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CFL2 (cofilin 2)

Identity

Alias_namescofilin 2 (muscle)
Alias_symbol (synonym)NEM7
Other alias
HGNC (Hugo) CFL2
LocusID (NCBI) 1073
Atlas_Id 52583
Location 14q13.1  [Link to chromosome band 14q13]
Location_base_pair Starts at 34710382 and ends at 34714555 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CFL2 (14q13.1) / NOSTRIN (2q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CFL2   1875
LRG (Locus Reference Genomic)LRG_213
Cards
Entrez_Gene (NCBI)CFL2  1073  cofilin 2
AliasesNEM7
GeneCards (Weizmann)CFL2
Ensembl hg19 (Hinxton)ENSG00000165410 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165410 [Gene_View]  chr14:34710382-34714555 [Contig_View]  CFL2 [Vega]
ICGC DataPortalENSG00000165410
TCGA cBioPortalCFL2
AceView (NCBI)CFL2
Genatlas (Paris)CFL2
WikiGenes1073
SOURCE (Princeton)CFL2
Genetics Home Reference (NIH)CFL2
Genomic and cartography
GoldenPath hg38 (UCSC)CFL2  -     chr14:34710382-34714555 -  14q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CFL2  -     14q13.1   [Description]    (hg19-Feb_2009)
EnsemblCFL2 - 14q13.1 [CytoView hg19]  CFL2 - 14q13.1 [CytoView hg38]
Mapping of homologs : NCBICFL2 [Mapview hg19]  CFL2 [Mapview hg38]
OMIM601443   610687   
Gene and transcription
Genbank (Entrez)AF087867 AF134802 AF134803 AI754134 AK314157
RefSeq transcript (Entrez)NM_001243645 NM_021914 NM_138638
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CFL2
Cluster EST : UnigeneHs.180141 [ NCBI ]
CGAP (NCI)Hs.180141
Alternative Splicing GalleryENSG00000165410
Gene ExpressionCFL2 [ NCBI-GEO ]   CFL2 [ EBI - ARRAY_EXPRESS ]   CFL2 [ SEEK ]   CFL2 [ MEM ]
Gene Expression Viewer (FireBrowse)CFL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1073
GTEX Portal (Tissue expression)CFL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y281   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y281  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y281
Splice isoforms : SwissVarQ9Y281
PhosPhoSitePlusQ9Y281
Domaine pattern : Prosite (Expaxy)ADF_H (PS51263)   
Domains : Interpro (EBI)ADF-H    ADF-H/Gelsolin-like_dom    ADF/Cofilin   
Domain families : Pfam (Sanger)Cofilin_ADF (PF00241)   
Domain families : Pfam (NCBI)pfam00241   
Domain families : Smart (EMBL)ADF (SM00102)  
Conserved Domain (NCBI)CFL2
DMDM Disease mutations1073
Blocks (Seattle)CFL2
SuperfamilyQ9Y281
Human Protein AtlasENSG00000165410
Peptide AtlasQ9Y281
HPRD03262
IPIIPI00413344   IPI01025275   IPI01026568   IPI00893115   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y281
IntAct (EBI)Q9Y281
FunCoupENSG00000165410
BioGRIDCFL2
STRING (EMBL)CFL2
ZODIACCFL2
Ontologies - Pathways
QuickGOQ9Y281
Ontology : AmiGOprotein binding  extracellular space  skeletal muscle tissue development  actin cytoskeleton  nuclear matrix  Z disc  actin filament depolymerization  actin filament depolymerization  actin filament fragmentation  positive regulation of actin filament depolymerization  I band  sarcomere organization  muscle cell cellular homeostasis  actin filament binding  extracellular exosome  
Ontology : EGO-EBIprotein binding  extracellular space  skeletal muscle tissue development  actin cytoskeleton  nuclear matrix  Z disc  actin filament depolymerization  actin filament depolymerization  actin filament fragmentation  positive regulation of actin filament depolymerization  I band  sarcomere organization  muscle cell cellular homeostasis  actin filament binding  extracellular exosome  
Pathways : KEGGAxon guidance    Fc gamma R-mediated phagocytosis    Regulation of actin cytoskeleton    Pertussis   
NDEx NetworkCFL2
Atlas of Cancer Signalling NetworkCFL2
Wikipedia pathwaysCFL2
Orthology - Evolution
OrthoDB1073
GeneTree (enSembl)ENSG00000165410
Phylogenetic Trees/Animal Genes : TreeFamCFL2
HOVERGENQ9Y281
HOGENOMQ9Y281
Homologs : HomoloGeneCFL2
Homology/Alignments : Family Browser (UCSC)CFL2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCFL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CFL2
dbVarCFL2
ClinVarCFL2
1000_GenomesCFL2 
Exome Variant ServerCFL2
ExAC (Exome Aggregation Consortium)CFL2 (select the gene name)
Genetic variants : HAPMAP1073
Genomic Variants (DGV)CFL2 [DGVbeta]
DECIPHERCFL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCFL2 
Mutations
ICGC Data PortalCFL2 
TCGA Data PortalCFL2 
Broad Tumor PortalCFL2
OASIS PortalCFL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCFL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCFL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CFL2
DgiDB (Drug Gene Interaction Database)CFL2
DoCM (Curated mutations)CFL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CFL2 (select a term)
intoGenCFL2
Cancer3DCFL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601443    610687   
Orphanet17908   
MedgenCFL2
Genetic Testing Registry CFL2
NextProtQ9Y281 [Medical]
TSGene1073
GENETestsCFL2
Huge Navigator CFL2 [HugePedia]
snp3D : Map Gene to Disease1073
BioCentury BCIQCFL2
ClinGenCFL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1073
Chemical/Pharm GKB GenePA26424
Clinical trialCFL2
Miscellaneous
canSAR (ICR)CFL2 (select the gene name)
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCFL2
EVEXCFL2
GoPubMedCFL2
iHOPCFL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:10:21 CEST 2017

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