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CERS4 (ceramide synthase 4)

Identity

Alias_namesLASS4
LAG1 longevity assurance homolog 4 (S. cerevisiae)
LAG1 homolog, ceramide synthase 4
Alias_symbol (synonym)FLJ12089
Trh1
Other alias
HGNC (Hugo) CERS4
LocusID (NCBI) 79603
Atlas_Id 55376
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 8209333 and ends at 8262420 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CERS4 (19p13.2) / SPAG17 (1p12)HNRNPM (19p13.2) / CERS4 (19p13.2)MARCH2 (19p13.2) / CERS4 (19p13.2)
SIRT6 (19p13.3) / CERS4 (19p13.2)SPEN (1p36.21) / CERS4 (19p13.2)CERS4 19p13.2 / SPAG17 1p12
HNRNPM 19p13.2 / CERS4 19p13.2MARCH2 19p13.2 / CERS4 19p13.2SIRT6 19p13.3 / CERS4 19p13.2
SPEN 1p36.21 / CERS4 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CERS4   23747
Cards
Entrez_Gene (NCBI)CERS4  79603  ceramide synthase 4
AliasesLASS4; Trh1
GeneCards (Weizmann)CERS4
Ensembl hg19 (Hinxton)ENSG00000090661 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000090661 [Gene_View]  chr19:8209333-8262420 [Contig_View]  CERS4 [Vega]
ICGC DataPortalENSG00000090661
TCGA cBioPortalCERS4
AceView (NCBI)CERS4
Genatlas (Paris)CERS4
WikiGenes79603
SOURCE (Princeton)CERS4
Genetics Home Reference (NIH)CERS4
Genomic and cartography
GoldenPath hg38 (UCSC)CERS4  -     chr19:8209333-8262420 +  19p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CERS4  -     19p13.2   [Description]    (hg19-Feb_2009)
EnsemblCERS4 - 19p13.2 [CytoView hg19]  CERS4 - 19p13.2 [CytoView hg38]
Mapping of homologs : NCBICERS4 [Mapview hg19]  CERS4 [Mapview hg38]
OMIM615334   
Gene and transcription
Genbank (Entrez)AK022151 AK055414 AK222621 AK225394 BC009828
RefSeq transcript (Entrez)NM_024552
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CERS4
Cluster EST : UnigeneHs.515111 [ NCBI ]
CGAP (NCI)Hs.515111
Alternative Splicing GalleryENSG00000090661
Gene ExpressionCERS4 [ NCBI-GEO ]   CERS4 [ EBI - ARRAY_EXPRESS ]   CERS4 [ SEEK ]   CERS4 [ MEM ]
Gene Expression Viewer (FireBrowse)CERS4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79603
GTEX Portal (Tissue expression)CERS4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HA82   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HA82  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HA82
Splice isoforms : SwissVarQ9HA82
PhosPhoSitePlusQ9HA82
Domaine pattern : Prosite (Expaxy)HOMEOBOX_2 (PS50071)    TLC (PS50922)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_dom    Lag1/Lac1    TLC-dom   
Domain families : Pfam (Sanger)Homeobox (PF00046)    TRAM_LAG1_CLN8 (PF03798)   
Domain families : Pfam (NCBI)pfam00046    pfam03798   
Domain families : Smart (EMBL)TLC (SM00724)  
Conserved Domain (NCBI)CERS4
DMDM Disease mutations79603
Blocks (Seattle)CERS4
SuperfamilyQ9HA82
Human Protein AtlasENSG00000090661
Peptide AtlasQ9HA82
HPRD13962
IPIIPI00002225   
Protein Interaction databases
DIP (DOE-UCLA)Q9HA82
IntAct (EBI)Q9HA82
FunCoupENSG00000090661
BioGRIDCERS4
STRING (EMBL)CERS4
ZODIACCERS4
Ontologies - Pathways
QuickGOQ9HA82
Ontology : AmiGODNA binding  endoplasmic reticulum  endoplasmic reticulum membrane  integral component of membrane  sphingolipid biosynthetic process  nuclear membrane  ceramide biosynthetic process  sphingosine N-acyltransferase activity  sphingosine N-acyltransferase activity  
Ontology : EGO-EBIDNA binding  endoplasmic reticulum  endoplasmic reticulum membrane  integral component of membrane  sphingolipid biosynthetic process  nuclear membrane  ceramide biosynthetic process  sphingosine N-acyltransferase activity  sphingosine N-acyltransferase activity  
Pathways : KEGGSphingolipid metabolism   
NDEx NetworkCERS4
Atlas of Cancer Signalling NetworkCERS4
Wikipedia pathwaysCERS4
Orthology - Evolution
OrthoDB79603
GeneTree (enSembl)ENSG00000090661
Phylogenetic Trees/Animal Genes : TreeFamCERS4
HOVERGENQ9HA82
HOGENOMQ9HA82
Homologs : HomoloGeneCERS4
Homology/Alignments : Family Browser (UCSC)CERS4
Gene fusions - Rearrangements
Fusion : MitelmanCERS4/SPAG17 [19p13.2/1p12]  
Fusion : MitelmanHNRNPM/CERS4 [19p13.2/19p13.2]  [t(19;19)(p13;p13)]  
Fusion : MitelmanMARCH2/CERS4 [19p13.2/19p13.2]  [t(19;19)(p13;p13)]  
Fusion : MitelmanSIRT6/CERS4 [19p13.3/19p13.2]  [t(19;19)(p13;p13)]  
Fusion : MitelmanSPEN/CERS4 [1p36.21/19p13.2]  [t(1;19)(p36;p13)]  
Fusion: TCGACERS4 19p13.2 SPAG17 1p12 BRCA
Fusion: TCGAHNRNPM 19p13.2 CERS4 19p13.2 BRCA
Fusion: TCGAMARCH2 19p13.2 CERS4 19p13.2 BRCA
Fusion: TCGASIRT6 19p13.3 CERS4 19p13.2 BRCA
Fusion: TCGASPEN 1p36.21 CERS4 19p13.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCERS4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CERS4
dbVarCERS4
ClinVarCERS4
1000_GenomesCERS4 
Exome Variant ServerCERS4
ExAC (Exome Aggregation Consortium)CERS4 (select the gene name)
Genetic variants : HAPMAP79603
Genomic Variants (DGV)CERS4 [DGVbeta]
DECIPHERCERS4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCERS4 
Mutations
ICGC Data PortalCERS4 
TCGA Data PortalCERS4 
Broad Tumor PortalCERS4
OASIS PortalCERS4 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCERS4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CERS4
DgiDB (Drug Gene Interaction Database)CERS4
DoCM (Curated mutations)CERS4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CERS4 (select a term)
intoGenCERS4
Cancer3DCERS4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615334   
Orphanet
MedgenCERS4
Genetic Testing Registry CERS4
NextProtQ9HA82 [Medical]
TSGene79603
GENETestsCERS4
Huge Navigator CERS4 [HugePedia]
snp3D : Map Gene to Disease79603
BioCentury BCIQCERS4
ClinGenCERS4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79603
Chemical/Pharm GKB GenePA134915173
Clinical trialCERS4
Miscellaneous
canSAR (ICR)CERS4 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCERS4
EVEXCERS4
GoPubMedCERS4
iHOPCERS4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:10:17 CEST 2017

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