CH25H (cholesterol 25-hydroxylase)

2021-06-01  

Identity

HGNC
LOCATION
10q23.31
LOCUSID
ALIAS
C25H

Other Information

Locus ID:

NCBI: 9023
MIM: 604551
HGNC: 1907
Ensembl: ENSG00000138135

Variants:

dbSNP: 9023
ClinVar: 9023
TCGA: ENSG00000138135
COSMIC: CH25H

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138135ENST00000371852O95992

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Primary bile acid biosynthesisKEGGko00120
Primary bile acid biosynthesisKEGGhsa00120
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Bile acid and bile salt metabolismREACTOMER-HSA-194068
Synthesis of bile acids and bile saltsREACTOMER-HSA-192105

References

Pubmed IDYearTitleCitations
205347412010Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.108
206993622010Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons.75
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
205354862010Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease.32
204138502010Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study.29
205745322010Intermediate phenotypes identify divergent pathways to Alzheimer's disease.24
259990472015Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation.24
259033452015Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection.23
169090032005Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease.21
188307242009Assessment of Alzheimer's disease case-control associations using family-based methods.21

Citation

Dessen P

CH25H (cholesterol 25-hydroxylase)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58304/ch25h