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CDKN3 (cyclin dependent kinase inhibitor 3)

Identity

Alias_symbol (synonym)KAP
CDI1
Other aliasCIP2
KAP1
HGNC (Hugo) CDKN3
LocusID (NCBI) 1033
Atlas_Id 40039
Location 14q22.2  [Link to chromosome band 14q22]
Location_base_pair Starts at 54396955 and ends at 54420216 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDKN3 (14q22.2) / SFTA3 (14q13.3)GRN (17q21.31) / CDKN3 (14q22.2)HSPA1A (6p21.33) / CDKN3 (14q22.2)
CDKN3 14q22.2 / SFTA3 14q13.3GRN 17q21.31 / CDKN3 14q22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CDKN3   1791
Cards
Entrez_Gene (NCBI)CDKN3  1033  cyclin dependent kinase inhibitor 3
AliasesCDI1; CIP2; KAP; KAP1
GeneCards (Weizmann)CDKN3
Ensembl hg19 (Hinxton)ENSG00000100526 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100526 [Gene_View]  chr14:54396955-54420216 [Contig_View]  CDKN3 [Vega]
ICGC DataPortalENSG00000100526
TCGA cBioPortalCDKN3
AceView (NCBI)CDKN3
Genatlas (Paris)CDKN3
WikiGenes1033
SOURCE (Princeton)CDKN3
Genetics Home Reference (NIH)CDKN3
Genomic and cartography
GoldenPath hg38 (UCSC)CDKN3  -     chr14:54396955-54420216 +  14q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CDKN3  -     14q22.2   [Description]    (hg19-Feb_2009)
EnsemblCDKN3 - 14q22.2 [CytoView hg19]  CDKN3 - 14q22.2 [CytoView hg38]
Mapping of homologs : NCBICDKN3 [Mapview hg19]  CDKN3 [Mapview hg38]
OMIM123832   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001130851 NM_001330173 NM_005192
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CDKN3
Cluster EST : UnigeneHs.84113 [ NCBI ]
CGAP (NCI)Hs.84113
Alternative Splicing GalleryENSG00000100526
Gene ExpressionCDKN3 [ NCBI-GEO ]   CDKN3 [ EBI - ARRAY_EXPRESS ]   CDKN3 [ SEEK ]   CDKN3 [ MEM ]
Gene Expression Viewer (FireBrowse)CDKN3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1033
GTEX Portal (Tissue expression)CDKN3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16667   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16667  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16667
Splice isoforms : SwissVarQ16667
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusQ16667
Domaine pattern : Prosite (Expaxy)TYR_PHOSPHATASE_2 (PS50056)   
Domains : Interpro (EBI)CDK_inhib_3    CDKN3    Prot-tyrosine_phosphatase-like    Tyr_Pase_cat    TYR_PHOSPHATASE_dom   
Domain families : Pfam (Sanger)CDKN3 (PF05706)   
Domain families : Pfam (NCBI)pfam05706   
Domain families : Smart (EMBL)PTPc_motif (SM00404)  
Conserved Domain (NCBI)CDKN3
DMDM Disease mutations1033
Blocks (Seattle)CDKN3
PDB (SRS)1FPZ    1FQ1   
PDB (PDBSum)1FPZ    1FQ1   
PDB (IMB)1FPZ    1FQ1   
PDB (RSDB)1FPZ    1FQ1   
Structural Biology KnowledgeBase1FPZ    1FQ1   
SCOP (Structural Classification of Proteins)1FPZ    1FQ1   
CATH (Classification of proteins structures)1FPZ    1FQ1   
SuperfamilyQ16667
Human Protein AtlasENSG00000100526
Peptide AtlasQ16667
HPRD00450
IPIIPI00003445   IPI00909462   IPI01013565   IPI01011644   IPI00941196   IPI00930337   IPI00477487   IPI00383959   IPI00942842   IPI01013964   IPI01024988   
Protein Interaction databases
DIP (DOE-UCLA)Q16667
IntAct (EBI)Q16667
FunCoupENSG00000100526
BioGRIDCDKN3
STRING (EMBL)CDKN3
ZODIACCDKN3
Ontologies - Pathways
QuickGOQ16667
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  protein serine/threonine phosphatase activity  protein tyrosine phosphatase activity  protein binding  nucleus  cytosol  cell cycle arrest  protein tyrosine/serine/threonine phosphatase activity  negative regulation of cell proliferation  peptidyl-tyrosine dephosphorylation  perinuclear region of cytoplasm  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  protein serine/threonine phosphatase activity  protein tyrosine phosphatase activity  protein binding  nucleus  cytosol  cell cycle arrest  protein tyrosine/serine/threonine phosphatase activity  negative regulation of cell proliferation  peptidyl-tyrosine dephosphorylation  perinuclear region of cytoplasm  
NDEx NetworkCDKN3
Atlas of Cancer Signalling NetworkCDKN3
Wikipedia pathwaysCDKN3
Orthology - Evolution
OrthoDB1033
GeneTree (enSembl)ENSG00000100526
Phylogenetic Trees/Animal Genes : TreeFamCDKN3
HOVERGENQ16667
HOGENOMQ16667
Homologs : HomoloGeneCDKN3
Homology/Alignments : Family Browser (UCSC)CDKN3
Gene fusions - Rearrangements
Fusion : MitelmanCDKN3/SFTA3 [14q22.2/14q13.3]  
Fusion : MitelmanGRN/CDKN3 [17q21.31/14q22.2]  [t(14;17)(q22;q21)]  
Fusion: TCGACDKN3 14q22.2 SFTA3 14q13.3 LUAD
Fusion: TCGAGRN 17q21.31 CDKN3 14q22.2 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCDKN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CDKN3
dbVarCDKN3
ClinVarCDKN3
1000_GenomesCDKN3 
Exome Variant ServerCDKN3
ExAC (Exome Aggregation Consortium)CDKN3 (select the gene name)
Genetic variants : HAPMAP1033
Genomic Variants (DGV)CDKN3 [DGVbeta]
DECIPHERCDKN3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCDKN3 
Mutations
ICGC Data PortalCDKN3 
TCGA Data PortalCDKN3 
Broad Tumor PortalCDKN3
OASIS PortalCDKN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCDKN3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCDKN3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CDKN3
DgiDB (Drug Gene Interaction Database)CDKN3
DoCM (Curated mutations)CDKN3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CDKN3 (select a term)
intoGenCDKN3
Cancer3DCDKN3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123832   
Orphanet
MedgenCDKN3
Genetic Testing Registry CDKN3
NextProtQ16667 [Medical]
TSGene1033
GENETestsCDKN3
Target ValidationCDKN3
Huge Navigator CDKN3 [HugePedia]
snp3D : Map Gene to Disease1033
BioCentury BCIQCDKN3
ClinGenCDKN3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1033
Chemical/Pharm GKB GenePA26324
Clinical trialCDKN3
Miscellaneous
canSAR (ICR)CDKN3 (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCDKN3
EVEXCDKN3
GoPubMedCDKN3
iHOPCDKN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:01:47 CEST 2017

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