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CES1 (carboxylesterase 1)

Identity

Alias_namescarboxylesterase 1 (monocyte/macrophage serine esterase 1)
Alias_symbol (synonym)HMSE
CES2
HMSE1
SES1
CEH
CES1A1
CES1A2
Other aliasACAT
CE-1
PCE-1
REH
TGH
hCE-1
HGNC (Hugo) CES1
LocusID (NCBI) 1066
Atlas_Id 40060
Location 16q12.2  [Link to chromosome band 16q12]
Location_base_pair Starts at 55836764 and ends at 55867075 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CES1 (16q12.2) / H2AFY2 (10q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CES1   1863
Cards
Entrez_Gene (NCBI)CES1  1066  carboxylesterase 1
AliasesACAT; CE-1; CEH; CES2; 
HMSE; HMSE1; PCE-1; REH; SES1; TGH; hCE-1
GeneCards (Weizmann)CES1
Ensembl hg19 (Hinxton)ENSG00000198848 [Gene_View]  chr16:55836764-55867075 [Contig_View]  CES1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000198848 [Gene_View]  chr16:55836764-55867075 [Contig_View]  CES1 [Vega]
ICGC DataPortalENSG00000198848
TCGA cBioPortalCES1
AceView (NCBI)CES1
Genatlas (Paris)CES1
WikiGenes1066
SOURCE (Princeton)CES1
Genetics Home Reference (NIH)CES1
Genomic and cartography
GoldenPath hg19 (UCSC)CES1  -     chr16:55836764-55867075 -  16q12.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CES1  -     16q12.2   [Description]    (hg38-Dec_2013)
EnsemblCES1 - 16q12.2 [CytoView hg19]  CES1 - 16q12.2 [CytoView hg38]
Mapping of homologs : NCBICES1 [Mapview hg19]  CES1 [Mapview hg38]
OMIM114835   
Gene and transcription
Genbank (Entrez)AB025026 AB119995 AB119996 AF177775 AK290623
RefSeq transcript (Entrez)NM_001025194 NM_001025195 NM_001266
RefSeq genomic (Entrez)NC_000016 NC_018927 NG_012057 NT_010498 NW_003315945 NW_004929402
Consensus coding sequences : CCDS (NCBI)CES1
Cluster EST : UnigeneHs.558865 [ NCBI ]
CGAP (NCI)Hs.558865
Alternative Splicing GalleryENSG00000198848
Gene ExpressionCES1 [ NCBI-GEO ]   CES1 [ EBI - ARRAY_EXPRESS ]   CES1 [ SEEK ]   CES1 [ MEM ]
Gene Expression Viewer (FireBrowse)CES1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1066
GTEX Portal (Tissue expression)CES1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23141   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23141  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23141
Splice isoforms : SwissVarP23141
PhosPhoSitePlusP23141
Domaine pattern : Prosite (Expaxy)CARBOXYLESTERASE_B_1 (PS00122)    CARBOXYLESTERASE_B_2 (PS00941)   
Domains : Interpro (EBI)AB_hydrolase    CarbesteraseB    Carboxylesterase_B_AS    Carboxylesterase_B_CS   
Domain families : Pfam (Sanger)COesterase (PF00135)   
Domain families : Pfam (NCBI)pfam00135   
Conserved Domain (NCBI)CES1
DMDM Disease mutations1066
Blocks (Seattle)CES1
PDB (SRS)1MX1    1MX5    1MX9    1YA4    1YA8    1YAH    1YAJ    2DQY    2DQZ    2DR0    2H7C    2HRQ    2HRR    3K9B    4AB1    5A7F    5A7G    5A7H   
PDB (PDBSum)1MX1    1MX5    1MX9    1YA4    1YA8    1YAH    1YAJ    2DQY    2DQZ    2DR0    2H7C    2HRQ    2HRR    3K9B    4AB1    5A7F    5A7G    5A7H   
PDB (IMB)1MX1    1MX5    1MX9    1YA4    1YA8    1YAH    1YAJ    2DQY    2DQZ    2DR0    2H7C    2HRQ    2HRR    3K9B    4AB1    5A7F    5A7G    5A7H   
PDB (RSDB)1MX1    1MX5    1MX9    1YA4    1YA8    1YAH    1YAJ    2DQY    2DQZ    2DR0    2H7C    2HRQ    2HRR    3K9B    4AB1    5A7F    5A7G    5A7H   
