Identity
HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
CE-2,CES2A1,PCE-2,iCE
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8824
MIM: 605278
HGNC: 1864
Ensembl: ENSG00000172831
Variants:
dbSNP: 8824
ClinVar: 8824
TCGA: ENSG00000172831
COSMIC: CES2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164748728 | mycophenolic acid | Chemical | Pathway | associated | 24220207 | ||
| PA165110775 | SN-38 | Chemical | Pathway | associated | |||
| PA450085 | irinotecan | Chemical | Pathway | associated | |||
| PA450566 | mycophenolate mofetil | Chemical | Pathway | associated | 24220207 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35790245 | 2022 | The COVID-19 Oral Drug Molnupiravir Is a CES2 Substrate: Potential Drug-Drug Interactions and Impact of CES2 Genetic Polymorphism In Vitro. | 8 |
| 36113774 | 2022 | Carboxylesterase 2 induces mitochondrial dysfunction via disrupting lipid homeostasis in oral squamous cell carcinoma. | 7 |
| 35790245 | 2022 | The COVID-19 Oral Drug Molnupiravir Is a CES2 Substrate: Potential Drug-Drug Interactions and Impact of CES2 Genetic Polymorphism In Vitro. | 8 |
| 36113774 | 2022 | Carboxylesterase 2 induces mitochondrial dysfunction via disrupting lipid homeostasis in oral squamous cell carcinoma. | 7 |
| 33291124 | 2021 | Discovery of hCES2A inhibitors from Glycyrrhiza inflata via combination of docking-based virtual screening and fluorescence-based inhibition assays. | 6 |
| 33291124 | 2021 | Discovery of hCES2A inhibitors from Glycyrrhiza inflata via combination of docking-based virtual screening and fluorescence-based inhibition assays. | 6 |
| 31836607 | 2020 | Identification and Characterization of a New Carboxylesterase 2 Isozyme, mfCES2C, in the Small Intestine of Cynomolgus Monkeys. | 0 |
| 31981591 | 2020 | Overexpressed CES2 has prognostic value in CRC and knockdown CES2 reverses L-OHP-resistance in CRC cells by inhibition of the PI3K signaling pathway. | 10 |
| 32779042 | 2020 | LncRNA KCNQ1OT1 ameliorates the liver injury induced by acetaminophen through the regulation of miR-122-5p/CES2 axis. | 3 |
| 31836607 | 2020 | Identification and Characterization of a New Carboxylesterase 2 Isozyme, mfCES2C, in the Small Intestine of Cynomolgus Monkeys. | 0 |
| 31981591 | 2020 | Overexpressed CES2 has prognostic value in CRC and knockdown CES2 reverses L-OHP-resistance in CRC cells by inhibition of the PI3K signaling pathway. | 10 |
| 32779042 | 2020 | LncRNA KCNQ1OT1 ameliorates the liver injury induced by acetaminophen through the regulation of miR-122-5p/CES2 axis. | 3 |
| 30867471 | 2019 | Prognostic Impact of Carboxylesterase 2 in Cholangiocarcinoma. | 6 |
| 30867471 | 2019 | Prognostic Impact of Carboxylesterase 2 in Cholangiocarcinoma. | 6 |
| 28532270 | 2018 | Predominant contributions of carboxylesterase 1 and 2 in hydrolysis of anordrin in humans. | 0 |
Citation
Dessen P
CES2 (carboxylesterase 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43893/ces2
