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CENPE (centromere protein E)

Identity

Alias_namesregulatory subunit 61
Alias_symbol (synonym)KIF10
PPP1R61
Other aliasCENP-E
MCPH13
HGNC (Hugo) CENPE
LocusID (NCBI) 1062
Atlas_Id 40056
Location 4q24  [Link to chromosome band 4q24]
Location_base_pair Starts at 104026963 and ends at 104119566 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FAHD1 (16p13.3) / CENPE (4q24)SPATA5 (4q28.1) / CENPE (4q24)SPATA5 4q28.1 / CENPE 4q24

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CENPE   1856
Cards
Entrez_Gene (NCBI)CENPE  1062  centromere protein E
AliasesCENP-E; KIF10; MCPH13; PPP1R61
GeneCards (Weizmann)CENPE
Ensembl hg19 (Hinxton)ENSG00000138778 [Gene_View]  chr4:104026963-104119566 [Contig_View]  CENPE [Vega]
Ensembl hg38 (Hinxton)ENSG00000138778 [Gene_View]  chr4:104026963-104119566 [Contig_View]  CENPE [Vega]
ICGC DataPortalENSG00000138778
TCGA cBioPortalCENPE
AceView (NCBI)CENPE
Genatlas (Paris)CENPE
WikiGenes1062
SOURCE (Princeton)CENPE
Genetics Home Reference (NIH)CENPE
Genomic and cartography
GoldenPath hg19 (UCSC)CENPE  -     chr4:104026963-104119566 -  4q24   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CENPE  -     4q24   [Description]    (hg38-Dec_2013)
EnsemblCENPE - 4q24 [CytoView hg19]  CENPE - 4q24 [CytoView hg38]
Mapping of homologs : NCBICENPE [Mapview hg19]  CENPE [Mapview hg38]
OMIM117143   616051   
Gene and transcription
Genbank (Entrez)AA210728 AA210858 AB209996 AK290362 AL596934
RefSeq transcript (Entrez)NM_001286734 NM_001813
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_041798 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)CENPE
Cluster EST : UnigeneHs.75573 [ NCBI ]
CGAP (NCI)Hs.75573
Alternative Splicing GalleryENSG00000138778
Gene ExpressionCENPE [ NCBI-GEO ]   CENPE [ EBI - ARRAY_EXPRESS ]   CENPE [ SEEK ]   CENPE [ MEM ]
Gene Expression Viewer (FireBrowse)CENPE [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1062
GTEX Portal (Tissue expression)CENPE
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02224   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02224  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02224
Splice isoforms : SwissVarQ02224
PhosPhoSitePlusQ02224
Domaine pattern : Prosite (Expaxy)KINESIN_MOTOR_1 (PS00411)    KINESIN_MOTOR_2 (PS50067)   
Domains : Interpro (EBI)CENP-E    Kinesin-like_fam    Kinesin_motor_CS    Kinesin_motor_dom    P-loop_NTPase   
Domain families : Pfam (Sanger)Kinesin (PF00225)   
Domain families : Pfam (NCBI)pfam00225   
Domain families : Smart (EMBL)KISc (SM00129)  
Conserved Domain (NCBI)CENPE
DMDM Disease mutations1062
Blocks (Seattle)CENPE
PDB (SRS)1T5C   
PDB (PDBSum)1T5C   
PDB (IMB)1T5C   
PDB (RSDB)1T5C   
Structural Biology KnowledgeBase1T5C   
SCOP (Structural Classification of Proteins)1T5C   
CATH (Classification of proteins structures)1T5C   
SuperfamilyQ02224
Human Protein AtlasENSG00000138778
Peptide AtlasQ02224
HPRD00316
IPIIPI00296365   IPI00868715   IPI00619925   IPI00967647   
Protein Interaction databases
DIP (DOE-UCLA)Q02224
IntAct (EBI)Q02224
FunCoupENSG00000138778
BioGRIDCENPE
STRING (EMBL)CENPE
ZODIACCENPE
Ontologies - Pathways
QuickGOQ02224
