CENPA (centromere protein A)

2003-11-01  

Identity

HGNC
CENPA
LOCATION
2p23.3
LOCUSID
1058
ALIAS
CENP-A,CenH3

Other Information

Locus ID:

NCBI: 1058
MIM: 117139
HGNC: 1851
Ensembl: ENSG00000115163

Variants:

dbSNP: 1058
ClinVar: 1058
TCGA: ENSG00000115163
COSMIC: CENPA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115163ENST00000233505P49450
ENSG00000115163ENST00000335756P49450
ENSG00000115163ENST00000419525F8WD88

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Chromosome MaintenanceREACTOMER-HSA-73886
Nucleosome assemblyREACTOMER-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromereREACTOMER-HSA-606279

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
166224192006The human CENP-A centromeric nucleosome-associated complex.295
194105442009Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP.256
173393802007Propagation of centromeric chromatin requires exit from mitosis.243
194105452009HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres.238
166224202006The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.195
152826082004Structural determinants for generating centromeric chromatin.173
217434762011Crystal structure of the human centromeric nucleosome containing CENP-A.161
171990382007Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1.158
205666832010Dual recognition of CENP-A nucleosomes is required for centromere assembly.150
217682892011HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore.136

Citation

Dessen P

CENPA (centromere protein A)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40054/cenpa