| Nomenclature |
|---|
| HGNC (Hugo) | CENPE 1856 |
| Cards |
|---|
| Entrez_Gene (NCBI) | CENPE centromere protein E |
| Aliases | CENP-E; KIF10; MCPH13; PPP1R61 |
| GeneCards (Weizmann) | CENPE |
| Ensembl hg19 (Hinxton) | ENSG00000138778 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000138778 [Gene_View] ENSG00000138778 [Sequence] chr4:103105811-103198343 [Contig_View] CENPE [Vega] |
| ICGC DataPortal | ENSG00000138778 |
| TCGA cBioPortal | CENPE |
| AceView (NCBI) | CENPE |
| Genatlas (Paris) | CENPE |
| SOURCE (Princeton) | CENPE |
| Genetics Home Reference (NIH) | CENPE |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | CENPE - chr4:103105811-103198343 - 4q24 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | CENPE - 4q24 [Description] (hg19-Feb_2009) |
| GoldenPath | CENPE - 4q24 [CytoView hg19] CENPE - 4q24 [CytoView hg38] |
| ImmunoBase | ENSG00000138778 |
| Genome Data Viewer NCBI | CENPE [Mapview hg19] |
| OMIM | 117143 616051 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AA210728 AA210858 AB209996 AK290362 AL596934 |
| RefSeq transcript (Entrez) | NM_001286734 NM_001813 |
| Consensus coding sequences : CCDS (NCBI) | CENPE |
| Gene Expression | CENPE [ NCBI-GEO ] CENPE [ EBI - ARRAY_EXPRESS ]
CENPE [ SEEK ] CENPE [ MEM ] |
| Gene Expression Viewer (FireBrowse) | CENPE [ Firebrowse - Broad ] |
| Genevisible | Expression of CENPE in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 1062 |
| GTEX Portal (Tissue expression) | CENPE |
| Human Protein Atlas | ENSG00000138778-CENPE [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q02224 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q02224 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q02224 |
| PhosPhoSitePlus | Q02224 |
| Domaine pattern : Prosite (Expaxy) | KINESIN_MOTOR_1 (PS00411) KINESIN_MOTOR_2 (PS50067) |
| Domains : Interpro (EBI) | Kinesin_motor_CS Kinesin_motor_dom Kinesin_motor_dom_sf P-loop_NTPase |
| Domain families : Pfam (Sanger) | Kinesin (PF00225) |
| Domain families : Pfam (NCBI) | pfam00225 |
| Domain families : Smart (EMBL) | KISc (SM00129) |
| Conserved Domain (NCBI) | CENPE |
| PDB (RSDB) | 1T5C 5JVP |
| PDB Europe | 1T5C 5JVP |
| PDB (PDBSum) | 1T5C 5JVP |
| PDB (IMB) | 1T5C 5JVP |
| Structural Biology KnowledgeBase | 1T5C 5JVP |
| SCOP (Structural Classification of Proteins) | 1T5C 5JVP |
| CATH (Classification of proteins structures) | 1T5C 5JVP |
| Superfamily | Q02224 |
| AlphaFold pdb e-kb | Q02224 |
| Human Protein Atlas [tissue] | ENSG00000138778-CENPE [tissue] |
| HPRD | 00316 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q02224 |
| IntAct (EBI) | Q02224 |
| BioGRID | CENPE |
| STRING (EMBL) | CENPE |
| ZODIAC | CENPE |
| Ontologies - Pathways |
|---|
| QuickGO | Q02224 |
| Ontology : AmiGO | mitotic cell cycle mitotic cell cycle chromosome, centromeric region kinetochore condensed chromosome, centromeric region microtubule motor activity microtubule motor activity protein binding ATP binding nucleus nucleoplasm chromosome kinetochore microtubule cytosol cytosol microtubule microtubule retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum microtubule-based movement microtubule-based movement mitotic spindle organization mitotic spindle organization chromosome segregation mitotic chromosome movement towards spindle pole mitotic metaphase plate congression multicellular organism development microtubule binding microtubule binding ATP-dependent microtubule motor activity, plus-end-directed microtubule cytoskeleton membrane antigen processing and presentation of exogenous peptide antigen via MHC class II regulation of mitotic metaphase/anaphase transition midbody kinetochore binding positive regulation of protein kinase activity spindle midzone cell division metaphase plate congression attachment of mitotic spindle microtubules to kinetochore kinetochore assembly microtubule plus-end directed mitotic chromosome migration lateral attachment of mitotic spindle microtubules to kinetochore mitotic spindle midzone |
