CENPS (centromere protein S)

2016-09-01 Affiliation

Identity

HGNC

CENPS

LOCATION

1p36.22

LOCUSID

378708

ALIAS

APITD1,CENP-S,FAAP16,MHF1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 378708
MIM: 609130
HGNC: 23163
Ensembl: ENSG00000175279

Variants:

dbSNP: 378708
ClinVar: 378708
TCGA: ENSG00000175279
COSMIC: CENPS

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000175279	ENST00000309048	Q8N2Z9
ENSG00000175279	ENST00000462462	A0A0U1RQL5
ENSG00000175279	ENST00000477755	K7ESB0

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Fanconi anemia pathway	KEGG	ko03460
Fanconi anemia pathway	KEGG	hsa03460
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases Activate Formins	REACTOME	R-HSA-5663220
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prometaphase	REACTOME	R-HSA-68877
Resolution of Sister Chromatid Cohesion	REACTOME	R-HSA-2500257
Mitotic Metaphase and Anaphase	REACTOME	R-HSA-2555396
Mitotic Anaphase	REACTOME	R-HSA-68882
Separation of Sister Chromatids	REACTOME	R-HSA-2467813
Chromosome Maintenance	REACTOME	R-HSA-73886
Nucleosome assembly	REACTOME	R-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromere	REACTOME	R-HSA-606279
DNA Repair	REACTOME	R-HSA-73894
Fanconi Anemia Pathway	REACTOME	R-HSA-6783310

References

Pubmed ID	Year	Title	Citations
20347429	2010	MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM.	102
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19620631	2009	The CENP-S complex is essential for the stable assembly of outer kinetochore structure.	70
22510687	2012	The structure of the FANCM-MHF complex reveals physical features for functional assembly.	26
24390579	2014	The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes.	13
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
24522885	2014	A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle.	10
24256282	2013	Emerging roles for centromere-associated proteins in DNA repair and genetic recombination.	8
24699063	2014	The histone-fold complex MHF is remodeled by FANCM to recognize branched DNA and protect genome stability.	8
23886707	2013	Structural peculiarities of the (MHF1-MHF2)4 octamer provide a long DNA binding patch to anchor the MHF-FANCM complex to chromatin: a solution SAXS study.	2

Citation

Dessen P

CENPS (centromere protein S)

Atlas Genet Cytogenet Oncol Haematol. 2016-09-01

Online version: http://atlasgeneticsoncology.org/gene/55946/cenps