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CENPA (centromere protein A)

Identity

Alias (NCBI)CENP-A
CenH3
HGNC (Hugo) CENPA
HGNC Alias symbCENP-A
CenH3
HGNC Alias namecentromere-specific histone
 histone H3-like centromeric protein A
HGNC Previous namecentromere protein A (17kD)
 centromere protein A, 17kDa
LocusID (NCBI) 1058
Atlas_Id 40054
Location 2p23.3  [Link to chromosome band 2p23]
Location_base_pair Starts at 26786056 and ends at 26794587 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CENPA   1851
Cards
Entrez_Gene (NCBI)CENPA    centromere protein A
AliasesCENP-A; CenH3
GeneCards (Weizmann)CENPA
Ensembl hg19 (Hinxton)ENSG00000115163 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115163 [Gene_View]  ENSG00000115163 [Sequence]  chr2:26786056-26794587 [Contig_View]  CENPA [Vega]
ICGC DataPortalENSG00000115163
TCGA cBioPortalCENPA
AceView (NCBI)CENPA
Genatlas (Paris)CENPA
SOURCE (Princeton)CENPA
Genetics Home Reference (NIH)CENPA
Genomic and cartography
GoldenPath hg38 (UCSC)CENPA  -     chr2:26786056-26794587 +  2p23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CENPA  -     2p23.3   [Description]    (hg19-Feb_2009)
GoldenPathCENPA - 2p23.3 [CytoView hg19]  CENPA - 2p23.3 [CytoView hg38]
ImmunoBaseENSG00000115163
Genome Data Viewer NCBICENPA [Mapview hg19]  
OMIM117139   
Gene and transcription
Genbank (Entrez)BC000881 BC002703 BC011013 BT007246 U14518
RefSeq transcript (Entrez)NM_001042426 NM_001809
Consensus coding sequences : CCDS (NCBI)CENPA
Gene ExpressionCENPA [ NCBI-GEO ]   CENPA [ EBI - ARRAY_EXPRESS ]   CENPA [ SEEK ]   CENPA [ MEM ]
Gene Expression Viewer (FireBrowse)CENPA [ Firebrowse - Broad ]
GenevisibleExpression of CENPA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1058
GTEX Portal (Tissue expression)CENPA
Human Protein AtlasENSG00000115163-CENPA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49450   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49450  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49450
PhosPhoSitePlusP49450
Domaine pattern : Prosite (Expaxy)HISTONE_H3_2 (PS00959)   
Domains : Interpro (EBI)Histone-fold    Histone_H2A/H2B/H3    Histone_H3/CENP-A   
Domain families : Pfam (Sanger)Histone (PF00125)   
Domain families : Pfam (NCBI)pfam00125   
Domain families : Smart (EMBL)H3 (SM00428)  
Conserved Domain (NCBI)CENPA
PDB (RSDB)3AN2    3NQJ    3NQU    3R45    3WTP    5CVD    5Z23    6BUZ    6C0W    6E0C    6E0P    6KDQ    6KDS    6L49    6MUO    6MUP    6O1D    6SE0    6SE6    6SEE    6SEF    6SEG    6TEM   
PDB Europe3AN2    3NQJ    3NQU    3R45    3WTP    5CVD    5Z23    6BUZ    6C0W    6E0C    6E0P    6KDQ    6KDS    6L49    6MUO    6MUP    6O1D    6SE0    6SE6    6SEE    6SEF    6SEG    6TEM   
PDB (PDBSum)3AN2    3NQJ    3NQU    3R45    3WTP    5CVD    5Z23    6BUZ    6C0W    6E0C    6E0P    6KDQ    6KDS    6L49    6MUO    6MUP    6O1D    6SE0    6SE6    6SEE    6SEF    6SEG    6TEM   
PDB (IMB)3AN2    3NQJ    3NQU    3R45    3WTP    5CVD    5Z23    6BUZ    6C0W    6E0C    6E0P    6KDQ    6KDS    6L49    6MUO    6MUP    6O1D    6SE0    6SE6    6SEE    6SEF    6SEG    6TEM   
Structural Biology KnowledgeBase3AN2    3NQJ    3NQU    3R45    3WTP    5CVD    5Z23    6BUZ    6C0W    6E0C    6E0P    6KDQ    6KDS    6L49    6MUO    6MUP    6O1D    6SE0    6SE6    6SEE    6SEF    6SEG    6TEM   
