CERK (ceramide kinase)

2010-01-01  

Identity

HGNC
CERK
LOCATION
22q13.31
LOCUSID
64781
ALIAS
LK4,dA59H18.2,dA59H18.3,hCERK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64781
MIM: 610307
HGNC: 19256
Ensembl: ENSG00000100422

Variants:

dbSNP: 64781
ClinVar: 64781
TCGA: ENSG00000100422
COSMIC: CERK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100422ENST00000216264Q8TCT0
ENSG00000100422ENST00000216264A0A024R4U8
ENSG00000100422ENST00000443629F8WFD8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Sphingolipid metabolismKEGGko00600
Sphingolipid metabolismKEGGhsa00600
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Glycosphingolipid metabolismREACTOMER-HSA-1660662

References

Pubmed IDYearTitleCitations
119562062002Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization.76
128556932003Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release.58
173922672007Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis.36
172749852007Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells.27
191252962009Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer.26
158998912005Ceramide 1-phosphate, a mediator of phagocytosis.23
161702082005Substrate specificity of human ceramide kinase.23
195011882009Subcellular localization of ceramide kinase and ceramide kinase-like protein requires interplay of their Pleckstrin Homology domain-containing N-terminal regions together with C-terminal domains.20
197788982009JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of group IVA phospholipase A2.17
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17

Citation

Dessen P

CERK (ceramide kinase)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51284/cerk