CEP131 (centrosomal protein 131)

2016-10-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
AZ1,AZI1,ZA1
FUSION GENES

Other Information

Locus ID:

NCBI: 22994
MIM: 613479
HGNC: 29511
Ensembl: ENSG00000141577

Variants:

dbSNP: 22994
ClinVar: 22994
TCGA: ENSG00000141577
COSMIC: CEP131

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141577ENST00000269392Q9UPN4
ENSG00000141577ENST00000374782Q9UPN4
ENSG00000141577ENST00000450824Q9UPN4
ENSG00000141577ENST00000570817I3L4M5
ENSG00000141577ENST00000571292I3L316
ENSG00000141577ENST00000573053I3L2X7
ENSG00000141577ENST00000575907I3L2J8

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
227979152012The centriolar satellite protein Cep131 is important for genome stability.49
266167342015p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1.20
286941052017CEP131 indicates poor prognosis and promotes cell proliferation and migration in hepatocellular carcinoma.9
231376372013Regulation of CEP131 gene expression by SP1.3
305381952018RNA-mediated gene fusion in mammalian cells.3
308042082019Polo-like kinase 4 maintains centriolar satellite integrity by phosphorylation of centrosomal protein 131 (CEP131).2

Citation

Dessen P

CEP131 (centrosomal protein 131)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56290/cep131