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CGAS (cyclic GMP-AMP synthase)

Identity

Other aliasC6orf150
MB21D1
h-cGAS
HGNC (Hugo) CGAS
LocusID (NCBI) 115004
Atlas_Id 57109
Location 6q13  [Link to chromosome band 6q13]
Location_base_pair Starts at 73425133 and ends at 73452320 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)CGAS   21367
Cards
Entrez_Gene (NCBI)CGAS  115004  cyclic GMP-AMP synthase
AliasesC6orf150; MB21D1; h-cGAS
GeneCards (Weizmann)CGAS
Ensembl hg19 (Hinxton)ENSG00000164430 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164430 [Gene_View]  ENSG00000164430 [Sequence]  chr6:73425133-73452320 [Contig_View]  CGAS [Vega]
ICGC DataPortalENSG00000164430
TCGA cBioPortalCGAS
AceView (NCBI)CGAS
Genatlas (Paris)CGAS
WikiGenes115004
SOURCE (Princeton)CGAS
Genetics Home Reference (NIH)CGAS
Genomic and cartography
GoldenPath hg38 (UCSC)CGAS  -     chr6:73425133-73452320 -  6q13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CGAS  -     6q13   [Description]    (hg19-Feb_2009)
EnsemblCGAS - 6q13 [CytoView hg19]  CGAS - 6q13 [CytoView hg38]
Mapping of homologs : NCBICGAS [Mapview hg19]  CGAS [Mapview hg38]
OMIM613973   
Gene and transcription
Genbank (Entrez)AK097148 BC012928 BC108714 BC113606 BC113608
RefSeq transcript (Entrez)NM_138441
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CGAS
Cluster EST : UnigeneHs.658405 [ NCBI ]
CGAP (NCI)Hs.658405
Alternative Splicing GalleryENSG00000164430
Gene ExpressionCGAS [ NCBI-GEO ]   CGAS [ EBI - ARRAY_EXPRESS ]   CGAS [ SEEK ]   CGAS [ MEM ]
Gene Expression Viewer (FireBrowse)CGAS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)115004
GTEX Portal (Tissue expression)CGAS
Human Protein AtlasENSG00000164430-CGAS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N884   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N884  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N884
Splice isoforms : SwissVarQ8N884
PhosPhoSitePlusQ8N884
Domains : Interpro (EBI)Mab-21_dom   
Domain families : Pfam (Sanger)Mab-21 (PF03281)   
Domain families : Pfam (NCBI)pfam03281   
Domain families : Smart (EMBL)Mab-21 (SM01265)  
Conserved Domain (NCBI)CGAS
DMDM Disease mutations115004
Blocks (Seattle)CGAS
PDB (SRS)4KM5    4LEV    4LEW    4MKP    4O67    4O68    4O69    5V8H    5V8J    5V8N    5V8O    5VDO    5VDP    5VDQ    5VDR    5VDS    5VDT    5VDU    5VDV    5VDW   
PDB (PDBSum)4KM5    4LEV    4LEW    4MKP    4O67    4O68    4O69    5V8H    5V8J    5V8N    5V8O    5VDO    5VDP    5VDQ    5VDR    5VDS    5VDT    5VDU    5VDV    5VDW   
PDB (IMB)4KM5    4LEV    4LEW    4MKP    4O67    4O68    4O69    5V8H    5V8J    5V8N    5V8O    5VDO    5VDP    5VDQ    5VDR    5VDS    5VDT    5VDU    5VDV    5VDW   
PDB (RSDB)4KM5    4LEV    4LEW    4MKP    4O67    4O68    4O69    5V8H    5V8J    5V8N    5V8O    5VDO    5VDP    5VDQ    5VDR    5VDS    5VDT    5VDU    5VDV    5VDW   
Structural Biology KnowledgeBase4KM5    4LEV    4LEW    4MKP    4O67    4O68    4O69    5V8H    5V8J    5V8N    5V8O    5VDO    5VDP    5VDQ    5VDR    5VDS    5VDT    5VDU    5VDV    5VDW   
SCOP (Structural Classification of Proteins)4KM5    4LEV    4LEW    4MKP    4O67    4O68    4O69    5V8H    5V8J    5V8N    5V8O    5VDO    5VDP    5VDQ    5VDR    5VDS    5VDT    5VDU    5VDV    5VDW   
CATH (Classification of proteins structures)4KM5    4LEV    4LEW    4MKP    4O67    4O68    4O69    5V8H    5V8J    5V8N    5V8O    5VDO    5VDP    5VDQ    5VDR    5VDS    5VDT    5VDU    5VDV    5VDW   
SuperfamilyQ8N884
Human Protein Atlas [tissue]ENSG00000164430-CGAS [tissue]
Peptide AtlasQ8N884
IPIIPI00298007   IPI00607846   IPI00853050   
