CEP55 (centrosomal protein 55)

2007-08-01  

Identity

HGNC
CEP55
LOCATION
10q23.33
LOCUSID
55165
ALIAS
C10orf3,CT111,MARCH,URCC6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55165
MIM: 610000
HGNC: 1161
Ensembl: ENSG00000138180

Variants:

dbSNP: 55165
ClinVar: 55165
TCGA: ENSG00000138180
COSMIC: CEP55

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138180ENST00000371485Q53EZ4
ENSG00000138180ENST00000445435H0Y432

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
175565482007Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery.304
178538932007Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.285
189485382008Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55.103
186411292008Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release.91
167904972006Cep55, a microtubule-bundling protein, associates with centralspindlin to control the midbody integrity and cell abscission during cytokinesis.84
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
210792442010Plk1 negatively regulates Cep55 recruitment to the midbody to ensure orderly abscission.56
172378222007FLJ10540-elicited cell transformation is through the activation of PI3-kinase/AKT pathway.38
195259752009Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion through increased FOXM1 and MMP-2 activity.37
259158442016Beyond cytokinesis: the emerging roles of CEP55 in tumorigenesis.37

Citation

Dessen P

CEP55 (centrosomal protein 55)

Atlas Genet Cytogenet Oncol Haematol. 2007-08-01

Online version: http://atlasgeneticsoncology.org/gene/47698/cep55