Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CERS2 (ceramide synthase 2)

Identity

Alias_namesLASS2
longevity assurance (LAG1, S. cerevisiae) homolog 2
LAG1 longevity assurance homolog 2 (S. cerevisiae)
LAG1 homolog, ceramide synthase 2
Alias_symbol (synonym)SP260
FLJ10243
Other aliasL3
TMSG1
HGNC (Hugo) CERS2
LocusID (NCBI) 29956
Atlas_Id 52300
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 150937649 and ends at 150947479 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CERS2 (1q21.3) / CALM1 (14q32.11)UBA1 (Xp11.23) / CERS2 (1q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CERS2   14076
Cards
Entrez_Gene (NCBI)CERS2  29956  ceramide synthase 2
AliasesL3; LASS2; SP260; TMSG1
GeneCards (Weizmann)CERS2
Ensembl hg19 (Hinxton)ENSG00000143418 [Gene_View]  chr1:150937649-150947479 [Contig_View]  CERS2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000143418 [Gene_View]  chr1:150937649-150947479 [Contig_View]  CERS2 [Vega]
ICGC DataPortalENSG00000143418
TCGA cBioPortalCERS2
AceView (NCBI)CERS2
Genatlas (Paris)CERS2
WikiGenes29956
SOURCE (Princeton)CERS2
Genetics Home Reference (NIH)CERS2
Genomic and cartography
GoldenPath hg19 (UCSC)CERS2  -     chr1:150937649-150947479 -  1q21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CERS2  -     1q21.3   [Description]    (hg38-Dec_2013)
EnsemblCERS2 - 1q21.3 [CytoView hg19]  CERS2 - 1q21.3 [CytoView hg38]
Mapping of homologs : NCBICERS2 [Mapview hg19]  CERS2 [Mapview hg38]
OMIM606920   
Gene and transcription
Genbank (Entrez)AF177338 AF189062 AK001105 AK290989 AY091458
RefSeq transcript (Entrez)NM_013384 NM_022075 NM_181746
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)CERS2
Cluster EST : UnigeneHs.744017 [ NCBI ]
CGAP (NCI)Hs.744017
Alternative Splicing GalleryENSG00000143418
Gene ExpressionCERS2 [ NCBI-GEO ]   CERS2 [ EBI - ARRAY_EXPRESS ]   CERS2 [ SEEK ]   CERS2 [ MEM ]
Gene Expression Viewer (FireBrowse)CERS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29956
GTEX Portal (Tissue expression)CERS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96G23   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96G23  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96G23
Splice isoforms : SwissVarQ96G23
PhosPhoSitePlusQ96G23
Domaine pattern : Prosite (Expaxy)HOMEOBOX_2 (PS50071)    TLC (PS50922)   
Domains : Interpro (EBI)Homeobox_dom    Homeodomain-like    Lag1/Lac1    TLC-dom   
Domain families : Pfam (Sanger)Homeobox (PF00046)    TRAM_LAG1_CLN8 (PF03798)   
Domain families : Pfam (NCBI)pfam00046    pfam03798   
Domain families : Smart (EMBL)HOX (SM00389)  TLC (SM00724)  
Conserved Domain (NCBI)CERS2
DMDM Disease mutations29956
Blocks (Seattle)CERS2
SuperfamilyQ96G23
Human Protein AtlasENSG00000143418
Peptide AtlasQ96G23
HPRD06080
IPIIPI00305304   IPI00472101   IPI00642378   IPI00642091   IPI00641435   IPI00641012   
Protein Interaction databases
DIP (DOE-UCLA)Q96G23
IntAct (EBI)Q96G23
FunCoupENSG00000143418
BioGRIDCERS2
STRING (EMBL)CERS2
ZODIACCERS2
Ontologies - Pathways
QuickGOQ96G23
Ontology : AmiGODNA binding  protein binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  membrane  integral component of membrane  sphingolipid biosynthetic process  nuclear membrane  ceramide biosynthetic process  negative regulation of axon regeneration  sphingosine N-acyltransferase activity  sphingosine N-acyltransferase activity  negative regulation of Schwann cell migration  negative regulation of Schwann cell proliferation involved in axon regeneration  
Ontology : EGO-EBIDNA binding  protein binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  membrane  integral component of membrane  sphingolipid biosynthetic process  nuclear membrane  ceramide biosynthetic process  negative regulation of axon regeneration  sphingosine N-acyltransferase activity  sphingosine N-acyltransferase activity  negative regulation of Schwann cell migration  negative regulation of Schwann cell proliferation involved in axon regeneration  
Pathways : KEGGSphingolipid metabolism   
NDEx NetworkCERS2
Atlas of Cancer Signalling NetworkCERS2
Wikipedia pathwaysCERS2
Orthology - Evolution
OrthoDB29956
GeneTree (enSembl)ENSG00000143418
Phylogenetic Trees/Animal Genes : TreeFamCERS2
HOVERGENQ96G23
HOGENOMQ96G23
Homologs : HomoloGeneCERS2
Homology/Alignments : Family Browser (UCSC)CERS2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCERS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CERS2
dbVarCERS2
ClinVarCERS2
1000_GenomesCERS2 
Exome Variant ServerCERS2
ExAC (Exome Aggregation Consortium)CERS2 (select the gene name)
Genetic variants : HAPMAP29956
Genomic Variants (DGV)CERS2 [DGVbeta]
DECIPHER (Syndromes)1:150937649-150947479  ENSG00000143418
CONAN: Copy Number AnalysisCERS2 
Mutations
ICGC Data PortalCERS2 
TCGA Data PortalCERS2 
Broad Tumor PortalCERS2
OASIS PortalCERS2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCERS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CERS2
DgiDB (Drug Gene Interaction Database)CERS2
DoCM (Curated mutations)CERS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CERS2 (select a term)
intoGenCERS2
Cancer3DCERS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606920   
Orphanet
MedgenCERS2
Genetic Testing Registry CERS2
NextProtQ96G23 [Medical]
TSGene29956
GENETestsCERS2
Huge Navigator CERS2 [HugePedia]
snp3D : Map Gene to Disease29956
BioCentury BCIQCERS2
ClinGenCERS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29956
Chemical/Pharm GKB GenePA30300
Clinical trialCERS2
Miscellaneous
canSAR (ICR)CERS2 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCERS2
EVEXCERS2
GoPubMedCERS2
iHOPCERS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:56:15 CEST 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.