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CERS4 (ceramide synthase 4)

Identity

Alias (NCBI)LASS4
Trh1
HGNC (Hugo) CERS4
HGNC Alias symbFLJ12089
Trh1
HGNC Previous nameLASS4
HGNC Previous nameLAG1 longevity assurance homolog 4 (S. cerevisiae)
 LAG1 homolog, ceramide synthase 4
LocusID (NCBI) 79603
Atlas_Id 55376
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 8209370 and ends at 8262420 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CERS4 (19p13.2) / SPAG17 (1p12)HNRNPM (19p13.2) / CERS4 (19p13.2)MARCH2 (19p13.2) / CERS4 (19p13.2)
SIRT6 (19p13.3) / CERS4 (19p13.2)SPEN (1p36.21) / CERS4 (19p13.2)CERS4 19p13.2 / SPAG17 1p12
HNRNPM 19p13.2 / CERS4 19p13.2MARCH2 19p13.2 / CERS4 19p13.2SIRT6 19p13.3 / CERS4 19p13.2
SPEN 1p36.21 / CERS4 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CERS4   23747
Cards
Entrez_Gene (NCBI)CERS4    ceramide synthase 4
AliasesLASS4; Trh1
GeneCards (Weizmann)CERS4
Ensembl hg19 (Hinxton)ENSG00000090661 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000090661 [Gene_View]  ENSG00000090661 [Sequence]  chr19:8209370-8262420 [Contig_View]  CERS4 [Vega]
ICGC DataPortalENSG00000090661
TCGA cBioPortalCERS4
AceView (NCBI)CERS4
Genatlas (Paris)CERS4
SOURCE (Princeton)CERS4
Genetics Home Reference (NIH)CERS4
Genomic and cartography
GoldenPath hg38 (UCSC)CERS4  -     chr19:8209370-8262420 +  19p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CERS4  -     19p13.2   [Description]    (hg19-Feb_2009)
GoldenPathCERS4 - 19p13.2 [CytoView hg19]  CERS4 - 19p13.2 [CytoView hg38]
ImmunoBaseENSG00000090661
Genome Data Viewer NCBICERS4 [Mapview hg19]  
OMIM615334   
Gene and transcription
Genbank (Entrez)AK022151 AK055414 AK222621 AK225394 BC009828
RefSeq transcript (Entrez)NM_024552
Consensus coding sequences : CCDS (NCBI)CERS4
Gene ExpressionCERS4 [ NCBI-GEO ]   CERS4 [ EBI - ARRAY_EXPRESS ]   CERS4 [ SEEK ]   CERS4 [ MEM ]
Gene Expression Viewer (FireBrowse)CERS4 [ Firebrowse - Broad ]
GenevisibleExpression of CERS4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79603
GTEX Portal (Tissue expression)CERS4
Human Protein AtlasENSG00000090661-CERS4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HA82   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HA82  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HA82
PhosPhoSitePlusQ9HA82
Domaine pattern : Prosite (Expaxy)TLC (PS50922)   
Domains : Interpro (EBI)Homeobox-like_sf    Homeobox_dom    Lag1/Lac1-like    TLC-dom   
Domain families : Pfam (Sanger)Homeodomain (PF00046)    TRAM_LAG1_CLN8 (PF03798)   
Domain families : Pfam (NCBI)pfam00046    pfam03798   
Domain families : Smart (EMBL)TLC (SM00724)  
Conserved Domain (NCBI)CERS4
SuperfamilyQ9HA82
AlphaFold pdb e-kbQ9HA82   
Human Protein Atlas [tissue]ENSG00000090661-CERS4 [tissue]
HPRD13962
Protein Interaction databases
DIP (DOE-UCLA)Q9HA82
IntAct (EBI)Q9HA82
BioGRIDCERS4
STRING (EMBL)CERS4
ZODIACCERS4
Ontologies - Pathways
QuickGOQ9HA82
Ontology : AmiGODNA binding  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  integral component of membrane  N-acyltransferase activity  sphingolipid biosynthetic process  ceramide biosynthetic process  ceramide biosynthetic process  sphingosine N-acyltransferase activity  sphingosine N-acyltransferase activity  
Ontology : EGO-EBIDNA binding  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  integral component of membrane  N-acyltransferase activity  sphingolipid biosynthetic process  ceramide biosynthetic process  ceramide biosynthetic process  sphingosine N-acyltransferase activity  sphingosine N-acyltransferase activity  
Pathways : KEGGSphingolipid metabolism   
NDEx NetworkCERS4
Atlas of Cancer Signalling NetworkCERS4
Wikipedia pathwaysCERS4
Orthology - Evolution
OrthoDB79603
GeneTree (enSembl)ENSG00000090661
Phylogenetic Trees/Animal Genes : TreeFamCERS4
Homologs : HomoloGeneCERS4
Homology/Alignments : Family Browser (UCSC)CERS4
Gene fusions - Rearrangements
Fusion : MitelmanCERS4/SPAG17 [19p13.2/1p12]  
Fusion : MitelmanHNRNPM/CERS4 [19p13.2/19p13.2]  
Fusion : MitelmanMARCH2/CERS4 [19p13.2/19p13.2]  
Fusion : MitelmanSIRT6/CERS4 [19p13.3/19p13.2]  
Fusion : MitelmanSPEN/CERS4 [1p36.21/19p13.2]  
Fusion : QuiverCERS4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCERS4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CERS4
dbVarCERS4
ClinVarCERS4
MonarchCERS4
1000_GenomesCERS4 
Exome Variant ServerCERS4
GNOMAD BrowserENSG00000090661
Varsome BrowserCERS4
ACMGCERS4 variants
VarityQ9HA82
Genomic Variants (DGV)CERS4 [DGVbeta]
DECIPHERCERS4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCERS4 
Mutations
ICGC Data PortalCERS4 
TCGA Data PortalCERS4 
Broad Tumor PortalCERS4
OASIS PortalCERS4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCERS4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCERS4
Mutations and Diseases : HGMDCERS4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCERS4
DgiDB (Drug Gene Interaction Database)CERS4
DoCM (Curated mutations)CERS4
CIViC (Clinical Interpretations of Variants in Cancer)CERS4
Cancer3DCERS4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615334   
Orphanet
DisGeNETCERS4
MedgenCERS4
Genetic Testing Registry CERS4
NextProtQ9HA82 [Medical]
GENETestsCERS4
Target ValidationCERS4
Huge Navigator CERS4 [HugePedia]
ClinGenCERS4
Clinical trials, drugs, therapy
MyCancerGenomeCERS4
Protein Interactions : CTDCERS4
Pharm GKB GenePA134915173
PharosQ9HA82
Clinical trialCERS4
Miscellaneous
canSAR (ICR)CERS4
HarmonizomeCERS4
DataMed IndexCERS4
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCERS4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:03:38 CEST 2021

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