Ontology : AmiGOmitotic cell cycle  chromosome, centromeric region  kinetochore  condensed chromosome, centromeric region  condensed chromosome outer kinetochore  microtubule motor activity  protein binding  ATP binding  nucleus  chromosome  cytoplasm  cytosol  kinesin complex  microtubule  retrograde vesicle-mediated transport, Golgi to ER  microtubule-based movement  chromosome segregation  sister chromatid cohesion  mitotic chromosome movement towards spindle pole  mitotic metaphase plate congression  multicellular organism development  microtubule binding  metabolic process  microtubule cytoskeleton  membrane  ATPase activity  antigen processing and presentation of exogenous peptide antigen via MHC class II  regulation of mitotic metaphase/anaphase transition  midbody  kinetochore binding  positive regulation of protein kinase activity  cell division  attachment of mitotic spindle microtubules to kinetochore  kinetochore assembly  mitotic spindle midzone  
Ontology : EGO-EBImitotic cell cycle  chromosome, centromeric region  kinetochore  condensed chromosome, centromeric region  condensed chromosome outer kinetochore  microtubule motor activity  protein binding  ATP binding  nucleus  chromosome  cytoplasm  cytosol  kinesin complex  microtubule  retrograde vesicle-mediated transport, Golgi to ER  microtubule-based movement  chromosome segregation  sister chromatid cohesion  mitotic chromosome movement towards spindle pole  mitotic metaphase plate congression  multicellular organism development  microtubule binding  metabolic process  microtubule cytoskeleton  membrane  ATPase activity  antigen processing and presentation of exogenous peptide antigen via MHC class II  regulation of mitotic metaphase/anaphase transition  midbody  kinetochore binding  positive regulation of protein kinase activity  cell division  attachment of mitotic spindle microtubules to kinetochore  kinetochore assembly  mitotic spindle midzone  
NDEx NetworkCENPE
Atlas of Cancer Signalling NetworkCENPE
Wikipedia pathwaysCENPE
Orthology - Evolution
OrthoDB1062
GeneTree (enSembl)ENSG00000138778
Phylogenetic Trees/Animal Genes : TreeFamCENPE
HOVERGENQ02224
HOGENOMQ02224
Homologs : HomoloGeneCENPE
Homology/Alignments : Family Browser (UCSC)CENPE
Gene fusions - Rearrangements
Fusion : MitelmanSPATA5/CENPE [4q28.1/4q24]  [t(4;4)(q24;q28)]  
Fusion: TCGASPATA5 4q28.1 CENPE 4q24 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCENPE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CENPE
dbVarCENPE
ClinVarCENPE
1000_GenomesCENPE 
Exome Variant ServerCENPE
ExAC (Exome Aggregation Consortium)CENPE (select the gene name)
Genetic variants : HAPMAP1062
Genomic Variants (DGV)CENPE [DGVbeta]
DECIPHER (Syndromes)4:104026963-104119566  ENSG00000138778
CONAN: Copy Number AnalysisCENPE 
Mutations
ICGC Data PortalCENPE 
TCGA Data PortalCENPE 
Broad Tumor PortalCENPE
OASIS PortalCENPE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCENPE  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCENPE
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CENPE
DgiDB (Drug Gene Interaction Database)CENPE
DoCM (Curated mutations)CENPE (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CENPE (select a term)
intoGenCENPE
Cancer3DCENPE(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM117143    616051   
Orphanet954   
MedgenCENPE
Genetic Testing Registry CENPE
NextProtQ02224 [Medical]
TSGene1062
GENETestsCENPE
Huge Navigator CENPE [HugePedia]
snp3D : Map Gene to Disease1062
BioCentury BCIQCENPE
ClinGenCENPE
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1062
Chemical/Pharm GKB GenePA26400
Clinical trialCENPE
Miscellaneous
canSAR (ICR)CENPE (select the gene name)
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCENPE
EVEXCENPE
GoPubMedCENPE
iHOPCENPE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:59:58 CET 2017

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