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CERS1 (ceramide synthase 1)

Identity

Alias_namesLASS1
longevity assurance (LAG1, S. cerevisiae) homolog 1
LAG1 longevity assurance homolog 1 (S. cerevisiae)
LAG1 homolog, ceramide synthase 1
Alias_symbol (synonym)LAG1
UOG1
Other aliasEPM8
HGNC (Hugo) CERS1
LocusID (NCBI) 10715
Atlas_Id 52780
Location 19p13.11  [Link to chromosome band 19p13]
Location_base_pair Starts at 18988718 and ends at 19007536 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CERS1   14253
Cards
Entrez_Gene (NCBI)CERS1  10715  ceramide synthase 1
AliasesEPM8; LAG1; LASS1; UOG1
GeneCards (Weizmann)CERS1
Ensembl hg19 (Hinxton)ENSG00000223802 [Gene_View]  chr19:18988718-19007536 [Contig_View]  CERS1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000223802 [Gene_View]  chr19:18988718-19007536 [Contig_View]  CERS1 [Vega]
ICGC DataPortalENSG00000223802
TCGA cBioPortalCERS1
AceView (NCBI)CERS1
Genatlas (Paris)CERS1
WikiGenes10715
SOURCE (Princeton)CERS1
Genetics Home Reference (NIH)CERS1
Genomic and cartography
GoldenPath hg19 (UCSC)CERS1  -     chr19:18988718-19007536 -  19p13.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CERS1  -     19p13.11   [Description]    (hg38-Dec_2013)
EnsemblCERS1 - 19p13.11 [CytoView hg19]  CERS1 - 19p13.11 [CytoView hg38]
Mapping of homologs : NCBICERS1 [Mapview hg19]  CERS1 [Mapview hg38]
OMIM606919   616230   
Gene and transcription
Genbank (Entrez)AI671814 AK293463 AL120193 BC032615 BC084582
RefSeq transcript (Entrez)NM_001290265 NM_021267 NM_198207
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_012070 NG_033056 NT_011295 NW_004929414
Consensus coding sequences : CCDS (NCBI)CERS1
Cluster EST : UnigeneHs.412355 [ NCBI ]
CGAP (NCI)Hs.412355
Alternative Splicing GalleryENSG00000223802
Gene ExpressionCERS1 [ NCBI-GEO ]   CERS1 [ EBI - ARRAY_EXPRESS ]   CERS1 [ SEEK ]   CERS1 [ MEM ]
Gene Expression Viewer (FireBrowse)CERS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10715
GTEX Portal (Tissue expression)CERS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP27544   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP27544  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP27544
Splice isoforms : SwissVarP27544
PhosPhoSitePlusP27544
Domaine pattern : Prosite (Expaxy)TLC (PS50922)   
Domains : Interpro (EBI)Lag1/Lac1    TLC-dom   
Domain families : Pfam (Sanger)TRAM_LAG1_CLN8 (PF03798)   
Domain families : Pfam (NCBI)pfam03798   
Domain families : Smart (EMBL)TLC (SM00724)  
Conserved Domain (NCBI)CERS1
DMDM Disease mutations10715
Blocks (Seattle)CERS1
SuperfamilyP27544
Human Protein AtlasENSG00000223802
Peptide AtlasP27544
HPRD12114
IPIIPI00019462   IPI00218587   IPI01012793   
Protein Interaction databases
DIP (DOE-UCLA)P27544
IntAct (EBI)P27544
FunCoupENSG00000223802
BioGRIDCERS1
STRING (EMBL)CERS1
ZODIACCERS1
Ontologies - Pathways
QuickGOP27544
Ontology : AmiGOGolgi membrane  molecular_function  endoplasmic reticulum  endoplasmic reticulum membrane  membrane  integral component of membrane  sphingolipid biosynthetic process  sphingolipid biosynthetic process  cellular response to drug  cellular response to mycotoxin  intracellular membrane-bounded organelle  ceramide biosynthetic process  ceramide biosynthetic process  sphingosine N-acyltransferase activity  sphingosine N-acyltransferase activity  sphingosine N-acyltransferase activity  negative regulation of telomerase activity  cellular response to UV-A  cellular response to dithiothreitol  
Ontology : EGO-EBIGolgi membrane  molecular_function  endoplasmic reticulum  endoplasmic reticulum membrane  membrane  integral component of membrane  sphingolipid biosynthetic process  sphingolipid biosynthetic process  cellular response to drug  cellular response to mycotoxin  intracellular membrane-bounded organelle  ceramide biosynthetic process  ceramide biosynthetic process  sphingosine N-acyltransferase activity  sphingosine N-acyltransferase activity  sphingosine N-acyltransferase activity  negative regulation of telomerase activity  cellular response to UV-A  cellular response to dithiothreitol  
Pathways : KEGGSphingolipid metabolism   
NDEx NetworkCERS1
Atlas of Cancer Signalling NetworkCERS1
Wikipedia pathwaysCERS1
Orthology - Evolution
OrthoDB10715
GeneTree (enSembl)ENSG00000223802
Phylogenetic Trees/Animal Genes : TreeFamCERS1
HOVERGENP27544
HOGENOMP27544
Homologs : HomoloGeneCERS1
Homology/Alignments : Family Browser (UCSC)CERS1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCERS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CERS1
dbVarCERS1
ClinVarCERS1
1000_GenomesCERS1 
Exome Variant ServerCERS1
ExAC (Exome Aggregation Consortium)CERS1 (select the gene name)
Genetic variants : HAPMAP10715
Genomic Variants (DGV)CERS1 [DGVbeta]
DECIPHER (Syndromes)19:18988718-19007536  ENSG00000223802
CONAN: Copy Number AnalysisCERS1 
Mutations
ICGC Data PortalCERS1 
TCGA Data PortalCERS1 
Broad Tumor PortalCERS1
OASIS PortalCERS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCERS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCERS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CERS1
DgiDB (Drug Gene Interaction Database)CERS1
DoCM (Curated mutations)CERS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CERS1 (select a term)
intoGenCERS1
Cancer3DCERS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606919    616230   
Orphanet23187   
MedgenCERS1
Genetic Testing Registry CERS1
NextProtP27544 [Medical]
TSGene10715
GENETestsCERS1
Huge Navigator CERS1 [HugePedia]
snp3D : Map Gene to Disease10715
BioCentury BCIQCERS1
ClinGenCERS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10715
Chemical/Pharm GKB GenePA30299
Clinical trialCERS1
Miscellaneous
canSAR (ICR)CERS1 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCERS1
EVEXCERS1
GoPubMedCERS1
iHOPCERS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:00:05 CET 2017

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