Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CES4A (carboxylesterase 4A)

Identity

Alias_namesCES8
carboxylesterase 8 (putative)
Alias_symbol (synonym)FLJ37464
Other aliasCES6
HGNC (Hugo) CES4A
LocusID (NCBI) 283848
Atlas_Id 61745
Location 16q22.1  [Link to chromosome band 16q22]
Location_base_pair Starts at 67000513 and ends at 67009756 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CBFB (16q22.1) / CES4A (16q22.1)CES4A (16q22.1) / AKT2 (19q13.2)COL7A1 (3p21.31) / CES4A (16q22.1)
TNFSF10 (3q26.31) / CES4A (16q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(16;16)(q22;q22) CBFB/CES4A

External links

Nomenclature
HGNC (Hugo)CES4A   26741
Cards
Entrez_Gene (NCBI)CES4A  283848  carboxylesterase 4A
AliasesCES6; CES8
GeneCards (Weizmann)CES4A
Ensembl hg19 (Hinxton)ENSG00000172824 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172824 [Gene_View]  ENSG00000172824 [Sequence]  chr16:67000513-67009756 [Contig_View]  CES4A [Vega]
ICGC DataPortalENSG00000172824
TCGA cBioPortalCES4A
AceView (NCBI)CES4A
Genatlas (Paris)CES4A
WikiGenes283848
SOURCE (Princeton)CES4A
Genetics Home Reference (NIH)CES4A
Genomic and cartography
GoldenPath hg38 (UCSC)CES4A  -     chr16:67000513-67009756 +  16q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CES4A  -     16q22.1   [Description]    (hg19-Feb_2009)
EnsemblCES4A - 16q22.1 [CytoView hg19]  CES4A - 16q22.1 [CytoView hg38]
Mapping of homologs : NCBICES4A [Mapview hg19]  CES4A [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA846813 AK094321 AK094783 AK293061 AK295483
RefSeq transcript (Entrez)NM_001190201 NM_001190202 NM_001318506 NM_173815
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CES4A
Cluster EST : UnigeneHs.734986 [ NCBI ]
CGAP (NCI)Hs.734986
Alternative Splicing GalleryENSG00000172824
Gene ExpressionCES4A [ NCBI-GEO ]   CES4A [ EBI - ARRAY_EXPRESS ]   CES4A [ SEEK ]   CES4A [ MEM ]
Gene Expression Viewer (FireBrowse)CES4A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)283848
GTEX Portal (Tissue expression)CES4A
Human Protein AtlasENSG00000172824-CES4A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5XG92   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5XG92  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5XG92
Splice isoforms : SwissVarQ5XG92
Catalytic activity : Enzyme3.1.1.- [ Enzyme-Expasy ]   3.1.1.-3.1.1.- [ IntEnz-EBI ]   3.1.1.- [ BRENDA ]   3.1.1.- [ KEGG ]   
PhosPhoSitePlusQ5XG92
Domaine pattern : Prosite (Expaxy)CARBOXYLESTERASE_B_1 (PS00122)    CARBOXYLESTERASE_B_2 (PS00941)   
Domains : Interpro (EBI)AB_hydrolase    CarbesteraseB    Carboxylesterase_B_AS    Carboxylesterase_B_CS   
Domain families : Pfam (Sanger)COesterase (PF00135)   
Domain families : Pfam (NCBI)pfam00135   
Conserved Domain (NCBI)CES4A
DMDM Disease mutations283848
Blocks (Seattle)CES4A
SuperfamilyQ5XG92
Human Protein Atlas [tissue]ENSG00000172824-CES4A [tissue]
Peptide AtlasQ5XG92
HPRD07116
IPIIPI00640345   IPI00411985   IPI00167706   IPI00973352   IPI00973041   IPI00872564   IPI01009540   IPI00971162   IPI01018938   IPI01015828   
Protein Interaction databases
DIP (DOE-UCLA)Q5XG92
IntAct (EBI)Q5XG92
FunCoupENSG00000172824
BioGRIDCES4A
STRING (EMBL)CES4A
ZODIACCES4A
Ontologies - Pathways
QuickGOQ5XG92
Ontology : AmiGOextracellular region  carboxylic ester hydrolase activity  
Ontology : EGO-EBIextracellular region  carboxylic ester hydrolase activity  
NDEx NetworkCES4A
Atlas of Cancer Signalling NetworkCES4A
Wikipedia pathwaysCES4A
Orthology - Evolution
OrthoDB283848
GeneTree (enSembl)ENSG00000172824
Phylogenetic Trees/Animal Genes : TreeFamCES4A
HOVERGENQ5XG92
HOGENOMQ5XG92
Homologs : HomoloGeneCES4A
Homology/Alignments : Family Browser (UCSC)CES4A
Gene fusions - Rearrangements
Fusion : QuiverCES4A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCES4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CES4A
dbVarCES4A
ClinVarCES4A
1000_GenomesCES4A 
Exome Variant ServerCES4A
ExAC (Exome Aggregation Consortium)ENSG00000172824
GNOMAD BrowserENSG00000172824
Varsome BrowserCES4A
Genetic variants : HAPMAP283848
Genomic Variants (DGV)CES4A [DGVbeta]
DECIPHERCES4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCES4A 
Mutations
ICGC Data PortalCES4A 
TCGA Data PortalCES4A 
Broad Tumor PortalCES4A
OASIS PortalCES4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCES4A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCES4A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CES4A
DgiDB (Drug Gene Interaction Database)CES4A
DoCM (Curated mutations)CES4A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CES4A (select a term)
intoGenCES4A
Cancer3DCES4A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETCES4A
MedgenCES4A
Genetic Testing Registry CES4A
NextProtQ5XG92 [Medical]
TSGene283848
GENETestsCES4A
Target ValidationCES4A
Huge Navigator CES4A [HugePedia]
snp3D : Map Gene to Disease283848
BioCentury BCIQCES4A
ClinGenCES4A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD283848
Chemical/Pharm GKB GenePA164717904
Clinical trialCES4A
Miscellaneous
canSAR (ICR)CES4A (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCES4A
EVEXCES4A
GoPubMedCES4A
iHOPCES4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 13:40:25 CEST 2018
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