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CENPW (centromere protein W)

Written2013-06Seyoung Jeon, Soojin Lee
Department of Microbiology, Molecular Biology, Chungnam National Institute, 305-764, Daejeon, Republic of Korea

(Note : for Links provided by Atlas : click)


Alias (NCBI)C6orf173
HGNC Alias symbCUG2
HGNC Alias namecancer-upregulated gene 2
HGNC Previous nameC6orf173
HGNC Previous namechromosome 6 open reading frame 173
LocusID (NCBI) 387103
Atlas_Id 51452
Location 6q22.32  [Link to chromosome band 6q22]
Location_base_pair Starts at 126339789 and ends at 126348875 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping CENPW.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)


  Figure 1. A genomic structure of the CENPW gene.
Description Exons: 3, coding exons: 3, introns: 2.
Transcription Transcript length: 750 bps, open reading frame: 264 bps.
Pseudogene No pseudogene.


  Figure 2. Schematic representation of CENPW protein. Each domain is represented with the unique color and name. One nuclear localization signal (NLS) sequence of 17 amino acids starts at amino acid 13.
Description CENP-W gene encodes 88-amino acid protein which shows ~27% of amino acid sequence similarity to a general transcription repressor, human DR1. It contains a typical NLS sequence and histone fold region which is critical for binding to centromeric DNA.
Expression Widely expressed; kidney, colon, breast, liver, lung, ovary, prostate, thyroid, etc.
Localisation Intracellular, nucleus, centromere, kinetochore, nucleus matrix, nucleolus.
Function CENP-W was originally identified as a cancer-upregulated gene 2 (CUG2) which is commonly overexpressed in various human cancer tissues. Although it has high oncogenic activities, CENP-W also induces cell apoptosis when overexpressed in certain cell lines. After it was revealed that CENP-W forms a stable heterodimer with CENP-T and is localized in kinetochores during mitosis, CENP-W become recognized as a new member of the inner centromere protein complex. Subsequent studies have also shown that CENP-T-W-S-X forms a unique centromeric nucleosome-like heterotetramer structure which binds to and supercoils DNA. As a nucleolus-associated protein, CENP-W may play critical role in the formation of functional kinetochore, possibly by facilitating the recruitment of other centromeric components during interphase, which is required for proper chromosome segregation during mitosis.
Homology According to NCBI-HomoloGene:
Pan troglodytes (chimpanzee): centromere protein W (NP_001012525.1, 88 aa)
Macacamulatta (Rhesus monkey): centromere protein W (XP_001107034.2, 88 aa)
Canis lupus familiaris (dog): centromere protein W-like (XP_003638832.1, 88 aa)
Bostaurus (cattle): centromere protein W (NP_001104731.1, 88 aa)
Mus musculus (house mouse): centromere protein W (NP_001103217.1, 86 aa)
Rattus norvegicus (Norway rat): centromere protein W (XP_001070657.1, 86 aa).


Note Over expressed in various cancer tissues; notably high in the ovary (6.3-fold), liver (6.0), lung (4.9), and pancreas (3.8).
  Figure 3. mRNA expression of CUG2 in various tumors. DNA chip microarray profile in tumors (closed bar) and normal (open bar) tissues from the Gene Express Oncology DatasuiteTM of Gene Logic Inc.

Implicated in

Entity Various human cancers
Oncogenesis CENP-W has been found to be upregulated in several tumor tissues. When the expression level of CENP-W was examined by DNA chip microarray and RT-PCR in tumors, six tissues (ovary, liver, lung, pancreas, colon, and stomach) showed high-fold increases in expression profiles. Also, CENP-W-transformed NIH3T3 cells exhibited exceptionally prominent cancerous phenotypes in vitro as well as in vivo tumor forming assays.


