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CHAC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1)

Identity

Alias_namesChaC
Alias_symbol (synonym)MGC4504
Other alias-
HGNC (Hugo) CHAC1
LocusID (NCBI) 79094
Atlas_Id 52619
Location 15q15.1  [Link to chromosome band 15q15]
Location_base_pair Starts at 40953149 and ends at 40956519 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CHAC1 (15q15.1) / C16orf72 (16p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CHAC1   28680
Cards
Entrez_Gene (NCBI)CHAC1  79094  ChaC glutathione specific gamma-glutamylcyclotransferase 1
Aliases
GeneCards (Weizmann)CHAC1
Ensembl hg19 (Hinxton)ENSG00000128965 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000128965 [Gene_View]  chr15:40953149-40956519 [Contig_View]  CHAC1 [Vega]
ICGC DataPortalENSG00000128965
TCGA cBioPortalCHAC1
AceView (NCBI)CHAC1
Genatlas (Paris)CHAC1
WikiGenes79094
SOURCE (Princeton)CHAC1
Genetics Home Reference (NIH)CHAC1
Genomic and cartography
GoldenPath hg38 (UCSC)CHAC1  -     chr15:40953149-40956519 +  15q15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CHAC1  -     15q15.1   [Description]    (hg19-Feb_2009)
EnsemblCHAC1 - 15q15.1 [CytoView hg19]  CHAC1 - 15q15.1 [CytoView hg38]
Mapping of homologs : NCBICHAC1 [Mapview hg19]  CHAC1 [Mapview hg38]
OMIM614587   
Gene and transcription
Genbank (Entrez)AY702027 BC001683 BC001847 BC019625 BM665296
RefSeq transcript (Entrez)NM_001142776 NM_024111
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CHAC1
Cluster EST : UnigeneHs.155569 [ NCBI ]
CGAP (NCI)Hs.155569
Alternative Splicing GalleryENSG00000128965
Gene ExpressionCHAC1 [ NCBI-GEO ]   CHAC1 [ EBI - ARRAY_EXPRESS ]   CHAC1 [ SEEK ]   CHAC1 [ MEM ]
Gene Expression Viewer (FireBrowse)CHAC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79094
GTEX Portal (Tissue expression)CHAC1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BUX1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BUX1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BUX1
Splice isoforms : SwissVarQ9BUX1
PhosPhoSitePlusQ9BUX1
Domains : Interpro (EBI)ChaC    GGCT-like   
Domain families : Pfam (Sanger)ChaC (PF04752)   
Domain families : Pfam (NCBI)pfam04752   
Conserved Domain (NCBI)CHAC1
DMDM Disease mutations79094
Blocks (Seattle)CHAC1
SuperfamilyQ9BUX1
Human Protein AtlasENSG00000128965
Peptide AtlasQ9BUX1
HPRD14634
IPIIPI00012214   IPI00784879   
Protein Interaction databases
DIP (DOE-UCLA)Q9BUX1
IntAct (EBI)Q9BUX1
FunCoupENSG00000128965
BioGRIDCHAC1
STRING (EMBL)CHAC1
ZODIACCHAC1
Ontologies - Pathways
QuickGOQ9BUX1
Ontology : AmiGOgamma-glutamylcyclotransferase activity  gamma-glutamylcyclotransferase activity  Notch binding  protein binding  trans-Golgi network  cytosol  cytosol  glutathione biosynthetic process  glutathione catabolic process  response to unfolded protein  Notch signaling pathway  negative regulation of protein processing  neurogenesis  negative regulation of Notch signaling pathway  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  
Ontology : EGO-EBIgamma-glutamylcyclotransferase activity  gamma-glutamylcyclotransferase activity  Notch binding  protein binding  trans-Golgi network  cytosol  cytosol  glutathione biosynthetic process  glutathione catabolic process  response to unfolded protein  Notch signaling pathway  negative regulation of protein processing  neurogenesis  negative regulation of Notch signaling pathway  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  
NDEx NetworkCHAC1
Atlas of Cancer Signalling NetworkCHAC1
Wikipedia pathwaysCHAC1
Orthology - Evolution
OrthoDB79094
GeneTree (enSembl)ENSG00000128965
Phylogenetic Trees/Animal Genes : TreeFamCHAC1
HOVERGENQ9BUX1
HOGENOMQ9BUX1
Homologs : HomoloGeneCHAC1
Homology/Alignments : Family Browser (UCSC)CHAC1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCHAC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CHAC1
dbVarCHAC1
ClinVarCHAC1
1000_GenomesCHAC1 
Exome Variant ServerCHAC1
ExAC (Exome Aggregation Consortium)CHAC1 (select the gene name)
Genetic variants : HAPMAP79094
Genomic Variants (DGV)CHAC1 [DGVbeta]
DECIPHERCHAC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCHAC1 
Mutations
ICGC Data PortalCHAC1 
TCGA Data PortalCHAC1 
Broad Tumor PortalCHAC1
OASIS PortalCHAC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCHAC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCHAC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CHAC1
DgiDB (Drug Gene Interaction Database)CHAC1
DoCM (Curated mutations)CHAC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CHAC1 (select a term)
intoGenCHAC1
Cancer3DCHAC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614587   
Orphanet
MedgenCHAC1
Genetic Testing Registry CHAC1
NextProtQ9BUX1 [Medical]
TSGene79094
GENETestsCHAC1
Target ValidationCHAC1
Huge Navigator CHAC1 [HugePedia]
snp3D : Map Gene to Disease79094
BioCentury BCIQCHAC1
ClinGenCHAC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79094
Chemical/Pharm GKB GenePA142672119
Clinical trialCHAC1
Miscellaneous
canSAR (ICR)CHAC1 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCHAC1
EVEXCHAC1
GoPubMedCHAC1
iHOPCHAC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 16:57:44 CEST 2017

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