Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CEBPB (CCAAT/enhancer binding protein beta)

Identity

Alias_namesTCF5
CCAAT/enhancer binding protein (C/EBP)
Alias_symbol (synonym)LAP
CRP2
NFIL6
IL6DBP
C/EBP-beta
Other aliasNF-IL6
HGNC (Hugo) CEBPB
LocusID (NCBI) 1051
Atlas_Id 40051
Location 20q13.13  [Link to chromosome band 20q13]
Location_base_pair Starts at 48807120 and ends at 48809227 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
IGH (14q32.33) / CEBPB (20q13.13)IGHG1 (14q32.33) / CEBPB (20q13.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 12 ]
  t(1;1)(p36;p36) PRDM16/SKI
t(1;1)(p36;q41) DUSP10/PRDM16
t(1;2)(p36;p21) THADA/PRDM16
t(1;3)(p36;q21) RPN1/PRDM16
t(1;7)(p36;p12) IKZF1/PRDM16
t(1;12)(p36;p13) ETV6/PRDM16
t(1;17)(p36;q21) WNT3 or NSF/PRDM16
t(1;22)(p36;q11) IGL/PRDM16
t(8;14)(q11;q32) IGH/CEBPD
t(14;14)(q11;q32) CEBPE/IGH::inv(14)(q11q32) CEBPE/IGH
t(14;19)(q32;q13) IGH/CEBPA
t(14;20)(q32;q13) IGH/CEBPB


