| Nomenclature |
|---|
| HGNC (Hugo) | CENPE 1856 |
| Cards |
|---|
| Entrez_Gene (NCBI) | CENPE 1062 centromere protein E |
| Aliases | CENP-E; KIF10; MCPH13; PPP1R61 |
| GeneCards (Weizmann) | CENPE |
| Ensembl hg19 (Hinxton) | ENSG00000138778 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000138778 [Gene_View] chr4:103105806-103198409 [Contig_View] CENPE [Vega] |
| ICGC DataPortal | ENSG00000138778 |
| TCGA cBioPortal | CENPE |
| AceView (NCBI) | CENPE |
| Genatlas (Paris) | CENPE |
| WikiGenes | 1062 |
| SOURCE (Princeton) | CENPE |
| Genetics Home Reference (NIH) | CENPE |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | CENPE - chr4:103105806-103198409 - 4q24 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | CENPE - 4q24 [Description] (hg19-Feb_2009) |
| Ensembl | CENPE - 4q24 [CytoView hg19] CENPE - 4q24 [CytoView hg38] |
| Mapping of homologs : NCBI | CENPE [Mapview hg19] CENPE [Mapview hg38] |
| OMIM | 117143 616051 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AA210728 AA210858 AB209996 AK290362 AL596934 |
| RefSeq transcript (Entrez) | NM_001286734 NM_001813 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | CENPE |
| Cluster EST : Unigene | Hs.75573 [ NCBI ] |
| CGAP (NCI) | Hs.75573 |
| Alternative Splicing Gallery | ENSG00000138778 |
| Gene Expression | CENPE [ NCBI-GEO ] CENPE [ EBI - ARRAY_EXPRESS ]
CENPE [ SEEK ] CENPE [ MEM ] |
| Gene Expression Viewer (FireBrowse) | CENPE [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 1062 |
| GTEX Portal (Tissue expression) | CENPE |
| Human Protein Atlas | ENSG00000138778-CENPE [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q02224 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q02224 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q02224 |
| Splice isoforms : SwissVar | Q02224 |
| PhosPhoSitePlus | Q02224 |
| Domaine pattern : Prosite (Expaxy) | KINESIN_MOTOR_1 (PS00411) KINESIN_MOTOR_2 (PS50067) |
| Domains : Interpro (EBI) | CENP-E Kinesin_motor_CS Kinesin_motor_dom P-loop_NTPase |
| Domain families : Pfam (Sanger) | Kinesin (PF00225) |
| Domain families : Pfam (NCBI) | pfam00225 |
| Domain families : Smart (EMBL) | KISc (SM00129) |
| Conserved Domain (NCBI) | CENPE |
| DMDM Disease mutations | 1062 |
| Blocks (Seattle) | CENPE |
| PDB (SRS) | 1T5C 5JVP |
| PDB (PDBSum) | 1T5C 5JVP |
| PDB (IMB) | 1T5C 5JVP |
| PDB (RSDB) | 1T5C 5JVP |
| Structural Biology KnowledgeBase | 1T5C 5JVP |
| SCOP (Structural Classification of Proteins) | 1T5C 5JVP |
| CATH (Classification of proteins structures) | 1T5C 5JVP |
| Superfamily | Q02224 |
| Human Protein Atlas [tissue] | ENSG00000138778-CENPE [tissue] |
| Peptide Atlas | Q02224 |
| HPRD | 00316 |
| IPI | IPI00296365 IPI00868715 IPI00619925 IPI00967647 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q02224 |
| IntAct (EBI) | Q02224 |
| FunCoup | ENSG00000138778 |
| BioGRID | CENPE |
| STRING (EMBL) | CENPE |
| ZODIAC | CENPE |
| Ontologies - Pathways |
|---|
| QuickGO | Q02224 |
| Ontology : AmiGO | mitotic cell cycle chromosome, centromeric region kinetochore condensed chromosome, centromeric region condensed chromosome outer kinetochore microtubule motor activity microtubule motor activity protein binding ATP binding nucleus nucleoplasm chromosome kinetochore microtubule cytosol cytosol kinesin complex microtubule retrograde vesicle-mediated transport, Golgi to ER microtubule-based movement mitotic spindle organization chromosome segregation sister chromatid cohesion mitotic chromosome movement towards spindle pole mitotic metaphase plate congression multicellular organism development microtubule binding microtubule cytoskeleton membrane ATPase activity antigen processing and presentation of exogenous peptide antigen via MHC class II regulation of mitotic metaphase/anaphase transition midbody kinetochore binding positive regulation of protein kinase activity cell division metaphase plate congression attachment of mitotic spindle microtubules to kinetochore kinetochore assembly microtubule plus-end directed mitotic chromosome migration lateral attachment of mitotic spindle microtubules to kinetochore mitotic spindle midzone |
