CERS5 (ceramide synthase 5)

2011-07-01  

Identity

HGNC
CERS5
LOCATION
12q13.12
LOCUSID
91012
ALIAS
LASS5,Trh4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 91012
MIM: 615335
HGNC: 23749
Ensembl: ENSG00000139624

Variants:

dbSNP: 91012
ClinVar: 91012
TCGA: ENSG00000139624
COSMIC: CERS5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139624ENST00000317551Q8N5B7
ENSG00000139624ENST00000380189Q49AQ3
ENSG00000139624ENST00000422340Q8N5B7
ENSG00000139624ENST00000438450B4DQR7
ENSG00000139624ENST00000542320Q49AQ3
ENSG00000139624ENST00000546514F8W1N7
ENSG00000139624ENST00000547455F8VSK7
ENSG00000139624ENST00000547787F8W1Z3
ENSG00000139624ENST00000547800H0YI10
ENSG00000139624ENST00000549389F8VY42
ENSG00000139624ENST00000550258F8W1K4
ENSG00000139624ENST00000550547H0YHG4
ENSG00000139624ENST00000550899F8VQZ6
ENSG00000139624ENST00000550919H0YIG1
ENSG00000139624ENST00000551697F8VXY1
ENSG00000139624ENST00000553122H0YHK2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Sphingolipid metabolismKEGGko00600
Sphingolipid metabolismKEGGhsa00600
Metabolic pathwaysKEGGhsa01100
Ceramide biosynthesisKEGGM00094
Sphingosine biosynthesisKEGGM00099
Ceramide biosynthesisKEGGhsa_M00094
Sphingosine biosynthesisKEGGhsa_M00099
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
204066832010Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.84
161001202005LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor.43
170305102006Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.33
186763722008Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells.32
268879522016Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.7
257790242015Linking the ceramide synthases (CerSs) 4 and 5 with apoptosis, endometrial and colon cancers.4
300597582018Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy.3
272804972016LASS5 Interacts with SDHB and Synergistically Represses p53 and p21 Activity.2
284244332017[Investigating the role of ceramide metabolism-associated CERS5 (LASS5) gene in atherosclerosis pathogenesis in endothelial cells].0

Citation

Dessen P

CERS5 (ceramide synthase 5)

Atlas Genet Cytogenet Oncol Haematol. 2011-07-01

Online version: http://atlasgeneticsoncology.org/gene/52286/cers5