Structural Biology KnowledgeBase1MX1    1MX5    1MX9    1YA4    1YA8    1YAH    1YAJ    2DQY    2DQZ    2DR0    2H7C    2HRQ    2HRR    3K9B    4AB1    5A7F    5A7G    5A7H   
SCOP (Structural Classification of Proteins)1MX1    1MX5    1MX9    1YA4    1YA8    1YAH    1YAJ    2DQY    2DQZ    2DR0    2H7C    2HRQ    2HRR    3K9B    4AB1    5A7F    5A7G    5A7H   
CATH (Classification of proteins structures)1MX1    1MX5    1MX9    1YA4    1YA8    1YAH    1YAJ    2DQY    2DQZ    2DR0    2H7C    2HRQ    2HRR    3K9B    4AB1    5A7F    5A7G    5A7H   
SuperfamilyP23141
Human Protein AtlasENSG00000198848
Peptide AtlasP23141
HPRD00268
IPIIPI00010180   IPI00607801   IPI00942507   IPI00607693   
Protein Interaction databases
DIP (DOE-UCLA)P23141
IntAct (EBI)P23141
FunCoupENSG00000198848
BioGRIDCES1
STRING (EMBL)CES1
ZODIACCES1
Ontologies - Pathways
QuickGOP23141
Ontology : AmiGOextracellular space  endoplasmic reticulum lumen  xenobiotic metabolic process  metabolic process  response to toxic substance  epithelial cell differentiation  methylumbelliferyl-acetate deacetylase activity  carboxylic ester hydrolase activity  
Ontology : EGO-EBIextracellular space  endoplasmic reticulum lumen  xenobiotic metabolic process  metabolic process  response to toxic substance  epithelial cell differentiation  methylumbelliferyl-acetate deacetylase activity  carboxylic ester hydrolase activity  
Pathways : KEGGDrug metabolism - other enzymes   
NDEx NetworkCES1
Atlas of Cancer Signalling NetworkCES1
Wikipedia pathwaysCES1
Orthology - Evolution
OrthoDB1066
GeneTree (enSembl)ENSG00000198848
Phylogenetic Trees/Animal Genes : TreeFamCES1
HOVERGENP23141
HOGENOMP23141
Homologs : HomoloGeneCES1
Homology/Alignments : Family Browser (UCSC)CES1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCES1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CES1
dbVarCES1
ClinVarCES1
1000_GenomesCES1 
Exome Variant ServerCES1
ExAC (Exome Aggregation Consortium)CES1 (select the gene name)
Genetic variants : HAPMAP1066
Genomic Variants (DGV)CES1 [DGVbeta]
DECIPHER (Syndromes)16:55836764-55867075  ENSG00000198848
CONAN: Copy Number AnalysisCES1 
Mutations
ICGC Data PortalCES1 
TCGA Data PortalCES1 
Broad Tumor PortalCES1
OASIS PortalCES1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCES1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CES1
DgiDB (Drug Gene Interaction Database)CES1
DoCM (Curated mutations)CES1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CES1 (select a term)
intoGenCES1
Cancer3DCES1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114835   
Orphanet
MedgenCES1
Genetic Testing Registry CES1
NextProtP23141 [Medical]
TSGene1066
GENETestsCES1
Huge Navigator CES1 [HugePedia]
snp3D : Map Gene to Disease1066
BioCentury BCIQCES1
ClinGenCES1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1066
Chemical/Pharm GKB GenePA107
Clinical trialCES1
Miscellaneous
canSAR (ICR)CES1 (select the gene name)
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCES1
EVEXCES1
GoPubMedCES1
iHOPCES1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:00:07 CET 2017

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