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
 
Nervous system: Astrocytoma with t(1;17)(p36;q21) SPOP/PRDM16


External links

Nomenclature
HGNC (Hugo)CEBPB   1834
Cards
Entrez_Gene (NCBI)CEBPB  1051  CCAAT/enhancer binding protein beta
AliasesC/EBP-beta; IL6DBP; NF-IL6; TCF5
GeneCards (Weizmann)CEBPB
Ensembl hg19 (Hinxton)ENSG00000172216 [Gene_View]  chr20:48807120-48809227 [Contig_View]  CEBPB [Vega]
Ensembl hg38 (Hinxton)ENSG00000172216 [Gene_View]  chr20:48807120-48809227 [Contig_View]  CEBPB [Vega]
ICGC DataPortalENSG00000172216
TCGA cBioPortalCEBPB
AceView (NCBI)CEBPB
Genatlas (Paris)CEBPB
WikiGenes1051
SOURCE (Princeton)CEBPB
Genetics Home Reference (NIH)CEBPB
Genomic and cartography
GoldenPath hg19 (UCSC)CEBPB  -     chr20:48807120-48809227 +  20q13.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CEBPB  -     20q13.13   [Description]    (hg38-Dec_2013)
EnsemblCEBPB - 20q13.13 [CytoView hg19]  CEBPB - 20q13.13 [CytoView hg38]
Mapping of homologs : NCBICEBPB [Mapview hg19]  CEBPB [Mapview hg38]
OMIM189965   
Gene and transcription
Genbank (Entrez)AF289608 AK291536 AW025406 BC005132 BC007538
RefSeq transcript (Entrez)NM_001285878 NM_001285879 NM_005194
RefSeq genomic (Entrez)NC_000020 NC_018931 NG_029019 NT_011362 NW_004929418
Consensus coding sequences : CCDS (NCBI)CEBPB
Cluster EST : UnigeneHs.720603 [ NCBI ]
CGAP (NCI)Hs.720603
Alternative Splicing GalleryENSG00000172216
Gene ExpressionCEBPB [ NCBI-GEO ]   CEBPB [ EBI - ARRAY_EXPRESS ]   CEBPB [ SEEK ]   CEBPB [ MEM ]
Gene Expression Viewer (FireBrowse)CEBPB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1051
GTEX Portal (Tissue expression)CEBPB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17676   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17676  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17676
Splice isoforms : SwissVarP17676
PhosPhoSitePlusP17676
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)   
Domains : Interpro (EBI)bZIP    C/EBP    C/EBP_chordates   
Domain families : Pfam (Sanger)bZIP_2 (PF07716)   
Domain families : Pfam (NCBI)pfam07716   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)CEBPB
DMDM Disease mutations1051
Blocks (Seattle)CEBPB
PDB (SRS)1GTW    1GU4    1GU5    1H88    1H89    1H8A    1HJB    1IO4    2E42    2E43   
PDB (PDBSum)1GTW    1GU4    1GU5    1H88    1H89    1H8A    1HJB    1IO4    2E42    2E43   
PDB (IMB)1GTW    1GU4    1GU5    1H88    1H89    1H8A    1HJB    1IO4    2E42    2E43   
PDB (RSDB)1GTW    1GU4    1GU5    1H88    1H89    1H8A    1HJB    1IO4    2E42    2E43   
Structural Biology KnowledgeBase1GTW    1GU4    1GU5    1H88    1H89    1H8A    1HJB    1IO4    2E42    2E43   
SCOP (Structural Classification of Proteins)1GTW    1GU4    1GU5    1H88    1H89    1H8A    1HJB    1IO4    2E42    2E43   
CATH (Classification of proteins structures)1GTW    1GU4    1GU5    1H88    1H89    1H8A    1HJB    1IO4    2E42    2E43   
SuperfamilyP17676
Human Protein AtlasENSG00000172216
Peptide AtlasP17676
HPRD01801
IPIIPI00289773   IPI00977352   
Protein Interaction databases
DIP (DOE-UCLA)P17676
IntAct (EBI)P17676
FunCoupENSG00000172216
BioGRIDCEBPB
STRING (EMBL)CEBPB
ZODIACCEBPB
Ontologies - Pathways
QuickGOP17676
Ontology : AmiGOcondensed chromosome, centromeric region  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  ovarian follicle development  embryonic placenta development  granuloma formation  granuloma formation  DNA binding  chromatin binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  acute-phase response  inflammatory response  immune response  memory  transcription factor binding  nuclear matrix  kinase binding  neuron differentiation  positive regulation of interleukin-4 production  mammary gland epithelial cell proliferation  response to endoplasmic reticulum stress  histone acetyltransferase binding  glucocorticoid receptor binding  T-helper 1 cell activation  T-helper 1 cell activation  CHOP-C/EBP complex  negative regulation of T cell proliferation  defense response to bacterium  protein homodimerization activity  histone deacetylase binding  negative regulation of neuron apoptotic process  ubiquitin-like protein ligase binding  regulation of interleukin-6 biosynthetic process  positive regulation of fat cell differentiation  positive regulation of osteoblast differentiation  regulation of osteoclast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  brown fat cell differentiation  mammary gland epithelial cell differentiation  regulation of transcription involved in cell fate commitment  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  cellular response to lipopolysaccharide  cellular response to amino acid stimulus  cellular response to interleukin-1  cellular response to organic cyclic compound  hepatocyte proliferation  liver regeneration  positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  
Ontology : EGO-EBIcondensed chromosome, centromeric region  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  ovarian follicle development  embryonic placenta development  granuloma formation  granuloma formation  DNA binding  chromatin binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  acute-phase response  inflammatory response  immune response  memory  transcription factor binding  nuclear matrix  kinase binding  neuron differentiation  positive regulation of interleukin-4 production  mammary gland epithelial cell proliferation  response to endoplasmic reticulum stress  histone acetyltransferase binding  glucocorticoid receptor binding  T-helper 1 cell activation  T-helper 1 cell activation  CHOP-C/EBP complex  negative regulation of T cell proliferation  defense response to bacterium  protein homodimerization activity  histone deacetylase binding  negative regulation of neuron apoptotic process  ubiquitin-like protein ligase binding  regulation of interleukin-6 biosynthetic process  positive regulation of fat cell differentiation  positive regulation of osteoblast differentiation  regulation of osteoclast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  brown fat cell differentiation  mammary gland epithelial cell differentiation  regulation of transcription involved in cell fate commitment  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  cellular response to lipopolysaccharide  cellular response to amino acid stimulus  cellular response to interleukin-1  cellular response to organic cyclic compound  hepatocyte proliferation  liver regeneration  positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  
Pathways : BIOCARTAIL 6 signaling pathway [Genes]   
Pathways : KEGGTNF signaling pathway    Tuberculosis    Transcriptional misregulation in cancer   
NDEx NetworkCEBPB
Atlas of Cancer Signalling NetworkCEBPB
Wikipedia pathwaysCEBPB
Orthology - Evolution
OrthoDB1051
GeneTree (enSembl)ENSG00000172216
Phylogenetic Trees/Animal Genes : TreeFamCEBPB
HOVERGENP17676
HOGENOMP17676
Homologs : HomoloGeneCEBPB
Homology/Alignments : Family Browser (UCSC)CEBPB
Gene fusions - Rearrangements
Fusion : MitelmanIGH/CEBPB [14q32.33/20q13.13]  [t(14;20)(q32;q13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCEBPB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CEBPB
dbVarCEBPB
ClinVarCEBPB
1000_GenomesCEBPB 
Exome Variant ServerCEBPB
ExAC (Exome Aggregation Consortium)CEBPB (select the gene name)
Genetic variants : HAPMAP1051
Genomic Variants (DGV)CEBPB [DGVbeta]
DECIPHER (Syndromes)20:48807120-48809227  ENSG00000172216
CONAN: Copy Number AnalysisCEBPB 
Mutations
ICGC Data PortalCEBPB 
TCGA Data PortalCEBPB 
Broad Tumor PortalCEBPB
OASIS PortalCEBPB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCEBPB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCEBPB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CEBPB
DgiDB (Drug Gene Interaction Database)CEBPB
DoCM (Curated mutations)CEBPB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CEBPB (select a term)
intoGenCEBPB
Cancer3DCEBPB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM189965   
Orphanet
MedgenCEBPB
Genetic Testing Registry CEBPB
NextProtP17676 [Medical]
TSGene1051
GENETestsCEBPB
Huge Navigator CEBPB [HugePedia]
snp3D : Map Gene to Disease1051
BioCentury BCIQCEBPB
ClinGenCEBPB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1051
Chemical/Pharm GKB GenePA26377
Clinical trialCEBPB
Miscellaneous
canSAR (ICR)CEBPB (select the gene name)
Probes
Litterature
PubMed367 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCEBPB
EVEXCEBPB
GoPubMedCEBPB
iHOPCEBPB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 12:59:54 CET 2017

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