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CERK (ceramide kinase)

Identity

Alias_symbol (synonym)hCERK
FLJ23239
dA59H18.3
DKFZp434E0211
FLJ21430
KIAA1646
LK4
dA59H18.2
Other alias
HGNC (Hugo) CERK
LocusID (NCBI) 64781
Atlas_Id 51284
Location 22q13.31  [Link to chromosome band 22q13]
Location_base_pair Starts at 47080307 and ends at 47134152 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CELSR1 (22q13.31) / CERK (22q13.31)CERK (22q13.31) / SCUBE1 (22q13.2)SERINC5 (5q14.1) / CERK (22q13.31)
SGOL1 (3p24.3) / CERK (22q13.31)CELSR1 22q13.31 / CERK 22q13.31CERK 22q13.31 / SCUBE1 22q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CERK   19256
Cards
Entrez_Gene (NCBI)CERK  64781  ceramide kinase
AliasesLK4; dA59H18.2; dA59H18.3; hCERK
GeneCards (Weizmann)CERK
Ensembl hg19 (Hinxton)ENSG00000100422 [Gene_View]  chr22:47080307-47134152 [Contig_View]  CERK [Vega]
Ensembl hg38 (Hinxton)ENSG00000100422 [Gene_View]  chr22:47080307-47134152 [Contig_View]  CERK [Vega]
ICGC DataPortalENSG00000100422
TCGA cBioPortalCERK
AceView (NCBI)CERK
Genatlas (Paris)CERK
WikiGenes64781
SOURCE (Princeton)CERK
Genetics Home Reference (NIH)CERK
Genomic and cartography
GoldenPath hg19 (UCSC)CERK  -     chr22:47080307-47134152 -  22q13.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CERK  -     22q13.31   [Description]    (hg38-Dec_2013)
EnsemblCERK - 22q13.31 [CytoView hg19]  CERK - 22q13.31 [CytoView hg38]
Mapping of homologs : NCBICERK [Mapview hg19]  CERK [Mapview hg38]
OMIM610307   
Gene and transcription
Genbank (Entrez)AB051433 AB079066 AJ457828 AK025083 AK026892
RefSeq transcript (Entrez)NM_022766 NM_182661
RefSeq genomic (Entrez)NC_000022 NC_018933 NT_011520 NW_004929430
Consensus coding sequences : CCDS (NCBI)CERK
Cluster EST : UnigeneHs.200668 [ NCBI ]
CGAP (NCI)Hs.200668
Alternative Splicing GalleryENSG00000100422
Gene ExpressionCERK [ NCBI-GEO ]   CERK [ EBI - ARRAY_EXPRESS ]   CERK [ SEEK ]   CERK [ MEM ]
Gene Expression Viewer (FireBrowse)CERK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64781
GTEX Portal (Tissue expression)CERK
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TCT0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TCT0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TCT0
Splice isoforms : SwissVarQ8TCT0
Catalytic activity : Enzyme2.7.1.138 [ Enzyme-Expasy ]   2.7.1.1382.7.1.138 [ IntEnz-EBI ]   2.7.1.138 [ BRENDA ]   2.7.1.138 [ KEGG ]   
PhosPhoSitePlusQ8TCT0
Domaine pattern : Prosite (Expaxy)DAGK (PS50146)   
Domains : Interpro (EBI)Diacylglycerol_kinase_cat_dom    NAD/diacylglycerol_kinase    PH_domain   
Domain families : Pfam (Sanger)DAGK_cat (PF00781)   
Domain families : Pfam (NCBI)pfam00781   
Domain families : Smart (EMBL)DAGKc (SM00046)  PH (SM00233)  
Conserved Domain (NCBI)CERK
DMDM Disease mutations64781
Blocks (Seattle)CERK
SuperfamilyQ8TCT0
Human Protein AtlasENSG00000100422
Peptide AtlasQ8TCT0
HPRD09878
IPIIPI00152433   IPI00009669   IPI01011264   IPI00877988   
Protein Interaction databases
DIP (DOE-UCLA)Q8TCT0
IntAct (EBI)Q8TCT0
FunCoupENSG00000100422
BioGRIDCERK
STRING (EMBL)CERK
ZODIACCERK
Ontologies - Pathways
QuickGOQ8TCT0
Ontology : AmiGOmagnesium ion binding  ceramide kinase activity  ceramide kinase activity  protein binding  ATP binding  mitochondrion  plasma membrane  ceramide metabolic process  ceramide metabolic process  glycosphingolipid metabolic process  integral component of membrane  lipid phosphorylation  lipid phosphorylation  lipid phosphorylation  
Ontology : EGO-EBImagnesium ion binding  ceramide kinase activity  ceramide kinase activity  protein binding  ATP binding  mitochondrion  plasma membrane  ceramide metabolic process  ceramide metabolic process  glycosphingolipid metabolic process  integral component of membrane  lipid phosphorylation  lipid phosphorylation  lipid phosphorylation  
Pathways : KEGGSphingolipid metabolism   
NDEx NetworkCERK
Atlas of Cancer Signalling NetworkCERK
Wikipedia pathwaysCERK
Orthology - Evolution
OrthoDB64781
GeneTree (enSembl)ENSG00000100422
Phylogenetic Trees/Animal Genes : TreeFamCERK
HOVERGENQ8TCT0
HOGENOMQ8TCT0
Homologs : HomoloGeneCERK
Homology/Alignments : Family Browser (UCSC)CERK
Gene fusions - Rearrangements
Fusion : MitelmanCELSR1/CERK [22q13.31/22q13.31]  [t(22;22)(q13;q13)]  
Fusion : MitelmanCERK/SCUBE1 [22q13.31/22q13.2]  [t(22;22)(q13;q13)]  
Fusion: TCGACELSR1 22q13.31 CERK 22q13.31 BRCA
Fusion: TCGACERK 22q13.31 SCUBE1 22q13.2 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCERK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CERK
dbVarCERK
ClinVarCERK
1000_GenomesCERK 
Exome Variant ServerCERK
ExAC (Exome Aggregation Consortium)CERK (select the gene name)
Genetic variants : HAPMAP64781
Genomic Variants (DGV)CERK [DGVbeta]
DECIPHER (Syndromes)22:47080307-47134152  ENSG00000100422
CONAN: Copy Number AnalysisCERK 
Mutations
ICGC Data PortalCERK 
TCGA Data PortalCERK 
Broad Tumor PortalCERK
OASIS PortalCERK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCERK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCERK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch CERK
DgiDB (Drug Gene Interaction Database)CERK
DoCM (Curated mutations)CERK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CERK (select a term)
intoGenCERK
Cancer3DCERK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610307   
Orphanet
MedgenCERK
Genetic Testing Registry CERK
NextProtQ8TCT0 [Medical]
TSGene64781
GENETestsCERK
Huge Navigator CERK [HugePedia]
snp3D : Map Gene to Disease64781
BioCentury BCIQCERK
ClinGenCERK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64781
Chemical/Pharm GKB GenePA134958321
Clinical trialCERK
Miscellaneous
canSAR (ICR)CERK (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCERK
EVEXCERK
GoPubMedCERK
iHOPCERK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:56:15 CEST 2017

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