SCOP (Structural Classification of Proteins)3AN2    3NQJ    3NQU    3R45    3WTP    5CVD    5Z23    6BUZ    6C0W    6E0C    6E0P    6KDQ    6KDS    6L49    6MUO    6MUP    6O1D    6SE0    6SE6    6SEE    6SEF    6SEG    6TEM   
CATH (Classification of proteins structures)3AN2    3NQJ    3NQU    3R45    3WTP    5CVD    5Z23    6BUZ    6C0W    6E0C    6E0P    6KDQ    6KDS    6L49    6MUO    6MUP    6O1D    6SE0    6SE6    6SEE    6SEF    6SEG    6TEM   
SuperfamilyP49450
AlphaFold pdb e-kbP49450   
Human Protein Atlas [tissue]ENSG00000115163-CENPA [tissue]
HPRD00313
Protein Interaction databases
DIP (DOE-UCLA)P49450
IntAct (EBI)P49450
BioGRIDCENPA
STRING (EMBL)CENPA
ZODIACCENPA
Ontologies - Pathways
QuickGOP49450
Ontology : AmiGOestablishment of mitotic spindle orientation  mitotic cytokinesis  chromosome, centromeric region  kinetochore  condensed chromosome, centromeric region  nucleosome  inner kinetochore  DNA binding  chromatin binding  protein binding  nucleus  nucleus  nucleus  nucleoplasm  nucleoplasm  pericentric heterochromatin  cytosol  CENP-A containing nucleosome  protein heterodimerization activity  kinetochore assembly  protein localization to chromosome, centromeric region  
Ontology : EGO-EBIestablishment of mitotic spindle orientation  mitotic cytokinesis  chromosome, centromeric region  kinetochore  condensed chromosome, centromeric region  nucleosome  inner kinetochore  DNA binding  chromatin binding  protein binding  nucleus  nucleus  nucleus  nucleoplasm  nucleoplasm  pericentric heterochromatin  cytosol  CENP-A containing nucleosome  protein heterodimerization activity  kinetochore assembly  protein localization to chromosome, centromeric region  
NDEx NetworkCENPA
Atlas of Cancer Signalling NetworkCENPA
Wikipedia pathwaysCENPA
Orthology - Evolution
OrthoDB1058
GeneTree (enSembl)ENSG00000115163
Phylogenetic Trees/Animal Genes : TreeFamCENPA
Homologs : HomoloGeneCENPA
Homology/Alignments : Family Browser (UCSC)CENPA
Gene fusions - Rearrangements
Fusion : QuiverCENPA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCENPA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CENPA
dbVarCENPA
ClinVarCENPA
MonarchCENPA
1000_GenomesCENPA 
Exome Variant ServerCENPA
GNOMAD BrowserENSG00000115163
Varsome BrowserCENPA
ACMGCENPA variants
VarityP49450
Genomic Variants (DGV)CENPA [DGVbeta]
DECIPHERCENPA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCENPA 
Mutations
ICGC Data PortalCENPA 
TCGA Data PortalCENPA 
Broad Tumor PortalCENPA
OASIS PortalCENPA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCENPA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCENPA
Mutations and Diseases : HGMDCENPA
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCENPA
DgiDB (Drug Gene Interaction Database)CENPA
DoCM (Curated mutations)CENPA
CIViC (Clinical Interpretations of Variants in Cancer)CENPA
Cancer3DCENPA
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM117139   
Orphanet
DisGeNETCENPA
MedgenCENPA
Genetic Testing Registry CENPA
NextProtP49450 [Medical]
GENETestsCENPA
Target ValidationCENPA
Huge Navigator CENPA [HugePedia]
ClinGenCENPA
Clinical trials, drugs, therapy
MyCancerGenomeCENPA
Protein Interactions : CTDCENPA
Pharm GKB GenePA26396
PharosP49450
Clinical trialCENPA
Miscellaneous
canSAR (ICR)CENPA
HarmonizomeCENPA
ARCHS4CENPA
DataMed IndexCENPA
Probes
Litterature
PubMed166 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCENPA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:27:02 CET 2022

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