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CERS6 (ceramide synthase 6)

Identity

Alias_namesLASS6
LAG1 longevity assurance homolog 6 (S. cerevisiae)
LAG1 homolog, ceramide synthase 6
Other aliasCERS5
HGNC (Hugo) CERS6
LocusID (NCBI) 253782
Atlas_Id 52298
Location 2q24.3  [Link to chromosome band 2q24]
Location_base_pair Starts at 168456249 and ends at 168775134 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CERS6 (2q24.3) / QSER1 (11p13)CERS6 (2q24.3) / SPP1 (4q22.1)CERS6 (2q24.3) / SVIL (10p11.23)
CERS6 (2q24.3) / TXNIP (1q21.1)LRFN5 (14q21.1) / CERS6 (2q24.3)MEST (7q32.2) / CERS6 (2q24.3)
TXNIP (1q21.1) / CERS6 (2q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CERS6   23826
Cards
Entrez_Gene (NCBI)CERS6  253782  ceramide synthase 6
AliasesCERS5; LASS6
GeneCards (Weizmann)CERS6
Ensembl hg19 (Hinxton)ENSG00000172292 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172292 [Gene_View]  ENSG00000172292 [Sequence]  chr2:168456249-168775134 [Contig_View]  CERS6 [Vega]
ICGC DataPortalENSG00000172292
TCGA cBioPortalCERS6
AceView (NCBI)CERS6
Genatlas (Paris)CERS6
WikiGenes253782
SOURCE (Princeton)CERS6
Genetics Home Reference (NIH)CERS6
Genomic and cartography
GoldenPath hg38 (UCSC)CERS6  -     chr2:168456249-168775134 +  2q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CERS6  -     2q24.3   [Description]    (hg19-Feb_2009)
EnsemblCERS6 - 2q24.3 [CytoView hg19]  CERS6 - 2q24.3 [CytoView hg38]
Mapping of homologs : NCBICERS6 [Mapview hg19]  CERS6 [Mapview hg38]
OMIM615336   
Gene and transcription
Genbank (Entrez)AI521447 AK023042 AK024891 AK091391 AK123214
RefSeq transcript (Entrez)NM_001256126 NM_203463
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CERS6
Cluster EST : UnigeneHs.743222 [ NCBI ]
CGAP (NCI)Hs.743222
Alternative Splicing GalleryENSG00000172292
Gene ExpressionCERS6 [ NCBI-GEO ]   CERS6 [ EBI - ARRAY_EXPRESS ]   CERS6 [ SEEK ]   CERS6 [ MEM ]
Gene Expression Viewer (FireBrowse)CERS6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)253782
GTEX Portal (Tissue expression)CERS6
Human Protein AtlasENSG00000172292-CERS6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZMG9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZMG9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZMG9
Splice isoforms : SwissVarQ6ZMG9
PhosPhoSitePlusQ6ZMG9
Domaine pattern : Prosite (Expaxy)HOMEOBOX_2 (PS50071)    TLC (PS50922)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_dom    Lag1/Lac1    TLC-dom   
Domain families : Pfam (Sanger)Homeobox (PF00046)    TRAM_LAG1_CLN8 (PF03798)   
Domain families : Pfam (NCBI)pfam00046    pfam03798   
Domain families : Smart (EMBL)TLC (SM00724)  
Conserved Domain (NCBI)CERS6
DMDM Disease mutations253782
Blocks (Seattle)CERS6
SuperfamilyQ6ZMG9
Human Protein Atlas [tissue]ENSG00000172292-CERS6 [tissue]
Peptide AtlasQ6ZMG9
HPRD17258
IPIIPI00409608   IPI00795030   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZMG9
IntAct (EBI)Q6ZMG9
FunCoupENSG00000172292
BioGRIDCERS6
STRING (EMBL)CERS6
ZODIACCERS6
Ontologies - Pathways
QuickGOQ6ZMG9
Ontology : AmiGODNA binding  endoplasmic reticulum  endoplasmic reticulum membrane  membrane  integral component of membrane  sphingolipid biosynthetic process  nuclear membrane  ceramide biosynthetic process  sphingosine N-acyltransferase activity  sphingosine N-acyltransferase activity  
Ontology : EGO-EBIDNA binding  endoplasmic reticulum  endoplasmic reticulum membrane  membrane  integral component of membrane  sphingolipid biosynthetic process  nuclear membrane  ceramide biosynthetic process  sphingosine N-acyltransferase activity  sphingosine N-acyltransferase activity  
NDEx NetworkCERS6
Atlas of Cancer Signalling NetworkCERS6
Wikipedia pathwaysCERS6
Orthology - Evolution
OrthoDB253782
GeneTree (enSembl)ENSG00000172292
Phylogenetic Trees/Animal Genes : TreeFamCERS6
HOVERGENQ6ZMG9
HOGENOMQ6ZMG9
Homologs : HomoloGeneCERS6
Homology/Alignments : Family Browser (UCSC)CERS6
Gene fusions - Rearrangements
Fusion : QuiverCERS6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCERS6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CERS6
dbVarCERS6
ClinVarCERS6
1000_GenomesCERS6 
Exome Variant ServerCERS6
ExAC (Exome Aggregation Consortium)ENSG00000172292
GNOMAD BrowserENSG00000172292
Genetic variants : HAPMAP253782
Genomic Variants (DGV)CERS6 [DGVbeta]
DECIPHERCERS6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCERS6 
Mutations
ICGC Data PortalCERS6 
TCGA Data PortalCERS6 
Broad Tumor PortalCERS6
OASIS PortalCERS6 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCERS6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CERS6
DgiDB (Drug Gene Interaction Database)CERS6
DoCM (Curated mutations)CERS6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CERS6 (select a term)
intoGenCERS6
Cancer3DCERS6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615336   
Orphanet
DisGeNETCERS6
MedgenCERS6
Genetic Testing Registry CERS6
NextProtQ6ZMG9 [Medical]
TSGene253782
GENETestsCERS6
Target ValidationCERS6
Huge Navigator CERS6 [HugePedia]
snp3D : Map Gene to Disease253782
BioCentury BCIQCERS6
ClinGenCERS6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD253782
Chemical/Pharm GKB GenePA134925480
Clinical trialCERS6
Miscellaneous
canSAR (ICR)CERS6 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCERS6
EVEXCERS6
GoPubMedCERS6
iHOPCERS6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:19:06 CEST 2018

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