CES2 (carboxylesterase 2)

2007-02-01  

Identity

HGNC
CES2
LOCATION
16q22.1
LOCUSID
8824
ALIAS
CE-2,CES2A1,PCE-2,iCE
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8824
MIM: 605278
HGNC: 1864
Ensembl: ENSG00000172831

Variants:

dbSNP: 8824
ClinVar: 8824
TCGA: ENSG00000172831
COSMIC: CES2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172831ENST00000317091O00748
ENSG00000172831ENST00000417689O00748
ENSG00000172831ENST00000561697J3QLP1
ENSG00000172831ENST00000564420J3QSC0
ENSG00000172831ENST00000568470H3BUN5
ENSG00000172831ENST00000570032H3BUN5

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Drug metabolism - other enzymesKEGGko00983
Drug metabolism - other enzymesKEGGhsa00983
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164748728mycophenolic acidChemicalPathwayassociated24220207
PA165110775SN-38ChemicalPathwayassociated
PA450085irinotecanChemicalPathwayassociated
PA450566mycophenolate mofetilChemicalPathwayassociated24220207

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
193495402009Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.74
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
129601092003Irinotecan pathway genotype analysis to predict pharmacokinetics.43
189838292009Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin.43
175378332007Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2.31
177647012007Carboxylesterase in the liver and small intestine of experimental animals and human.30
199566352009Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.27
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
195081812009Human carboxylesterases: an update on CES1, CES2 and CES3.26

Citation

Dessen P

CES2 (carboxylesterase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43893/ces2