CERS2 (ceramide synthase 2)

2011-07-01  

Identity

HGNC
CERS2
LOCATION
1q21.3
LOCUSID
29956
ALIAS
L3,LASS2,SP260,TMSG1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29956
MIM: 606920
HGNC: 14076
Ensembl: ENSG00000143418

Variants:

dbSNP: 29956
ClinVar: 29956
TCGA: ENSG00000143418
COSMIC: CERS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143418ENST00000271688Q96G23
ENSG00000143418ENST00000361419Q5SZE4
ENSG00000143418ENST00000368949Q5SZE1
ENSG00000143418ENST00000368954Q96G23
ENSG00000143418ENST00000421609Q5SZE3
ENSG00000143418ENST00000457392Q5SZE2
ENSG00000143418ENST00000558062H0YKH6
ENSG00000143418ENST00000560793H0YLQ6
ENSG00000143418ENST00000561294H0YNU7

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Sphingolipid metabolismKEGGko00600
Sphingolipid metabolismKEGGhsa00600
Metabolic pathwaysKEGGhsa01100
Ceramide biosynthesisKEGGM00094
Sphingosine biosynthesisKEGGM00099
Ceramide biosynthesisKEGGhsa_M00094
Sphingosine biosynthesisKEGGhsa_M00099
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203831462010New loci associated with kidney function and chronic kidney disease.337
181652332008Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate.154
204066832010Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.84
197288612009Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response.54
225806062013LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump.24
261503382015miR-9 promotes cell proliferation and inhibits apoptosis by targeting LASS2 in bladder cancer.24
236909712013Ceramide synthases expression and role of ceramide synthase-2 in the lung: insight from human lung cells and mouse models.22
199129912010Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression.21
235382982013The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.17
225735532012Silencing of a novel tumor metastasis suppressor gene LASS2/TMSG1 promotes invasion of prostate cancer cell in vitro through increase of vacuolar ATPase activity.14

Citation

Dessen P

CERS2 (ceramide synthase 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-07-01

Online version: http://atlasgeneticsoncology.org/gene/52300/cers2