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CER1 (cerberus 1, DAN family BMP antagonist)

Identity

Alias_namescerberus 1 (Xenopus laevis) homolog (cysteine knot superfamily)
cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)
Alias_symbol (synonym)DAND4
Other alias
HGNC (Hugo) CER1
LocusID (NCBI) 9350
Atlas_Id 56476
Location 9p22.3  [Link to chromosome band 9p22]
Location_base_pair Starts at 14719734 and ends at 14722717 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CER1   1862
Cards
Entrez_Gene (NCBI)CER1  9350  cerberus 1, DAN family BMP antagonist
AliasesDAND4
GeneCards (Weizmann)CER1
Ensembl hg19 (Hinxton)ENSG00000147869 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147869 [Gene_View]  chr9:14719734-14722717 [Contig_View]  CER1 [Vega]
ICGC DataPortalENSG00000147869
TCGA cBioPortalCER1
AceView (NCBI)CER1
Genatlas (Paris)CER1
WikiGenes9350
SOURCE (Princeton)CER1
Genetics Home Reference (NIH)CER1
Genomic and cartography
GoldenPath hg38 (UCSC)CER1  -     chr9:14719734-14722717 -  9p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CER1  -     9p22.3   [Description]    (hg19-Feb_2009)
EnsemblCER1 - 9p22.3 [CytoView hg19]  CER1 - 9p22.3 [CytoView hg38]
Mapping of homologs : NCBICER1 [Mapview hg19]  CER1 [Mapview hg38]
OMIM603777   
Gene and transcription
Genbank (Entrez)AF400435 BC069371 BC069405 BC069491 BC069503
RefSeq transcript (Entrez)NM_005454
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CER1
Cluster EST : UnigeneHs.248204 [ NCBI ]
CGAP (NCI)Hs.248204
Alternative Splicing GalleryENSG00000147869
Gene ExpressionCER1 [ NCBI-GEO ]   CER1 [ EBI - ARRAY_EXPRESS ]   CER1 [ SEEK ]   CER1 [ MEM ]
Gene Expression Viewer (FireBrowse)CER1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9350
GTEX Portal (Tissue expression)CER1
Human Protein AtlasENSG00000147869-CER1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95813   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95813  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95813
Splice isoforms : SwissVarO95813
PhosPhoSitePlusO95813
Domaine pattern : Prosite (Expaxy)CTCK_2 (PS01225)   
Domains : Interpro (EBI)Cerberus    Cys_knot_C    DAN   
Domain families : Pfam (Sanger)DAN (PF03045)   
Domain families : Pfam (NCBI)pfam03045   
Domain families : Smart (EMBL)CT (SM00041)  
Conserved Domain (NCBI)CER1
DMDM Disease mutations9350
Blocks (Seattle)CER1
SuperfamilyO95813
Human Protein Atlas [tissue]ENSG00000147869-CER1 [tissue]
Peptide AtlasO95813
HPRD04802
IPIIPI00023129   IPI00982297   
Protein Interaction databases
DIP (DOE-UCLA)O95813
IntAct (EBI)O95813
FunCoupENSG00000147869
BioGRIDCER1
STRING (EMBL)CER1
ZODIACCER1
Ontologies - Pathways
QuickGOO95813
Ontology : AmiGOureteric bud development  growth plate cartilage chondrocyte proliferation  cytokine activity  extracellular region  extracellular region  extracellular space  extracellular space  gastrulation  nervous system development  negative regulation of cell proliferation  anterior/posterior axis specification  anterior/posterior pattern specification  morphogen activity  signal transduction involved in regulation of gene expression  signal transduction involved in regulation of gene expression  negative regulation of Wnt signaling pathway  bone mineralization  BMP signaling pathway  negative regulation of BMP signaling pathway  negative regulation of activin receptor signaling pathway  negative regulation of activin receptor signaling pathway  sequestering of BMP in extracellular matrix  sequestering of BMP in extracellular matrix  BMP binding  cell migration involved in gastrulation  protein homodimerization activity  determination of dorsal identity  determination of heart left/right asymmetry  cellular response to BMP stimulus  negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  negative regulation of mesoderm development  negative regulation of mesoderm development  
Ontology : EGO-EBIureteric bud development  growth plate cartilage chondrocyte proliferation  cytokine activity  extracellular region  extracellular region  extracellular space  extracellular space  gastrulation  nervous system development  negative regulation of cell proliferation  anterior/posterior axis specification  anterior/posterior pattern specification  morphogen activity  signal transduction involved in regulation of gene expression  signal transduction involved in regulation of gene expression  negative regulation of Wnt signaling pathway  bone mineralization  BMP signaling pathway  negative regulation of BMP signaling pathway  negative regulation of activin receptor signaling pathway  negative regulation of activin receptor signaling pathway  sequestering of BMP in extracellular matrix  sequestering of BMP in extracellular matrix  BMP binding  cell migration involved in gastrulation  protein homodimerization activity  determination of dorsal identity  determination of heart left/right asymmetry  cellular response to BMP stimulus  negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  negative regulation of mesoderm development  negative regulation of mesoderm development  
Pathways : KEGGWnt signaling pathway   
NDEx NetworkCER1
Atlas of Cancer Signalling NetworkCER1
Wikipedia pathwaysCER1
Orthology - Evolution
OrthoDB9350
GeneTree (enSembl)ENSG00000147869
Phylogenetic Trees/Animal Genes : TreeFamCER1
HOVERGENO95813
HOGENOMO95813
Homologs : HomoloGeneCER1
Homology/Alignments : Family Browser (UCSC)CER1
Gene fusions - Rearrangements
Tumor Fusion PortalCER1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCER1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CER1
dbVarCER1
ClinVarCER1
1000_GenomesCER1 
Exome Variant ServerCER1
ExAC (Exome Aggregation Consortium)ENSG00000147869
GNOMAD BrowserENSG00000147869
Genetic variants : HAPMAP9350
Genomic Variants (DGV)CER1 [DGVbeta]
DECIPHERCER1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCER1 
Mutations
ICGC Data PortalCER1 
TCGA Data PortalCER1 
Broad Tumor PortalCER1
OASIS PortalCER1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCER1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCER1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CER1
DgiDB (Drug Gene Interaction Database)CER1
DoCM (Curated mutations)CER1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CER1 (select a term)
intoGenCER1
Cancer3DCER1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603777   
Orphanet
DisGeNETCER1
MedgenCER1
Genetic Testing Registry CER1
NextProtO95813 [Medical]
TSGene9350
GENETestsCER1
Target ValidationCER1
Huge Navigator CER1 [HugePedia]
snp3D : Map Gene to Disease9350
BioCentury BCIQCER1
ClinGenCER1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9350
Chemical/Pharm GKB GenePA26417
Clinical trialCER1
Miscellaneous
canSAR (ICR)CER1 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCER1
EVEXCER1
GoPubMedCER1
iHOPCER1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:07:25 CET 2017

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