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CES2 (carboxylesterase 2)

Identity

Alias_namescarboxylesterase 2 (intestine
Alias_symbol (synonym)CE-2
iCE
CES2A1
Other aliasPCE-2
HGNC (Hugo) CES2
LocusID (NCBI) 8824
Atlas_Id 43893
Location 16q22.1  [Link to chromosome band 16q22]
Location_base_pair Starts at 66934444 and ends at 66945091 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CES2 (16q22.1) / CCDC92 (12q24.31)CES2 (16q22.1) / CES2 (16q22.1)CES2 (16q22.1) / EEF2 (19p13.3)
CTCF (16q22.1) / CES2 (16q22.1)ECE1 (1p36.12) / CES2 (16q22.1)PTTG1IP (21q22.3) / CES2 (16q22.1)
CTCF 16q22.1 / CES2 16q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CES2   1864
Cards
Entrez_Gene (NCBI)CES2  8824  carboxylesterase 2
AliasesCE-2; CES2A1; PCE-2; iCE
GeneCards (Weizmann)CES2
Ensembl hg19 (Hinxton)ENSG00000172831 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172831 [Gene_View]  chr16:66934444-66945091 [Contig_View]  CES2 [Vega]
ICGC DataPortalENSG00000172831
TCGA cBioPortalCES2
AceView (NCBI)CES2
Genatlas (Paris)CES2
WikiGenes8824
SOURCE (Princeton)CES2
Genetics Home Reference (NIH)CES2
Genomic and cartography
GoldenPath hg38 (UCSC)CES2  -     chr16:66934444-66945091 +  16q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CES2  -     16q22.1   [Description]    (hg19-Feb_2009)
EnsemblCES2 - 16q22.1 [CytoView hg19]  CES2 - 16q22.1 [CytoView hg38]
Mapping of homologs : NCBICES2 [Mapview hg19]  CES2 [Mapview hg38]
OMIM605278   
Gene and transcription
Genbank (Entrez)AI601196 AK095522 AK222724 AK290482 AL713761
RefSeq transcript (Entrez)NM_003869 NM_198061
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CES2
Cluster EST : UnigeneHs.282975 [ NCBI ]
CGAP (NCI)Hs.282975
Alternative Splicing GalleryENSG00000172831
Gene ExpressionCES2 [ NCBI-GEO ]   CES2 [ EBI - ARRAY_EXPRESS ]   CES2 [ SEEK ]   CES2 [ MEM ]
Gene Expression Viewer (FireBrowse)CES2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8824
GTEX Portal (Tissue expression)CES2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00748   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00748  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00748
Splice isoforms : SwissVarO00748
Catalytic activity : Enzyme3.1.1.84 [ Enzyme-Expasy ]   3.1.1.843.1.1.84 [ IntEnz-EBI ]   3.1.1.84 [ BRENDA ]   3.1.1.84 [ KEGG ]   
PhosPhoSitePlusO00748
Domaine pattern : Prosite (Expaxy)CARBOXYLESTERASE_B_1 (PS00122)    CARBOXYLESTERASE_B_2 (PS00941)   
Domains : Interpro (EBI)AB_hydrolase    CarbesteraseB    Carboxylesterase_B_AS    Carboxylesterase_B_CS   
Domain families : Pfam (Sanger)COesterase (PF00135)   
Domain families : Pfam (NCBI)pfam00135   
Conserved Domain (NCBI)CES2
DMDM Disease mutations8824
Blocks (Seattle)CES2
SuperfamilyO00748
Human Protein AtlasENSG00000172831
Peptide AtlasO00748
HPRD07062
IPIIPI00419920   IPI00332828   
Protein Interaction databases
DIP (DOE-UCLA)O00748
IntAct (EBI)O00748
FunCoupENSG00000172831
BioGRIDCES2
STRING (EMBL)CES2
ZODIACCES2
Ontologies - Pathways
QuickGOO00748
Ontology : AmiGOendoplasmic reticulum  endoplasmic reticulum lumen  xenobiotic metabolic process  catabolic process  methylumbelliferyl-acetate deacetylase activity  carboxylic ester hydrolase activity  carboxylic ester hydrolase activity  
Ontology : EGO-EBIendoplasmic reticulum  endoplasmic reticulum lumen  xenobiotic metabolic process  catabolic process  methylumbelliferyl-acetate deacetylase activity  carboxylic ester hydrolase activity  carboxylic ester hydrolase activity  
Pathways : KEGGDrug metabolism - other enzymes   
NDEx NetworkCES2
Atlas of Cancer Signalling NetworkCES2
Wikipedia pathwaysCES2
Orthology - Evolution
OrthoDB8824
GeneTree (enSembl)ENSG00000172831
Phylogenetic Trees/Animal Genes : TreeFamCES2
HOVERGENO00748
HOGENOMO00748
Homologs : HomoloGeneCES2
Homology/Alignments : Family Browser (UCSC)CES2
Gene fusions - Rearrangements
Fusion : MitelmanCTCF/CES2 [16q22.1/16q22.1]  [t(16;16)(q22;q22)]  
Fusion: TCGACTCF 16q22.1 CES2 16q22.1 SKCM
Fusion Cancer (Beijing)CES2 [16q22.1]  -  EEF2 [19p13.3]  [FUSC000267]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCES2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CES2
dbVarCES2
ClinVarCES2
1000_GenomesCES2 
Exome Variant ServerCES2
ExAC (Exome Aggregation Consortium)CES2 (select the gene name)
Genetic variants : HAPMAP8824
Genomic Variants (DGV)CES2 [DGVbeta]
DECIPHERCES2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCES2 
Mutations
ICGC Data PortalCES2 
TCGA Data PortalCES2 
Broad Tumor PortalCES2
OASIS PortalCES2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCES2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCES2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CES2
DgiDB (Drug Gene Interaction Database)CES2
DoCM (Curated mutations)CES2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CES2 (select a term)
intoGenCES2
Cancer3DCES2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605278   
Orphanet
MedgenCES2
Genetic Testing Registry CES2
NextProtO00748 [Medical]
TSGene8824
GENETestsCES2
Target ValidationCES2
Huge Navigator CES2 [HugePedia]
snp3D : Map Gene to Disease8824
BioCentury BCIQCES2
ClinGenCES2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8824
Chemical/Pharm GKB GenePA377
Clinical trialCES2
Miscellaneous
canSAR (ICR)CES2 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCES2
EVEXCES2
GoPubMedCES2
iHOPCES2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:02:05 CEST 2017

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