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CFL1 (cofilin 1)

Identity

Alias_namesCFL
cofilin 1 (non-muscle)
Other aliasHEL-S-15
cofilin
HGNC (Hugo) CFL1
LocusID (NCBI) 1072
Atlas_Id 40064
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 65854814 and ends at 65858333 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CAPZB (1p36.13) / CFL1 (11q13.1)CFL1 (11q13.1) / CCDC88C (14q32.11)CFL1 (11q13.1) / CFL1 (11q13.1)
CFL1 (11q13.1) / EED (11q14.2)CFL1 (11q13.1) / MTPN (7q33)CFL1 (11q13.1) / TXNDC5 (6p24.3)
CFL1 (11q13.1) / ZC3H12A (1p34.3)MCRS1 (12q13.12) / CFL1 (11q13.1)SLC29A4 (7p22.1) / CFL1 (11q13.1)
CAPZB 1p36.13 / CFL1 11q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;11)(p36;q13) CAPZB/CFL1


External links

Nomenclature
HGNC (Hugo)CFL1   1874
Cards
Entrez_Gene (NCBI)CFL1  1072  cofilin 1
AliasesCFL; HEL-S-15; cofilin
GeneCards (Weizmann)CFL1
Ensembl hg19 (Hinxton)ENSG00000172757 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172757 [Gene_View]  ENSG00000172757 [Sequence]  chr11:65854814-65858333 [Contig_View]  CFL1 [Vega]
ICGC DataPortalENSG00000172757
TCGA cBioPortalCFL1
AceView (NCBI)CFL1
Genatlas (Paris)CFL1
WikiGenes1072
SOURCE (Princeton)CFL1
Genetics Home Reference (NIH)CFL1
Genomic and cartography
GoldenPath hg38 (UCSC)CFL1  -     chr11:65854814-65858333 -  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CFL1  -     11q13.1   [Description]    (hg19-Feb_2009)
EnsemblCFL1 - 11q13.1 [CytoView hg19]  CFL1 - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBICFL1 [Mapview hg19]  CFL1 [Mapview hg38]
OMIM601442   
Gene and transcription
Genbank (Entrez)AK097690 AK303614 BC011005 BC012265 BC012318
RefSeq transcript (Entrez)NM_005507
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CFL1
Cluster EST : UnigeneHs.170622 [ NCBI ]
CGAP (NCI)Hs.170622
Alternative Splicing GalleryENSG00000172757
Gene ExpressionCFL1 [ NCBI-GEO ]   CFL1 [ EBI - ARRAY_EXPRESS ]   CFL1 [ SEEK ]   CFL1 [ MEM ]
Gene Expression Viewer (FireBrowse)CFL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1072
GTEX Portal (Tissue expression)CFL1
Human Protein AtlasENSG00000172757-CFL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23528   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23528  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23528
Splice isoforms : SwissVarP23528
PhosPhoSitePlusP23528
Domaine pattern : Prosite (Expaxy)ADF_H (PS51263)   
Domains : Interpro (EBI)ADF-H    ADF-H/Gelsolin-like_dom_sf    ADF/Cofilin    Cofilin_1   
Domain families : Pfam (Sanger)Cofilin_ADF (PF00241)   
Domain families : Pfam (NCBI)pfam00241   
Domain families : Smart (EMBL)ADF (SM00102)  
Conserved Domain (NCBI)CFL1
DMDM Disease mutations1072
Blocks (Seattle)CFL1
PDB (RSDB)1Q8G    1Q8X    3J0S    4BEX    5HVK    5L6W   
PDB Europe1Q8G    1Q8X    3J0S    4BEX    5HVK    5L6W   
PDB (PDBSum)1Q8G    1Q8X    3J0S    4BEX    5HVK    5L6W   
PDB (IMB)1Q8G    1Q8X    3J0S    4BEX    5HVK    5L6W   
Structural Biology KnowledgeBase1Q8G    1Q8X    3J0S    4BEX    5HVK    5L6W   
SCOP (Structural Classification of Proteins)1Q8G    1Q8X    3J0S    4BEX    5HVK    5L6W   
CATH (Classification of proteins structures)1Q8G    1Q8X    3J0S    4BEX    5HVK    5L6W   
SuperfamilyP23528
Human Protein Atlas [tissue]ENSG00000172757-CFL1 [tissue]
Peptide AtlasP23528
HPRD03261
IPIIPI00012011   IPI00978796   IPI00984795   IPI00979518   IPI01018892   IPI00979735   IPI00978302   
Protein Interaction databases
DIP (DOE-UCLA)P23528
IntAct (EBI)P23528
FunCoupENSG00000172757
BioGRIDCFL1
STRING (EMBL)CFL1
ZODIACCFL1
Ontologies - Pathways
QuickGOP23528