New centromeric component CENP-W is an RNA-associated nuclear matrix protein that interacts with nucleophosmin/B23 protein.
Chun Y, Park B, Koh W, Lee S, Cheon Y, Kim R, Che L, Lee S.
J Biol Chem. 2011 Dec 9;286(49):42758-69. doi: 10.1074/jbc.M111.228411. Epub 2011 Oct 14.
PMID 22002061
Cancer-upregulated gene 2 (CUG2), a new component of centromere complex, is required for kinetochore function.
Kim H, Lee M, Lee S, Park B, Koh W, Lee DJ, Lim DS, Lee S.
Mol Cells. 2009 Jun 30;27(6):697-701. doi: 10.1007/s10059-009-0083-2. Epub 2009 Jun 12.
PMID 19533040
Sp1 and Sp3 mediate basal and serum-induced expression of human CENP-W.
Kim H, Lee S, Park B, Che L, Lee S.
Mol Biol Rep. 2010 Oct;37(7):3593-600. doi: 10.1007/s11033-010-0008-3. Epub 2010 Feb 24.
PMID 20180024
Cug2 is essential for normal mitotic control and CNS development in zebrafish.
Kim HT, So JH, Jung SH, Ahn DG, Koh W, Kim NS, Kim SH, Lee S, Kim CH.
BMC Dev Biol. 2011 Aug 15;11:49. doi: 10.1186/1471-213X-11-49.
PMID 21838932
Molecular cloning and functional analysis of a novel oncogene, cancer-upregulated gene 2 (CUG2).
Lee S, Gang J, Jeon SB, Choo SH, Lee B, Kim YG, Lee YS, Jung J, Song SY, Koh SS.
Biochem Biophys Res Commun. 2007 Aug 31;360(3):633-9. Epub 2007 Jun 28.
PMID 17610844
Cancer-upregulated gene 2 (CUG2) overexpression induces apoptosis in SKOV-3 cells.
Lee S, Koh W, Kim HT, Kim CH, Lee S.
Cell Biochem Funct. 2010 Aug;28(6):461-8. doi: 10.1002/cbf.1678.
PMID 20648695
CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold.
Nishino T, Takeuchi K, Gascoigne KE, Suzuki A, Hori T, Oyama T, Morikawa K, Cheeseman IM, Fukagawa T.
Cell. 2012 Feb 3;148(3):487-501. doi: 10.1016/j.cell.2011.11.061.
PMID 22304917
CUG2, a novel oncogene confers reoviral replication through Ras and p38 signaling pathway.
Park EH, Park EH, Cho IR, Srisuttee R, Min HJ, Oh MJ, Jeong YJ, Jhun BH, Johnston RN, Lee S, Koh SS, Chung YH.
Cancer Gene Ther. 2010 May;17(5):307-14. doi: 10.1038/cgt.2009.83. Epub 2010 Jan 15.
PMID 20075984
Premitotic assembly of human CENPs -T and -W switches centromeric chromatin to a mitotic state.
Prendergast L, van Vuuren C, Kaczmarczyk A, Doering V, Hellwig D, Quinn N, Hoischen C, Diekmann S, Sullivan KF.
PLoS Biol. 2011 Jun;9(6):e1001082. doi: 10.1371/journal.pbio.1001082. Epub 2011 Jun 14.
PMID 21695110


This paper should be referenced as such :
Jeon, S ; Lee, S
CENPW (centromere protein W)
Atlas Genet Cytogenet Oncol Haematol. 2014;18(1):5-7.
Free journal version : [ pdf ]   [ DOI ]

