 (PF12796)   
Domain families : Pfam (NCBI)pfam12796   
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)CDKN2D
PDB (RSDB)1BD8    1BI8   
PDB Europe1BD8    1BI8   
PDB (PDBSum)1BD8    1BI8   
PDB (IMB)1BD8    1BI8   
Structural Biology KnowledgeBase1BD8    1BI8   
SCOP (Structural Classification of Proteins)1BD8    1BI8   
CATH (Classification of proteins structures)1BD8    1BI8   
SuperfamilyP55273
AlphaFold pdb e-kbP55273   
Human Protein Atlas [tissue]ENSG00000129355-CDKN2D [tissue]
HPRD02957
Protein Interaction databases
DIP (DOE-UCLA)P55273
IntAct (EBI)P55273
BioGRIDCDKN2D
STRING (EMBL)CDKN2D
ZODIACCDKN2D
Ontologies - Pathways
QuickGOP55273
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  DNA synthesis involved in DNA repair  cyclin-dependent protein serine/threonine kinase inhibitor activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  cytosol  sensory perception of sound  negative regulation of cell population proliferation  response to UV  protein kinase binding  negative regulation of cell growth  response to retinoic acid  response to vitamin D  negative regulation of phosphorylation  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of cyclin-dependent protein serine/threonine kinase activity  autophagic cell death  regulation of cell cycle  cyclin D2-CDK4 complex  negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  negative regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  DNA synthesis involved in DNA repair  cyclin-dependent protein serine/threonine kinase inhibitor activity  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  cytosol  sensory perception of sound  negative regulation of cell population proliferation  response to UV  protein kinase binding  negative regulation of cell growth  response to retinoic acid  response to vitamin D  negative regulation of phosphorylation  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of cyclin-dependent protein serine/threonine kinase activity  autophagic cell death  regulation of cell cycle  cyclin D2-CDK4 complex  negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  negative regulation of G1/S transition of mitotic cell cycle  
Pathways : BIOCARTACell Cycle: G2/M Checkpoint [Genes]    Cyclins and Cell Cycle Regulation [Genes]   
Pathways : KEGGFoxO signaling pathway    Cell cycle   
NDEx NetworkCDKN2D
Atlas of Cancer Signalling NetworkCDKN2D
Wikipedia pathwaysCDKN2D
Orthology - Evolution
OrthoDB1032
GeneTree (enSembl)ENSG00000129355
Phylogenetic Trees/Animal Genes : TreeFamCDKN2D
Homologs : HomoloGeneCDKN2D
Homology/Alignments : Family Browser (UCSC)CDKN2D
Gene fusions - Rearrangements
Fusion : MitelmanCDKN2D/WDFY2 [19p13.2/13q14.3]  
Fusion : QuiverCDKN2D
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDKN2D [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDKN2D
dbVarCDKN2D
ClinVarCDKN2D
MonarchCDKN2D
1000_GenomesCDKN2D 
Exome Variant ServerCDKN2D
GNOMAD BrowserENSG00000129355
Varsome BrowserCDKN2D
Genomic Variants (DGV)CDKN2D [DGVbeta]
DECIPHERCDKN2D [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDKN2D 
Mutations
ICGC Data PortalCDKN2D 
TCGA Data PortalCDKN2D 
Broad Tumor PortalCDKN2D
OASIS PortalCDKN2D [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDKN2D  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCDKN2D
Mutations and Diseases : HGMDCDKN2D
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutasearch CDKN2D
DgiDB (Drug Gene Interaction Database)CDKN2D
DoCM (Curated mutations)CDKN2D (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDKN2D (select a term)
Cancer3DCDKN2D(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600927   
Orphanet3560   
DisGeNETCDKN2D
MedgenCDKN2D
Genetic Testing Registry CDKN2D
NextProtP55273 [Medical]
GENETestsCDKN2D
Target ValidationCDKN2D
Huge Navigator CDKN2D [HugePedia]
ClinGenCDKN2D
Clinical trials, drugs, therapy
MyCancerGenomeCDKN2D
Protein Interactions : CTDCDKN2D
Pharm GKB GenePA26323
PharosP55273
Clinical trialCDKN2D
Miscellaneous
canSAR (ICR)CDKN2D
HarmonizomeCDKN2D
DataMed IndexCDKN2D
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCDKN2D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Sep 15 22:07:35 CEST 2021

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