CHD1L (chromodomain helicase DNA binding protein 1 like)

2005-11-01  

Identity

HGNC
LOCATION
1q21.1
LOCUSID
ALIAS
ALC1,CHDL
FUSION GENES

Other Information

Locus ID:

NCBI: 9557
MIM: 613039
HGNC: 1916
Ensembl: ENSG00000131778

Variants:

dbSNP: 9557
ClinVar: 9557
TCGA: ENSG00000131778
COSMIC: CHD1L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131778ENST00000361293A0A0A0MRH8
ENSG00000131778ENST00000369258Q86WJ1
ENSG00000131778ENST00000369259Q86WJ1
ENSG00000131778ENST00000431239A0A0A0MSH9
ENSG00000131778ENST00000467213A0A087WTM4
ENSG00000131778ENST00000488864A0A087WZM7
ENSG00000131778ENST00000622533A0A087WWW4
ENSG00000131778ENST00000639534A0A1W2PP16
ENSG00000131778ENST00000650714A0A494C1P7
ENSG00000131778ENST00000650721A0A494C0J6
ENSG00000131778ENST00000650828A0A494C1F3
ENSG00000131778ENST00000651070A0A494C0J6
ENSG00000131778ENST00000651206A0A494C0F0
ENSG00000131778ENST00000651207A0A494C1H1
ENSG00000131778ENST00000651226A0A494C0B8
ENSG00000131778ENST00000651231A0A494C1F7
ENSG00000131778ENST00000651407A0A494C0J6
ENSG00000131778ENST00000651410A0A494C111
ENSG00000131778ENST00000651420A0A494C1S1
ENSG00000131778ENST00000651510A0A494C1I3
ENSG00000131778ENST00000651820A0A494C0M4
ENSG00000131778ENST00000652161A0A494C1S1
ENSG00000131778ENST00000652188A0A494C0Q0
ENSG00000131778ENST00000652278A0A494C1I3
ENSG00000131778ENST00000652346A0A087WZM7
ENSG00000131778ENST00000652357A0A494C1H1
ENSG00000131778ENST00000652486A0A494C1H0
ENSG00000131778ENST00000652494A0A494C1I3
ENSG00000131778ENST00000652587A0A494C179
ENSG00000131778ENST00000652616A0A494C1H1

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395
Dual Incision in GG-NERREACTOMER-HSA-5696400

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
196613792009Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.235
196664852009Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler.152
196664852009Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler.152
230455482012PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1.76
180230262008Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma.53
203356582010CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients.52
219535522012Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development.31
204530002010A Large-scale genetic association study of esophageal adenocarcinoma risk.23
231328532012Activation of the SNF2 family ATPase ALC1 by poly(ADP-ribose) in a stable ALC1·PARP1·nucleosome intermediate.22
239261042013Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein.21

Citation

Dessen P

CHD1L (chromodomain helicase DNA binding protein 1 like)

Atlas Genet Cytogenet Oncol Haematol. 2005-11-01

Online version: http://atlasgeneticsoncology.org/gene/43051/chd1l