External links


HGNC (Hugo)CENPW   21488
Entrez_Gene (NCBI)CENPW    centromere protein W
AliasesC6orf173; CENP-W; CUG2
GeneCards (Weizmann)CENPW
Ensembl hg19 (Hinxton)ENSG00000203760 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000203760 [Gene_View]  ENSG00000203760 [Sequence]  chr6:126339789-126348875 [Contig_View]  CENPW [Vega]
ICGC DataPortalENSG00000203760
Genatlas (Paris)CENPW
Genetics Home Reference (NIH)CENPW
Genomic and cartography
GoldenPath hg38 (UCSC)CENPW  -     chr6:126339789-126348875 +  6q22.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CENPW  -     6q22.32   [Description]    (hg19-Feb_2009)
GoldenPathCENPW - 6q22.32 [CytoView hg19]  CENPW - 6q22.32 [CytoView hg38]
Genome Data Viewer NCBICENPW [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AI207187 AL832235 AY902475 BC017928 BC039556
RefSeq transcript (Entrez)NM_001012507 NM_001286524 NM_001286525
Consensus coding sequences : CCDS (NCBI)CENPW
Gene Expression Viewer (FireBrowse)CENPW [ Firebrowse - Broad ]
GenevisibleExpression of CENPW in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)387103
GTEX Portal (Tissue expression)CENPW
Human Protein AtlasENSG00000203760-CENPW [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5EE01   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5EE01  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5EE01
Domains : Interpro (EBI)CENP-W    Histone-fold   
Domain families : Pfam (Sanger)CENP-W (PF15510)   
Domain families : Pfam (NCBI)pfam15510   
Conserved Domain (NCBI)CENPW
AlphaFold pdb e-kbQ5EE01   
Human Protein Atlas [tissue]ENSG00000203760-CENPW [tissue]
Protein Interaction databases
IntAct (EBI)Q5EE01
Complex Portal (EBI)Q5EE01 CPX-5646 Kinetochore CCAN complex
Ontologies - Pathways
Ontology : AmiGOmitotic cell cycle  mitotic cell cycle  chromosome, centromeric region  kinetochore  kinetochore  DNA binding  protein binding  nucleoplasm  nucleoplasm  nucleoplasm  nucleolus  chromosome segregation  chromosome segregation  chromosome segregation  nuclear matrix  CENP-A containing nucleosome assembly  protein heterodimerization activity  chromosome organization  cell division  kinetochore assembly  kinetochore assembly  
Ontology : EGO-EBImitotic cell cycle  mitotic cell cycle  chromosome, centromeric region  kinetochore  kinetochore  DNA binding  protein binding  nucleoplasm  nucleoplasm  nucleoplasm  nucleolus  chromosome segregation  chromosome segregation  chromosome segregation  nuclear matrix  CENP-A containing nucleosome assembly  protein heterodimerization activity  chromosome organization  cell division  kinetochore assembly  kinetochore assembly  
REACTOMEQ5EE01 [protein]
REACTOME PathwaysR-HSA-606279 [pathway]   
Atlas of Cancer Signalling NetworkCENPW
Wikipedia pathwaysCENPW
Orthology - Evolution
GeneTree (enSembl)ENSG00000203760
Phylogenetic Trees/Animal Genes : TreeFamCENPW
Homologs : HomoloGeneCENPW
Homology/Alignments : Family Browser (UCSC)CENPW
Gene fusions - Rearrangements
Fusion : QuiverCENPW
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCENPW [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CENPW
Exome Variant ServerCENPW
GNOMAD BrowserENSG00000203760
Varsome BrowserCENPW
ACMGCENPW variants
Genomic Variants (DGV)CENPW [DGVbeta]
DECIPHERCENPW [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCENPW 
ICGC Data PortalCENPW 
TCGA Data PortalCENPW 
Broad Tumor PortalCENPW
OASIS PortalCENPW [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCENPW  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCENPW
Mutations and Diseases : HGMDCENPW
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
DgiDB (Drug Gene Interaction Database)CENPW
DoCM (Curated mutations)CENPW
CIViC (Clinical Interpretations of Variants in Cancer)CENPW
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry CENPW
NextProtQ5EE01 [Medical]
Target ValidationCENPW
Huge Navigator CENPW [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTDCENPW
Pharm GKB GenePA165617841
Clinical trialCENPW
DataMed IndexCENPW
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Oct 8 21:14:53 CEST 2021

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