| Ontology : EGO-EBI | mitotic cell cycle mitotic cell cycle chromosome, centromeric region kinetochore condensed chromosome, centromeric region microtubule motor activity microtubule motor activity protein binding ATP binding nucleus nucleoplasm chromosome kinetochore microtubule cytosol cytosol microtubule microtubule retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum microtubule-based movement microtubule-based movement mitotic spindle organization mitotic spindle organization chromosome segregation mitotic chromosome movement towards spindle pole mitotic metaphase plate congression multicellular organism development microtubule binding microtubule binding ATP-dependent microtubule motor activity, plus-end-directed microtubule cytoskeleton membrane antigen processing and presentation of exogenous peptide antigen via MHC class II regulation of mitotic metaphase/anaphase transition midbody kinetochore binding positive regulation of protein kinase activity spindle midzone cell division metaphase plate congression attachment of mitotic spindle microtubules to kinetochore kinetochore assembly microtubule plus-end directed mitotic chromosome migration lateral attachment of mitotic spindle microtubules to kinetochore mitotic spindle midzone |
| NDEx Network | CENPE |
| Atlas of Cancer Signalling Network | CENPE |
| Wikipedia pathways | CENPE |
| Orthology - Evolution |
|---|
| OrthoDB | 1062 |
| GeneTree (enSembl) | ENSG00000138778 |
| Phylogenetic Trees/Animal Genes : TreeFam | CENPE |
| Homologs : HomoloGene | CENPE |
| Homology/Alignments : Family Browser (UCSC) | CENPE |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | SPATA5/CENPE [4q28.1/4q24] |
| Fusion : Quiver | CENPE |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | CENPE [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | CENPE |
| dbVar | CENPE |
| ClinVar | CENPE |
| Monarch | CENPE |
| 1000_Genomes | CENPE |
| Exome Variant Server | CENPE |
| GNOMAD Browser | ENSG00000138778 |
| Varsome Browser | CENPE |
| ACMG | CENPE variants |
| Varity | Q02224 |
| Genomic Variants (DGV) | CENPE [DGVbeta] |
| DECIPHER | CENPE [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | CENPE |
| Mutations |
|---|
| ICGC Data Portal | CENPE |
| TCGA Data Portal | CENPE |
| Broad Tumor Portal | CENPE |
| OASIS Portal | CENPE [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | CENPE [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | CENPE |
| Mutations and Diseases : HGMD | CENPE |
| LOVD (Leiden Open Variation Database) | [gene] [transcripts] [variants] |
| BioMuta | CENPE |
| DgiDB (Drug Gene Interaction Database) | CENPE |
| DoCM (Curated mutations) | CENPE |
| CIViC (Clinical Interpretations of Variants in Cancer) | CENPE |
| Cancer3D | CENPE |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 117143 616051 |
| Orphanet | 954 |
| DisGeNET | CENPE |
| Medgen | CENPE |
| Genetic Testing Registry | CENPE
|
| NextProt | Q02224 [Medical] |
| GENETests | CENPE |
| Target Validation | CENPE |
| Huge Navigator |
CENPE [HugePedia] |
| ClinGen | CENPE |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | CENPE |
| Protein Interactions : CTD | CENPE |
| Pharm GKB Gene | PA26400 |
| Pharos | Q02224 |
| Clinical trial | CENPE |
| Miscellaneous |
|---|
| canSAR (ICR) | CENPE |
| Harmonizome | CENPE |
| DataMed Index | CENPE |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 101 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | CENPE |
