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CEBPE (CCAAT/enhancer binding protein epsilon)

Identity

Alias_namesCCAAT/enhancer binding protein (C/EBP)
Alias_symbol (synonym)CRP1
Other aliasC/EBP-epsilon
HGNC (Hugo) CEBPE
LocusID (NCBI) 1053
Atlas_Id 42984
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 23586515 and ends at 23588820 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CEBPE (14q11.2) / IGH (14q32.33)IGH (14q32.33) / CEBPE (14q11.2)IGHG1 (14q32.33) / CEBPE (14q11.2)
TRA () / CEBPE (14q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(8;14)(q11;q32) IGH/CEBPD
t(14;14)(q11;q32) CEBPE/IGH::inv(14)(q11q32) CEBPE/IGH
t(14;19)(q32;q13) IGH/CEBPA
t(14;20)(q32;q13) IGH/CEBPB


External links

Nomenclature
HGNC (Hugo)CEBPE   1836
LRG (Locus Reference Genomic)LRG_45
Cards
Entrez_Gene (NCBI)CEBPE  1053  CCAAT/enhancer binding protein epsilon
AliasesC/EBP-epsilon; CRP1
GeneCards (Weizmann)CEBPE
Ensembl hg19 (Hinxton)ENSG00000092067 [Gene_View]  chr14:23586515-23588820 [Contig_View]  CEBPE [Vega]
Ensembl hg38 (Hinxton)ENSG00000092067 [Gene_View]  chr14:23586515-23588820 [Contig_View]  CEBPE [Vega]
ICGC DataPortalENSG00000092067
TCGA cBioPortalCEBPE
AceView (NCBI)CEBPE
Genatlas (Paris)CEBPE
WikiGenes1053
SOURCE (Princeton)CEBPE
Genetics Home Reference (NIH)CEBPE
Genomic and cartography
GoldenPath hg19 (UCSC)CEBPE  -     chr14:23586515-23588820 -  14q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CEBPE  -     14q11.2   [Description]    (hg38-Dec_2013)
EnsemblCEBPE - 14q11.2 [CytoView hg19]  CEBPE - 14q11.2 [CytoView hg38]
Mapping of homologs : NCBICEBPE [Mapview hg19]  CEBPE [Mapview hg38]
OMIM245480   600749   
Gene and transcription
Genbank (Entrez)BC035797 BG387972 BX346756 BY995857 EU446853
RefSeq transcript (Entrez)NM_001805
RefSeq genomic (Entrez)NC_000014 NC_018925 NG_009617 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)CEBPE
Cluster EST : UnigeneHs.558308 [ NCBI ]
CGAP (NCI)Hs.558308
Alternative Splicing GalleryENSG00000092067
Gene ExpressionCEBPE [ NCBI-GEO ]   CEBPE [ EBI - ARRAY_EXPRESS ]   CEBPE [ SEEK ]   CEBPE [ MEM ]
Gene Expression Viewer (FireBrowse)CEBPE [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1053
GTEX Portal (Tissue expression)CEBPE
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15744   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15744  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15744
Splice isoforms : SwissVarQ15744
PhosPhoSitePlusQ15744
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)   
Domains : Interpro (EBI)bZIP    C/EBP    C/EBP_chordates   
Domain families : Pfam (Sanger)bZIP_2 (PF07716)   
Domain families : Pfam (NCBI)pfam07716   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)CEBPE
DMDM Disease mutations1053
Blocks (Seattle)CEBPE
PDB (SRS)3T92   
PDB (PDBSum)3T92   
PDB (IMB)3T92   
PDB (RSDB)3T92   
Structural Biology KnowledgeBase3T92   
SCOP (Structural Classification of Proteins)3T92   
CATH (Classification of proteins structures)3T92   
SuperfamilyQ15744
Human Protein AtlasENSG00000092067
Peptide AtlasQ15744
HPRD02852
IPIIPI00217782   
Protein Interaction databases
DIP (DOE-UCLA)Q15744
IntAct (EBI)Q15744
FunCoupENSG00000092067
BioGRIDCEBPE
STRING (EMBL)CEBPE
ZODIACCEBPE
Ontologies - Pathways
QuickGOQ15744
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  nucleoplasm  transcription from RNA polymerase II promoter  phagocytosis  defense response  macrophage differentiation  cytokine biosynthetic process  defense response to bacterium  protein homodimerization activity  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  cellular response to lipopolysaccharide  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  nucleoplasm  transcription from RNA polymerase II promoter  phagocytosis  defense response  macrophage differentiation  cytokine biosynthetic process  defense response to bacterium  protein homodimerization activity  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  cellular response to lipopolysaccharide  
Pathways : KEGGTranscriptional misregulation in cancer   
NDEx NetworkCEBPE
Atlas of Cancer Signalling NetworkCEBPE
Wikipedia pathwaysCEBPE
Orthology - Evolution
OrthoDB1053
GeneTree (enSembl)ENSG00000092067
Phylogenetic Trees/Animal Genes : TreeFamCEBPE
HOVERGENQ15744
HOGENOMQ15744
Homologs : HomoloGeneCEBPE
Homology/Alignments : Family Browser (UCSC)CEBPE
Gene fusions - Rearrangements
Fusion : MitelmanIGH/CEBPE [14q32.33/14q11.2]  [inv(14)(q11q32)]  [t(14;14)(q11;q32)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCEBPE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CEBPE
dbVarCEBPE
ClinVarCEBPE
1000_GenomesCEBPE 
Exome Variant ServerCEBPE
ExAC (Exome Aggregation Consortium)CEBPE (select the gene name)
Genetic variants : HAPMAP1053
Genomic Variants (DGV)CEBPE [DGVbeta]
DECIPHER (Syndromes)14:23586515-23588820  ENSG00000092067
CONAN: Copy Number AnalysisCEBPE 
Mutations
ICGC Data PortalCEBPE 
TCGA Data PortalCEBPE 
Broad Tumor PortalCEBPE
OASIS PortalCEBPE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCEBPE  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCEBPE
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch CEBPE
DgiDB (Drug Gene Interaction Database)CEBPE
DoCM (Curated mutations)CEBPE (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CEBPE (select a term)
intoGenCEBPE
Cancer3DCEBPE(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM245480    600749   
Orphanet17826   
MedgenCEBPE
Genetic Testing Registry CEBPE
NextProtQ15744 [Medical]
TSGene1053
GENETestsCEBPE
Huge Navigator CEBPE [HugePedia]
snp3D : Map Gene to Disease1053
BioCentury BCIQCEBPE
ClinGenCEBPE
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1053
Chemical/Pharm GKB GenePA26379
Clinical trialCEBPE
Miscellaneous
canSAR (ICR)CEBPE (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCEBPE
EVEXCEBPE
GoPubMedCEBPE
iHOPCEBPE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 12:59:54 CET 2017

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