CGNL1 (cingulin like 1)

2014-11-01  

Identity

HGNC
LOCATION
15q21.3
LOCUSID
ALIAS
JACOP,PCING
FUSION GENES

Other Information

Locus ID:

NCBI: 84952
MIM: 607856
HGNC: 25931
Ensembl: ENSG00000128849

Variants:

dbSNP: 84952
ClinVar: 84952
TCGA: ENSG00000128849
COSMIC: CGNL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128849ENST00000281282Q0VF96

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
186534652008Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions.38
241632462014CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1.30
152921972004JACOP, a novel plaque protein localizing at the apical junctional complex with sequence similarity to cingulin.28
214544772011A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells.23
248079072014MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly.23
290168732017Cgnl1, an endothelial junction complex protein, regulates GTPase mediated angiogenesis.5

Citation

Dessen P

CGNL1 (cingulin like 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61782/cgnl1