CGN (cingulin)

2012-09-01  

Identity

HGNC
LOCATION
1q21.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 57530
MIM: 609473
HGNC: 17429
Ensembl: ENSG00000143375

Variants:

dbSNP: 57530
ClinVar: 57530
TCGA: ENSG00000143375
COSMIC: CGN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143375ENST00000271636Q9P2M7
ENSG00000143375ENST00000416743H0Y4A8
ENSG00000143375ENST00000427934A6PVU7
ENSG00000143375ENST00000502442A2A3M4
ENSG00000143375ENST00000505188A2A3M4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)REACTOMER-HSA-2173791

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
200861752010Smad signaling is required to maintain epigenetic silencing during breast cancer progression.74
248079072014MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly.23
222455832012Identification of new interacting partners of the shuttling protein ubinuclein (Ubn-1).9
268219492016Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo.9
110420842000Human and Xenopus cingulin share a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assembly.8
275903422016Role of Cingulin in Agonist-induced Vascular Endothelial Permeability.2

Citation

Dessen P

CGN (cingulin)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52896/cgn