Ontology : AmiGOmitotic cytokinesis  neural crest cell migration  neural fold formation  signaling receptor binding  protein binding  extracellular space  nucleus  cytoplasm  cytoplasm  cytosol  cell-cell junction  focal adhesion  protein phosphorylation  cytoskeleton organization  Rho protein signal transduction  response to virus  membrane  nuclear matrix  regulation of cell morphogenesis  establishment of cell polarity  lamellipodium  actin cytoskeleton organization  actin filament depolymerization  actin filament depolymerization  actin filament fragmentation  positive regulation of actin filament depolymerization  cortical actin cytoskeleton  lamellipodium membrane  vesicle  ruffle membrane  interleukin-12-mediated signaling pathway  negative regulation of apoptotic process  response to amino acid  positive regulation by host of viral process  actin filament binding  actin filament binding  regulation of dendritic spine morphogenesis  extracellular exosome  
Ontology : EGO-EBImitotic cytokinesis  neural crest cell migration  neural fold formation  signaling receptor binding  protein binding  extracellular space  nucleus  cytoplasm  cytoplasm  cytosol  cell-cell junction  focal adhesion  protein phosphorylation  cytoskeleton organization  Rho protein signal transduction  response to virus  membrane  nuclear matrix  regulation of cell morphogenesis  establishment of cell polarity  lamellipodium  actin cytoskeleton organization  actin filament depolymerization  actin filament depolymerization  actin filament fragmentation  positive regulation of actin filament depolymerization  cortical actin cytoskeleton  lamellipodium membrane  vesicle  ruffle membrane  interleukin-12-mediated signaling pathway  negative regulation of apoptotic process  response to amino acid  positive regulation by host of viral process  actin filament binding  actin filament binding  regulation of dendritic spine morphogenesis  extracellular exosome  
Pathways : KEGGAxon guidance    Fc gamma R-mediated phagocytosis    Regulation of actin cytoskeleton    Pertussis   
NDEx NetworkCFL1
Atlas of Cancer Signalling NetworkCFL1
Wikipedia pathwaysCFL1
Orthology - Evolution
OrthoDB1072
GeneTree (enSembl)ENSG00000172757
Phylogenetic Trees/Animal Genes : TreeFamCFL1
HOGENOMP23528
Homologs : HomoloGeneCFL1
Homology/Alignments : Family Browser (UCSC)CFL1
Gene fusions - Rearrangements
Fusion : MitelmanCAPZB/CFL1 [1p36.13/11q13.1]  [t(1;11)(p36;q13)]  
Fusion PortalCAPZB 1p36.13 CFL1 11q13.1 PRAD
Fusion : QuiverCFL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCFL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CFL1
dbVarCFL1
ClinVarCFL1
1000_GenomesCFL1 
Exome Variant ServerCFL1
ExAC (Exome Aggregation Consortium)ENSG00000172757
GNOMAD BrowserENSG00000172757
Varsome BrowserCFL1
Genetic variants : HAPMAP1072
Genomic Variants (DGV)CFL1 [DGVbeta]
DECIPHERCFL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCFL1 
Mutations
ICGC Data PortalCFL1 
TCGA Data PortalCFL1 
Broad Tumor PortalCFL1
OASIS PortalCFL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCFL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCFL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CFL1
DgiDB (Drug Gene Interaction Database)CFL1
DoCM (Curated mutations)CFL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CFL1 (select a term)
intoGenCFL1
Cancer3DCFL1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601442   
Orphanet
DisGeNETCFL1
MedgenCFL1
Genetic Testing Registry CFL1
NextProtP23528 [Medical]
TSGene1072
GENETestsCFL1
Target ValidationCFL1
Huge Navigator CFL1 [HugePedia]
snp3D : Map Gene to Disease1072
BioCentury BCIQCFL1
ClinGenCFL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1072
Chemical/Pharm GKB GenePA26423
Clinical trialCFL1
Miscellaneous
canSAR (ICR)CFL1 (select the gene name)
DataMed IndexCFL1
Probes
Litterature
PubMed284 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCFL1
EVEXCFL1
GoPubMedCFL1
iHOPCFL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 17 18:06:10 CET 2019

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