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CENPA (centromere protein A)

Identity

Alias_namescentromere protein A (17kD)
centromere protein A, 17kDa
Alias_symbol (synonym)CENP-A
CenH3
Other alias
HGNC (Hugo) CENPA
LocusID (NCBI) 1058
Atlas_Id 40054
Location 2p23.3  [Link to chromosome band 2p23]
Location_base_pair Starts at 27008883 and ends at 27017455 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CENPA   1851
Cards
Entrez_Gene (NCBI)CENPA  1058  centromere protein A
AliasesCENP-A; CenH3
GeneCards (Weizmann)CENPA
Ensembl hg19 (Hinxton)ENSG00000115163 [Gene_View]  chr2:27008883-27017455 [Contig_View]  CENPA [Vega]
Ensembl hg38 (Hinxton)ENSG00000115163 [Gene_View]  chr2:27008883-27017455 [Contig_View]  CENPA [Vega]
ICGC DataPortalENSG00000115163
TCGA cBioPortalCENPA
AceView (NCBI)CENPA
Genatlas (Paris)CENPA
WikiGenes1058
SOURCE (Princeton)CENPA
Genetics Home Reference (NIH)CENPA
Genomic and cartography
GoldenPath hg19 (UCSC)CENPA  -     chr2:27008883-27017455 +  2p23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CENPA  -     2p23.3   [Description]    (hg38-Dec_2013)
EnsemblCENPA - 2p23.3 [CytoView hg19]  CENPA - 2p23.3 [CytoView hg38]
Mapping of homologs : NCBICENPA [Mapview hg19]  CENPA [Mapview hg38]
OMIM117139   
Gene and transcription
Genbank (Entrez)BC000881 BC002703 BC011013 BT007246 HQ448742
RefSeq transcript (Entrez)NM_001042426 NM_001809
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)CENPA
Cluster EST : UnigeneHs.1594 [ NCBI ]
CGAP (NCI)Hs.1594
Alternative Splicing GalleryENSG00000115163
Gene ExpressionCENPA [ NCBI-GEO ]   CENPA [ EBI - ARRAY_EXPRESS ]   CENPA [ SEEK ]   CENPA [ MEM ]
Gene Expression Viewer (FireBrowse)CENPA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1058
GTEX Portal (Tissue expression)CENPA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49450   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49450  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49450
Splice isoforms : SwissVarP49450
PhosPhoSitePlusP49450
Domaine pattern : Prosite (Expaxy)HISTONE_H3_2 (PS00959)   
Domains : Interpro (EBI)Histone-fold    Histone_H2A/H2B/H3    Histone_H3/CENP-A   
Domain families : Pfam (Sanger)Histone (PF00125)   
Domain families : Pfam (NCBI)pfam00125   
Domain families : Smart (EMBL)H3 (SM00428)  
Conserved Domain (NCBI)CENPA
DMDM Disease mutations1058
Blocks (Seattle)CENPA
PDB (SRS)3AN2    3NQJ    3NQU    3R45    3WTP    5CVD   
PDB (PDBSum)3AN2    3NQJ    3NQU    3R45    3WTP    5CVD   
PDB (IMB)3AN2    3NQJ    3NQU    3R45    3WTP    5CVD   
PDB (RSDB)3AN2    3NQJ    3NQU    3R45    3WTP    5CVD   
Structural Biology KnowledgeBase3AN2    3NQJ    3NQU    3R45    3WTP    5CVD   
SCOP (Structural Classification of Proteins)3AN2    3NQJ    3NQU    3R45    3WTP    5CVD   
CATH (Classification of proteins structures)3AN2    3NQJ    3NQU    3R45    3WTP    5CVD   
SuperfamilyP49450
Human Protein AtlasENSG00000115163
Peptide AtlasP49450
HPRD00313
IPIIPI00027152   IPI00333218   IPI00893283   
Protein Interaction databases
DIP (DOE-UCLA)P49450
IntAct (EBI)P49450
FunCoupENSG00000115163
BioGRIDCENPA
STRING (EMBL)CENPA
ZODIACCENPA
Ontologies - Pathways
QuickGOP49450
Ontology : AmiGOestablishment of mitotic spindle orientation  chromosome, centromeric region  condensed nuclear chromosome kinetochore  condensed nuclear chromosome, centromeric region  nucleosome  condensed chromosome inner kinetochore  DNA binding  chromatin binding  protein binding  nucleus  nucleoplasm  cytosol  sister chromatid cohesion  viral process  CENP-A containing nucleosome assembly  protein heterodimerization activity  kinetochore assembly  protein localization to chromosome, centromeric region  
Ontology : EGO-EBIestablishment of mitotic spindle orientation  chromosome, centromeric region  condensed nuclear chromosome kinetochore  condensed nuclear chromosome, centromeric region  nucleosome  condensed chromosome inner kinetochore  DNA binding  chromatin binding  protein binding  nucleus  nucleoplasm  cytosol  sister chromatid cohesion  viral process  CENP-A containing nucleosome assembly  protein heterodimerization activity  kinetochore assembly  protein localization to chromosome, centromeric region  
NDEx NetworkCENPA
Atlas of Cancer Signalling NetworkCENPA
Wikipedia pathwaysCENPA
Orthology - Evolution
OrthoDB1058
GeneTree (enSembl)ENSG00000115163
Phylogenetic Trees/Animal Genes : TreeFamCENPA
HOVERGENP49450
HOGENOMP49450
Homologs : HomoloGeneCENPA
Homology/Alignments : Family Browser (UCSC)CENPA
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCENPA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CENPA
dbVarCENPA
ClinVarCENPA
1000_GenomesCENPA 
Exome Variant ServerCENPA
ExAC (Exome Aggregation Consortium)CENPA (select the gene name)
Genetic variants : HAPMAP1058
Genomic Variants (DGV)CENPA [DGVbeta]
DECIPHER (Syndromes)2:27008883-27017455  ENSG00000115163
CONAN: Copy Number AnalysisCENPA 
Mutations
ICGC Data PortalCENPA 
TCGA Data PortalCENPA 
Broad Tumor PortalCENPA
OASIS PortalCENPA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCENPA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCENPA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CENPA
DgiDB (Drug Gene Interaction Database)CENPA
DoCM (Curated mutations)CENPA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CENPA (select a term)
intoGenCENPA
Cancer3DCENPA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM117139   
Orphanet
MedgenCENPA
Genetic Testing Registry CENPA
NextProtP49450 [Medical]
TSGene1058
GENETestsCENPA
Huge Navigator CENPA [HugePedia]
snp3D : Map Gene to Disease1058
BioCentury BCIQCENPA
ClinGenCENPA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1058
Chemical/Pharm GKB GenePA26396
Clinical trialCENPA
Miscellaneous
canSAR (ICR)CENPA (select the gene name)
Probes
Litterature
PubMed103 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCENPA
EVEXCENPA
GoPubMedCENPA
iHOPCENPA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:56:09 CEST 2017

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