Protein Interaction databases
DIP (DOE-UCLA)Q8N884
IntAct (EBI)Q8N884
FunCoupENSG00000164430
BioGRIDCGAS
STRING (EMBL)CGAS
ZODIACCGAS
Ontologies - Pathways
QuickGOQ8N884
Ontology : AmiGOactivation of innate immune response  activation of innate immune response  positive regulation of defense response to virus by host  positive regulation of defense response to virus by host  DNA binding  chromatin binding  double-stranded DNA binding  protein binding  ATP binding  GTP binding  cytosol  cytosol  cellular response to DNA damage stimulus  positive regulation of cGMP-mediated signaling  positive regulation of type I interferon production  positive regulation of type I interferon production  paracrine signaling  positive regulation of cAMP-mediated signaling  innate immune response  metal ion binding  defense response to virus  cyclic-GMP-AMP synthase activity  cyclic-GMP-AMP synthase activity  cellular response to exogenous dsRNA  positive regulation of cellular senescence  
Ontology : EGO-EBIactivation of innate immune response  activation of innate immune response  positive regulation of defense response to virus by host  positive regulation of defense response to virus by host  DNA binding  chromatin binding  double-stranded DNA binding  protein binding  ATP binding  GTP binding  cytosol  cytosol  cellular response to DNA damage stimulus  positive regulation of cGMP-mediated signaling  positive regulation of type I interferon production  positive regulation of type I interferon production  paracrine signaling  positive regulation of cAMP-mediated signaling  innate immune response  metal ion binding  defense response to virus  cyclic-GMP-AMP synthase activity  cyclic-GMP-AMP synthase activity  cellular response to exogenous dsRNA  positive regulation of cellular senescence  
NDEx NetworkCGAS
Atlas of Cancer Signalling NetworkCGAS
Wikipedia pathwaysCGAS
Orthology - Evolution
OrthoDB115004
GeneTree (enSembl)ENSG00000164430
Phylogenetic Trees/Animal Genes : TreeFamCGAS
HOVERGENQ8N884
HOGENOMQ8N884
Homologs : HomoloGeneCGAS
Homology/Alignments : Family Browser (UCSC)CGAS
Gene fusions - Rearrangements
Fusion : QuiverCGAS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCGAS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CGAS
dbVarCGAS
ClinVarCGAS
1000_GenomesCGAS 
Exome Variant ServerCGAS
ExAC (Exome Aggregation Consortium)ENSG00000164430
GNOMAD BrowserENSG00000164430
Varsome BrowserCGAS
Genetic variants : HAPMAP115004
Genomic Variants (DGV)CGAS [DGVbeta]
DECIPHERCGAS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCGAS 
Mutations
ICGC Data PortalCGAS 
TCGA Data PortalCGAS 
Broad Tumor PortalCGAS
OASIS PortalCGAS [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCGAS
BioMutasearch CGAS
DgiDB (Drug Gene Interaction Database)CGAS
DoCM (Curated mutations)CGAS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CGAS (select a term)
intoGenCGAS
Cancer3DCGAS(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613973   
Orphanet
DisGeNETCGAS
MedgenCGAS
Genetic Testing Registry CGAS
NextProtQ8N884 [Medical]
TSGene115004
GENETestsCGAS
Target ValidationCGAS
Huge Navigator CGAS [HugePedia]
snp3D : Map Gene to Disease115004
BioCentury BCIQCGAS
ClinGenCGAS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD115004
Chemical/Pharm GKB GenePA134956015
Clinical trialCGAS
Miscellaneous
canSAR (ICR)CGAS (select the gene name)
Probes
Litterature
PubMed74 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCGAS
EVEXCGAS
GoPubMedCGAS
iHOPCGAS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 10:57:56 CET 2018

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