Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 253782
MIM: 615336
HGNC: 23826
Ensembl: ENSG00000172292
Variants:
dbSNP: 253782
ClinVar: 253782
TCGA: ENSG00000172292
COSMIC: CERS6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000172292 | ENST00000305747 | Q6ZMG9 |
| ENSG00000172292 | ENST00000392687 | Q6ZMG9 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164713366 | Tumor necrosis factor alpha (TNF-alpha) inhibitors | Chemical | ClinicalAnnotation | associated | PD | ||
| PA443434 | Arthritis, Rheumatoid | Disease | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37230220 | 2023 | CerS6 triggered by high glucose activating the TLR4/IKKβ pathway regulates ferroptosis of LO2 cells through mitochondrial oxidative stress. | 4 |
| 37714377 | 2023 | Ceramide synthase 6 (CerS6) is upregulated in alcohol-associated liver disease and exhibits sex-based differences in the regulation of energy homeostasis and lipid droplet accumulation. | 0 |
| 37230220 | 2023 | CerS6 triggered by high glucose activating the TLR4/IKKβ pathway regulates ferroptosis of LO2 cells through mitochondrial oxidative stress. | 4 |
| 37714377 | 2023 | Ceramide synthase 6 (CerS6) is upregulated in alcohol-associated liver disease and exhibits sex-based differences in the regulation of energy homeostasis and lipid droplet accumulation. | 0 |
| 34915026 | 2022 | Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer. | 4 |
| 35676548 | 2022 | CircCERS6 Suppresses the Development of Epithelial Ovarian Cancer Through Mediating miR-630/RASSF8. | 4 |
| 34915026 | 2022 | Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer. | 4 |
| 35676548 | 2022 | CircCERS6 Suppresses the Development of Epithelial Ovarian Cancer Through Mediating miR-630/RASSF8. | 4 |
| 33934437 | 2021 | CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation. | 8 |
| 34343636 | 2021 | AKT1/FOXP3 axis-mediated expression of CerS6 promotes p53 mutant pancreatic tumorigenesis. | 11 |
| 34488809 | 2021 | Comprehensive analysis of LASS6 expression and prognostic value in ovarian cancer. | 2 |
| 33934437 | 2021 | CEBPγ facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation. | 8 |
| 34343636 | 2021 | AKT1/FOXP3 axis-mediated expression of CerS6 promotes p53 mutant pancreatic tumorigenesis. | 11 |
| 34488809 | 2021 | Comprehensive analysis of LASS6 expression and prognostic value in ovarian cancer. | 2 |
| 31701672 | 2020 | Long noncoding RNA CERS6-AS1 functions as a malignancy promoter in breast cancer by binding to IGF2BP3 to enhance the stability of CERS6 mRNA. | 26 |
Citation
Dessen P
CERS6 (ceramide synthase 6)
Atlas Genet Cytogenet Oncol Haematol. 2011-07-01
Online version: http://atlasgeneticsoncology.org/gene/52298/cers6
