CEP76 (centrosomal protein 76)

2014-01-01  

Identity

HGNC
LOCATION
18p11.21
LOCUSID
ALIAS
C18orf9,HsT1705
FUSION GENES

Other Information

Locus ID:

NCBI: 79959
HGNC: 25727
Ensembl: ENSG00000101624

Variants:

dbSNP: 79959
ClinVar: 79959
TCGA: ENSG00000101624
COSMIC: CEP76

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101624ENST00000262127Q8TAP6
ENSG00000101624ENST00000423709Q8TAP6
ENSG00000101624ENST00000585751K7EP44
ENSG00000101624ENST00000587666K7EIV8
ENSG00000101624ENST00000587929B4DP81
ENSG00000101624ENST00000590143K7EII2
ENSG00000101624ENST00000591034K7EPF5
ENSG00000101624ENST00000593250K7EII2

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
194603422009Cep76, a centrosomal protein that specifically restrains centriole reduplication.33
270653282016Opposing post-translational modifications regulate Cep76 function to suppress centriole amplification.7

Citation

Dessen P

CEP76 (centrosomal protein 76)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53572/cep76