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CERS3 (ceramide synthase 3)

Identity

Alias_namesLASS3
LAG1 longevity assurance homolog 3 (S. cerevisiae)
LAG1 homolog, ceramide synthase 3
Alias_symbol (synonym)MGC27091
Other aliasARCI9
HGNC (Hugo) CERS3
LocusID (NCBI) 204219
Atlas_Id 61739
Location 15q26.3  [Link to chromosome band 15q26]
Location_base_pair Starts at 100940600 and ends at 101084531 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADAMTS17 (15q26.3) / CERS3 (15q26.3)LTBP3 (11q13.1) / CERS3 (15q26.3)SEMA4B (15q26.1) / CERS3 (15q26.3)
LTBP3 CERS3SEMA4B CERS3ADAMTS17 CERS3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CERS3   23752
Cards
Entrez_Gene (NCBI)CERS3  204219  ceramide synthase 3
AliasesARCI9; LASS3
GeneCards (Weizmann)CERS3
Ensembl hg19 (Hinxton)ENSG00000154227 [Gene_View]  chr15:100940600-101084531 [Contig_View]  CERS3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000154227 [Gene_View]  chr15:100940600-101084531 [Contig_View]  CERS3 [Vega]
ICGC DataPortalENSG00000154227
TCGA cBioPortalCERS3
AceView (NCBI)CERS3
Genatlas (Paris)CERS3
WikiGenes204219
SOURCE (Princeton)CERS3
Genetics Home Reference (NIH)CERS3
Genomic and cartography
GoldenPath hg19 (UCSC)CERS3  -     chr15:100940600-101084531 -  15q26.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CERS3  -     15q26.3   [Description]    (hg38-Dec_2013)
EnsemblCERS3 - 15q26.3 [CytoView hg19]  CERS3 - 15q26.3 [CytoView hg38]
Mapping of homologs : NCBICERS3 [Mapview hg19]  CERS3 [Mapview hg38]
OMIM615023   615276   
Gene and transcription
Genbank (Entrez)AK307191 BC027616 BC028703 BC034500 BC034970
RefSeq transcript (Entrez)NM_001290341 NM_001290342 NM_001290343 NM_178842
RefSeq genomic (Entrez)NC_000015 NC_018926 NT_010194 NW_004929399
Consensus coding sequences : CCDS (NCBI)CERS3
Cluster EST : UnigeneHs.662371 [ NCBI ]
CGAP (NCI)Hs.662371
Alternative Splicing GalleryENSG00000154227
Gene ExpressionCERS3 [ NCBI-GEO ]   CERS3 [ EBI - ARRAY_EXPRESS ]   CERS3 [ SEEK ]   CERS3 [ MEM ]
Gene Expression Viewer (FireBrowse)CERS3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)204219
GTEX Portal (Tissue expression)CERS3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IU89   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IU89  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IU89
Splice isoforms : SwissVarQ8IU89
Catalytic activity : Enzyme2.3.1.24 [ Enzyme-Expasy ]   2.3.1.242.3.1.24 [ IntEnz-EBI ]   2.3.1.24 [ BRENDA ]   2.3.1.24 [ KEGG ]   
PhosPhoSitePlusQ8IU89
Domaine pattern : Prosite (Expaxy)HOMEOBOX_2 (PS50071)    TLC (PS50922)   
Domains : Interpro (EBI)Homeobox_dom    Homeodomain-like    Lag1/Lac1    TLC-dom   
Domain families : Pfam (Sanger)Homeobox (PF00046)    TRAM_LAG1_CLN8 (PF03798)   
Domain families : Pfam (NCBI)pfam00046    pfam03798   
Domain families : Smart (EMBL)HOX (SM00389)  TLC (SM00724)  
Conserved Domain (NCBI)CERS3
DMDM Disease mutations204219
Blocks (Seattle)CERS3
SuperfamilyQ8IU89
Human Protein AtlasENSG00000154227
Peptide AtlasQ8IU89
HPRD13961
IPIIPI00796378   IPI00216667   
Protein Interaction databases
DIP (DOE-UCLA)Q8IU89
IntAct (EBI)Q8IU89
FunCoupENSG00000154227
BioGRIDCERS3
STRING (EMBL)CERS3
ZODIACCERS3
Ontologies - Pathways
QuickGOQ8IU89
Ontology : AmiGODNA binding  endoplasmic reticulum membrane  sphingolipid metabolic process  integral component of membrane  sphingolipid biosynthetic process  keratinocyte differentiation  nuclear membrane  small molecule metabolic process  ceramide biosynthetic process  sphingosine N-acyltransferase activity  
Ontology : EGO-EBIDNA binding  endoplasmic reticulum membrane  sphingolipid metabolic process  integral component of membrane  sphingolipid biosynthetic process  keratinocyte differentiation  nuclear membrane  small molecule metabolic process  ceramide biosynthetic process  sphingosine N-acyltransferase activity  
Pathways : KEGGSphingolipid metabolism   
NDEx NetworkCERS3
Atlas of Cancer Signalling NetworkCERS3
Wikipedia pathwaysCERS3
Orthology - Evolution
OrthoDB204219
GeneTree (enSembl)ENSG00000154227
Phylogenetic Trees/Animal Genes : TreeFamCERS3
HOVERGENQ8IU89
HOGENOMQ8IU89
Homologs : HomoloGeneCERS3
Homology/Alignments : Family Browser (UCSC)CERS3
Gene fusions - Rearrangements
Fusion: TCGALTBP3 CERS3
Fusion: TCGASEMA4B CERS3
Fusion: TCGAADAMTS17 CERS3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCERS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CERS3
dbVarCERS3
ClinVarCERS3
1000_GenomesCERS3 
Exome Variant ServerCERS3
ExAC (Exome Aggregation Consortium)CERS3 (select the gene name)
Genetic variants : HAPMAP204219
Genomic Variants (DGV)CERS3 [DGVbeta]
DECIPHER (Syndromes)15:100940600-101084531  ENSG00000154227
CONAN: Copy Number AnalysisCERS3 
Mutations
ICGC Data PortalCERS3 
TCGA Data PortalCERS3 
Broad Tumor PortalCERS3
OASIS PortalCERS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCERS3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCERS3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CERS3
DgiDB (Drug Gene Interaction Database)CERS3
DoCM (Curated mutations)CERS3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CERS3 (select a term)
intoGenCERS3
Cancer3DCERS3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615023    615276   
Orphanet22357    11420   
MedgenCERS3
Genetic Testing Registry CERS3
NextProtQ8IU89 [Medical]
TSGene204219
GENETestsCERS3
Huge Navigator CERS3 [HugePedia]
snp3D : Map Gene to Disease204219
BioCentury BCIQCERS3
ClinGenCERS3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD204219
Chemical/Pharm GKB GenePA134873153
Clinical trialCERS3
Miscellaneous
canSAR (ICR)CERS3 (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCERS3
EVEXCERS3
GoPubMedCERS3
iHOPCERS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 11:59:12 CET 2017

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