CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1)

2012-03-01  

Identity

HGNC
LOCATION
15q15.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 79094
MIM: 614587
HGNC: 28680
Ensembl: ENSG00000128965

Variants:

dbSNP: 79094
ClinVar: 79094
TCGA: ENSG00000128965
COSMIC: CHAC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128965ENST00000444189Q9BUX1
ENSG00000128965ENST00000487220H0YK90
ENSG00000128965ENST00000617768Q9BUX1

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Glutathione synthesis and recyclingREACTOMER-HSA-174403

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
259311272015Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element.37
233422792012Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1.31
221085172012Elevated mRNA expression of CHAC1 splicing variants is associated with poor outcome for breast and ovarian cancer patients.19
247679952014Botch is a γ-glutamyl cyclotransferase that deglycinates and antagonizes Notch.13
279865952017The CHAC1-inhibited Notch3 pathway is involved in temozolomide-induced glioma cytotoxicity.7
290545452017CHAC2 is essential for self-renewal and glutathione maintenance in human embryonic stem cells.6
305554872018CHAC1 Is Differentially Expressed in Normal and Cystic Fibrosis Bronchial Epithelial Cells and Regulates the Inflammatory Response Induced by Pseudomonas aeruginosa.1
311115702019CHAC1 overexpression in human gastric parietal cells with Helicobacter pylori infection in the secretory canaliculi.1

Citation

Dessen P

CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52619/chac1