CENPC (centromere protein C)

2015-10-01  

Identity

HGNC
LOCATION
4q13.2
LOCUSID
ALIAS
CENP-C,CENPC1,MIF2,hcp-4
FUSION GENES

Other Information

Locus ID:

NCBI: 1060
MIM: 117141
HGNC: 1854
Ensembl: ENSG00000145241

Variants:

dbSNP: 1060
ClinVar: 1060
TCGA: ENSG00000145241
COSMIC: CENPC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145241ENST00000273853Q03188
ENSG00000145241ENST00000506882Q03188
ENSG00000145241ENST00000513216H0Y8J2
ENSG00000145241ENST00000515140H0Y9W1

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Chromosome MaintenanceREACTOMER-HSA-73886
Nucleosome assemblyREACTOMER-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromereREACTOMER-HSA-606279

References

Pubmed IDYearTitleCitations
213535562011Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore.114
176238122007Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere.98
259540102015Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere.66
259426232015DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function.65
194828742009DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions.57
225400252012CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin.54
261242892015CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochores.52
256605452015Distinct organization and regulation of the outer kinetochore KMN network downstream of CENP-C and CENP-T.39
287875902017Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C.36
176514962007Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres.32

Citation

Dessen P

CENPC (centromere protein C)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55465/cenpc