CER1 (cerberus 1, DAN family BMP antagonist)

2016-10-01  

Identity

HGNC
LOCATION
9p22.3
LOCUSID
ALIAS
DAND4

Other Information

Locus ID:

NCBI: 9350
MIM: 603777
HGNC: 1862
Ensembl: ENSG00000147869

Variants:

dbSNP: 9350
ClinVar: 9350
TCGA: ENSG00000147869
COSMIC: CER1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147869ENST00000380911O95813

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
Signal TransductionREACTOMER-HSA-162582
Signaling by BMPREACTOMER-HSA-201451
Developmental BiologyREACTOMER-HSA-1266738
Signaling by NODALREACTOMER-HSA-1181150
Regulation of signaling by NODALREACTOMER-HSA-1433617

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
184521922008Clinical and cytogenetic characterization of 13 Dutch patients with deletion 9p syndrome: Delineation of the critical region for a consensus phenotype.23
197891902009A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.23
193905752009Lung cancer susceptibility model based on age, family history and genetic variants.20
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
191139212009Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with BMD and fracture in southern Chinese women.9
191139212009Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with BMD and fracture in southern Chinese women.9
268023592016New Ligand Binding Function of Human Cerberus and Role of Proteolytic Processing in Regulating Ligand-Receptor Interactions and Antagonist Activity.7
241388422013CER1 gene variations associated with bone mineral density, bone markers, and early menopause in postmenopausal women.5
237175842013Secreted cerberus1 as a marker for quantification of definitive endoderm differentiation of the pluripotent stem cells.4
225438712012Novel sequence variations in the CER1 gene are strongly associated with low bone mineral density and risk of osteoporotic fracture in postmenopausal women.1

Citation

Dessen P

CER1 (cerberus 1, DAN family BMP antagonist)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56476/cer1