CFL1 (cofilin 1)

2003-06-01  

Identity

HGNC
LOCATION
11q13.1
LOCUSID
ALIAS
CFL,HEL-S-15,cofilin
FUSION GENES

Other Information

Locus ID:

NCBI: 1072
MIM: 601442
HGNC: 1874
Ensembl: ENSG00000172757

Variants:

dbSNP: 1072
ClinVar: 1072
TCGA: ENSG00000172757
COSMIC: CFL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172757ENST00000308162P23528
ENSG00000172757ENST00000308162V9HWI5
ENSG00000172757ENST00000524553G3V1A4
ENSG00000172757ENST00000525451P23528
ENSG00000172757ENST00000525451V9HWI5
ENSG00000172757ENST00000526975E9PS23
ENSG00000172757ENST00000527344G3V1A4
ENSG00000172757ENST00000530413E9PQB7
ENSG00000172757ENST00000531407G3V1A4
ENSG00000172757ENST00000531413G3V1A4
ENSG00000172757ENST00000532134E9PP50
ENSG00000172757ENST00000534769E9PK25
ENSG00000172757ENST00000534784E9PLJ3

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Regulation of actin cytoskeletonKEGGko04810
Axon guidanceKEGGhsa04360
Regulation of actin cytoskeletonKEGGhsa04810
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
PertussisKEGGko05133
PertussisKEGGhsa05133
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Sema3A PAK dependent Axon repulsionREACTOMER-HSA-399954
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
187753112008HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells.151
156601332005Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin.94
146346652003Mitochondrial translocation of cofilin is an early step in apoptosis induction.90
156710202005Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin.80
197348902009Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin.76
151594162004A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia.75
193392772009Reactive oxygen species regulate a slingshot-cofilin activation pathway.75
196836832009HIV-1 Nef interferes with host cell motility by deregulation of Cofilin.67
217238252011Cofilin-linked changes in actin filament flexibility promote severing.63
195676722009Protein kinase D regulates cell migration by direct phosphorylation of the cofilin phosphatase slingshot 1 like.59

Citation

Dessen P

CFL1 (cofilin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40064/cfl1