CEP70 (centrosomal protein 70)

2017-01-01 Affiliation

Identity

HGNC

CEP70

LOCATION

3q22.3

LOCUSID

80321

ALIAS

BITE

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 80321
MIM: 614310
HGNC: 29972
Ensembl: ENSG00000114107

Variants:

dbSNP: 80321
ClinVar: 80321
TCGA: ENSG00000114107
COSMIC: CEP70

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000114107	ENST00000264982	Q8NHQ1
ENSG00000114107	ENST00000264982	A0A140VJG2
ENSG00000114107	ENST00000459695	H7C4Y6
ENSG00000114107	ENST00000462419	C9J710
ENSG00000114107	ENST00000464035	Q8NHQ1
ENSG00000114107	ENST00000468900	C9J966
ENSG00000114107	ENST00000470159	C9JZ04
ENSG00000114107	ENST00000474781	Q8NHQ1
ENSG00000114107	ENST00000481834	Q8NHQ1
ENSG00000114107	ENST00000484888	Q8NHQ1
ENSG00000114107	ENST00000484888	A0A140VJG2
ENSG00000114107	ENST00000485115	C9J0F4
ENSG00000114107	ENST00000489254	B7Z2D2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Organelle biogenesis and maintenance	REACTOME	R-HSA-1852241
Cilium Assembly	REACTOME	R-HSA-5617833
Anchoring of the basal body to the plasma membrane	REACTOME	R-HSA-5620912
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G2-G2/M phases	REACTOME	R-HSA-453274
G2/M Transition	REACTOME	R-HSA-69275
Regulation of PLK1 Activity at G2/M Transition	REACTOME	R-HSA-2565942
Centrosome maturation	REACTOME	R-HSA-380287
Recruitment of mitotic centrosome proteins and complexes	REACTOME	R-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosome	REACTOME	R-HSA-380284
Loss of Nlp from mitotic centrosomes	REACTOME	R-HSA-380259
AURKA Activation by TPX2	REACTOME	R-HSA-8854518

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20734064	2010	A large-scale candidate gene association study of age at menarche and age at natural menopause.	38
21795687	2011	CEP70 protein interacts with γ-tubulin to localize at the centrosome and is critical for mitotic spindle assembly.	15
26112604	2015	Cep70 regulates microtubule stability by interacting with HDAC6.	4
28063737	2017	Discovery of Centrosomal Protein 70 as an Important Player in the Development and Progression of Breast Cancer.	4
22427462	2012	Cep70 promotes microtubule assembly in vitro by increasing microtubule elongation.	3
26893288	2016	Cep70 overexpression stimulates pancreatic cancer by inducing centrosome abnormality and microtubule disorganization.	3
28632150	2017	Centrosomal Protein 70 Is a Mediator of Paclitaxel Sensitivity.	2

Citation

Dessen P

CEP70 (centrosomal protein 70)

Atlas Genet Cytogenet Oncol Haematol. 2017-01-01

Online version: http://atlasgeneticsoncology.org/gene/56716/cep70