| Ontology : EGO-EBI | mitotic cell cycle chromosome, centromeric region kinetochore condensed chromosome, centromeric region condensed chromosome outer kinetochore microtubule motor activity microtubule motor activity protein binding ATP binding nucleus nucleoplasm chromosome kinetochore microtubule cytosol cytosol kinesin complex microtubule retrograde vesicle-mediated transport, Golgi to ER microtubule-based movement mitotic spindle organization chromosome segregation sister chromatid cohesion mitotic chromosome movement towards spindle pole mitotic metaphase plate congression multicellular organism development microtubule binding microtubule cytoskeleton membrane ATPase activity antigen processing and presentation of exogenous peptide antigen via MHC class II regulation of mitotic metaphase/anaphase transition midbody kinetochore binding positive regulation of protein kinase activity cell division metaphase plate congression attachment of mitotic spindle microtubules to kinetochore kinetochore assembly microtubule plus-end directed mitotic chromosome migration lateral attachment of mitotic spindle microtubules to kinetochore mitotic spindle midzone |
| NDEx Network | CENPE |
| Atlas of Cancer Signalling Network | CENPE |
| Wikipedia pathways | CENPE |
| Orthology - Evolution |
|---|
| OrthoDB | 1062 |
| GeneTree (enSembl) | ENSG00000138778 |
| Phylogenetic Trees/Animal Genes : TreeFam | CENPE |
| HOVERGEN | Q02224 |
| HOGENOM | Q02224 |
| Homologs : HomoloGene | CENPE |
| Homology/Alignments : Family Browser (UCSC) | CENPE |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | SPATA5/CENPE [4q28.1/4q24] [t(4;4)(q24;q28)] |
| Fusion: TCGA_MDACC | SPATA5 4q28.1 CENPE 4q24 BRCA |
| Fusion Portal | SPATA5 4q28.1 CENPE 4q24 BRCA |
| Fusion : Quiver | CENPE |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | CENPE [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | CENPE |
| dbVar | CENPE |
| ClinVar | CENPE |
| 1000_Genomes | CENPE |
| Exome Variant Server | CENPE |
| ExAC (Exome Aggregation Consortium) | ENSG00000138778 |
| GNOMAD Browser | ENSG00000138778 |
| Genetic variants : HAPMAP | 1062 |
| Genomic Variants (DGV) | CENPE [DGVbeta] |
| DECIPHER | CENPE [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | CENPE |
| Mutations |
|---|
| ICGC Data Portal | CENPE |
| TCGA Data Portal | CENPE |
| Broad Tumor Portal | CENPE |
| OASIS Portal | CENPE [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | CENPE [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | CENPE |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search CENPE |
| DgiDB (Drug Gene Interaction Database) | CENPE |
| DoCM (Curated mutations) | CENPE (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | CENPE (select a term) |
| intoGen | CENPE |
| Cancer3D | CENPE(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 117143 616051 |
| Orphanet | 954 |
| DisGeNET | CENPE |
| Medgen | CENPE |
| Genetic Testing Registry | CENPE
|
| NextProt | Q02224 [Medical] |
| TSGene | 1062 |
| GENETests | CENPE |
| Target Validation | CENPE |
| Huge Navigator |
CENPE [HugePedia] |
| snp3D : Map Gene to Disease | 1062 |
| BioCentury BCIQ | CENPE |
| ClinGen | CENPE |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 1062 |
| Chemical/Pharm GKB Gene | PA26400 |
| Clinical trial | CENPE |
| Miscellaneous |
|---|
| canSAR (ICR) | CENPE (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 79 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | CENPE |
| EVEX | CENPE |
| GoPubMed | CENPE |
| iHOP | CENPE |
